|
T83243 |
7'-Hydroxy ABA
|
7'-OH ABA |
|
|
7'-Hydroxy ABA (7'-OH ABA), a metabolite of Abscisic acid (ABA), arises from the hydroxylation at the 7'-carbon of ABA. This compound demonstrates notable hormonal activity [1]. |
|
T15116 |
Dichlorophenyl-ABA
|
|
Others
|
|
Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells. |
|
T24695 |
Quinabactin
|
LC-66C6,ABA mimics 1,AM1,LC66C6,LC 66C6 |
Others
|
|
Quinabactin（LC-66C6） is a potent sulfonamide abscisic acid ABA agonist.Quinabactin promotes guard cell closure, inhibits water loss, suppresses seed germination, and improves drought tolerance in adult Arabidopsis thalia... |
|
T6329 |
3-Aminobenzamide
|
3-AB,INO1001,INO-1001,3-ABA,PARP-IN-1,INO 1001 |
PARP
|
|
3-Aminobenzamide (PARP-IN-1) is an effective inhibitor of PARP (IC50<50 nM in CHO cells) and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
|
T74995 |
8′-Hydroxy ABA
|
|
|
|
8′-Hydroxy ABA (8'-OH-ABA), a key metabolite of abscisic acid (ABA), exhibits hormonal activity by promoting enhanced oil synthesis. This compound is labile [1]. |
|
T10174 |
5-R-Rivaroxaban
|
|
Factor Xa
|
|
5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct Factor Xa (FXa) inhibitor (IC50 0.7 nM; Ki 0.4 nM). |
|
T1796 |
Otenabant hydrochloride
|
Otenabant (CP-945598) HCl,CP 945598 Hydrochloride,Otenabant |
Cannabinoid Receptor
|
|
Otenabant hydrochloride (Otenabant) (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM). |
|
T7216 |
Mirogabalin
|
DS5565 |
Calcium Channel
|
|
Mirogabalin (DS5565) is a calcium channel blocker with analgesic effects. |
|
T4341 |
Betrixaban
|
PRT054021 |
Factor Xa
|
|
Betrixaban (PRT054021) is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa [1]. It was selected among all lead compounds due to its low hERG channel ... |
|
T29215 |
Zifaxaban
|
TY 602,TY602,TY-602 |
Factor Xa
|
|
Zifaxaban (TY-602) is an orally active, competitive and selective inhibitor of factor Xa (FXa) with an IC50 of 11.1 nM for human FXa.Zifaxaban has a very high affinity, more than 10,000-fold higher than that of other ser... |
|
TP1215L |
Abaloparatide acetate(247062-33-5 free base)
|
|
Others
|
|
Abaloparatide acetate is a parathyroid hormone receptor 1 PTHR1 analogue and an effective and selective activator of the PTHR1 signaling pathway. |
|
T31597 |
Ecabapide
|
DQ2511,DQ 2511,DQ-2511 |
Others
|
|
Ecabapide (DQ-2511) is a novel gastrointestinal motility promoter that significantly enhances gastric emptying in SHRSP.Ecabapide activates cyclic GMP-dependent housekeeping Cl- channels in rabbit gastric wall cells. |
|
T6367 |
Abacavir sulfate
|
Abacavir Hemisulfate,1592U89,ABC sulfate,Ziagen |
Apoptosis
,
HIV Protease
,
Reverse Transcriptase
|
|
Abacavir sulfate (Ziagen) , a nucleoside analogue, effectively utilize its antiviral activity |
|
T77408 |
Abagovomab
|
ACA 125 |
Others
|
|
Abagovomab (Anti-Human CA-125 Recombinant Antibody) is a murine monoclonal antibody that targets the tumor-associated antigen CA-125. Abagovomab is produced by hybridoma cells in mice. Abagovomab can be used to study ova... |
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T11137 |
(E)-GABAB receptor antagonist 1
|
|
GABA Receptor
|
|
(E)-GABAB receptor antagonist 1 is a trans-GABAB receptor antagonist 1. (E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM. GABAB receptor antagonist 1 is ... |
|
T40659L |
γ-Acetylenic GABA hydrochloride
|
γ-Acetylenic GABA hydrochloride(57659-38-8 Free base) |
Transaminase
,
GABA Receptor
|
|
γ-Acetylenic GABA hydrochloride is a GABA transaminase inhibitor. |
|
T7459 |
Abametapir
|
HA-44,BRN 0123183 |
MMP
,
Others
,
Parasite
|
|
Abametapir (BRN 0123183), a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development. |
|
T4690 |
Betrixaban hydrochloride(330942-05-7(free base))
|
PRT054021 hydrochloride |
Factor Xa
|
|
Betrixaban hydrochloride(330942-05-7(free base)) (PRT054021 hydrochloride) is a potent, selective, and orally efficacious factor Xa (fXa) inhibitor (IC50: 1.5 nM). |
|
T1267 |
Abacavir
|
Epzicom,Ziagen,Abacavir sulfate |
Apoptosis
,
HIV Protease
,
Reverse Transcriptase
|
|
Abacavir (Ziagen) is a nucleoside reverse transcriptase inhibitor analog of guanosine. This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. |
|
T31206 |
Darexaban
|
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa
|
|
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati... |
|
T6507 |
Gabapentin hydrochloride
|
Neurontin HCl,Gabapentin HCl |
Calcium Channel
,
GABA Receptor
|
|
Gabapentin hydrochloride (Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain. |
|
T4980 |
Betrixaban maleate
|
|
Factor Xa
|
|
Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa. |
|
T68092 |
Letaxaban
|
TAK-442 |
Factor Xa
|
|
Letaxaban (TAK-442) is a small molecule Xa factor inhibitor that can be used to study polar coronary syndromes and thrombotic blockages. |
|
T30188L1 |
(Iso)-Atagabalin HCl
|
(Iso)-Atagabalin HCl((Iso)-223445-75-8) |
Others
|
|
(Iso)-Atagabalin HCl(isomer-Atagabalin HCl) is an alpha -2- delta ligand that can be used to treat non-restorative sleep. |
|
T27318 |
Fidexaban
|
CI-1031,BX-807834,PD-200022,CI1031,BX807834,ZK-807834 |
Factor Xa
|
|
Fidexaban (CI1031) is a novel, potent, selective and orally active factor Xa inhibitor that has demonstrated antithrombotic activity in a variety of assays |
|
T10217L |
Abarelix
|
R3827,PPI 149 |
GNRH Receptor
|
|
Abarelix (PPI 149) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, which is used for prostate cancer treatment. |
|
T4654 |
(±)-Ibipinabant
|
(±)-BMS6462,SLV319,(±)-SLV319 |
Cannabinoid Receptor
|
|
(±)-Ibipinabant ((±)-SLV319) has been used in trials studying the treatment of Obesity and Obesity and Type 2 Diabetes. |
|
T7622 |
Gabazine
|
SR95531 |
GABA Receptor
|
|
Gabazine (SR95531) is an antagonist of GABAA receptors (Ki : 74-150 nM) |
|
T0128 |
Vigabatrin
|
Sabril,Vigabatrine |
GABA Receptor
,
ABC
|
|
Vigabatrin (Sabril), an analogue of gamma-aminobutyric acid, is an irreversible inhibitor of 4-aminobutyrate Transaminase responsible for the catabolism of γ-aminobutyric acid. |
|
T1184 |
Rivaroxaban
|
BAY 59-7939 |
Factor Xa
,
Thrombin
|
|
Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both ... |
|
T0702 |
Gabapentin
|
Neurontin,Gabapentine,Aclonium |
Calcium Channel
,
GABA Receptor
|
|
Gabapentin (Neurontin) is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity. |
|
T1736 |
Apixaban
|
BMS-562247-01 |
Factor Xa
|
|
Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and pr... |
|
T21448 |
Abafungin
|
Bay w 6341,UNII-11DI31LWXF |
Others
|
|
Abafungin (Bay w 6341) is an antifungal agent with a broad-spectrum. |
|
T67853 |
Rivaroxaban Impurity
|
Rivaroxaban-10 |
Factor Xa
|
|
Rivaroxaban Impurity (Rivaroxaban-10) is a potent Blood-coagulation factor Xa inhibitor, IC50= 66 nM. |
|
T14083 |
Abaperidone
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Abaperidone is a potent 5-HT2A receptor and dopamine D2 receptor antagonist with an IC50 of 6.2 for 5-HT2A receptors and 17 nM for dopamine D2 receptors.Abaperidone is a potentially atypical anti-psychotropic compound th... |
|
T77795 |
L-DABA hydrobromide
|
L-2,4-Diaminobutyric acid hydrobromide |
Others
,
Endogenous Metabolite
|
|
L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) is a potent GABA transaminase inhibitor with antitumor and anticonvulsant activity for the study of neurological disorders. |
|
TP1215 |
Abaloparatide TFA
|
BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA |
Others
|
|
Abaloparatide TFA (BIM 44058 TFA) is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis like the related drug teriparatide. |
|
T78215 |
Dechloro Rivaroxaban
|
|
Factor Xa
,
Others
|
|
Dechloro Rivaroxaban is an orally active and highly selective Factor Xa inhibitor.Dechloro Rivaroxaban has a significant inhibitory effect on free FXa in humans.Dechloro Rivaroxaban also has an inhibitory effect on throm... |
|
T76699 |
Sabatolimab
|
MBG453,NVP-MBG453 |
Others
|
|
Sabatolimab (MBG453), a humanized IgG4 (S228P) antibody targeting TIM-3, is a potent inhibitory receptor that regulates adaptive and innate immune responses. Sabatolimab has potential immunosuppressive activity and selec... |
|
T17649 |
Boc-GABA-OH
|
|
Others
,
PROTAC Linker
|
|
Boc-GABA-OH serves as a PROTAC linker essential for synthesizing UNC6852, an EED-targeted PROTAC[1]. |
|
T16489 |
Darigabat
|
CVL-865,PF-6372865,PF-06372865 |
GABA Receptor
|
|
Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for α2, α1 PAM, and α2... |
|
T30188L |
Atagabalin HCl
|
PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base） |
Calcium Channel
|
|
Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia. |
|
T31668 |
Eribaxaban
|
PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292 |
Factor Xa
|
|
Eribaxaban (PD348292) is an orally available factor Xa inhibitor for the prevention and treatment of venous thromboembolism. |
|
T13080L |
Taranabant
|
MK-0364 |
Cannabinoid Receptor
|
|
|
|
T1519 |
Rimonabant hydrochloride
|
SR 151716A,SR 141716A |
Cannabinoid Receptor
,
Antibacterial
|
|
Rimonabant hydrochloride (SR 141716A) is a cannabinoid receptor antagonist, binding selectively to central cannabinoid receptors (CB1) with high affinity. |
|
T11349 |
GABAA receptor agent 1
|
|
GABA Receptor
|
|
GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor. |
|
T16716 |
Rabacfosadine
|
VDC-1101,GS-9219 |
Others
|
|
Rabacfosadine (GS-9219) is a novel prodrug of PMEG, an acyclic nucleotide phosphonate, with antitumor activity for the study of lymphoma. |
|
T2368L |
Edoxaban
|
Lixiana |
Factor Xa
,
Thrombin
|
|
Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is a... |
|
T21861 |
Drinabant
|
AVE-1625,AVE1625 |
Cannabinoid Receptor
|
|
Drinabant (AVE-1625) is an orally active CB1 receptor antagonist. Drinabant inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective f... |
|
T3530 |
Otenabant
|
CP-945598 |
Cannabinoid Receptor
|
|
Otenabant (CP-945598) has been investigated for the treatment of Obesity. |
