検索結果

Search Results for " keratinocytes "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T67858	STIMA-1	2-Vinylquinazolin-4-ol,p53 Activator VII	Others
	STIMA-1 (2-Vinylquinazolin-4-ol), an active compound, can restore the activity of p63. STIMA-1 can stimulate the proliferation and differentiation of keratinocytes.		Others
T15410	GNF351		Aryl Hydrocarbon Receptor
	GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes wit...		Aryl Hydrocarbon Receptor
TP1293	Jagged-1 (188-204) TFA(219127-21-6 free base)	Jagged-1 (188-204) TFA	Gamma-secretase
	Jagged-1 (188-204) TFA(219127-21-6 free base) is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing sub...		Gamma-secretase
T76924	Efalizumab	Hu1124,HU 1124	Integrin
	Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinoc...		Integrin
T77677	12R-LOX-IN-2		Lipoxygenase
	12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein...		Lipoxygenase
T24094	Glycerophosphoinositol lysine	Distinctive gpi lysine,Gpi lysine
	Glycerophosphoinositol lysine has an anti-dandruff, anti-inflammatory, anti-aging activity. It significantly suppresses UVB - induced PGE secretion in NHEK keratinocytes.
T68470	ASB-16165
	ASB-16165 is a phosphodiesterase 7A inhibitor that impairs proliferation of keratinocytes in vitro and in vivo. Inhibitors of PDE7A including ASB16165 might be useful for the treatment of psoriasis.
T31126	CX-659S	CX659S,UNII-YG2F04AVMQ,CX 659S
	CX-659S is a novel diaminuracil derivative that indirectly inhibits Langerhans cell function by blocking the MEK1/2 -- ERK1/2 pathway in keratinocytes. CX-659S can inhibit the contact hypersensitivity induced by haptens ...
T80280	TLN-58
	TLN-58, an antimicrobial peptide, exhibits antibacterial activity against S. aureus, S. epidermidis, and group A Streptococcus. It also promotes the upregulation of inflammatory cytokine mRNAs in normal human keratinocyt...
T36004	1-O-Hexadecyl-sn-glycerol	1-O-Hexadecyl-sn-glycerol,(S)-(+)-Chimyl Alcohol,α-Chimyl Alcohol
	1-O-Hexadecyl-sn-glycerol is a bioactive alkyl glyceryl ether. It reduces UVB-induced cell death and production of reactive oxygen species (ROS) and prostaglandin E2 in normal human epidermal keratinocytes (NHEKs). 1-O-H...
TP1540	Jagged-1 （188-204）	Jagged-1 188-204	Gamma-secretase
	Jagged-1 （188-204）is a fragment of the JAG-1 protein. JAG-1 is Notch ligand, a peptide that is the most conspicuously expressed ligand in skin. JAG-1 induces epidermal maturation. Exposing submerged keratinocytes monolay...		Gamma-secretase
T35452	β-Defensin-3 (human) (trifluoroacetate salt)
	β-Defensin-3 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It inhibits the growth of the periodontopathogenic and ...
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at...
T35553	Ganglioside GQ1b Mixture (sodium salt)
	Ganglioside GQ1b is a tetrasialoganglioside that contains two sialic acid residues linked to an inner galactose unit. It stimulates phosphorylation of several ecto-type protein kinase substrates on the surface of GOTO hu...
T80090	Lugdunin		Antibiotic
	Lugdunin is an antibiotic peptide that disrupts membrane potential in bacteria, demonstrating activity against Gram-positive species including S. aureus, and effectively reducing skin and nasal colonization of this patho...		Antibiotic
T36671	C2 Phytoceramide (t18:0/2:0)
	C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK...
T83457	12R-LOX-IN-1
	12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX. It suppresses the hyperproliferative condition and the ability to form colonies in Imiquimod-induced psoriatic keratinocytes, as well as r...
T69395	Nicotinamide-d4
	Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized i...
T36379	Halometasone
	Halometasone is a synthetic corticosteroid.1,2Formulations containing halometasone have been used in the treatment of psoriasis vulgaris and eczematous dermatoses. 1.de la Brassine, M., Kint, A., Lachapelle, J.M., et al....
T83744	Tiger17 TFA	H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferati...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cari...
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocyt...
T83735	Pap12-6 TFA
	Pap12-6, an antibacterial peptide originating from the first twelve N-terminal amino acids of papiliocin found in P. xuthus larvae, exhibits activity against a range of eight Gram-negative bacteria (e.g., E. coli, P. aer...

Compounds

STIMA-1

T67858

Synonym: 2-Vinylquinazolin-4-ol,p53 Activator VII

Target: Aryl Hydrocarbon Receptor

Jagged-1 (188-204) TFA(219127-21-6 free base)

TP1293

Synonym: Jagged-1 (188-204) TFA

Target: Gamma-secretase

Efalizumab

T76924

Synonym: Hu1124,HU 1124

Glycerophosphoinositol lysine

T24094

Synonym: Distinctive gpi lysine,Gpi lysine

Synonym: CX659S,UNII-YG2F04AVMQ,CX 659S

1-O-Hexadecyl-sn-glycerol

T36004

Synonym: 1-O-Hexadecyl-sn-glycerol,(S)-(+)-Chimyl Alcohol,α-Chimyl Alcohol

Target:

Jagged-1 （188-204）

TP1540

Synonym: Jagged-1 188-204

Target: Gamma-secretase

β-Defensin-3 (human) (trifluoroacetate salt)

T35452

Synonym:

Target:

β-Defensin-4 (human) (trifluoroacetate salt)

T35453

Synonym:

Target:

Ganglioside GQ1b Mixture (sodium salt)

C2 Phytoceramide (t18:0/2:0)

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

Target:

β-Defensin-2 (human) (trifluoroacetate salt)

カタログ番号	製品名	別名	ターゲット
T6S0923	Hypericin	Hypericine,Cyclosan	Apoptosis , Antiviral , Influenza Virus , Tyrosine Kinases , Antibacterial , PKC
	1. Hypericin (Cyclosan) has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoamine oxidase enzyme. 4. Hypericin inhibits RANKL...
TN1675	Gardenin B		Apoptosis , ROS , Caspase , NO Synthase
	Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .		Apoptosis , ROS , Caspase , NO Synthase
TN2286	Tsugaric acid A		NO Synthase
	Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates t...		NO Synthase
T5S1286	(+)-Columbianetin	(S)-Columbianetin,Columbianetin	Antifungal
	(+)-Columbianetin ((S)-Columbianetin) is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. (+)-Columbianetin has anti-inflammatory effect...		Antifungal
T3717	Hinokitiol	4-Isopropyltropolone,β-thujaplicin	DNA Methyltransferase , Virus Protease , Estrogen/progestogen Receptor , Nrf2
	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent...
T6S1572	Sauchinone		ERK , p38 MAPK , NF-κB
	1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation of HSCs, to prevent liver fibrosis, and to inhibit oxidative...		ERK , p38 MAPK , NF-κB
T24025	Eckol
	Eckol inhibits ultraviolet B-induced cell damage by a decrease in oxidative stress in human keratinocytes.
TN1235	3,4,5-Tricaffeoylquinic acid		TNF , Akt , HIV Protease
	3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and N...		TNF , Akt , HIV Protease
T13670L	(Z)-Ligustilide	cis-Ligustilide,Ligustilide A	Antibacterial
	(Z)-Ligustilide (Ligustilide A) , an active ingredient isolated from the medicinal plants Angelica acutiloba and Cnidium officinale, inhibits benzo(a)pyrene-induced CYP1A1 upregulation in cultured human keratinocytes via...		Antibacterial
T38036	Lumisterol
	Lumisterol (9β,10α-Ergosterol), a steroid compound and the (9β,10α)-stereoisomer of Ergosterol, serves as a photoprotective agent shielding against UVB-induced DNA damage and exhibits anti-proliferative activities[1].

天然物製品

Hypericin

T6S0923

Synonym: Hypericine,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Gardenin B

TN1675

Synonym:

Target: Apoptosis, ROS, Caspase, NO Synthase

Synonym: (S)-Columbianetin,Columbianetin

Target: Antifungal

Hinokitiol

T3717

Synonym: 4-Isopropyltropolone,β-thujaplicin

Target: DNA Methyltransferase, Virus Protease, Estrogen/progestogen Receptor, Nrf2

Sauchinone

T6S1572

Synonym:

Target: ERK, p38 MAPK, NF-κB

3,4,5-Tricaffeoylquinic acid

TN1235

Synonym:

Target: TNF, Akt, HIV Protease

(Z)-Ligustilide

T13670L

Synonym: cis-Ligustilide,Ligustilide A

Target: Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00348	CD316 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Immunoglobulin Superfamily Member 8 (IGSF8) is a single-pass membrane protein. IGSF8 contains four Ig-like C2 type domains. The Ig-like C2-type domains 3 and 4 are required for interactions with CD81. IGSF8 may regulate ...
TMPJ-01210	IL-33 Protein, Mouse, Recombinant	Mouse	E. coli
	Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identifi...
TMPJ-00051	IL-3 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenit...
TMPJ-00042	TSLP Protein, Human, Recombinant	Human	E. coli
	Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino aci...
TMPH-02117	SPRR3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Cross-linked envelope protein of keratinocytes. SPRR3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 34.0 kDa and the accession...
TMPJ-01119	GPNMB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one...
TMPH-02909	Sprr2a1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the f...
TMPY-03963	CALCB Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	CALCB, also known as CGPR and calcitonin 2, belongs to the calcitonin family. CALCB is a calcitonin (CT) peptide which may play a role in the mediation of human inflammatory diseases. It is highly expressed in the skin, ...
TMPH-01116	COL17A1 Protein, Human, Recombinant (His)	Human	E. coli
	May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane.; The 120 kDa linear IgA disease antigen is an anchoring filament component involved in derm...
TMPY-02117	Marapsin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), is a member of the peptidase S1 family. Pancreasi...
TMPH-02116	SPRR2B Protein, Human, Recombinant (His & Myc)	Human	P. pastoris (Yeast)
	Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the f...
TMPK-01280	HER3/ERBB3 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)	Cynomolgus,Rhesus	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and ...
TMPK-00453	HER3/ERBB3 Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and ...
TMPK-00452	HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled	Human	HEK293 Cells
	Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and ...
TMPY-02766	PSPH Protein, Human, Recombinant	Human	E. coli
	Phosphoserine phosphatase (PSPH) belongs to a subfamily of the phosphotransferases. PSPH is the rate-limiting enzyme in l-serine biosynthesis. It has previously been found that Phosphoserine phosphatase (PSPH) plays a ro...
TMPY-01346	Psoriasin/S100A7 Protein, Human, Recombinant	Human	E. coli
	Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can b...
TMPJ-00003	DEFB1 Protein, Human, Recombinant	Human	E. coli
	β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a si...
TMPJ-00073	FGF-7/KGF Protein, Human, Recombinant	Human	E. coli
	Fibroblast growth factor 7 (FGF7) is a secreted protein which is mainly located in epithelial cells and belongs to the heparin-binding growth factors family. FGF family members possess broad mitogenic and cell survival a...
TMPY-02198	ILKAP Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Integrin-linked kinase-associated serine/threonine phosphatase 2C, also known as ILKAP, is a cytoplasm protein that belongs to the PP2C family. ILKAP contains one PP2C-like domain. ILKAP is widely expressed. Highest leve...
TMPJ-01073	FABP5 Protein, Human, Recombinant (His)	Human	E. coli
	Fatty acid-binding protein 5 (FABP5) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytopl...
TMPY-02838	FGFBP3 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	FGFBP3 is a member of the fibroblast growth factor-binding protein family. Members of this family binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. Fibroblast growth factors (FGFs) are impo...
TMPY-02497	S100A15 Protein, Mouse, Recombinant (His & MBP)	Mouse	E. coli
	Koebnerisin is also known as protein S100-A7A (S100A7A), S100 calcium-binding protein A7-like 1 (S100A7L1) or S100 calcium-binding protein A15 (S100A15). Human S100A7A / S100A15 is a novel member of the S100 family of EF...
TMPJ-00271	SMAD3 Protein, Human, Recombinant (His & Flag)	Human	E. coli
	Mothers against decapentaplegic homolog 3(SMAD3) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so...
TMPJ-01234	IL-36 gamma Protein, Mouse, Recombinant	Mouse	E. coli
	Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in b...
TMPJ-00045	Podoplanin Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weak...
TMPJ-00957	MMP-9 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-9 (gelatinase B) can degrade a broad range of s...
TMPJ-00072	IL-18BPd Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin 18 binding protein (IL-18BP) is a physiological inhibitor that acts through binding to the receptor-binding site of IL-18. IL-18 stimulates INF-γ, which then stimulates 18BP production via NF-κB. The interact...
TMPY-02174	FABP5 Protein, Human, Recombinant	Human	E. coli
	Fatty acid-binding protein, also known as Epidermal-type fatty acid-binding protein, Fatty acid-binding protein 5, Psoriasis-associated fatty acid-binding protein homolog, E-FABP and FABP5, is a cytoplasm protein whic...
TMPJ-01337	IL-21R Protein, Mouse, Recombinant (aa 20-236, His)	Mouse	HEK293 Cells
	Interleukin-21 receptor (IL-21R) is a type I transmembrane glycoprotein within the class I cytokine receptor family, type 4 subfamily. IL-21R is expressed mainly on B cells, NK cells, and activated T cells, but is also f...
TMPJ-00330	GPC1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling. Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 a...
TMPJ-01056	IL-18 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63...
TMPY-01953	CALML5 Protein, Human, Recombinant (His & GST)	Human	E. coli
	Calmodulin-like protein 5, also known as Calmodulin-like skin protein, CALML5 and CLSP, is a protein which contains fourEF-hand domains. CALML5 / CLSP is particularly abundant in the epidermis where its expression is ...
TMPJ-00047	IL-31 Protein, Human, Recombinant	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes...
TMPY-02242	Serpin B6 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	SerpinB6, also known as Cytoplasmic antiproteinase, Peptidase inhibitor 6, Placental thrombin inhibitor, SERPINB6 and PI-6, is a cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB6 / PI-...
TMPJ-00055	Podoplanin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Podoplanin belongs to the podoplanin family, also known as Glycoprotein 38. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmem...
TMPY-01632	Serpin B4 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...