|
T4327 |
Prexasertib dihydrochloride
|
LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 |
Apoptosis
,
Chk
,
S6 Kinase
|
|
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. |
|
T4310 |
Prexasertib
|
LY2606368 |
Apoptosis
,
Chk
|
|
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. |
|
T4488 |
GSK-25
|
GSK25 |
ROCK
,
S6 Kinase
,
mTOR
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested). |
|
T6877 |
LJH685
|
|
Apoptosis
,
S6 Kinase
|
|
LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM). |
|
T27471 |
GSK299115A
|
GSK 299115A,GSK-299115A |
GRK
|
|
GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively. |
|
T6878 |
LJI308
|
|
S6 Kinase
|
|
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. |
|
T27467 |
GSK270822A
|
GSK 270822A,GSK-270822A |
GRK
|
|
GSK270822A is a selective ROCK1 inhibitor. GSK270822A exhibits IC50 of 9nM, 1100nM, 1550nM for ROCK1, RSK1, p70S6K, respectively. |
|
T14779 |
BRD7389
|
|
SGK
,
FLT
,
Pim
,
CDK
,
S6 Kinase
,
DAPK
|
|
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. |
|
T6171 |
BI-D1870
|
|
S6 Kinase
,
Autophagy
|
|
BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4). |
|
T9652 |
SB-747651A Dihydrochloride
|
|
ROCK
|
|
SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC50 of 11 nM. Additionally, this compound effectively inhibit... |
|
T6948 |
Pluripotin
|
SC1 |
ERK
,
Raf
,
S6 Kinase
|
|
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. |
|
T24020 |
DTS
|
Dibenzyl trisulfide |
|
|
DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential. |
|
T30776 |
C-Ceritinib TFA salt
|
Coupleable ceritinib |
|
|
c-Ceritinib TFA salt is a coupleable ceritinib analog with a linker which also binds multiple other kinases, including FAK1, RSK1/2, ERK1/2, CAMKK2 and FER. |
|
T10275 |
AKT-IN-3
|
|
Akt
|
|
AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kin... |
|
T38620 |
Prexasertib dimesylate
|
LY2606368 dimesylate |
|
|
Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectivel... |
|
T63152 |
Prexasertib Mesylate Hydrate
|
|
|
|
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP-competitive, selective, second generation cell cycle detection site kinase 1 (CHK1) inhibitor (IC50<1 nM, Ki: 0.9 nM). Prexasertib Mesylate Hydrate inhi... |
|
T39733 |
Hu7691 free base
|
|
Akt
|
|
Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces ... |
|
T11961 |
MBM-55S
|
|
GSK-3
,
MAPK
,
Akt
,
Bcr-Abl
,
CDK
,
S6 Kinase
,
Aurora Kinase
|
|
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities. |
|
T11960 |
MBM-55
|
|
GSK-3
,
MAPK
,
DYRK
,
Akt
,
Chk
,
Bcr-Abl
,
CDK
,
S6 Kinase
,
Aurora Kinase
|
|
|
|
T10274 |
AKT-IN-2
|
|
Akt
|
|
AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1). |
|
T39899 |
Hu7691
|
|
Akt
|
|
Hu7691 is an orally active, selective and potent Akt inhibitor that inhibits Akt1, Akt2 and Akt3, inhibits proliferation of neuroblastoma cells and induces differentiation of neuroblastoma cells. |
|
T39519 |
GSK269962A hydrochloride
|
GSK 269962 hydrochloride |
|
|
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inf... |
