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Search Results for " anti-nociceptive "

ターゲット

阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T10466	BAY-1797		P2X Receptor
	BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displays no or very weak activity on the other P2X ion channels.		P2X Receptor
T9244	σ1 Receptor antagonist-1		Sigma receptor
	σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.		Sigma receptor
T4552	Fursultiamine	Diteftin,Judolor,Alinamin F	Others
	Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency.		Others
T9132	Emorfazone	PH011085	Others
	Emorfazone (PH011085) has an anti-nociceptive effect.		Others
T7675	Substance P (1-7) 2TFA(68060-49-1(free base))		Others
	Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effec...		Others
T1092	Zolmitriptan	311C90,BW-311C90	5-HT Receptor
	Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and...		5-HT Receptor
T25843	N(G)-Nitroarginine-4-nitroanilide	NAPNA,N(omega)-Nitro-L-arginine p-nitroanilide,L-Napna
	N(G)-Nitroarginine-4-nitroanilide is an anti-nociceptive in mice.
T35087	VVZ-149	VVZ 149
	VVZ-149 is an antagonist of both serotonin receptor 2A (5HT2A) and glycine transporter type 2 (GlyT2), with potential anti-nociceptive activity.
T76274	Dolcanatide
	Dolcanatide, an orally active guanylate cyclase-C (GC-C) agonist, exhibits laxative, anti-nociceptive, and anti-inflammatory properties. It is utilized in research concerning inflammatory bowel disease [1] [2].
T7396	Substance P(1-7)	Substance P 1-7	Others , Neurokinin receptor
	Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects		Others , Neurokinin receptor
T60911	SSTR4 agonist 4
	SSTR4 agonist 4 is a potent SSTR4 agonist that has the potential for the pain research. SSTR4 agonists are effective in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and a...

Compounds

σ1 Receptor antagonist-1

T9244

Synonym:

Target: Sigma receptor

Fursultiamine

T4552

Synonym: Diteftin,Judolor,Alinamin F

Substance P (1-7) 2TFA(68060-49-1(free base))

Synonym: 311C90,BW-311C90

Target: 5-HT Receptor

N(G)-Nitroarginine-4-nitroanilide

T25843

Synonym: NAPNA,N(omega)-Nitro-L-arginine p-nitroanilide,L-Napna

Synonym: Substance P 1-7

Target: Others, Neurokinin receptor

カタログ番号	製品名	別名	ターゲット
TN6791	Palvanil	Hexadecanamide	TRP/TRPV Channel
	Palvanil (Hexadecanamide) is a fast desensitizing agonist of TRPV1. it may be promising agents in the therapy of IBS since it modulates intestinal motility and reduces visceral pain.		TRP/TRPV Channel
T8249	Hexahydrofarnesyl acetone	Phytone	Others , Antibacterial
	Hexahydrofarnesyl acetone (Phytone) enhanced both the sticky materials production and cell growth, plays some role in the increase of sticky materials and cell growth.		Others , Antibacterial
TN6729	Azadiradione	AZD	Others
	Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica		Others
T6S1369	Vitexin	Apigenin-8-C-glucoside	Antioxidant
	1. Vitexin has antinociceptive and antispasmodic activities. 2. Vitexin exhibits a prominent first-pass effect. 3. Vitexin has antioxidant, antimyeloperoxidase, and α-glucosidase inhibitory activities. 4. Vitexin can eit...		Antioxidant
T2786	Oxysophocarpine		Prostaglandin Receptor
	Oxysophocarpine is extracted from Sophra flavescens Ait.		Prostaglandin Receptor
T8846	Beta-Escin	B-escin,AESCINE	Immunology/Inflammation related
	beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.		Immunology/Inflammation related
T4S0536	Bullatine A		Apoptosis , P2X Receptor
	1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treatment of neurodegenerative diseases such as arthritis.		Apoptosis , P2X Receptor
T2860	Vanillyl Alcohol	4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol	Apoptosis , Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ...		Apoptosis , Others
T10109	3-Carene	Delta-3-Carene	COX , Antifungal
			COX , Antifungal
T3S0209	Vincristine		ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
	Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristine can treat MM, ERK1/2, Akt, and NF-ÎºB inhibitors are pote...		ERK , p38 MAPK , NF-κB , Akt , JNK , mTOR
T6677	Sophocarpine		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT
	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.		ERK , p38 MAPK , NF-κB , TLR , COX , HER , JNK , STAT