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T23164 |
PIT
|
2,2'-Pyridylisatogen tosylate |
P2Y Receptor
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PIT (2,2'-Pyridylisatogen tosylate) is a specific and non-competitive antagonist of the Purinergic receptor P2Y1 with an IC50 of 0.14 μM for human P2Y1. PIT does not affect nucleotide binding and can be used in studies a... |
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T23163 |
PIT 1
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Others
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Akt signaling inhibitor |
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T35491 |
3,5-dimethyl PIT-1
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|
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PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is impor... |
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T12490 |
Pitavastatin lactone
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Others
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Pitavastatin lactone is a major Pitavastatin metabolite in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes. |
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T29096L |
Vapitadine
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R 129160 |
Histamine Receptor
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Vapitadine is a non-sedative antihistamine compound that relieves itching caused by atopic dermatitis. |
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T13329 |
Vofopitant
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GR 205171 |
Neurokinin receptor
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T14524 |
Befetupitant
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Ro67-5930 |
Neurokinin receptor
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Befetupitant (Ro67-5930) is a potent and selective tachykinin 1 receptor (NK1R) antagonist for the study of corneal neovascularization. |
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T4466 |
Pitofenone hydrochloride
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Baralgin Ketone Hydrochloride,Pitophenone hydrochloride |
AChE
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Pitofenone hydrochloride (Pitophenone hydrochloride), a spasmolytic compound, inhibits the acetylcholinesterase (AChE) activity from bovine erythrocytes and from electric eel with Kis of 36 and 45 μM, respectively. |
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T17156 |
Tradipitant
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VLY-686,LY686017 |
Neurokinin receptor
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Tradipitant (VLY-686) is an antagonist of neurokinin-1. |
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T1916 |
Apitolisib
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RG 7422,GNE 390,GDC-0980 |
Apoptosis
,
PI3K
,
mTOR
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Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce... |
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T68068 |
Ezlopitant
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CJ 11974,CJ-11974,CJ11974 |
Neurokinin receptor
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Ezlopitant (CJ-11974) is a small molecule neurokinin-1-receptor (NK1) antagonist used to treat nausea, vomiting and pain. |
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T25672 |
Lesopitron
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5-HT Receptor
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Lesopitron is an anxiolytic with pre- and postsynaptic 5-HT1A agonist activity and is more effective than 5-HT1A agonists in rat social interaction and marmoset anxiety models. lesopitron counteracts benzodiazepine withd... |
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T26363L |
Napitane
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A75200,A-75200,A 75200,ABT 200 |
Adrenergic Receptor
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napitane (A 75200) is a novel catecholamine uptake inhibitor with inhibitory effects on α-adrenergic receptors and potential antidepressant activity for the study of depression. |
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T2534 |
Pitavastatin calcium
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P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,NK-104 |
Apoptosis
,
Mitophagy
,
Endogenous Metabolite
,
HMG-CoA Reductase
,
Autophagy
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Pitavastatin calcium (NK-104) is a potent inhibitor of HMG-CoA reductase (Ki: 1.7 nM). It lowers both total cholesterol and low-density lipoprotein cholesterol in animals and humans. Metabolism of pitavastatin by the cyt... |
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T6905 |
Netupitant
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Ro 67-31898/000,CID 6451149 |
Neurokinin receptor
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Netupitant (CID 6451149) is a specific neurokinin 1 (NK1) receptor antagonist (Ki: 0.95 nM). |
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T3716 |
Rolapitant
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SCH619734 |
Neurokinin receptor
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Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ... |
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T3724 |
Rolapitant hydrochloride
|
Rolapitant HCl |
Neurokinin receptor
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Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a K i of 0.66 nM. Rolapitant hydrochloride (Rolapitant HCl) does not interact with CY... |
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T25615 |
Lanepitant
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LY303870,LY-303870,LY 303870 |
Others
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Lanepitant (LY303870) is a nonpeptide neurokinin-1 (NK-1) antagonist with analgesic activity that inhibits neurogenic dura mater inflammation and is used for the prevention of migraine. |
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T8439 |
Clobenpropit dihydrobromide
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Apoptosis
,
Histamine Receptor
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Clobenpropit dihydrobromide is a potent antagonist and inverse agonist of histamine H3R (histamine H3LR,pEC50 of 8.07) |
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T29096 |
Vapitadine dihydrochloride
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Vapitadine 2HCl,R129160,R-129160 2HCl,Vapitadine HCl,R 129160 2HCl,R-129160,R 129160,R129160 2HCl |
Histamine Receptor
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Vapitadine dihydrochloride(R-129160 2HCl) is a novel, potent, selective and non-sedating compound with inhibitory effects on histamine H1. |
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T7176 |
Pitolisant hydrochloride
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BF 2649,Ciproxidine |
Histamine Receptor
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Pitolisant hydrochloride (Ciproxidine) is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM). |
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T7209 |
Maropitant
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Neurokinin receptor
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Maropitant is a selective neurokinin (NK1) receptor antagonist. |
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TP2189L |
V5 Epitope Tag Peptide acetate
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Others
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V5 Epitope Tag Peptide acetate is a peptide |
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T69140 |
Burapitant
|
SSR 240600 |
Neurokinin receptor
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Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity. |
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T13131 |
Tert-Buthyl Pitavastatin
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HMG-CoA Reductase
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tert-Buthyl Pitavastatin is Pitavastatin metabolite. Pitavastatin is a potent inhibitor of HMG-CoA reductase. |
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T76698 |
Rovalpituzumab
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Gamma-secretase
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Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjugates (ADCs). Rovalpituzumab has anticancer activity and is ... |
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T35914 |
Epitinib succinate
|
HMPL-813 succinate |
EGFR
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Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer. |
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T11839L |
Lesopitron HCl
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Lesopitron HCl(132449-89-9 Free base) |
5-HT Receptor
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Lesopitron HCl is a 5-HT1A receptor agonist with anxiolytic effects that reverses dark avoidance behavior associated with cocaine withdrawal in mice. |
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T77445 |
Apitegromab
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SRK-015 |
Opioid Receptor
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Apitegromab (SRK-015) is a new myostatin inhibitor, an antibody targeting myostatin precursor, which can be used to study neuromuscular diseases including spinal muscular atrophy. |
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T1860 |
Imepitoin
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AWD 131-138,ELB-138 |
GABA Receptor
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Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models. |
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T1790 |
Fosaprepitant dimeglumine
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L785298,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor
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Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion... |
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T26357 |
Pitstop 2
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Apoptosis
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Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle rec... |
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T13329L |
Vofopitant dihydrochloride
|
GR 205171A,Vofopitant 2HCl |
Neurokinin receptor
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Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.Vofopitant dihydrochloride is... |
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TP1291 |
Epithalon TFA (307297-39-8 free base)
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Epithalon TFA |
Others
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Epithalon TFA (307297-39-8 free base) (Epithalon TFA) is an anti-aging agent and telomerase activator. |
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T25616 |
Lanepitant 2HCl
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LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride |
Neurokinin receptor
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Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist with analgesic and anti-inflammatory activity.Lanepitant 2HCl inhibits the binding of Substance P to the neurokinin-1 receptor, inhibits neurogenic inflam... |
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TNU0839 |
1,4-Dideoxy-1,4-epithio-D-ribitol
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Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
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1,4-Dideoxy-1,4-epithio-D-ribitol is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and possesses a broad spectrum of antitumor activity.1,4-Dideoxy-1,4-epithio-D-ribitol induces a... |
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T60636 |
Pitolisant
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Tiprolisant,BF-2.649,BF-2649 |
Histamine Receptor
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Pitolisant (Tiprolisant) is a selective and potent non-imidazole recombinant human histamine H3 receptor antagonist for the study of excessive daytime sleepiness and sudden collapse in patients with episodic narcolepsy. |
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T1743 |
Aprepitant
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MK-869,MK-0869,L-754030,Aprepitant` |
HIV Protease
,
Antibacterial
,
Antibiotic
,
Neurokinin receptor
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Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and C... |
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T6092 |
Sapitinib
|
AZD-8931 |
EGFR
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Sapitinib (AZD-8931) , a reversible, ATP competitive inhibitor of EGFR(IC50=4 nM), ErbB2(IC50=3 nM) and ErbB3(IC50=4 nM), is more effective over Gefitinib or Lapatinib against NSCLC cell, 100-fold more specific for the E... |
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TP2311 |
C-MYC PEPTIDE EPITOPE TFA
|
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Others
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C-MYC PEPTIDE EPITOPE TFA, the product of the c-myc proto-oncogene, is a helix-loop-helix leucine zipper phosphoprotein that regulates gene transcription in cell proliferation, cell differentiation and apoptosis. This pe... |
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TP1865L |
Rhodopsin Epitope Tag acetate
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Others
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Rhodopsin Epitope Tag acetate is a 9-amino acid peptide representing C terminus of bovine rhodopsin widely used as an epitope tag. A number of anti-rhodopsin antibodies can recognize this epitope. |
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T19762 |
Clobenpropit 2HBr
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VUF-9153,VUF 9153,Clobenpropit Dihydrobromide,VUF9153 |
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Clobenpropit 2HBr is a histamine H3 receptor antagonist. It has neuroprotective effects via stimulation of GABA release in the brain. |
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T16786 |
Ropitoin
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TR 2985 |
Others
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Ropitoin is a novel drug of antiarrhythmics. |
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T62397 |
Epitinib
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|
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Epitinib is an orally active, selective, blood-brain barrier crossing epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). |
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T76513 |
2F5 epitope
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The 2F5 epitope, a peptide gp41 (659-671), encompasses the complete sequential epitope recognized by one of the three broadly neutralizing antibodies against a wide range of primary HIV-1 isolates. This epitope is unique... |
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TP1456 |
Epitalon
|
Epithalon |
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Epithalon (also known as Epitalon or Epithalone) is the synthetic version of the polypeptide Epithalamin which is naturally produced in the pineal gland. |
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T68399 |
Pitrazepin
|
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Pitrazepin is a new GABAA receptor antagonist reported to antagonize electrophysiological effects of GABA |
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T69420 |
Vestipitant
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Vestipitant, also known as GW597599, is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utilit... |
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T68566 |
Pitavastatin methyl ester
|
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Pitavastatin methyl ester is the methyl ester derivative of Pitavastatin -- a competitive inhibitor of HMG-CoA reductase and an anti-lipemic agent. |
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T9471 |
Imnopitant
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Imnopitant is an antagonist of the NK1 receptor [1]. |
