|
T15371 |
Gardiquimod
|
|
TLR
,
HIV Protease
|
|
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells... |
|
T24984 |
5J-4
|
|
Calcium Channel
|
|
5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt. |
|
T6649 |
(S)-(+)-Rolipram
|
(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram |
Apoptosis
,
PDE
|
|
(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. |
|
TQ0221 |
Rufloxacin hydrochloride
|
MF-934 hydrochloride |
Antibacterial
|
|
Rufloxacin hydrochloride (MF-934 hydrochloride) is a fluoroquinolone antibacterial and inhibits topoisomerase. Rufloxacin hydrochloride inhibits B-cell differentiation in human mononuclear cells. |
|
T8311 |
Obefazimod
|
ABX-464,ABX464 |
HIV Protease
|
|
Obefazimod (ABX-464) is a potent anti-HIV agent. ABX464 inhibits HIV-1 replication in stimulated peripheral blood mononuclear cells (PBMCs) (IC50 : 0.1 μM - 0.5 μM) |
|
T1639 |
Amlexanox
|
CHX3673,Amoxanox,AA673 |
IL Receptor
,
FGFR
,
Others
,
IκB/IKK
|
|
Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan... |
|
T21618L |
Myelin Basic Protein (87-99) Acetate
|
Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base) |
Others
|
|
Myelin Basic Protein (87-99) Acetate (Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein (87-99) Ac... |
|
T9682 |
AZD-4877
|
AZD4877 |
Apoptosis
,
Kinesin
|
|
AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and med... |
|
T14381 |
AZD7624
|
AZD-7624 |
p38 MAPK
,
TNF
|
|
AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity. |
|
T27642 |
I-XW-053 sodium
|
I-XW-053 Na,I XW 053 sodium,IXW053 sodium,I XW 053 Na,IXW053 Na |
|
|
I-XW-053 sodium inhibits the replication of a diverse panel of primary HIV-1 isolates in Peripheral blood mononuclear cell with no appreciable cytotoxicity. |
|
T23585 |
5-Et-ddU
|
ddEtUrd,D2EtU,5-Ethyl-2',3'-dideoxyuridine |
|
|
5-Et-ddU, Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells. |
|
T27030 |
CK176
|
HIV-1 inhibitor-34,HIV-1 inhibitor 34,CK 176,CK-176,HIV-1 inhibitor34 |
|
|
CK176 is a capsid targeted inhibitor of HIV-1 replication. CK176 shows an 11-fold improvement over I-XW-053 in blocking HIV-1 replication in primary human peripheral blood mononuclear cells (PBMCs). |
|
TP1962 |
Pam2CSK4
|
|
|
|
Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells. |
|
T40979 |
XJB-5-131
|
|
|
|
XJB-5-131 is a synthetic, bi-functional antioxidant specifically designed to target mitochondria for the scavenging of reactive oxygen species (ROS) and electrons, thereby acting as a radical scavenger. Additionally, it ... |
|
T74915 |
ODN D-SL03
|
|
|
|
ODN D-SL03, a class C CpG oligonucleotide, effectively stimulates peripheral blood mononuclear cells (PBMCs) to produce high levels of IFN-α. It activates human B cells, NK cells, and mononuclear cells, elevating the exp... |
|
T35420 |
(S)-p38 MAPK Inhibitor III
|
(S)-p38 MAPK Inhibitor III |
|
|
(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononucle... |
|
T36011 |
P38 MAP Kinase Inhibitor IV
|
p38 MAPK Inhibitor IV |
|
|
p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α an... |
|
T70881 |
Dolutegravir RR Isomer
|
|
|
|
Dolutegravir RR Isomer is an isomer of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mono... |
|
T71009 |
Dolutegravir SR Isomer
|
|
|
|
Dolutegravir SR Isomer is an isomeric derivative of Dolutegravir -- a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripher... |
|
T14374 |
AZD2906
|
|
|
|
AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and ... |
|
T37590 |
ML 3403
|
|
|
|
p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).
Laufer et al (2003) Novel substituted pyr... |
|
T82515 |
E104
|
|
|
|
E104 (compound 1), a selective TLR7 agonist, exhibits potent anticancer activity when delivered via antibody-drug conjugate (ADC) technology. It effectively activates mouse macrophages and human peripheral blood mononucl... |
|
T79751 |
TLR7 agonist 16
|
|
|
|
TLR7 agonist 16 (compound 16d) is a potent activator of TLR7 with an EC50 value of 18 nM. It effectively triggers the activation of both mouse macrophages and human peripheral blood mononuclear cells (hPBMCs) at low-nano... |
|
T78370 |
Myelin Basic Protein(87-99) TFA
|
|
|
|
Myelin Basic Protein(87-99) TFA, an encephalitogenic peptide, promotes basic protein-specific T cell proliferation and induces Th1 polarization in peripheral blood mononuclear cells, which is associated with the pathogen... |
|
T36109 |
L Moses dihydrochloride
|
|
|
|
High affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM). Exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). Exhibits >4500-fo... |
|
T79749 |
TLR7 agonist 14
|
|
|
|
Compound 17b, a TLR7 agonist also known as TLR7 agonist 14, exhibits high potency with an EC50 of 18 nM. It effectively activates mouse macrophages and human peripheral blood mononuclear cells (hPBMCs) at low-nanomolar c... |
|
T74718 |
STING modulator-5
|
|
|
|
STING modulator-5 (compound 38), a STING modulator, exhibits a pIC50 value of 9.5 and antagonizes peripheral blood mononuclear cells (PBMC) with a pIC50 value of 8.1. Additionally, it acts as an antagonist of THP-1 cells... |
|
T39106 |
BMSpep-57
|
|
|
|
BMSpep-57, a potent macrocyclic peptide inhibitor, competitively disrupts the PD-1/PD-L1 interaction, demonstrating a significant inhibitory concentration (IC50) of 7.68 nM. It exhibits binding affinity towards PD-L1 wit... |
|
T69009 |
Gnidimacrin
|
|
|
|
Gnidimacrin activated HIV-1 replication and killed persistently-infected cells at picomolar concentrations. In addition to its potential to purge HIV-1 from latently infected cells, gnidimacrin potently inhibited a panel... |
|
T80964 |
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78)
|
|
|
|
Toxic Shock Syndrome Toxin-1 (TSST-1) (58-78) acts as a T cell proliferation activator by promoting the in vitro proliferation of human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner and is utilized... |
|
T78755 |
PD-1/PD-L1-IN-31
|
|
PD-1/PD-L1
|
|
PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral blood mononuclear cells (PBMCs), resulting in the inhibition of tumor cells... |
|
T79170 |
Immuno modulator-1
|
|
|
|
Immuno modulator-1 (compound 22) effectively suppresses the secretion of TNFα and IL-2 in human peripheral blood mononuclear cells (hPBMC) with IC50 values of 4.7 nM and 26 nM, respectively. Additionally, this compound e... |
|
T61574 |
PD-L1-IN-1
|
|
|
|
PD-L1-IN-1, a powerful PD-L1 inhibitor, demonstrated an IC50 of 115 nM. By forming a robust bond with the PD-L1 protein, PD-L1-IN-1 effectively suppressed tumor growth by enhancing the antitumor immune activity of periph... |
|
T74062 |
PROTAC IRAK4 degrader-2
|
|
|
|
PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels... |
|
T63287 |
HPK1-IN-3
|
|
|
|
HPK1-IN-3 is a selective, potent, ATP-competitive inhibitor of hematopoietic progenitor cell kinase 1 (HPK1; MAP4K1) (IC50: 0.25 nM). HPK1-IN-3 has IL-2 cellular potency and is able to act on human peripheral blood monon... |
|
T35929 |
O-Demethyl Apremilast
|
|
|
|
O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripher... |
|
T74990 |
ICeD-2
|
|
|
|
ICeD-2, an inducer of cell death, effectively induces the killing of HIV-1 infected cells, a process reliant on HIV-1 protease activity. It significantly inhibits the hydrolysis of Gly-Pro-AMC by dipeptidyl peptidases DP... |
|
T80130 |
SDF-1α (human)
|
|
CXCR
|
|
SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processes such as stem cell homing, retention, survival, and proliferat... |
|
T37273 |
BLX3887
|
|
|
|
BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 n... |
|
T79770 |
FB49
|
|
Autophagy
|
|
FB49 is a selective Bcl-2-associated athanogene 3 (BAG3) inhibitor with a Ki of 45 μM. It inhibits the proliferation of human tumoral cells without affecting the viability of human peripheral mononuclear cells. Additiona... |
|
T5499 |
Gardiquimod TFA salt
|
|
|
|
Gardiquimod diTFA, an imidazoquinoline analog, is a TLR7/8 agonist. Gardiquimod diTFA could inhibit HIV-1 infection of macrophages and activated peripheral blood mononuclear cells (PBMCs). Gardiquimod diTFA specifically ... |
|
T37523 |
Tenofovir diphosphate (sodium salt)
|
|
|
|
Tenofovir diphosphate is an inhibitor of HIV reverse transcriptase (Kis = 0.022 and 1.55 μM for RNA and DNA, respectively) and hepatitis B virus (HBV) polymerase (Ki = 0.18 μM). It is selective for these enzymes over DNA... |
|
T82254 |
GSK-LSD1
|
|
Histone Demethylase
|
|
GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (... |
|
T37355 |
CAY10703
|
|
|
|
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis ... |
|
T83846 |
HOXB7 (8-25) TFA
|
Homeobox B7 (8-25) |
|
|
HOXB7 (8-25), a peptide fragment derived from homeobox B7 (HOXB7)—a key controller of cell growth and oncogene activator—facilitates antigen presentation when pulsed onto dendritic cells obtained from human peripheral bl... |
|
T69081 |
KRH-1636
|
|
|
|
KRH-1636 is an orally active, selective and extremely potent CXC chemokine receptor 4 antagonist. KRH-1636 exhibits a potent and selective anti-HIV-1 activity. KRH-1636 efficiently blocked replication of various T cell ... |
|
T36862 |
Ganglioside GT1b Mixture (sodium salt)
|
Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture |
|
|
Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetan... |
|
T36461 |
CAY10748
|
CAY10748 |
|
|
CAY10748 is an agonist of stimulator of interferon genes (STING; IC50= 0.3794 μM in a competition binding assay).1It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 μM, re... |
|
T64280 |
ODN 2216
|
|
|
|
ODN 2216 is a TLR9 (toll-like receptor 9) ligand or agonist that induces the production of large amounts of IFN-α and IFN-β. ODN 2216 can induce IFN-α using pDC (plasma cell-like DC) and IL-12 (p40) using DC (dendritic c... |
|
T83698 |
Cathelicidin-2 (128-153) (chicken) TFA
|
Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153) |
|
|
Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globi... |
