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T39502 |
Lipid 5
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Others
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Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity. |
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T4313 |
Tinoridine hydrochloride
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Nonflamin,Y-3642 hydrochloride |
COX
,
Glutathione Peroxidase
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Tinoridine hydrochloride (Y-3642 hydrochloride) is a non-steroidal anti-inflammatory drug. Tinoridine hydrochloride (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxid... |
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T14775 |
Bragsin2
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6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one,Bragsin 2 |
Others
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Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase acti... |
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T35689 |
MTP 131 acetate
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Others
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MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T73742 |
98N12-5
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Others
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98N12-5, a novel multi-tail ionizable lipid, demonstrates efficient in vivo siRNA delivery to the liver. |
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T68684 |
Piritrexim isethionate
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Others
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Piritrexim isethionate is a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that appears to be an active agent in patients with metastatic urothelial cancer when administered as a 5-day, low-dose oral schedule. |
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T40753 |
Cytidine-5'-triphosphate
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Cytidine triphosphate,Cytidine-5'-triphosphate,5'-CTP |
Others
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Cytidine 5'-triphosphate (5'-CTP), also known as cytidine triphosphate, is a nucleoside triphosphate that plays a crucial role as a building block for nucleotides and nucleic acids, as well as lipid biosynthesis. It is s... |
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T35646 |
4-oxo-2-Nonenal
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4-oxo-2-Nonenal,4-ONE |
Others
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4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid and linoleic acid. [1] [2] It exhibits various biological activities such as cytotoxicity, ... |
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T36169 |
15-LOX-1 inhibitor 1
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Others
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9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1; IC50 = 0.19 μM).1 It decreases LPS- and IFN-γ-induced NF- B activity in RAW-Blue cells when used at concentrations of 0.2, 1, and 5 μM. 9c(i472) reduces LPS- and I... |
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T74716 |
Curcumin 5-8
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Others
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Curcumin 5-8 (CUR5-8), a naturally active analog of curcumin (CUR), exhibits potent oral activity. It effectively inhibits lipid droplet formation, enhances autophagy, and reduces apoptosis. Additionally, Curcumin 5-8 ha... |
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TP1970 |
Prosaptide TX14(A)
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Potent GPR37L1 and GPR37 agonist (EC50 values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes m... |
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T37649 |
5(S),12(S)-DiHETE
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Others
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5(S),12(S)-DiHETE is a natural bioactive lipid derived from arachidonic acid . It is synthesized by glycogen-induced rabbit peritoneal polymorphonuclear leukocytes (PMNLs) incubated with AA. 5(S),12(S)-DiHETE can be prod... |
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T36003 |
1(R)-(Trifluoromethyl)oleyl alcohol
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Others
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1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder c... |
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T36175 |
AAPH
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Others
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AAPH is a water-soluble azo compound which is used extensively as a free radical generator, often in the study of lipid peroxidation and the characterization of antioxidants.[1],[2],[3],[4] Decomposition of AAPH produces... |
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T82228 |
HD5
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HD5, a naturally occurring lectin-like peptide from human defensins-5, is secreted by Paneth cells in the crypts of Lieberkühn and has the capability to bind with glycosylated proteins and lipid components. |
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T34707 |
SST-02
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SST 02,SST02 |
Others
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SST-02 is a potent cationic lipid for siRNA-Lipid Nanoparticles. SST-02 possesses a simple chemical structure and is synthesized just in one step. SST-02 showed an ID50 of 0.02 mg/kg in the factor VII (FVII) model. Rats ... |
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T36322 |
C8 D-threo Ceramide (d18:1/8:0)
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C8 D-threo Ceramide (d18:1/8:0) |
Others
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C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently th... |
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T38196 |
Prostaglandin F2α isopropyl ester
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Prostaglandin F2α isopropyl ester |
Others
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PGF2α isopropyl ester is an ester prodrug of PGF2α with enhanced lipid solubility. Due to better membrane penetration, PGF2α isopropyl ester is more suitable than PGF2α or PGF2α tromethamine salt for topical application ... |
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T37169 |
Resolvin D2 methyl ester
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Others
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Resolvin D2 (RvD2) is a lipid mediator biosynthesized by the sequential oxygenation of docosahexaenoic acid by 15- and 5-lipoxygenase. It evokes diverse anti-inflammatory effects which may mediate the resolution of infla... |
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T63345 |
Lp-PLA2-IN-5
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Others
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Lp-PLA2-IN-5 is a potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor. Lp-PLA2-IN-5 has the potential to be studied in diseases associated with Lp-PLA2 activity, such as Alzheimer's disease, atherosclerosi... |
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T36324 |
C8 L-threo Ceramide (d18:1/8:0)
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C8 L-threo Ceramide (d18:1/8:0) |
Others
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C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5... |
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T36160 |
8-iso Prostaglandin E2
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8-iso Prostaglandin E2 |
Others
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8-iso PGE2 is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. It is a potent renal vasoconstrictor in the rat. 8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with ... |
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T36545 |
Prostaglandin D2 methyl ester
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Prostaglandin D2 methyl ester |
Others
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Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten... |
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T36889 |
Methyl alpha-eleostearate
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Others
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Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about... |
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T38341 |
11(Z),14(Z)-Eicosadienoic Acid methyl ester
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Others
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11(Z),14(Z)-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid , a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inos... |
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T84424 |
5-SAHSA
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Others
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15-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), is recognized for its involvement in metabolic regulation. This compound comprises stearic acid esterified to 5-hydroxy stearic acid and is notably i... |
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T38296 |
Alamethicin F50
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Alamethicin F50 |
Others
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Alamethicin F50 is a peptaibol isolated from Trichoderma. It is a polymer of 20 amino acids that includes modified and non-proteinogenic amino acids. Alamethicin F50 is a mixture of 13 different peptides, with the most a... |
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T36888 |
9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester
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Others
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9(Z),11(E),13(E)-Octadecatrienoic Acid ethyl ester (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter... |
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T83888 |
(S)-5-hydroxy-6-methoxy Duloxetine maleate
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Others
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(S)-5-hydroxy-6-methoxy Duloxetine, an active metabolite of the (S)-duloxetine, functions as a serotonin (5-HT) and norepinephrine reuptake inhibitor. Its formation occurs through the cytochrome P450 (CYP) isoforms CYP1A... |
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T35994 |
Erastin2
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Erastin2 |
Others
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Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter.[1] [2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM).[2] It induces cell death in HAP1 cells... |
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T74461 |
Chalcones A-N-5
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Others
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Chalcones A-N-5, a trihydroxy chalcone derivative, exhibits no cytotoxicity at concentrations below 100 µM (with IC 50 > 1 mM) and notably enhances cell proliferation. It is particularly effective in encouraging neuronal... |
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T38336 |
W140 (trifluoroacetate salt)
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W140 (trifluoroacetate salt) |
Others
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Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its ac... |
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T36424 |
DSPE-PEG(2000)-amine (sodium salt)
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Others
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DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3D... |
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T36218 |
19R(20S)-EpDPA
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Others
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19R(20S)-EpDPA is an oxylipin and a metabolite of docosahexaenoic acid .1,2It is formed from DHA by various cytochrome P450 (CYP) isoforms in a stereoselective manner.219R(20S)-EpDPA (30 nM) prevents calcium-induced incr... |
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T36605 |
(±)5-iPF2α-VI
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(±)5-iPF2α-VI |
Others
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Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can... |
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T37394 |
13(S)-HpOTrE
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Others
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13(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced in soybeans by the action of soybean LO-2 on esterified α-linolenic acid.[1] Incubation of soybean seedling biomembranes with soybean LO-2 catalyzes t... |
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T36698 |
9(Z),11(E),13(E)-Octadecatrienoic Acid
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Others
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9(Z),11(E),13(E)-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed ... |
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T37606 |
Resolvin D5
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7(S),17(S)-diHDHA |
Others
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Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid . [1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory respons... |
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T37265 |
15(R)-Lipoxin A4
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15(R)-Lipoxin A4,AT-Lipoxin A4 |
Others
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Lipid-derived lipoxins are produced at the site of vascular and mucosal inflammation where they down-regulate polymorphonuclear leukocyte recruitment and function. 15(R)-Lipoxin A4 (15(R)-LXA4) is derived from the aspiri... |
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T79446 |
INF200
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NOD-like Receptor (NLR)
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INF200 (compound 5), a sulfonylurea-based inhibitor of NLRP3 and associated pyroptosis, exhibits cardiometabolic benefits in a rat model of high-fat diet (HFD)-induced metaflammation and demonstrates anti-inflammatory ef... |
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T36176 |
AMK (hydrochloride)
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Others
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AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitro... |
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T35946 |
17(R)-Resolvin D1
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Aspirin-triggered Resolvin D1,17(R)-Resolvin D1 |
Others
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Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response ... |
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T35881 |
Resolvin E2
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Others
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Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-... |
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T35504 |
(±)10-HDHA
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Others
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(±)10-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.[1][2] It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.[3][4][5] (±)10-HDHA is a potential marker of... |
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T37178 |
Norhyodeoxycholic Acid
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Others
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Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid .1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as... |
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T35445 |
1-Stearoyl-3-Oleoyl-rac-glycerol
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Others
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1-Stearoyl-3-oleoyl-rac-glycerol is a diacylglycerol that contains stearic acid at the sn-1 position and oleic acid at the sn-3 position. Intermittent fasting decreases skeletal muscle and hepatic levels of 1-stearoyl-3-... |
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T37582 |
Ganglioside GM1 Mixture (ovine) (ammonium salt)
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Others
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Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched i... |
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T36668 |
Geranylgeranoic Acid
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Others
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Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not... |
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T36132 |
3β-OH-7-Oxocholenic Acid
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Others
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3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C.... |
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T37971 |
12-oxo-13-HOME
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Others
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12-oxo-13-HOME is an oxylipin derived from linoleic acid .1It is formedviaa 13-HpODE intermediate that is produced by lipoxygenase-mediated metabolism of linoleic acid.2,3,112-oxo-13-HOME has been found in corn and sunfl... |
