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T0839 |
Ketoprofen
|
RP-19583 |
Apoptosis
,
COX
,
MRP
|
|
Ketoprofen (RP-19583) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenas... |
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T1634 |
Glibenclamide
|
Glyburide |
Potassium Channel
,
Mitochondrial Metabolism
,
CFTR
,
P-gp
,
Autophagy
|
|
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide. |
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T77621 |
Z16078526
|
|
p38 MAPK
,
Mitochondrial Metabolism
|
|
Z16078526 enhances thermogenesis in mice by inducing endogenous Ucp1 expression, promoting p38 MAPK phosphorylation, and stimulating lipolysis in primary mouse brown adipocytes. Additionally, it activates thermogenic gen... |
|
T3433 |
TUG-891
|
TUG 891,TUG891 |
GPR
|
|
TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. |
|
T8997 |
WWL229
|
|
Others
|
|
WWL229 is a selective inhibitor of Ces3 . WWL229 acts by inhibiting recombinant Ces3 but not Ces1f, ABHD6 or other tested serine hydrolases, and recapitulating the effects of WWL113 in adipocytes. |
|
T19700 |
IBC 293
|
IBC293,IBC-293 |
GPR
|
|
IBC 293 is selective for GPR109B over niacin receptor GPR109A. IBC 293 is a highly selective agonist for GPR109B, a human orphan G-protein-coupled receptor expressed in adipocytes. |
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T69146 |
Suksdorfin
|
|
PPAR
|
|
Suksdorfin has hypoglycemic effects, promotes adipocyte differentiation and enhances lipocalin production, activates peroxisome proliferator-activated receptor gamma (PPARγ), promotes insulin-dependent glucose uptake by ... |
|
T33412 |
MitoPQ
|
MitoParaquat |
Glucokinase
,
transporter
|
|
MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of... |
|
T8760 |
NNMTi
|
5-Amino-1-methylquinolinium |
Others
|
|
NNMTi (5-Amino-1-methylquinolinium) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adip... |
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T62656 |
GPR81 agonist 1
|
|
GPR
|
|
GPR81 agonist 1 is a potent and selective GPR81 agonist with high affinity for human and mouse GPR81.GPR81 agonist 1 inhibits lipolysis of differentiated 3T3-L1 adipocytes, improves insulin sensitivity and glycaemic cont... |
|
T73499 |
NG-497
|
NG497 |
Lipase
|
|
NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adja... |
|
TP1930L1 |
Spexin acetate(1370290-58-6 free base)
|
|
Neuropeptide Y Receptor
|
|
Spexin acetate is a potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits... |
|
T24365 |
L 858051
|
7B-Forskolin,L858051,Dmpb-forskolin,L-858051 |
|
|
L 858051 activates adenylate cyclase. It also inhibits glucose transport in rat adipocytes. |
|
T31669 |
ERthermAC
|
|
|
|
ERthermAC is a novel thermosensitive fluorescent dye, visualizing thermogenesis in stimulated single-cell brown adipocytes. |
|
T30261 |
AZD6482 (S-isomer)
|
AZD-6482,AZD 6482,AZD6482 (S),AZD6482 |
|
|
AZD6482 (S-isomer) is a potent, selective, ATP-competitive PI3Kβ inhibitor (IC(50) 0.01 μm), which can inhibit insulin-induced in vitro glucose uptake by human adipocytes (IC(50) is 4.4 μm). |
|
T38488 |
S32826
|
|
|
|
S32826 is a highly potent inhibitor of autotaxin, exhibiting an IC50 value of 8.8 nM. It displays comparable inhibitory properties towards various autotaxin isoforms, including α, β, and γ. Furthermore, S32826 effectivel... |
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T40058 |
IQZ23
|
IQZ23 |
|
|
IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given i... |
|
T39418 |
Leptin (93-105), human
|
|
|
|
Leptin (93-105), human, refers to the peptide fragment consisting of amino acids 93 to 105 from the human leptin protein. Leptin is a peptide hormone comprising 167 amino acids, predominantly synthesized by adipocytes. I... |
|
TP2093 |
Apelin-36(human)
|
Apelin-36 (human) |
|
|
Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, ... |
|
TP1930 |
Spexin
|
|
|
|
Potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty ac... |
|
TP2094 |
Apelin-36(rat, mouse)
|
Apelin-36 (rat, mouse) |
|
|
Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiov... |
|
T76002 |
Spexin TFA
|
|
|
|
Spexin TFA, a potent agonist for galanin receptor 2/3 (GAL2/GAL3) with EC50 values of 45.7 and 112.2 nM respectively, shows no significant activity towards galanin receptor 1. As an endogenous peptide promoting satiety, ... |
|
T36471 |
Ternatin
|
|
|
|
Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and become... |
|
T35588 |
Ganglioside GM3 Mixture (sodium salt)
|
|
|
|
Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduce... |
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T72907 |
Ac-SVVVRT-NH2
|
|
|
|
Ac-SVVVRT-NH2, a PGC-1α modulator, enhances the activity of the human PGC-1α promoter (114%), elevates PGC-1α mRNA levels (125%), and promotes intracellular lipid accumulation (128%) in subcutaneous human adipocytes. Thi... |
|
T80060 |
Pyruvate carboxylase
|
|
Endogenous Metabolite
|
|
Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP. This enzyme is crucial for regulating whole-body energetics, influencing... |
|
T36106 |
Coumermycin A1
|
|
|
|
Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.
Coumermycin A1-induced-JAK2 signal activation increases the mRNA level of SCOS2, but reducea... |
|
TP2215 |
Agouti-related Protein (AGRP) (25-82), human
|
|
Others
|
|
Agouti-related peptide (AgRP) is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is only synthesized in NPY containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalam... |
|
T61133 |
SSAO/VAP-1 inhibitor 1
|
|
|
|
SSAO/VAP-1 Inhibitor 1 is a potent compound aimed at inhibiting SSAO/VAP-1, a protein involved in facilitating the translocation of Glucose Transport 4 (GLUT 4) to the cell membrane in adipocytes, thus playing a crucial ... |
|
T36830 |
9-Nitrooleate
|
|
|
|
Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate , cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as p... |
|
T35854 |
9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
|
|
|
|
9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a r... |
|
T35457 |
(±)12(13)-DiHOME
|
(±)12(13)-DiHOME,Isoleukotoxin diol |
|
|
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. [1] It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils... |
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T72034 |
LI-2242
|
|
Others
|
|
LI-2242 is a potent inositol hexakisphosphate kinase (IP6K) inhibitor with IC50s of 31 nM, 42 nM, 8.7 nM, and 1944 nM for IP6K1, IP6K2, IP6K3, and IPMK, respectively.LI-2242 ameliorated hepatic steatosis by reducing the ... |
|
T35812 |
CAY10591
|
CAY10591 |
|
|
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been shown to regulate the... |
|
TP2176 |
Amyloid A protein fragment [Homo sapiens]
|
|
Others
|
|
Amyloid A proteins (H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH) are a family of apolipoproteins associated with high-density lipoprotein in plasma. Different isoforms of SAA are expressed constitutively at different levels or in... |
|
T37579 |
GW 1929 hydrochloride
|
|
|
|
Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and tr... |
|
T36720 |
Deacetylforskolin
|
|
|
|
Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos... |
