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Search Results for " RNA-dependent "

ターゲット

80

阻害剤

7

天然化合物

59

リコンビナントタンパク質

2

ライブラリー

カタログ番号 製品名 別名 ターゲット
T14495 Baloxavir Baloxavir acid,S-033447 Influenza Virus
Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.
T4686 Simeprevir TMC435,TMC-435350,Olysio HCV Protease , SARS-CoV
Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.
T8972 FIT-039 Others , DNA/RNA Synthesis , CDK , HSV
FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...
T5539 GS-443902 Nucleoside Antimetabolite/Analog , HCV Protease , SARS-CoV , DNA/RNA Synthesis , RSV , Drug Metabolite
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks
T6833 Favipiravir T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
T27696 JTK-109 JTK109 HCV Protease
JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.
T15282 Filibuvir PF-00868554 HCV Protease , DNA/RNA Synthesis
Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.
T1501 Rifabutin LM-427,Ansamycin HSP , DNA/RNA Synthesis , Antibacterial , Antibiotic
Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin...
T9617 RdRP-IN-2 SARS-CoV
RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. It significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.It also inhibits Feline coronavirus (FIPV) replication.
T9618 HeE1-2Tyr SARS-CoV
HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.
TQ0090 Nesbuvir HCV-796 HCV Protease
Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons.
T10491 Galidesivir BCX4430,Immucillin-A Others
T3489 Dasabuvir ABT-333 HCV Protease
Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...
T82568 DHX9-IN-2 DNA/RNA Synthesis
DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.
T63253 AVG-233 DNA/RNA Synthesis , RSV
AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytia...
T7766 Remdesivir GS-5734 SARS-CoV , DNA/RNA Synthesis
Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viru...
T1154 Rifaximin DNA/RNA Synthesis , Antibacterial , Antibiotic
Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting...
T11760 KIN101 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene HCV Protease , Influenza Virus , RSV , Antifection
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and R...
T61334 DMA-135 hydrochloride DMA-135 HCl Virus Protease
DMA-135 hydrochloride (DMA-135 HCl) Antivirally active compounds that target RNA and inhibit enterovirus type 71 (EV71) IRES-dependent translation and replication.DMA-135 hydrochloride can be used in the study of enterov...
T19836 2-Aminopurine DNA/RNA Synthesis , PKA
2-Aminopurine is a double-stranded RNA-dependent protein kinase, protein kinase R (PKR) inhibitor.
T77520 AOH1996 Apoptosis , DNA/RNA Synthesis
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ...
T79404 A09-003 Apoptosis , BCL , CDK
A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.A0...
T27260 Emivirine MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302 HIV Protease
Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
T10491L Galidesivir hydrochloride BCX 4430 hydrochloride,Immucillin-A hydrochloride Others
Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.
T40267 RdRP-IN-3
RdRP-IN-3, a potential anti-influenza drug candidate, functions by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).
T21225 Rifamycin Rifocin,Rifamycin SV
Rifamycin, a natural antibiotic, inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis, leading to the block of RNA-polymerase transcription initiation.
T71825 BEPP monohydrochloride
BEPP monohydrochloride is a double-strand RNA-dependent protein kinase (PKR) activator.
T28538 Rifamycin SV
Rifamycin SV, a natural antibiotic, blocks RNA-polymerase transcription initiation, modulating ß2m aggregation; inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis.
T71748 RK-0404678
RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
T27485 GSK-625433
GSK-625433, a homochiral inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, has the ability to inhibit the polymerase of both HCV genotypes 1a and 1b.
T63598 DENV-IN-4
DENV-IN-4 is a potent inhibitor of DENV (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9). The antiviral effect was demonstrated by the concentration-dependent reduction of DENV2 expression and the inhibition of RNA-depende...
T11062 DmDNA31 Others
dmDNA31 is a rifamycin antibiotic that can inhibit the DNA-dependent RNA polymerase of bacteria and has strong bactericidal activity against Staphylococcus aureus.
T70855 Favipiravir sodium
Favipiravir sodium is a selective inhibitor of viral RNA-dependent RNA polymerase with activity against many RNA viruses, influenza viruses, West Nile virus, yellow fever virus, foot-and-mouth disease virus as well as o...
T11352 Galidesivir triphosphate BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870 Others
Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA pol...
T25106 Aranotin L53185,Lilly 53185,L 53185,L-53185,Antibiotic A 21101-IL
Aranotin is a fungal toxin isolated from Arachniotus aureus with activity against RNA viruses such as poliovirus, coxsackie virus, and rhino- and parainfluenza viruses. Aranotin inhibits viral RNA synthesis by impeding t...
T73323 RdRP-IN-5 Influenza Virus
RdRP-IN-5 (compound 20), a potent inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), has potential application in influenza research [1].
T72896 Cis-RdRP-IN-5
Cis-RdRP-IN-5 is an effective inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), employed in influenza virus research.
T38616 Teprasiran QPI-1002
Teprasiran (QPI-1002) is an RNA-based compound that transiently suppresses p53-dependent apoptosis, a process involved in the development of acute kidney injury (AKI).
T72792 Trans-RdRP-IN-5
Trans-RdRP-IN-5 is a potent inhibitor of the influenza virus RNA-dependent RNA polymerase (RdRP), with applications in influenza virus research.
T63073 Cap-dependent endonuclease-IN-19
Cap-dependent endonuclease-IN-19 is a spirocyclic pyridinone derivative and a potent inhibitor of cap-dependent nucleic acid endonuclease (CEN). cap-dependent endonuclease-IN-19 potently inhibits the RNA polymerase activ...
T62160 AS-136A
AS-136A is an orally active, non-nucleoside inhibitor of measles virus RNA-dependent RNA polymerase (RdRp) that acts against measles virus (IC50: 2 μM).
T41177 Galidesivir dihydrochloride BCX 4430
Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arena...
T64177 Cap-dependent endonuclease-IN-2
Cap-dependent endonuclease-IN-2 is a potent inhibitor of cap-dependent nucleic acid endonucleases (CEN). Cap-dependent endonuclease-IN-2 significantly inhibits influenza A virus RNA polymerase activity.
T35657 3'-Deoxyuridine-5'-triphosphate
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that not only inhibits DNA-dependent RNA polymerases I and II, but also competitively and strongly inhibits the incorporation of UTP into RNA, exhibiting...
T38761 GS-443902 trisodium GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
GS-443902 trisodium (GS-441524 triphosphate trisodium), the active triphosphate metabolite of Remdesivir (GS-5734), serves as a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), displaying inhibitory concen...
T83251 7-51A Influenza Virus
7-51A is an effective inhibitor of the PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRP), with a dissociation constant (K_D) of 1.64 nM as determined by isothermal titration calorimetry (ITC).
T35658 3'-Deoxyuridine-5'-triphosphate trisodium
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that suppresses DNA-dependent RNA polymerases I and II activity. It competitively obstructs the inclusion of UTP into RNA, demonstrat...
T79233 RdRP-IN-6 DNA/RNA Synthesis
RdRP-IN-6 (compound 27) is an inhibitor of RNA-dependent RNA polymerase (RdRp), exhibiting an IC90 value of 14.1 μM. It has potential applications in antiviral and anticancer research [1].
T16749 Rifalazil KRM-1648,ABI-1648 DNA/RNA Synthesis
T40616 8-Azido-ATP 8-Azidoadenosine 5'-triphosphate,8-N3-ATP,8-Azido-ATP
8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase acti...

Compounds

Baloxavir
T14495
Synonym: Baloxavir acid,S-033447
Target: Influenza Virus
Simeprevir
T4686
Synonym: TMC435,TMC-435350,Olysio
Target: HCV Protease, SARS-CoV
FIT-039
T8972
Synonym:
Target: Others, DNA/RNA Synthesis, CDK, HSV
GS-443902
T5539
Synonym:
Target: Nucleoside Antimetabolite/Analog, HCV Protease, SARS-CoV, DNA/RNA Synthesis, RSV, Drug Metabolite
Favipiravir
T6833
Synonym: T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide
Target: Others, SARS-CoV, Influenza Virus, DNA/RNA Synthesis
JTK-109
T27696
Synonym: JTK109
Target: HCV Protease
Filibuvir
T15282
Synonym: PF-00868554
Target: HCV Protease, DNA/RNA Synthesis
Rifabutin
T1501
Synonym: LM-427,Ansamycin
Target: HSP, DNA/RNA Synthesis, Antibacterial, Antibiotic
RdRP-IN-2
T9617
Synonym:
Target: SARS-CoV
HeE1-2Tyr
T9618
Synonym:
Target: SARS-CoV
Nesbuvir
TQ0090
Synonym: HCV-796
Target: HCV Protease
Galidesivir
T10491
Synonym: BCX4430,Immucillin-A
Target: Others
Dasabuvir
T3489
Synonym: ABT-333
Target: HCV Protease
DHX9-IN-2
T82568
Synonym:
Target: DNA/RNA Synthesis
AVG-233
T63253
Synonym:
Target: DNA/RNA Synthesis, RSV
Remdesivir
T7766
Synonym: GS-5734
Target: SARS-CoV, DNA/RNA Synthesis
Rifaximin
T1154
Synonym:
Target: DNA/RNA Synthesis, Antibacterial, Antibiotic
KIN101
T11760
Synonym: 3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene
Target: HCV Protease, Influenza Virus, RSV, Antifection
DMA-135 hydrochloride
T61334
Synonym: DMA-135 HCl
Target: Virus Protease
2-Aminopurine
T19836
Synonym:
Target: DNA/RNA Synthesis, PKA
AOH1996
T77520
Synonym:
Target: Apoptosis, DNA/RNA Synthesis
A09-003
T79404
Synonym:
Target: Apoptosis, BCL, CDK
Emivirine
T27260
Synonym: MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302
Target: HIV Protease
Galidesivir hydrochloride
T10491L
Synonym: BCX 4430 hydrochloride,Immucillin-A hydrochloride
Target: Others
RdRP-IN-3
T40267
Synonym:
Target:
Rifamycin
T21225
Synonym: Rifocin,Rifamycin SV
Target:
BEPP monohydrochloride
T71825
Synonym:
Target:
Rifamycin SV
T28538
Synonym:
Target:
RK-0404678
T71748
Synonym:
Target:
GSK-625433
T27485
Synonym:
Target:
DENV-IN-4
T63598
Synonym:
Target:
dmDNA31
T11062
Synonym:
Target: Others
Favipiravir sodium
T70855
Synonym:
Target:
Galidesivir triphosphate
T11352
Synonym: BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870
Target: Others
Aranotin
T25106
Synonym: L53185,Lilly 53185,L 53185,L-53185,Antibiotic A 21101-IL
Target:
RdRP-IN-5
T73323
Synonym:
Target: Influenza Virus
cis-RdRP-IN-5
T72896
Synonym:
Target:
Teprasiran
T38616
Synonym: QPI-1002
Target:
trans-RdRP-IN-5
T72792
Synonym:
Target:
Cap-dependent endonuclease-IN-19
T63073
Synonym:
Target:
AS-136A
T62160
Synonym:
Target:
Galidesivir dihydrochloride
T41177
Synonym: BCX 4430
Target:
Cap-dependent endonuclease-IN-2
T64177
Synonym:
Target:
3'-Deoxyuridine-5'-triphosphate
T35657
Synonym:
Target:
GS-443902 trisodium
T38761
Synonym: GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
Target:
7-51A
T83251
Synonym:
Target: Influenza Virus
3'-Deoxyuridine-5'-triphosphate trisodium
T35658
Synonym:
Target:
RdRP-IN-6
T79233
Synonym:
Target: DNA/RNA Synthesis
Rifalazil
T16749
Synonym: KRM-1648,ABI-1648
Target: DNA/RNA Synthesis
8-Azido-ATP
T40616
Synonym: 8-Azidoadenosine 5'-triphosphate,8-N3-ATP,8-Azido-ATP
Target:
1 2
カタログ番号 製品名 別名 ターゲット
T17143 Toyocamycin Vengicide Apoptosis , Others , IRE1 , Antibiotic , Antifungal
Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.
T8347 Rifamycin S Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
TN1258 3-Acetyl-beta-boswellic acid 3-O-Acetyl-beta-boswellic acid DNA/RNA Synthesis
3-Acetyl-beta-boswellic acid has antitumor activity, it inhibits synthesis of DNA, RNA and protein in human leukemia HL-60 cells in a dose dependent manner with IC50 values ranging from 0.6 to 7.1 microM.
T5003 Rifamycin sodium Rifamycin sodium salt Antibacterial , Antibiotic
Rifamycin sodium (Rifamycin sodium salt) salt is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase. It is effective against Gram-positive bacteria.
T5075 Phytic acid potassium Inositol hexakisphosphate dipotassium salt,Phytic acid dipotassium salt,Fytic Acid dipotassium salt,Inositol polyphosphate dipotassium salt Others , Endogenous Metabolite
Phytic acid potassium (Inositol polyphosphate dipotassium salt) exists in all eukaryotic cells. In plants, it is known to function as a [PO4]3 storage depot and precursor for other inositol phosphates and pyrophosphates....
TN2222 Sotetsuflavone Others
Sotetsuflavone, with an IC50 of 0.16 μM, stands as the most active compound in its series, acting as a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase).
T11233 Erythromycin thiocyanate Antibacterial
Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nuc...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPY-06071 SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) SARS-CoV-2 Baculovirus Insect Cells
SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 108.3 kDa and the accession number is YP_009725307.1.
TMPH-01900 DDX5 Protein, Human, Recombinant (His & Myc) Human E. coli
DDX5 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 74.1 kDa and the accession number is P17844.
TMPH-01902 DDX60 Protein, Human, Recombinant (His) Human E. coli
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-...
TMPH-00980 DHX33 Protein, Human, Recombinant (His) Human E. coli
DHX33 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-00979 DDX3Y Protein, Human, Recombinant (His & Myc) Human Baculovirus Insect Cells
DDX3Y Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.
TMPH-00976 DDX19A Protein, Human, Recombinant (His & SUMO) Human E. coli
DDX19A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-00975 DDX1 Protein, Human, Recombinant (His & Myc) Human E. coli
DDX1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02133 DDX39B Protein, Human, Recombinant (GST) Human E. coli
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mR...
TMPH-00974 DHX9 Protein, Human, Recombinant (His & SUMO) Human E. coli
DHX9 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-01899 ALKBH5 Protein, Human, Recombinant (His) Human E. coli
ALKBH5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.2 kDa and the accession number is Q6P6C2.
TMPH-00973 DHX36 Protein, Human, Recombinant (His & Myc) Human E. coli
DHX36 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 18.2 kDa and the accession number is Q9H2U1.
TMPH-00978 DDX3X Protein, Human, Recombinant (His & Myc) Human Baculovirus Insect Cells
DDX3X Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 77 kDa and the accession number is O00571.
TMPH-00977 DDX3X Protein, Human, Recombinant (B2M & His) Human E. coli
DDX3X Protein, Human, Recombinant (B2M & His) is expressed in E. coli.
TMPH-01901 DDX53 Protein, Human, Recombinant (His & Myc) Human E. coli
N/A. DDX53 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 76.2 kDa and the accession number is Q86TM3.
TMPY-02219 Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) H1N1 E. coli
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the N...
TMPY-05024 Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His) ZIKV Baculovirus Insect Cells
Zika virus NS5 is involved in methytransferase and RNA guanylytransferase activities and capping and synthesis of RNA. And, NS5 is also an RNA-dependent RNA polymerase.
TMPH-00741 Rho Protein, E. coli, Recombinant (His) E. coli E. coli
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template. RNA-dependent NTPase wh...
TMPH-03184 P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc) Pseudomonas phage phi6 E. coli
Rna-dependent RNA polymerase part of the packaging complex that packages the viral RNA segments, replicate them into a double-stranded form and transcribe them. P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc)...
TMPH-00732 RtcB Protein, E. coli, Recombinant (His) E. coli P. pastoris (Yeast)
GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splici...
TMPY-05749 SARS-CoV-2 NSP8 Protein (Avi) SARS-CoV-2 E. coli
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarka...
TMPY-06416 SARS-CoV-2 NSP8 Protein SARS-CoV-2 E. coli
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarka...
TMPH-03404 Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His) Reo-3 E. coli
Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase...
TMPH-00147 IBV (strain KB8523) Replicase polyprotein 1ab (His) IBV Baculovirus Insect Cells
The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as...
TMPH-01247 POLR3K Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs....
TMPH-02380 RPB5 Protein, Kluyveromyces marxianus, Recombinant (His) Kluyveromyces marxianus E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precurs...
TMPH-02385 Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc) MARV E. coli
Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA secondary ...
TMPH-00094 HSP21, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc) Arabidopsis thaliana E. coli
Chaperone protein required for seedling and chloroplast development under heat stress, probably by maintaining plastid-encoded RNA polymerase (PEP)-dependent transcription. HSP21, chloroplastic Protein, Arabidopsis thali...
TMPH-01248 ADAR Protein, Human, Recombinant (His & SUMO) Human E. coli
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translatio...
TMPJ-01428 SARS-CoV-2 NSP8 Protein (His) SARS-CoV-2 E. coli
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are...
TMPH-01306 EIF4A1 Protein, Human, Recombinant (His & Myc) Human E. coli
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary str...
TMPH-00561 30S ribosomal protein S4 Protein, E. coli, Recombinant (His) E. coli E. coli
One of two assembly initiator proteins for the 30S subunit, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.; With S5 and S12 plays an important role in translational accuracy; ma...
TMPY-05727 SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi) SARS-CoV-2 E. coli
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPY-02311 AGO3 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Argonaute (Ago) protein family plays a key role in the RNA interference (RNAi) process in different insects including Lepidopteran. AGO3 also coexists and interacts with Armitage in the mitochondrial fraction. Furthermo...
TMPY-05752 SARS-CoV-2 3CLpro/3C-like protease Protein (His) SARS-CoV-2 Baculovirus Insect Cells
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication an...
TMPH-00533 T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc) Escherichia phage T7 E. coli
Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short tr...
TMPH-01246 POLR3A Protein, Human, Recombinant (His) Human E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs,...
TMPH-01697 MORC3 Protein, Human, Recombinant (His & SUMO) Human E. coli
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in ...
TMPH-02134 U2AF1 Protein, Human, Recombinant (GST) Human E. coli
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the b...
TMPY-03288 USP30 Protein, Human, Recombinant (SUMO) Human Baculovirus Insect Cells
Ubiquitin specific peptidase 30, also known as USP30, is a deubiquitinating enzyme that is embedded in the mitochondrial outer membrane. Depletion of USP30 expression by RNA interference induced elongated and interconnec...
TMPH-02186 TERT Protein, Human, Recombinant (His) Human E. coli
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic c...
TMPJ-01425 SARS-CoV-2 NSP1 Protein (His) SARS-CoV-2 E. coli
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, po...
TMPY-03390 LSM1 Protein, Human, Recombinant (His) Human E. coli
LSM1 is an Sm-like protein. Sm-like proteins can be detected in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins include the Sm sequence motif, which consists of two regions ...
TMPH-02217 SMARCA4 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic acti...
TMPJ-00338 LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
The type I transmembrane protein 15-leucine-rich repeat containing membrane protein (LRRC15) is a member of the LRR superfamily. The LRR family is a structural module for protein-protein and protein-matrix interactions u...
TMPJ-00696 NOL3 Protein, Human, Recombinant Human E. coli
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in...
TMPY-02883 C1D Protein, Human, Recombinant (GST) Human E. coli
C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a corepressor for the thyroid h...
TMPY-01869 SIRT1 Protein, Human, Recombinant (His) Human E. coli
SIRT1 belongs to the sirtuin family. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. SIRT1 is included in class I of the sirtuin family. It is a NAD-dependent prote...
TMPH-03264 P53 Protein, Rat, Recombinant (His) Rat E. coli
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02574 P53 Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPY-02402 WTAP Protein, Human, Recombinant (GST) Human E. coli
Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identif...
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SARS-CoV-2 RNA-dependent RNA polymerase/RDRP Protein (His)
TMPY-06071
Species: SARS-CoV-2
Expression System: Baculovirus Insect Cells
DDX5 Protein, Human, Recombinant (His & Myc)
TMPH-01900
Species: Human
Expression System: E. coli
DDX60 Protein, Human, Recombinant (His)
TMPH-01902
Species: Human
Expression System: E. coli
DHX33 Protein, Human, Recombinant (His)
TMPH-00980
Species: Human
Expression System: E. coli
DDX3Y Protein, Human, Recombinant (His & Myc)
TMPH-00979
Species: Human
Expression System: Baculovirus Insect Cells
DDX19A Protein, Human, Recombinant (His & SUMO)
TMPH-00976
Species: Human
Expression System: E. coli
DDX1 Protein, Human, Recombinant (His & Myc)
TMPH-00975
Species: Human
Expression System: E. coli
DDX39B Protein, Human, Recombinant (GST)
TMPH-02133
Species: Human
Expression System: E. coli
DHX9 Protein, Human, Recombinant (His & SUMO)
TMPH-00974
Species: Human
Expression System: E. coli
ALKBH5 Protein, Human, Recombinant (His)
TMPH-01899
Species: Human
Expression System: E. coli
DHX36 Protein, Human, Recombinant (His & Myc)
TMPH-00973
Species: Human
Expression System: E. coli
DDX3X Protein, Human, Recombinant (His & Myc)
TMPH-00978
Species: Human
Expression System: Baculovirus Insect Cells
DDX3X Protein, Human, Recombinant (B2M & His)
TMPH-00977
Species: Human
Expression System: E. coli
DDX53 Protein, Human, Recombinant (His & Myc)
TMPH-01901
Species: Human
Expression System: E. coli
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
TMPY-02219
Species: H1N1
Expression System: E. coli
Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-NS5 protein (His)
TMPY-05024
Species: ZIKV
Expression System: Baculovirus Insect Cells
Rho Protein, E. coli, Recombinant (His)
TMPH-00741
Species: E. coli
Expression System: E. coli
P2 Protein, Pseudomonas phage phi6, Recombinant (His & Myc)
TMPH-03184
Species: Pseudomonas phage phi6
Expression System: E. coli
RtcB Protein, E. coli, Recombinant (His)
TMPH-00732
Species: E. coli
Expression System: P. pastoris (Yeast)
SARS-CoV-2 NSP8 Protein (Avi)
TMPY-05749
Species: SARS-CoV-2
Expression System: E. coli
SARS-CoV-2 NSP8 Protein
TMPY-06416
Species: SARS-CoV-2
Expression System: E. coli
Reovirus type 3 (strain Dearing) Outer capsid protein sigma-3 (His)
TMPH-03404
Species: Reo-3
Expression System: E. coli
IBV (strain KB8523) Replicase polyprotein 1ab (His)
TMPH-00147
Species: IBV
Expression System: Baculovirus Insect Cells
POLR3K Protein, Human, Recombinant (His)
TMPH-01247
Species: Human
Expression System: Baculovirus Insect Cells
RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)
TMPH-02380
Species: Kluyveromyces marxianus
Expression System: E. coli
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP30 Protein (His & Myc)
TMPH-02385
Species: MARV
Expression System: E. coli
HSP21, chloroplastic Protein, Arabidopsis thaliana, Recombinant (His & Myc)
TMPH-00094
Species: Arabidopsis thaliana
Expression System: E. coli
ADAR Protein, Human, Recombinant (His & SUMO)
TMPH-01248
Species: Human
Expression System: E. coli
SARS-CoV-2 NSP8 Protein (His)
TMPJ-01428
Species: SARS-CoV-2
Expression System: E. coli
EIF4A1 Protein, Human, Recombinant (His & Myc)
TMPH-01306
Species: Human
Expression System: E. coli
30S ribosomal protein S4 Protein, E. coli, Recombinant (His)
TMPH-00561
Species: E. coli
Expression System: E. coli
SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)
TMPY-05727
Species: SARS-CoV-2
Expression System: E. coli
AGO3 Protein, Human, Recombinant (His)
TMPY-02311
Species: Human
Expression System: Baculovirus Insect Cells
SARS-CoV-2 3CLpro/3C-like protease Protein (His)
TMPY-05752
Species: SARS-CoV-2
Expression System: Baculovirus Insect Cells
T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)
TMPH-00533
Species: Escherichia phage T7
Expression System: E. coli
POLR3A Protein, Human, Recombinant (His)
TMPH-01246
Species: Human
Expression System: E. coli
MORC3 Protein, Human, Recombinant (His & SUMO)
TMPH-01697
Species: Human
Expression System: E. coli
U2AF1 Protein, Human, Recombinant (GST)
TMPH-02134
Species: Human
Expression System: E. coli
USP30 Protein, Human, Recombinant (SUMO)
TMPY-03288
Species: Human
Expression System: Baculovirus Insect Cells
TERT Protein, Human, Recombinant (His)
TMPH-02186
Species: Human
Expression System: E. coli
SARS-CoV-2 NSP1 Protein (His)
TMPJ-01425
Species: SARS-CoV-2
Expression System: E. coli
LSM1 Protein, Human, Recombinant (His)
TMPY-03390
Species: Human
Expression System: E. coli
SMARCA4 Protein, Human, Recombinant (His)
TMPH-02217
Species: Human
Expression System: P. pastoris (Yeast)
LRRC15 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00338
Species: Human
Expression System: HEK293 Cells
NOL3 Protein, Human, Recombinant
TMPJ-00696
Species: Human
Expression System: E. coli
C1D Protein, Human, Recombinant (GST)
TMPY-02883
Species: Human
Expression System: E. coli
SIRT1 Protein, Human, Recombinant (His)
TMPY-01869
Species: Human
Expression System: E. coli
p53 Protein, Rat, Recombinant (His)
TMPH-03264
Species: Rat
Expression System: E. coli
p53 Protein, Mouse, Recombinant (His & SUMO)
TMPH-02574
Species: Mouse
Expression System: E. coli
WTAP Protein, Human, Recombinant (GST)
TMPY-02402
Species: Human
Expression System: E. coli
カタログ番号 製品名
L6120 Flavonoid Natural Product Library

514 compounds
A unique collection of 514 flavonoids can be used for high throughput and high content screening;
L1710 Anti-COVID-19 Compound Library

1133 compounds
A unique collection of 1133 compounds with confirmed anti-SARS-CoV-2 activity or potential activity and part of them are broad-spectrum antiviral agents;