|
T1532 |
Pidotimod
|
|
Others
,
Antibacterial
|
|
Pidotimod is a synthetic dipeptide with immunomodulatory properties. |
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T2320 |
Indacaterol
|
|
Adrenergic Receptor
|
|
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist. |
|
T25376 |
Ensifentrine
|
Ensifentrina,Ensifentrinum |
PDE
|
|
Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and... |
|
T9448 |
IL-17A inhibitor 1
|
|
IL Receptor
|
|
IL-17A inhibitor 1 is a IL-17A inhibitor with IC50 of <9.45 nM in alphalisa assay. IL-17A inhibitor 1 inhibits HT-29 cells with IC50 of 9.3 nM. |
|
T9499 |
Icenticaftor
|
QBW251 |
CFTR
|
|
Icenticaftor (QBW251) is an orally active potentiator of CFTR channel. |
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T15430 |
GSK2256294A
|
GSK 2256294 |
Others
,
Epoxide Hydrolase
|
|
GSK2256294A (GSK 2256294) is potent, selective inhibitor of recombinant human, rat and mouse sEH with IC50 of 27 pM, 61 pM and 189 pM, respectively. |
|
T30258 |
AZD-4818
|
CCR1 antagonist |
CCR
|
|
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease. |
|
T4503 |
Talniflumate
|
Somalgen |
Chloride channel
,
COX
,
N-Acetylglucosaminyltransferase
,
Anion Exchanger
|
|
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o... |
|
T22245 |
Arformoterol Tartrate
|
(R,R)-Formoterol tartrate |
Adrenergic Receptor
|
|
Arformoterol Tartrate ((R,R)-Formoterol tartrate) is the tartrate salt of arformoterol. Arformoterol is a long-acting beta-2 adrenergic agonist with bronchodilator activity[2]. |
|
T6445 |
Cilomilast
|
SB-207499,Ariflo |
PDE
|
|
Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3. |
|
T0794 |
Mepenzolate Bromide
|
Colibantil,Cantil,Cantilaque |
AChR
|
|
Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions. |
|
T1239 |
Indacaterol maleate
|
QAB149 |
Adrenergic Receptor
|
|
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist. |
|
T5159 |
Olodaterol hydrochloride
|
BI-1744 HCl,BI 1744 hydrochloride |
Adrenergic Receptor
|
|
Olodaterol hydrochloride (BI-1744 HCl) is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and activating β2-adrenergic receptors... |
|
T3457 |
Olodaterol
|
BI1744,Striverdi Respimat |
Adrenergic Receptor
|
|
Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. |
|
T31207 |
GSK233705
|
Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B |
AChR
|
|
GSK233705 (Darotropium bromide) is a muscarinic receptor antagonist used in conjunction with the prevention and treatment of chronic obstructive pulmonary disease (COPD) and asthma in humans. |
|
T33386 |
Milveterol HCl
|
Milveterol,GSK-159797,GSK 159797,GSK159797 |
Adrenergic Receptor
|
|
Milveterol HCl is a long-acting β(2) -adrenergic receptor agonist for the potential treatment of chronic obstructive pulmonary disease (COPD). |
|
T30232 |
AWD 12-281
|
GSK 842470,GSK-842470,AWD12-281,AWD-12-281,GW 842470 |
PDE
|
|
AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory and bronchodilator activity used in the study of chronic obstructive pulmonary disease (COPD). |
|
T83168 |
Aderamastat
|
FP-003,FP-025 |
MMP
|
|
Aderamastat (FP-025) is an orally active matrix metalloproteinase 12 (MMP-12) inhibitor indicated for the study of allergic asthma, COPD and pulmonary fibrosis. |
|
T33941 |
PF-03635659
|
PF03635659,PF 03635659 |
AChR
|
|
PF-03635659 is a potent and long dissociative half-life muscarinic M3 antagonist (Ki: 0.2 nM) that shows potential for the treatment of chronic obstructive pulmonary disease (COPD). |
|
T76910 |
Astegolimab
|
RG 6149,MSTT 1041A |
Interleukin
|
|
Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe ast... |
|
T6505 |
Formoterol fumarate
|
Formoterol Hemifumarate,NSC 299587,Eformoterol Hemifumarate,CGP 25827A,Eformoterol,YM 08316 |
Adrenergic Receptor
|
|
Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma. |
|
T70047 |
Bedoradrine
|
Bedoradrine free base |
Adrenergic Receptor
|
|
Bedoradrine free base is a novel, highly selective β2-adrenoceptor agonist for the treatment of asthma and chronic obstructive pulmonary disease (COPD). |
|
T72031 |
BI 1015550
|
|
PDE
|
|
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmo... |
|
T72918 |
JNJ-49095397
|
RV568 |
Antiviral
,
p38 MAPK
|
|
JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and resp... |
|
T39719 |
Nrf2 activator-1
|
Nrf2 activator-1 |
Nrf2
|
|
Nrf2 activator-1 is a potent activator of NF-E2-related factor 2 (Nrf2).Nrf2 activator-1 can be used to study COPD and other respiratory diseases including asthma, acute lung injury (ALI), acute respiratory distress synd... |
|
T60196 |
IHMT-PI3Kδ-372 S-isomer
|
|
PI3K
|
|
IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM. IHMT-PI3Kδ-372 S-isomer shows high selectivity over other class I PI3Ks (56∼83 fold) and other protein kinases. IHMT-PI3Kδ-372 can ... |
|
T6653 |
Salmeterol Xinafoate
|
Salmetedur,GR 33343X xinafoate,Arial |
HIV Protease
,
Adrenergic Receptor
|
|
Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptom... |
|
T77601 |
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid
|
|
GPR
|
|
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and con... |
|
T1179 |
Tiotropium bromide
|
Tiopropium,BA679 BR |
AChR
|
|
Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical a... |
|
T6547 |
Ipratropium Bromide
|
Sch 1000,Itrop,Atrovent |
AChR
|
|
Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema. |
|
T6707 |
Tiotropium Bromide hydrate
|
BA-679 BR hydrate,BA 679BR |
AChR
|
|
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a... |
|
T2555 |
Aclidinium bromide
|
LAS 34273,LAS-W 330 |
AChR
|
|
Aclidinium bromide (LAS-W 330) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis or emphysema. Aclidinium has not been implicated in causing li... |
|
T1139 |
Salbutamol
|
Albuterol,AH-3365 |
Adrenergic Receptor
|
|
Salbutamol (Albuterol) stimulates beta2-adrenergic receptors in the lungs, thereby activating the enzyme adenylate cyclase that catalyzes the conversion of ATP to cyclic-3', 5'-adenosine monophosphate (cAMP). Salbutamol ... |
|
TP2406 |
Seretide
|
Adoair,Advair,Fluticasone/Salmeterol |
|
|
Seretide, a combination of fluticasone and salmeterol, controls symptoms of asthma and chronic obstructive pulmonary disease (COPD). |
|
T27290 |
Etamiphylline Camsylate
|
R 3588,Etamiphylline Camsilate,Milliphylline,Soluphyline,R-3588,R3588 |
|
|
Etamiphylline Camsylate is used for the treatment of chronic obstructive pulmonary disease (COPD). |
|
T60071 |
PF 00356231
|
|
MMP
|
|
PF 00356231 is a selectivity inhibitor MMP-12 and can be used in studies about the treatment of emphysema and chronic obstructive pulmonary disease (COPD). |
|
T28519 |
Reproterol hydrochloride
|
D 1959,D1959,D-1959,W-2946M,W 2946M |
|
|
Reproterol hydrochloride, a β2 adrenoreceptor agonist, is used to treat asthma and chronic obstructive pulmonary disease (COPD). |
|
T28878 |
Sul-121 HCl
|
Sul-121 Hydrochloride |
|
|
Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidati... |
|
T20829 |
Pivampicillin
|
|
|
|
Pivampicillin, a pivalate ester analog of Ampicillin, is used to treat chronic obstructive pulmonary disease (COPD) in children and young adults. |
|
T30265 |
Navafenterol saccharinate
|
AZD8871 saccharinate,LAS-191351 saccharinate,LAS191351 saccharinate,AZD-8871 saccharinate |
|
|
AZD-8871 saccharinate is a dual-acting bronchodilator which may be useful in the treatment of Chronic Obstructive Pulmonary Disease (COPD). |
|
T68240 |
AZD-9819
|
|
|
|
AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease (COPD). |
|
T30264 |
Navafenterol
|
AZD8871,LAS-191351,AZD 8871,LAS191351,AZD-8871,LAS 191351 |
|
|
AZD-8871 can present a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]). |
|
T13106 |
TD-5471 hydrochloride
|
|
Adrenergic Receptor
|
|
|
|
T38944 |
Tetomilast
|
OPC-6535,Tetomilast |
|
|
Tetomilast (OPC-6535) is a phosphodiesterase-4 (PDE4) inhibitor, potentially effective in treating inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). |
|
T13277 |
Valategrast
|
R-411 free base |
Others
|
|
Valategrast is a potent and orally active dual antagonist of integrin α4β1 (VLA-4) and α4β7, with the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment. |
|
T2645 |
Vilanterol
|
GW642444,GW642444X |
Adrenergic Receptor
|
|
Vilanterol is a selective long-acting beta2-adrenergic agonist (LABA) used in the treatment of COPD and asthma. |
|
T25030 |
Albuterol stearate
|
|
|
|
Albuterol stearate is a salt of Albuterol. Albuterol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 r... |
|
T26628 |
Andolast
|
CR2039,CR-2039,CR 2039 |
|
|
Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesi... |
|
T71240 |
AS 703026
|
|
|
|
AS 703026 has been shown to inhibit LPS-induced TNFα production in macrophages/monocytes as well as protect from LPS-induced endotoxin shock. AS 703026 may be useful as an anti-inflammatory therapy for COPD patients. |
|
T79538 |
PDE4-IN-13
|
|
|
|
PDE4-IN-13 is a phosphodiesterase 4 (PDE4) inhibitor exhibiting anti-inflammatory and antioxidant activities, with an half maximal inhibitory concentration (IC50) value of 1.56 μM. It is used in the research of chronic o... |
