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阻害剤 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK
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シグナル伝達経路 血管新生 アポトーシス オートファジー 細胞周期・チェックポイント クロマチン・エピジェネティック 細胞骨格シグナル
DNA損傷・DNA修復 内分泌・ホルモン GPCR/Gタンパク質 免疫・炎症 JAK・STATシグナル MAPK 膜輸送体・イオンチャネル
代謝 微生物学・ウィルス学 神経科学 NF-Κb 酸化還元 PI3K/Akt/mTORシグナル プロテアーゼ・プロテアソーム
幹細胞 チロシンキナーゼ・アダプター ユビキチン その他 PROTAC
生物活性化合物ライブラリー ゼネラルバイオウアクティヴライブラリー 承認/再開発 医薬品ライブラリー 疾患別 化合物ライブラリー 標的/経路別 化合物ライブラリー 特徴的な生物活性化合物ライブラリー
天然化合物ライブラリー HTS用天然物ライブラリー 分野別 天然化合物ライブラリー 天然物誘導体ライブラリー CADD用天然物ライブラリー
ドラッグライク 化合物ライブラリー ドラッグライクライブラリー
フラグメントライブラリー ゼネラルフラグメントライブラリー 特徴的なフラグメントライブラリー カスタム化合物ライブラリー
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

検索結果

Search Results for " cAMP-signaling "

ターゲット

cAMP Ras

18

阻害剤

5

天然化合物

14

リコンビナントタンパク質

1

ライブラリー

カタログ番号 製品名 別名 ターゲット
T15485 HJC0197 cAMP , Ras
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2).
T40279 GLP-1R modulator L7-028 GLP-1R modulator L7-028 cAMP , Glucagon Receptor
GLP-1R modulator L7-028 is a variant modulator that enhances affinity for GLP-1 and cAMP signaling.
T11662L INT-777 S-EMCA GPCR19
T50023 Ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate Others
ethyl 1-(4-aminophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, also known as EAPT, is a potent and selective PDE4 inhibitor that regulates intracellular cyclic adenosine monophosphate (cAMP) levels. It has been u...
T1024 Roflumilast B9302-107,BYK 20869,APTA 2217,BY 217 PDE , RSV
Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplastic activities. Upon administration, roflumilast and its act...
T22529 6-Bnz-cAMP sodium salt Others
6-Bnz-cAMP is a PKA-selective activator. It regulates the PKA dependent signaling pathways. The proliferative signaling pathway which activated by the 6-Bnz-cAMP involves activation of the epidermal growth factor recepto...
T68650 AH 23848
AH 23848 is a Thromboxane antagonist which accelerates inducible nitric oxide synthase degradation through attenuation of cAMP signaling in glomerular mesangial cells.
T30808 CG500354 CG-500354,CG 500354
CG500354 plays a tumor suppressive role through the cAMP/CREB signaling pathway and is a novel inducer of neural differentiation and growth arrest in primary HUMAN GBM derived cells.
TP1283 VIP(6-28)(human, rat, porcine, bovine)
VIP(6-28)(human, rat, porcine, bovine) is a potent antagonist that effectively counteracts the effects of exogenous vasoactive intestinal peptide (VIP) on cyclic adenosine monophosphate (cAMP) signaling.
T28891 SW106
SW106 is a selective antagonist of PTHR1-mediated cAMP signaling, not functioning as an inverse agonist on either PTHR1-T410P or PTHR1-H223R, which have activating mutations at the cytoplasmic ends of TMD helices-2 and -...
T37477 L-858,051 (hydrochloride)
L-858,051 is a water-soluble analog of forskolin , a cell-permeant activator of adenylate cyclase. L-858,051 activates adenylate cyclase (EC50 = 3 μM), inhibits glucose transport, and blocks cytochalasin B binding in rat...
T82989 AP-C6
AP-C6 is a potent inhibitor of guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), exhibiting a pIC50 of 6.5. It inhibits human cGKII activity in vitro in a concentration-dependent manner and...
T36072 Skyrin Endothianin,Rhodophyscin
Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor. At 10 μM, skyrin reduces both glucago...
T73690 Abaloparatide
Abaloparatide (BA 058), a parathyroid hormone receptor 1 (PTHR1) analog and selective activator, promotes Gs/cAMP signaling and β-arrestin recruitment, thereby enhancing bone formation and improving cortical structure in...
T36781 St-Ht31 P st-Ht31 P
Negative control for st-Ht31 . Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID:28192412 |Vijayaraghavan et al (1997) Protein kinase A-a...
T37896 AZ 1729
FFA2 allosteric agonist. Inhibits forskolin-induced cAMP increase and stimulates 35SGTPγS binding in biochemical assays (pEC50 values are 6.9 and 7.23, respectively). Binds at allosteric binding site. In functional assay...
T61617 Hcyb1
Hcyb1 is a potent and specific inhibitor of phosphodiesterase 2 (PDE2). It exhibits a high degree of selectivity for inhibiting PDE2A with an IC50 value of 0.57 μM. In addition, Hcyb1 displays over 250-fold selectivity a...
T65994 (6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ...
カタログ番号 製品名 別名 ターゲット
T3826 Polygalasaponin F NF-κB , TLR , Akt , PI3K
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...
TMA0003 Trans-caffeic acid cAMP , Tyrosinase
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyr...
T13762 Luteolin 7-sulfate Others
Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and micro...
TN2039 Panaxydol cAMP , p38 MAPK , JNK
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through ...
TN1694 Gliotoxin Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.

天然物製品

Polygalasaponin F
T3826
Synonym:
Target: NF-κB, TLR, Akt, PI3K
Trans-caffeic acid
TMA0003
Synonym:
Target: cAMP, Tyrosinase
Luteolin 7-sulfate
T13762
Synonym:
Target: Others
Panaxydol
TN2039
Synonym:
Target: cAMP, p38 MAPK, JNK
Gliotoxin
TN1694
Synonym:
Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection

Recombinant Proteins

Species：
Human (10)
Bovine (1)
Canine (1)
Mouse (1)
Rat (1)
Expression System：
E. coli (8)
Baculovirus Insect Cells (4)
HEK293 Cells (2)
Tag：
N-6xHis (6)
N-6xHis-SUMO (2)
C-6xHis (1)
C-His (1)
His, GST (1)
N-10xHis (1)
N-10xHis, C-Myc (1)
N-His (1)
カタログ番号 製品名 Species Expression System
TMPK-00677 PKA/PRKACA Protein, Canine, Recombinant (His) Canine E. coli
The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide varie...
TMPH-00221 Agouti-signaling Protein, Bovine, Recombinant (His) Bovine Baculovirus Insect Cells
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) an...
TMPH-01348 FSHR Protein, Human, Recombinant (His) Human HEK293 Cells
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (His) is expresse...
TMPH-01347 FSHR Protein, Human, Recombinant (E. coli, His) Human E. coli
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is...
TMPH-01422 GNAS Protein, Human, Recombinant (His & SUMO) Human E. coli
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting...
TMPH-01385 GLP1R Protein, Human, Recombinant (His) Human HEK293 Cells
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-03301 GLP1R Protein, Rat, Recombinant (E. coli, His) Rat E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-02676 GLP1R Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-01384 GLP1R Protein, Human, Recombinant (E. coli, His) Human E. coli
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a ...
TMPH-02143 NR5A1 Protein, Human, Recombinant (His) Human E. coli
Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B an...
TMPH-02218 JUN Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali...
TMPH-02219 JUN Protein, Human, Recombinant (His & Myc) Human E. coli
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signali...
TMPY-02081 PDE2A Protein, Human, Recombinant (aa 215-900, His) Human Baculovirus Insect Cells
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub...
TMPY-02444 ATF2 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-ac...
カタログ番号 製品名
L7700 Neural Regeneration Compound Library

524 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;

ライブラリー

Neural Regeneration Compound Library
L7700
Compounds: 524
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