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T23513 |
VU10010
|
VU 10010 |
AChR
|
|
VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors. |
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T8702 |
SKF-83566
|
|
Dopamine Receptor
,
5-HT Receptor
,
AChR
|
|
SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
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T1566 |
Aripiprazole
|
OPC-14597 |
5-HT Receptor
|
|
Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a... |
|
T19333 |
Gadoteridol
|
ProHance,SQ-32692,Gd-HP-DO3A |
Others
|
|
Gadoteridol (Gd-HP-DO3A) is a gadolinium-based MRI contrast agent that can be used for central nervous system imaging. |
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T12617L |
(R)-CR8
|
(R)-CR8,(R)-Isomer,CR8 |
Apoptosis
,
CDK
|
|
(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor. |
|
T4297 |
Flibanserin
|
BIMT-17BS,Girosa,BIMT-17 |
Dopamine Receptor
,
5-HT Receptor
|
|
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n... |
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T5468 |
YF-2
|
|
Others
,
Epigenetic Reader Domain
,
Histone Acetyltransferase
|
|
YF-2 is blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, CBP, PCAF, and GCN5 with EC50s of 2.75 μM, 29.04 μM and 49.31 μM , respectively |
|
T16816 |
S 18986
|
|
GluR
|
|
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine... |
|
T11800 |
L-803087
|
|
Somatostatin
|
|
|
|
T37190 |
L-Allylglycine
|
|
Dehydrogenase
,
GABA Receptor
|
|
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo in mouse brain preparations. L-Allylglycine (1.2 mmol/kg, ... |
|
T61934 |
Repinotan
|
BAY x 3702 free base |
5-HT Receptor
|
|
Repinotan (BAY x 3702 free base) is an orally active and selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), has neuroprotective activity, antagonizes morphine-induced depression of ventilation ... |
|
T13975 |
ZSET-845
|
|
Others
|
|
|
|
T28139 |
NCFP
|
|
|
|
NCFP is a mGlu5 positive allosteric modulator. It positively modulates mGlu5 without the induction of long-term potentiation and long-term depression in the hippocampus. |
|
T38217 |
1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE
|
|
|
|
1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid and adrenic acid at thesn-1 andsn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with s... |
|
T10542 |
Bifeprunox
|
|
Others
|
|
Bifeprunox is a potent partial agonist of dopamine D2-like and 5-HT1A receptor (pEC50: 6.37 for hippocampus 5-HT1A; pKis: 7.19 and 8.83 for cortex 5-HT1A and striatum D2). It is an antipsychotic for the research of schiz... |
|
TP1188 |
Cortistatin 14, human, rat
|
CST-14, human, rat |
|
|
Cortistatin 14 is a somatastatin-like neuropeptide with neuronal depressant and sleep modulating properties. Cortistatin 14 is present primarily in the cortex and hippocampus. |
|
T68059 |
Ebalzotan
|
|
|
|
NAE-086 is a high-affinity and selective 5-HT(1A) receptor ligand with a K(i) value of 4.5 nM in membranes from rat hippocampus. |
|
T36178 |
Aspalatone
|
|
|
|
Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generat... |
|
T25558 |
JNJ-55511118
|
JNJ 55511118 |
|
|
JNJ-55511118 is a selective negative modulator of AMPA receptors containing TARP-γ8 (Ki: 26 nM). It had excellent pharmacokinetic properties. JNJ-55511118 exhibited a dose-dependent inhibition of neurotransmission within... |
|
TP1685 |
Cortistatin-14 TFA (186901-48-4 free base)
|
Cortistatin-14 TFA |
|
|
Cortistatin-14 is a neuropeptide have structural similarity to somatostatin-14. It is produced in the cortex and hippocampus of central nervous system. |
|
T70365 |
JTP-4819
|
|
|
|
JTP-4819 is a potent and selective prolyl endopeptidase (PEP) inhibitor with potential for treating Alzheimer's disease. At nanomolar concentration, JTP-4819 inhibited the degradation of substance P, arginine-vasopressin... |
|
T24919 |
UBP714
|
UBP 714,UBP-714 |
|
|
UBP714 is a derivative of the NMDA receptor negative allosteric modulator UBP608. It also enhanced NMDAR mediated field EPSPs in the CA1 region of the hippocampus. UBP714 is a novel template for the development of potent... |
|
T38281 |
C22 Galactosylceramide (d18:1/22:0)
|
|
|
|
C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricte... |
|
T38711 |
YF-2 hydrochloride
|
|
|
|
YF-2 hydrochloride is a potent histone acetyltransferase activator that exhibits high selectivity and can pass through the blood-brain barrier. It specifically acetylates H3 in the hippocampus, with EC50 values of 2.75 μ... |
|
T61130 |
SSTR4 agonist 3
|
|
|
|
SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease... |
|
TP1662 |
Galanin Receptor Ligand M35
|
|
|
|
The chimeric peptide M35 [galanin (1-13)-bradykinin(2-9) amide] is a high-affinity galanin receptor ligand acting as a galanin receptor antagonist in the rat spinal cord, rat hippocampus and isolated mouse pancreatic isl... |
|
T70595 |
Artemisinin B
|
|
|
|
Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neurop... |
|
TP2136 |
(d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin
|
|
|
|
Selective vasopressin V1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC50 values are 5 and 30 nM respectively). Exhibits potent and prolonge... |
|
T37478 |
Acetyl β-Endorphin (1-26) (human) (trifluoroacetate salt)
|
|
|
|
Acetyl β-endorphin (1-26) is a neuropeptide found in rat hippocampus, brain stem, and pituitary. It is also present in the human hypothalamus, where it comprises approximately 4.9% of total β-endorphin peptides. Acetyl β... |
|
T35809 |
C20 Sphingomyelin (d18:1/20:0)
|
|
|
|
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlate... |
|
T76358 |
Neuropeptide Y (1-24) (human)
|
|
|
|
Neuropeptide Y (1-24) (human) is a neuropeptide that inhibits the electrically stimulated twitch response in rat vas deferens and activates neurons in the rat CA3 region of the dorsal hippocampus in vivo following N-meth... |
|
T80170 |
Tamapin
|
|
Potassium Channel
|
|
Tamapin, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small-conductance Ca(2+)-activated K(+) (SK) channels, particularily SK2 (Potassium Channel). It inh... |
|
T28653 |
S-8510 free base
|
SB 737552,SB-737552,S8510,SB737552,S-8510,S 8510 |
|
|
S-8510 is a GABA-A receptor inverse agonist. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimal electroconvulsive shock- or strychnine-induced convulsion in ddY mice. S-8510 ame... |
|
T76493 |
(Glu2)-TRH
|
|
|
|
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH), acts as a negative modulator of TRH's cholinergic effect in the mouse brain, significantly reducing TRH-induced release of extracellular... |
|
T80185 |
Huwentoxin I
|
HWTX-I |
Calcium Channel
|
|
Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels. It effectively inhibits sodium channels in the rat hippocampus and cockroach dorsal unpai... |
|
T76221 |
Leptin (116-130)
|
|
|
|
Leptin (116-130), a bioactive fragment of leptin, enhances synaptic plasticity in the hippocampus by promoting AMPA receptor trafficking to synapses. It preserves hippocampal synapse integrity and prevents neuronal cell ... |
|
T35663 |
Cortistatin-29 (rat) (trifluoroacetate salt)
|
|
|
|
Cortistatin-29 is a neuropeptide that is structurally similar to somatostatin-28. It is produced by cleavage of preprocortistatin to procortistatin, which is cleaved at dibasic amino acids to form cortistatin-29 and cort... |
|
T36521 |
Alaproclate (hydrochloride)
|
|
|
|
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s =... |
|
T11827 |
Pradigastat
|
ANJ908,LCQ908-NXA,LCQ908A,LCQ-908 |
Transferase
|
|
Pradigastat (LCQ-908) is an orally active, potent and selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor for the treatment of constipation, which may be used in the study of obesity and diabetes. |
|
T70063 |
GYKI 52466 HCl
|
|
|
|
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... |
|
T73511 |
SZM679
|
|
RIP kinase
|
|
SZM679 is an orally active, selective RIPK1 inhibitor displaying potent affinity with a dissociation constant (Kd) of 8.6 nM for RIPK1, while exhibiting minimal activity towards RIPK3, with a Kd of >5000 nM. It effective... |
|
T60911 |
SSTR4 agonist 4
|
|
|
|
SSTR4 agonist 4 is a potent SSTR4 agonist that has the potential for the pain research. SSTR4 agonists are effective in rodent models of pain associated with acute and chronic associated anti-peripheral nociceptive and a... |
|
T61930 |
Yhhu-3792
|
|
|
|
Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 enhanced the self-renewal ability of neural stem cells (NSCs), expanded the NSC pool and promoted endogenous neurogenesi... |
|
T79718 |
CaMKIIα-PHOTAC
|
|
CaMK
|
|
CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα). This molecule facilitates the ubiquitination and subsequent proteasome-medi... |
|
T83909 |
6-hydroxy Buspirone
|
BMY 28674,BMS-52821 |
|
|
6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4. This compound exhibits affinity for the serotonin (5-HT) receptor subtype 5-HT1A, ... |
|
T71142 |
Tebuconazole-d9
|
|
|
|
Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-... |
|
T64672 |
Colivelin TFA
|
|
|
|
Colivelin (sequence SALLRSIPAPAGASRLLLLTGEIDLP) is composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative. It works as a neuroprotective peptide and activat... |
|
T37718 |
Galanin (rat, mouse) (trifluoroacetate salt)
|
GAL (rat, mouse),Galanin (rat, mouse) (trifluoroacetate salt) |
|
|
Galanin is a neuropeptide with diverse biological activities. [1][2][3][4][5] It binds to rat galanin (GAL) receptor subtypes GAL1-3 (IC50s = 0.339, 1.35, and 3.31 nM, respectively) and human GAL1-3 (IC50s = 0.288, 1.62,... |
|
T38145 |
Eltoprazine
|
|
|
|
Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro... |
|
T36947 |
Pyrithiamine (hydrobromide)
|
|
|
|
Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growt... |
