|
T7695 |
PNU-282987 S enantiomer free base
|
|
AChR
|
|
PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR). |
|
T7058 |
Selisistat S-enantiomer
|
EX-527 S-enantiomer,EX-527 (S-enantiomer) |
Sirtuin
|
|
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3. |
|
T10819 |
Cipropride S enantiomer
|
|
Others
|
|
Cipropride S enantiomer is the S enantiomer of cipropride which is an antiemetic drug. |
|
T17102 |
Tipifarnib (S enantiomer)
|
Tipifarnib S enantiomer,(S)-(-)-R-115777,(S)-Tipifarnib,IND-58359 S enantiomer |
Transferase
|
|
Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM). |
|
T80678 |
(S)-AK-242
|
(-)-Resatorvid,(S)-Resatorvid,AK-242 (S enantiomer),(-)-AK-242 |
Others
|
|
(S)-AK-242 ((S)-Resatorvid) is a cytokine inhibitor used in the treatment of heart disease, autoimmune disease, and inflammatory disease. |
|
T6156 |
Ruxolitinib (S enantiomer)
|
S-Ruxolitinib,Ruxolitinib S enantiomer,INCB018424,INCB18424 |
Tyrosine Kinases
,
JAK
|
|
Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor. |
|
T11391 |
Gepotidacin S enantiomer
|
GSK2140944 S enantiomer |
Others
|
|
Gepotidacin S enantiomer is an S enantionmer of gepotidacin. |
|
T11173 |
Elacestrant S enantiomer
|
RAD1901 S enantiomer |
Others
|
|
Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. |
|
T11335 |
Fulvestrant (S enantiomer)
|
ZM 182780 S enantiomer,ICI 182780 S enantiomer,Fulvestrant S enantiomer,ZD 9238 S enantiomer |
Others
|
|
Fulvestrant S enantiomer is the less active S enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. |
|
T10465 |
Atuveciclib S-Enantiomer
|
BAY-1143572 S-Enantiomer |
CDK
|
|
Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM. |
|
T12200 |
Firsocostat S enantiomer
|
ND-630 S enantiomer,NDI-010976 S enantiomer,GS-0976 S enantiomer |
Others
|
|
Firsocostat S enantiomer is the less active S enantiomer of Firsocostat. |
|
T11156 |
Nazartinib S-enantiomer
|
EGF816 (S-enantiomer) |
Others
|
|
Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib. |
|
T22401 |
PNU-282987 S enantiomer hydrochloride
|
(S)-PNU-282987 HCl |
Others
|
|
(S)-PNU-282987 is the absolute stereochemistry form of PNU-282987. PNU 282987, a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs) with Ki of 26 nM for the rat receptor, has negligible a... |
|
T11628 |
IACS-8968 S-enantiomer
|
IDO/TDO Inhibitor (S-enantiomer) |
IDO
|
|
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO). |
|
T11173L |
Elacestrant S enantiomer dihydrochloride
|
RAD1901 S enantiomer dihydrochloride,RAD-1901 S enantiomer dihydrochloride,RAD 1901 S enantiomer dihydrochloride |
Others
|
|
Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant S enantiomer dihydrochloride is an l... |
|
T12203 |
Necrostatin 2 S enantiomer
|
|
Others
|
|
Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2 |
|
T12067 |
MK-7246 S enantiomer
|
|
Others
|
|
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist. |
|
T11378 |
GDC-0834 S-enantiomer
|
|
Others
|
|
GDC-0834, the S-enantiomer, is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK). |
|
T11902 |
LY 344864 S-enantiomer
|
|
Others
|
|
LY 344864 S-enantiomer, the S-enantiomer of LY344864, serves as a 5-HT1F receptor agonist. |
|
T9848 |
GSK2850163 (S enantiomer)
|
|
IRE1
|
|
GSK2850163 (S enantiomer) is the inactive enantiomer of GSK2850163. GSK2850163 is an novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1a). |
|
T13294 |
Veledimex (S enantiomer)
|
RG-115932 S enantiome,INXN-1001 S enantiome |
Others
|
|
Veledimex S enantiomer is the S enantiomer of veledimex. Veledimex is an oral activator ligand for a proprietary gene therapy promoter system and CYP3A4/5 inhibitor. |
|
T10517 |
BET-BAY 002 (S enantiomer)
|
|
Others
|
|
The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins). |
|
T10297 |
AMG 487 (S-enantiomer)
|
|
Others
|
|
AMG 487 S-enantiomer is the S enantiomer of AMG 487. AMG 487 is an CXCR3 antagonist. |
|
T75251 |
Firsocostat (S enantiomer)
|
|
|
|
Firsocostat S enantiomer (ND-630 S enantiomer) is the less active S enantiomer of Firsocostat. Firsocostat is an acetyl-CoA carboxylase ( ACC ) inhibitor. |
|
T0448 |
(S)-(+)-Ibuprofen
|
Dexibuprofen,(S)-Ibuprofen |
BCL
,
Thrombin
,
Cysteine Protease
,
COX
,
PPAR
|
|
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX). |
|
T6493 |
Escitalopram Oxalate
|
Cipralex,(S)-(+)Citalopram oxalate |
Others
,
5-HT Receptor
,
Serotonin Transporter
|
|
Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. |
|
T11662 |
INT-777 R-enantiomer
|
S-EMCA R enantiomer |
Others
|
|
INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5. |
|
T13869 |
Ribocil B
|
Ribocil S enantiomer,ent-Ribocil A |
Others
|
|
Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN,KD of 6.6 nM). |
|
T10252L |
ADU-S100 enantiomer ammonium salt
|
MIW815 enantiomer ammonium salt,ML RR-S2 CDA enantiomer ammonium salt |
Others
|
|
ADU-S100 (MIW815) enantiomer ammonium salt is the less active enantiomer of ADU-S100. ADU-S100 is an activator of the stimulator of interferon genes (STING). |
|
T12632L |
(S)-Mirtazapine
|
(S)-6-Azamianserin,(S)-Org3770 |
5-HT Receptor
|
|
(S)-Mirtazapine ((S)-Org3770) is the S(+)-enantiomer of Mirtazapine. (S)-Mirtazapine is a selective 5-HT2 receptor antagonist with pro-nociceptive effects and is often used in combination with the R(-)-enantiomer of Mirt... |
|
T39979 |
(S)-ErSO
|
|
Others
|
|
(S)-ErSO is an inactive dextrorotatory enantiomer of ErSO. |
|
T12809 |
(S)-PF-06873600
|
|
CDK
|
|
(S)-PF-06873600 is the S enantiomer of PF-06873600 which is an inhibitor of CDK. |
|
T22359 |
MDL 100009
|
|
5-HT Receptor
|
|
MDL 100009, the S-enantiomer of MDL 100151 and the opposite enantiomer of MDL 100907, is a selective antagonist of 5-HT2A. |
|
T12814 |
(S)-Tenofovir
|
(S)-PMPA,(S)-GS 1278,(S)-TDF |
Others
|
|
(S)-Tenofovir ((S)-PMPA) is the less active S-enantiomer of Tenofovir which is a nucleotide reverse transcriptase inhibitor. |
|
T10012 |
P7C3-OMe
|
|
Others
|
|
P7C3-OMe, a pro-neurogenic agent, has therapeutic benefits in neurodegenerative diseases. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer. |
|
T6566 |
Levobupivacaine hydrochloride
|
Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride |
Sodium Channel
|
|
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic... |
|
T22148 |
(S)-Lisofylline
|
|
Others
|
|
(S)-Lisofylline is the inactive optical enantiomer of (R)-lisofylline which is an anti-inflammatory agent. (S)-Lisofylline is exclusively converted to pentoxifylline in human liver microsomes. |
|
T6038 |
(-)-Blebbistatin
|
(S)-(-)-Blebbistatin |
ATPase
,
Myosin
|
|
(-)-Blebbistatin ((S)-(-)-Blebbistatin) is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM. |
|
T1211 |
Levosulpiride
|
RV-12309,S-(-)-Sulpiride |
Dopamine Receptor
|
|
Levosulpiride (S-(-)-Sulpiride) is the (S)-enantiomer of sulpiride, which is a D2 receptor antagonist, an atypical antipsychotic drug of the benzamide class. |
|
T10003 |
α1 adrenoceptor-MO-1
|
|
Others
|
|
α1 adrenoceptor-MO-1 (S enantiomer) has affinity at alpha 1 adrenergic receptor with alphalytic activity and analgesic action. It has more active than R enantiomer. |
|
T22354 |
Levocetirizine Dihydrochloride
|
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor
|
|
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydro... |
|
T6357 |
(S)-crizotinib
|
ent-crizotinib |
Apoptosis
,
DNA/RNA Synthesis
,
MTH1
|
|
(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib. |
|
T9828 |
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide
|
|
PAD
|
|
N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide is a racemic form of Cl-amidine (S enantiomer). Cl-amidine is an orally active peptidylarginine deminase (PAD) inhibitor. |
|
T4295 |
(R)-GNE-140
|
GNE-140 |
Dehydrogenase
|
|
(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer. |
|
T6649 |
(S)-(+)-Rolipram
|
(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram |
Apoptosis
,
PDE
|
|
(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
|
T1545 |
Levamlodipine
|
(S)-Amlodipine,S-amlodipine |
Calcium Channel
|
|
Levamlodipine (S-amlodipine) belongs to the dihydropyridine group of calcium channel blockers. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and an... |
|
T20828 |
Citalopram
|
Cipram,Lu 10-171,Lu-10-171 Lu10-171 |
5-HT Receptor
|
|
Citalopram (Lu 10-171 is an orally active, selective serotonin reuptake inhibitor (SSRI), a selective 5-hydroxytryptamine reuptake inhibitor, and a racemic mixture of the S(+)-enantiomer (Escitalopram) and the R(-)-enant... |
|
T4284 |
Levamlodipine besylate
|
(S)-Amlodipine Besylate (103129-82-4(free base)) |
Calcium Channel
|
|
Levamlodipine besylate ((S)-Amlodipine Besylate (103129-82-4(free base))) , also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and anti-anginal medication. Levamlodipi... |
|
T1787 |
Levobupivacaine
|
|
Sodium Channel
|
|
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ... |
|
T12817 |
(S)-TXNIP-IN-1
|
|
Others
|
|
(S)-TXNIP-IN-1 is the S-enantiomer of TXNIP-IN-1. |
