|
T11882 |
Pulrodemstat benzenesulfonate
|
LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate |
Histone Demethylase
|
|
Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity. |
|
T1602 |
Valproic acid sodium salt
|
Sodium Valproate |
Mitophagy
,
Gamma-secretase
,
HIV Protease
,
GABA Receptor
,
HDAC
,
Autophagy
|
|
Valproic acid sodium salt (Sodium Valproate) is the sodium salt form of valproic acid with anti-epileptic activity. Valproic acid sodium salt is converted into its active form, valproate ion, in blood. Although the mecha... |
|
T20168 |
Aurothiomalate sodium
|
Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate |
Others
,
PKC
|
|
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ... |
|
T6474 |
Divalproex Sodium
|
Valproate semisodium,Epival |
HDAC
|
|
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzyme... |
|
T14685 |
BMS-986158
|
|
Epigenetic Reader Domain
|
|
BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells. |
|
T76698 |
Rovalpituzumab
|
|
Gamma-secretase
|
|
Rovalpituzumab is a humanized monoclonal antibody targeting delta-like protein 3 (DLL3). Rovalpituzumab can be used to synthesize antibody-active molecule conjugates (ADCs). Rovalpituzumab has anticancer activity and is ... |
|
T67934 |
MRT-2359
|
|
Others
|
|
MRT-2359 is a potent and orally available GSPT1 reducer with antitumour activity.MRT-2359 inhibits the growth of drug-resistant non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) cells.MRT-2359 exhibits... |
|
T3062 |
WIKI4
|
|
PARP
,
Wnt/beta-catenin
|
|
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2). |
|
T71620 |
IBAP-II
|
|
|
|
iBAP-II represses neuroendocrine lineage-specific ASCL1/MYCL/E2F signaling in SCLC cell lines, and dramatically inhibits SCLC cell viability and tumor growth in vivo. |
|
T28999 |
TPC-144
|
TPC144,TPC 144 |
|
|
TPC-144 is a potent and selective LSD1 inhibitor with a reversible inhibition mechanism. TPC-144 has antitumor activity in several human AML and SCLC cell lines and xenograft models. |
|
T4134L |
OTS514
|
OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514 |
Apoptosis
,
TOPK
|
|
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen... |
|
T76899 |
Adebrelimab
|
|
|
|
Adebrelimab (SHR-1316), a humanized IgG4 monoclonal antibody targeting PD-L1 (PD-1/PD-L1), exhibits promising antitumor activity, notably in solid tumors and extensive-stage small-cell lung cancer (SCLC) [1] [2]. |
|
T39258 |
Pulrodemstat
|
LSD1-IN-7,CC-90011 |
|
|
Pulrodemstat (CC-90011) is a highly potent and selective inhibitor of lysine specific demethylase-1 (LSD1). It exhibits a reversible mode of action and can be administered orally. With an impressive IC50 of 0.25 nM, Pulr... |
|
T76986 |
Tarlatamab
|
|
|
|
Tarlatamab (AMG-757) is a first-in-class, high-affinity, bispecific T-cell engager (BiTE) antibody that selectively targets delta-like ligand 3 (DLL3), a protein predominantly expressed in small-cell lung cancer (SCLC) t... |
