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天然化合物

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カタログ番号	製品名	別名	ターゲット
T9499	Icenticaftor	QBW251	CFTR
	Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.		CFTR
T16681	Nesolicaftor	PTI-428	CFTR , Autophagy
	Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.		CFTR , Autophagy
T14935	Elexacaftor	VX-445	CFTR , Autophagy
	Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.		CFTR , Autophagy
T3135	KM11060		CFTR , Autophagy
	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.		CFTR , Autophagy
T1634	Glibenclamide	Glyburide	Potassium Channel , Mitochondrial Metabolism , CFTR , P-gp , Autophagy
	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1805	Ataluren	PTC124	CFTR , Autophagy
	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and olde...		CFTR , Autophagy
T5312	CFTR corrector 2	FDL169	CFTR , Autophagy
	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.		CFTR , Autophagy
T2486	IOWH-032	IOWH032,IOWH 032	CFTR , Autophagy
	IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.		CFTR , Autophagy
T2451	GlyH-101	GlyH 101	CFTR , Autophagy
	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.		CFTR , Autophagy
T1874	PPQ-102	PPQ102,CFTR Inhibitor,PPQ 102	CFTR , Autophagy
	PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).		CFTR , Autophagy
T2588	Ivacaftor	Ivacaftor (VX-770),VX-770	CFTR , Autophagy
	Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.		CFTR , Autophagy
T4503	Talniflumate	Somalgen	Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
	Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T7083	GLPG1837	ABBV-974	CFTR , Autophagy
	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.		CFTR , Autophagy
T10591	BPO-27 racemate	BPO-27 (racemate)	CFTR , Autophagy
			CFTR , Autophagy
T2595	Lumacaftor	VX-809,VRT 826809	CFTR , Autophagy
	Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).		CFTR , Autophagy
T1394	Ibuprofen	Brufen,(±)-Ibuprofe,Motrin,Advil	COX
	Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...		COX
T6540	Ibuprofen Lysine	Neoprofen	COX
	Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.		COX
T2355	CFTR(inh)-172	CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172	CFTR , Autophagy
	CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.		CFTR , Autophagy
T15543	IA-Alkyne	N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne	TRP/TRPV Channel
	IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of r...		TRP/TRPV Channel
T2263	Tezacaftor	VX661	CFTR , Autophagy
	Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.		CFTR , Autophagy
T131553	Echinocystic acid (Albizziagenin)
	Echinocystic acid (Albizziagenin) is a useful organic compound for research related to life sciences and the catalog number is T131553.
T20341	DNDS		CFTR
	DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).		CFTR
T29041	UCCF-853	UCCF853,UCCF 853	CFTR
	UCCF-853 is a small-molecule CFTR modulator that can be used to study cystic fibrosis.		CFTR
T63806	CFTR corrector 8		CFTR
	CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic...		CFTR
T26955	Cavosonstat	N91115,N 91115,N-91115	GSNOR , CFTR
	Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR) maturation and plasma membrane stabilization.Cavosonstat ...		GSNOR , CFTR
T60653	CFTR corrector 9		CFTR
	CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders [1].		CFTR
T10776	CFTR corrector 4		CFTR
	CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface a...		CFTR
T31014	Corrector C4	Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a	Others
	Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and protein homeostasis.		Others
T29114	VRT-532	CFpot-532,CFpot-532)	CFTR
	VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glyc...		CFTR
T30293	Bamocaftor	VX-659	CFTR
	Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of c...		CFTR
T77604	WAY-326766		CFTR
	WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).		CFTR
T72918	JNJ-49095397	RV568	Antiviral , p38 MAPK
	JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and resp...		Antiviral , p38 MAPK
T25376	Ensifentrine	Ensifentrina,Ensifentrinum	PDE
	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...		PDE
T37744	N-octanoyl-L-Homoserine lactone	C8-HSL,N-octanoyl-L-Homoserine lactone,OHL	Antibacterial
	N-octanoyl-L-Homoserine lactone (C8-HSL) is a diffusible exogenous Yersinia pestis population-sensing molecule that modulates LcrV virulence factors, controls gene expression by participating in population sensing, and a...		Antibacterial
T111959	IFB-088 acetate
	IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein...
T27098	Ivacaftor-D9	deutivacaftor,CTP-656
	CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
T27734	KM-003 (sulfite)	KM 003,P-552,KM003,P552,P 552,KM-003
	KM-003, a sodium channel blocker, is used potentially for the treatment of cystic fibrosis.
T22252	Galicaftor		Others
	ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).		Others
T13742	Ivacaftor benzenesulfonate	VX-770 benzenesulfonate	Others
			Others
T25136	Aztreonam lysine	Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate
	Aztreonam lysine is an inhaled anti-pseudomonal treatment for people who have pulmonary Pseudomonas aeruginosa infection with cystic fibrosis (CF).
T13704	GLPG-3221		Others
	GLPG-3221 can be uesd for the treatment of cystic fibrosis.GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM.		Others
T29040	UCCF-029	UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029
	UCCF-029 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR).
T36519	Posenacaftor sodium
	Posenacaftor (PTI-801) sodium, a cystic fibrosis transmembrane regulator (CFTR) modulator, corrects CFTR protein folding and trafficking. It is utilized in researching cystic fibrosis (CF)[1].
T13705	GLPG2451		Cysteine Protease
	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1 nM).		Cysteine Protease
T27146	Denufosol tetrasodium	INS37217,INS 37217,INS-37217
	Denufosol is a P2Y2 agonist potentially for the treatment of cystic fibrosis.
T23648	AF-2785
	In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.
T13742L	Ivacaftor hydrate	VX-770 hydrate	Others
	Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.		Others
T74417	Vanzacaftor
	Vanzacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator researched for cystic fibrosis treatment.
T25898	Olacaftor	VX 440,VX-440,VX440
	Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).
T74748	Zatonacaftor
	Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].

Compounds

Target: CFTR, Autophagy

Elexacaftor

T14935

Synonym: VX-445

Target: CFTR, Autophagy

KM11060

T3135

Synonym:

Target: CFTR, Autophagy

Glibenclamide

T1634

Synonym: Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Ataluren

T1805

Synonym: PTC124

Target: CFTR, Autophagy

CFTR corrector 2

T5312

Synonym: FDL169

Target: CFTR, Autophagy

IOWH-032

T2486

Synonym: IOWH032,IOWH 032

Target: CFTR, Autophagy

GlyH-101

T2451

Synonym: GlyH 101

Target: CFTR, Autophagy

PPQ-102

T1874

Synonym: PPQ102,CFTR Inhibitor,PPQ 102

Target: CFTR, Autophagy

Ivacaftor

T2588

Synonym: Ivacaftor (VX-770),VX-770

Target: CFTR, Autophagy

Talniflumate

T4503

Synonym: Somalgen

Target: Chloride channel, COX, N-Acetylglucosaminyltransferase, Anion Exchanger

GLPG1837

T7083

Synonym: ABBV-974

Target: CFTR, Autophagy

BPO-27 racemate

T10591

Synonym: BPO-27 (racemate)

Target: CFTR, Autophagy

Lumacaftor

T2595

Synonym: VX-809,VRT 826809

Target: CFTR, Autophagy

Ibuprofen

T1394

Synonym: Brufen,(±)-Ibuprofe,Motrin,Advil

Synonym: CFTRinh 172,CFTR Inhibitor-172,CFTRinh-172,CFTRinh172

Target: CFTR, Autophagy

IA-Alkyne

T15543

Synonym: N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne

Target: TRP/TRPV Channel

Tezacaftor

T2263

Synonym: VX661

Target: CFTR, Autophagy

Echinocystic acid (Albizziagenin)

Synonym: UCCF853,UCCF 853

Synonym: N91115,N 91115,N-91115

Synonym: Corr 4a,Corrector C-4,Corr4a,Corrector C 4,Corr-4a

Target: Others

VRT-532

T29114

Synonym: CFpot-532,CFpot-532)

Target: Antiviral, p38 MAPK

Ensifentrine

T25376

Synonym: Ensifentrina,Ensifentrinum

Target: PDE

N-octanoyl-L-Homoserine lactone

T37744

Synonym: C8-HSL,N-octanoyl-L-Homoserine lactone,OHL

Target: Antibacterial

Synonym: deutivacaftor,CTP-656

Target:

KM-003 (sulfite)

T27734

Synonym: KM 003,P-552,KM003,P552,P 552,KM-003

Ivacaftor benzenesulfonate

T13742

Synonym: VX-770 benzenesulfonate

Target: Others

Aztreonam lysine

T25136

Synonym: Corus 1020,Corus1020,Corus-1020,Aztreonam lysinate

Synonym: UC(CF)-029,UC(CF) 029,UCCF029,UC(CF)029

Target: Cysteine Protease

Denufosol tetrasodium

T27146

Synonym: INS37217,INS 37217,INS-37217

Synonym: VX-770 hydrate

Synonym: VX 440,VX-440,VX440

カタログ番号	製品名	別名	ターゲット
T2866	Echinocystic acid		Apoptosis , Antioxidant , Reactive Oxygen Species
	Echinocystic acid (EA), a natural triterpone enriched in various herbs, shows a range of pharmacological activities including anti-inflammatory and antioxidant effects.		Apoptosis , Antioxidant , Reactive Oxygen Species
T41139	Echinocystic acid 28-O-β-D-glucoside
	Echinocystic acid 28-O-β-D-glucoside is a metabolite resulting from the microbial oxidation and glucosidation of Echinocystic acid. It exhibits inhibitory activity towards the tissue factor pathway, with an IC50 value me...
T2532	Tauroursodeoxycholate	Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
	Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode...		Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
T11124	Duramycin	Lancovutide,Moli1901	Others
	Duramycin is a cyclic peptide lantibiotic derived from Streptomyces cinnamoneuma. Duramycin interacts with phosphatidylethanolamine (PE) and has antibacterial, antiviral effects. Duramycin stimulates chloride secretion ...		Others

天然物製品

Echinocystic acid

T2866

Synonym:

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Echinocystic acid 28-O-β-D-glucoside

T41139

Synonym:

Target:

Tauroursodeoxycholate

T2532

Synonym: Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA

Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite

Duramycin

T11124

Synonym: Lancovutide,Moli1901

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-03855	DNase I Protein, Human, Recombinant (His)	Human	HEK293 Cells
	DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phos...
TMPJ-01350	XPNPEP3 Protein, Human, Recombinant (His)	Human	E. coli
	Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of an...
TMPY-04633	Frizzled 2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	FZD2 may be a tumor suppressor gene in salivary adenoid cystic carcinomas (SACCs) that inhibits cell growth and migration. OMOD2 is a rare skeletal dysplasia and characterized by facial dysmorphism and shortness of the u...
TMPY-03629	Syntaxin 8 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated...
TMPJ-00991	S100A8 Protein, Rat, Recombinant (His)	Rat	E. coli
	Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100 proteins are localized in the cytop...
TMPY-02769	RNASET2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular r...