|
T6196 |
PP1
|
EI 275,AGL 1872 |
Apoptosis
,
EGFR
,
Bcr-Abl
,
Src
,
c-Kit
|
|
PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively. |
|
T2153 |
1-NM-PP1
|
PP1 Analog II,1 nM-PP1 |
Serine/threonin kinase
,
CDK
,
Src
|
|
1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. |
|
T3935 |
1-Naphthyl PP1
|
1-NA-PP 1 |
Src
|
|
1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively) |
|
T21678 |
3MB-PP1
|
|
PLK
|
|
3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 alleles, 3MB-PP1 blocks mitotic progression and cell division arise by targeting Plk1. 3MB-PP1 specifi... |
|
T7371 |
1-Naphthyl PP1 hydrochloride
|
1-NA-PP 1 hydrochloride |
Src
|
|
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases v-Src |
|
T41113 |
3BrB-PP1
|
3BrB-PP1 |
|
|
3BrB-PP1 is an ATP-competitive analog that exhibits specific inhibitory activity towards protein kinase. It is effective in inhibiting protein kinase with mutations in the ATP-binding pocket, specifically the mutation of... |
|
T60718 |
3-IN-PP1
|
|
|
|
3-IN-PP1, a potent protein kinase D (PKD) inhibitor, exhibits pan-PKD inhibitory activity with IC50 values of 108 nM for PKD1, 94 nM for PKD2, and 108 nM for PKD3. Additionally, it serves as a broad-spectrum anticancer a... |
|
T14022 |
2OH-BNPP1
|
|
Others
|
|
2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer. |
|
T2415 |
PP121
|
|
Apoptosis
,
VEGFR
,
Bcr-Abl
,
PDGFR
,
Src
,
mTOR
,
Hck
|
|
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM). |
|
T28818 |
SMAPP1
|
|
|
|
SMAPP1 is an activator of protein phosphatase 1 (PP1). SMAPP1 induces PP1 activity in vitro and activates latent HIV-1 provirus in cultured and primary T cells. |
|
T80288 |
PP13
|
|
|
|
PP13 is an antimicrobial peptide with efficacy against both Gram-negative and Gram-positive bacteria, displaying minimum inhibitory concentrations (MIC) of 16.7 µM for E. coli, 13.3 µM for B. subtilis, 23.3 µM for S. aur... |
|
T69560 |
ENPP1 inhibitor 43
|
|
|
|
ENPP1 inhibitor 43 is a novel small molecule for cancer immunotherapy. |
|
T75913 |
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA
|
|
|
|
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent, selective neuropeptide Y Y5 receptor agonist, demonstrating binding affinity with an IC50 of 0.24 nM for the hY5 receptor. This compound significan... |
|
T37431 |
ENPP1 Inhibitor C
|
ENPP1 Inhibitor C |
|
|
ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 ac... |
|
T61782 |
NPP1-IN-1
|
|
|
|
NPP1-IN-1 is a highly potent inhibitor of NPP enzymes, effectively inhibiting NPP1 with an IC 50 value of 0.15 μM and NPP3 with an IC 50 value of 40 μM [1]. |
|
T80290 |
PP102
|
|
|
|
PP102, an antimicrobial peptide, exhibits activity against gram-positive bacteria, including B. subtilis (MIC: 25 µM), S. aureus (MIC: 13.3 µM), S. lutea (MIC: 63 µM), and B. pumilus (MIC: 23 µM) [1]. |
|
TP1963 |
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
|
cpp1-7-npy19-23-ala31-aib32-gln34-hpancreatic-polypeptide,[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide |
|
|
Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM)... |
|
T80291 |
PP113
|
|
|
|
PP113 is an antimicrobial peptide with activity against both Gram-negative and Gram-positive bacteria, exhibiting minimum inhibitory concentrations (MICs) of 73.3 µM for E. coli, 23.3 µM for B. subtilis, 13 µM for S. aur... |
|
T3045 |
Salubrinal
|
|
Apoptosis
,
Phosphatase
,
PERK
,
Autophagy
,
HSV
|
|
Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α). |
|
T32108 |
HXJ42
|
HXJ-42,HXJ 42 |
Others
|
|
HXJ42 is a PP1 analog that selectively and effectively acts on wild-type ZAP-70 (AS). |
|
T2747 |
Endothall
|
|
Others
|
|
Endothall is an effective protein phosphatase 2A (PP2A) inhibitor, exerting inhibitory effects on both PP2A and PP1, with IC50 values of 90 nM and 5 µM, respectively. It exhibits anticancer activity, making it suitable f... |
|
T14859 |
Calyculin A
|
(-)-Calyculin A |
Others
|
|
Calyculin A is a potent and cell-permeable inhibitor of protein phosphatase 1 (PP1; IC50s: 2 nM). It also is a protein phosphatase 2A (PP2A) inhibitor (IC50s: 0.5-1 nM). |
|
T13095 |
Tautomycin
|
|
Others
|
|
Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticill... |
|
T68749 |
EBOV-IN-C31
|
|
|
|
EBOV-IN-C31 is a novel PP1-targeting Ebola Virus (EBOV) inhibitor with improved pharmacological properties. |
|
T70441 |
1E7-03
|
|
|
|
1E7-03 is an inhibitor of HIV-1 transcription, by targeting host Protein Phosphatase-1 (PP1). |
|
TP1698 |
Microcystin-LA
|
|
|
|
Microcystin LA, a natural toxin, exerts its cytotoxic exects by inhibiting the serine-threonine protein phosphatases PP1 and PP2A with IC50s of 0.3 and 0.3 nM, respectively. |
|
T68721 |
Cantharidin imide
|
|
|
|
Cantharidin imide is a PP1/2A inhibitor found in Canarthis vesicatoria. It inhibits proliferation of colorectal cancer cells, increases MCP-1, IL-6, and IL-β levels, and inhibits differentiation and resorptive activity o... |
|
TP2054 |
Calcineurin Autoinhibitory Peptide
|
|
|
|
Selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 μM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM). |
|
T39183 |
Okadaic acid ammonium salt
|
|
|
|
Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50... |
|
T68458 |
Fostriecin (free base)
|
|
|
|
Fostriecin (free base) is an inhibitor of the serine/threonine protein phosphatases 2A (PP2A) and 4 (PP4) (IC50s = 3.2 and 3 nM, respectively). It less effectively inhibits topoisomerase II and PP1 (IC50s = 40 and 131 μM... |
|
T35613 |
Cytostatin (sodium salt)
|
|
|
|
Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectivel... |
|
T35777 |
Nodularin
|
|
|
|
The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatot... |
