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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T3100	GSK-J4	GSK J4 HCl	Apoptosis , Histone Demethylase
	GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit...		Apoptosis , Histone Demethylase
T19675	SM360320	CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR
	SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ...		TLR
T4383	GSK-J4 Hydrochloride	GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base)	Histone Demethylase
	GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.		Histone Demethylase
T67864	TH1760	MKB	NUDIX hydrolase
	TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia ef...		NUDIX hydrolase
T8727	TH1020		TLR , Antibacterial
	TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.		TLR , Antibacterial
T60034	TH1085		Others
	TH1085 is an enhancer of OGG1. TH1085 stimulates DNA repair and protects cells from the environmental hazard paraquat (PQ).		Others
T38271	TH1217	TH 1217	Others
	TH1217, a potent and selective inhibitor of dCTPase pyrophosphatase 1 (dCTPase), demonstrates an IC50 value of 47 nM. It amplifies the cytotoxic impact of cytidine analogues on leukemia cells and exhibits potential again...		Others
T12122	MTH1-IN-2		MTH1
	MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.		MTH1
T37313	ITH15004
	ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor whe...
T78681	ITH12711		Phosphatase
	ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].		Phosphatase
T17068	TH1834 dihydrochloride		Others
	TH1834 dihydrochloride is a specific Tip60 histone acetyltransferase inhibitor. TH1834 dihydrochloride causes apoptosis and enhances DNA damage in breast cancer.		Others
T39554	TH1834	TH1834
	TH1834 is a selective inhibitor of the Tip60 (KAT5) histone acetyltransferase (HAT). It effectively induces apoptosis and promotes DNA damage in breast cancer cells. Notably, TH1834 does not influence the activity of the...
T28959	TH1338	TH-1318,TH 1318,TH1318
	TH-1318 is a brain penetrable antitumor agent.
T16425	PA452		Retinoid Receptor , RAR/RXR
	PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.		Retinoid Receptor , RAR/RXR
T76884	Spesolimab	BI 655130	IL Receptor
	Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the immune system and is associated with a reduction in biomarkers associated with congenital Th1/Th17 and neutrophil p...		IL Receptor
T21618L	Myelin Basic Protein (87-99) Acetate	Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)	Others
	Myelin Basic Protein (87-99) Acetate (Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)) is an encephalitogenic peptide that induces basic protein-specific T cell proliferation. Myelin Basic Protein (87-99) Ac...		Others
T7649	Tyrphostin A1	AG9,Tyrphostin 1	EGFR , Interleukin
	Tyrphostin A1 (Tyrphostin 1) is an inhibitor of EGFR tyrosine kinase .		EGFR , Interleukin
T6964	Resiquimod	R848,S28463	HCV Protease , TLR
	Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti...		HCV Protease , TLR
T5821	BC-1215		Others , Ligand for E3 Ligase
	BC-1215 is an inhibitor of F-box protein 3 (FBXO3, a ubiquitin E3 ligase component, IC50=0.9 μg/mL for IL-1β release).		Others , Ligand for E3 Ligase
T37587	ML 209		ROR
	ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM...		ROR
T19590	Trehalose 6-behenate		Others
	Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.		Others
T33891	PBI-1393	PBI1393,BCH1393,BCH 1393,BCH-1393,PBI 1393
	PBI-1393 can be used as an enhancer for Th1 type cytokine production and primary T cell activation.
T28916	TAK-603	TAK603,TAK 603
	TAK-603 is an anti-rheumatic drug and is also anti-inflammatory compound. It selectively suppresses Th1 cytokine production and inhibits the progression of adjuvant arthritis.
T27279	ER819762	ER-819762,ER 819762
	ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion.
T19933	GTS-21	DMXB-A,GTS21,GTS 21	AChR
	GTS-21 (DMXB-A) is an α7 nAChR agonist. GTS-21 suppresses inflammation associated with rheumatoid arthritis by inhibiting RA Th1 cell differentiation.		AChR
T40590	NY-ESO-1 (87-111)
	NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide that interacts with various HLA-DR and HLA-DP4 molecules, inducing activation of CD4+ T cells with Th1-type and Th-2/Th0-type responses, when presented in conjun...
T10850	CMP-5		Antiviral , Histone Methyltransferase
	CMP-5 is a PRMT5 inhibitor with antiviral activity, inhibits PRMT5 methyltransferase activity, and can be used in the study of SARS virus infection.		Antiviral , Histone Methyltransferase
T78370	Myelin Basic Protein(87-99) TFA
	Myelin Basic Protein(87-99) TFA, an encephalitogenic peptide, promotes basic protein-specific T cell proliferation and induces Th1 polarization in peripheral blood mononuclear cells, which is associated with the pathogen...
T62944	CCR8 antagonist 2
	CCR8 antagonist 2 is a potent antagonist of CCR8 that inhibits the activity of CCR8 (C-C Motif chemokine receptor 8), which is predominantly expressed on Treg and Th2 cells, and not on Th1 cells. CCR8 antagonist 2 can be...
T64300	Vimirogant hydrochloride
	Vimirogant (VTP-43742) hydrochloride is an orally active, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM) that is more than 1000 times more selective than RORα and RORβ. Vimirogant hydrochloride inhibits Th17 differe...
T62860	YM-341619
	YM-341619 (AS1617612) is a potent, orally active STAT6 inhibitor (IC50: 0.70 nM). YM-341619 inhibits IL-4-induced Th2 differentiation in mouse splenic T cells with an IC50 value of 0.28 nM, but does not affect Th1 cell d...
T78541	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA	MOG (35-55) (TFA)
	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA, a minor constituent of central nervous system (CNS) myelin, demonstrates encephalitogenic properties by inducing T cell proliferation and...
T69615	AWD12-281 sodium
	AWD 12-281 is a selective phosphodiesterase 4 (PDE4) inhibitor for the treatment of lung inflammation using inhalative administration. AWD 12-281 Is Active in a New Guinea-Pig Model of Allergic Skin Inflammation Predicti...
T64265	JAK1/TYK2-IN-3
	JAK1/TYK2-IN-3 is a selective, potent, orally active dual inhibitor of TYK2 (IC50: 6 nM) and JAK1 (IC50: 37 nM).JAK1/TYK2-IN-3 selectively acts on both JAK2 and JAK3 with IC50 values of 140 nM and 362 nM.JAK1/TYK2 -IN-3 ...
T78542	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate	MOG (35-55) (acetate)
	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) acetate, a minor component of CNS myelin, exhibits encephalitogenic activity by inducing T cell proliferation and a Th1 cytokine response, alo...
T83690	[Leu144, Arg147]-PLP (139-151) TFA	[Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH
	[Leu144,Arg147]-PLP (139-151) is a mutated fragment of the myelin proteolipid protein (PLP), featuring substitutions of tryptophan to leucine and histidine to arginine at positions 144 and 147, respectively. Immunizing m...
T36984	Cyclic di-IMP (sodium salt)
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with ...

Compounds

GSK-J4

T3100

Synonym: GSK J4 HCl

Target: Apoptosis, Histone Demethylase

SM360320

T19675

Synonym: CL-087,SM 360320,CL 087,1V136,SM-360320,CL087

Target: TLR

GSK-J4 Hydrochloride

T4383

Synonym: GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base)

Target: Histone Demethylase

TH1760

T67864

Synonym: MKB

Target: NUDIX hydrolase

TH1020

T8727

Synonym:

Target: TLR, Antibacterial

TH1834 dihydrochloride

Synonym: TH-1318,TH 1318,TH1318

Target: Retinoid Receptor, RAR/RXR

Myelin Basic Protein (87-99) Acetate

T21618L

Synonym: Myelin Basic Protein (87-99) Acetate (118506-26-6 Free base)

Target: Others

Tyrphostin A1

T7649

Synonym: AG9,Tyrphostin 1

Target: EGFR, Interleukin

Resiquimod

T6964

Synonym: R848,S28463

Target: HCV Protease, TLR

BC-1215

T5821

Synonym:

Target: Others, Ligand for E3 Ligase

Synonym: PBI1393,BCH1393,BCH 1393,BCH-1393,PBI 1393

Target:

TAK-603

T28916

Synonym: TAK603,TAK 603

Target:

ER819762

T27279

Synonym: ER-819762,ER 819762

Target:

GTS-21

T19933

Synonym: DMXB-A,GTS21,GTS 21

Target: Antiviral, Histone Methyltransferase

Myelin Basic Protein(87-99) TFA

Vimirogant hydrochloride

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA

T78541

Synonym: MOG (35-55) (TFA)

Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate

T78542

Synonym: MOG (35-55) (acetate)

Target:

[Leu144, Arg147]-PLP (139-151) TFA

T83690

Synonym: [Leu144, Arg147] Proteolipid Peptide (139-151),H-His-Ser-Leu-Gly-Lys-Leu-Leu-Gly-Arg-Pro-Asp-Lys-Phe-OH

Target:

Cyclic di-IMP (sodium salt)

T36984

Synonym:

Target:

カタログ番号	製品名	別名	ターゲット
T34295	Resiniferatoxin	RTX,[3H]resiniferatoxin	IL Receptor
	Resiniferatoxin ([3H]resiniferatoxin) inhibits the production of Th1 cytokines, contributing to the defense against T. spiralis infection, and can be used in studies about the modulator of the immune response.		IL Receptor
TN2088	Platycodin D2		IL Receptor , HBV
	Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice, it could be safely used as adjuvant eliciting Th1 and Th2 immune responses. Polygalaci...		IL Receptor , HBV
T4A2462	Telocinobufagin	Telobufotoxin,Telocinobufogenin	Others
	1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice chall...		Others
T5681	ETHYL CAFFEATE	ETHYL 3,4-DIHYDROXYCINNAMATE	NF-κB , COX , PGE Synthase , NO Synthase
	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s...		NF-κB , COX , PGE Synthase , NO Synthase
T38838	QS-21	Stimulon,QS-21
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, Q...
TN4778	Physalin H		gp120/CD4 , Antifection , Autophagy
	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunos...		gp120/CD4 , Antifection , Autophagy

天然物製品

Resiniferatoxin

T34295

Synonym: RTX,[3H]resiniferatoxin

Target: IL Receptor, HBV

Telocinobufagin

T4A2462

Synonym: Telobufotoxin,Telocinobufogenin

Target: Others

ETHYL CAFFEATE

T5681

Synonym: ETHYL 3,4-DIHYDROXYCINNAMATE

Target: NF-κB, COX, PGE Synthase, NO Synthase

QS-21

T38838

Synonym: Stimulon,QS-21

Target: gp120/CD4, Antifection, Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02711	Ferritin heavy chain 1/FTH1 Protein, Human, Recombinant	Human	E. coli
	FTH1 (ferritin, heavy polypeptide 1) is the heavy subunit of ferritin which is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin cha...
TMPY-00116	MTH1 Protein, Human, Recombinant (His)	Human	E. coli
	NUDT1 (Nudix Hydrolase 1) is a Protein Coding gene. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates to monophosphates, thereby preventing misincorporation. The NUDT1...
TMPY-02236	PTH1R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane pr...
TMPJ-00387	IL-4R alpha Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions a...
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proli...
TMPK-00076	IL-18 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated	Human	E. coli
	Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop...
TMPK-00317	IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPK-00512	IL-18R alpha Protein, Cynomolgus, Recombinant (aa 22-329, His)	Cynomolgus	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPJ-00599	TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Hepatitis A virus cellular receptor 2（HAVCR2）is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family o...
TMPK-00316	IL-18R alpha Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced I...
TMPJ-00398	IL-12RB2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits tha...
TMPJ-00216	IL-12B Protein, Human, Recombinant	Human	HEK293 Cells
	Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, a...
TMPJ-00189	TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, an...
TMPH-01558	IL12RB2 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenoty...
TMPK-01105	IL-22RA1 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPY-02122	IFNGR2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Interferon-gamma receptor beta chain (IFNgammaR2), also known as IFNGR2, belongs to the type II cytokine receptor family, whose deficiency is a cause of autosomal recessive mendelian susceptibility to mycobacterial disea...
TMPJ-00203	Galectin-9 Protein, Human, Recombinant (GST)	Human	E. coli
	Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forss...
TMPJ-01084	CXCL9 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Chemokine (C-X-C Motif) Ligand 9 (CXCL9) belongs to the intercrine alpha (chemokine CXC) family. It is secreted by interferon stimulated monocytes, macrophages and endothelial cells, which elicits chemotactic functions b...
TMPK-01071	IL-22RA1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin (IL)-22 is a member of the IL-10 family of cytokines and represents an important effector molecule of activated Th22, Th1, and Th17 cells, as well as Tc-cell subsets, gammadelta T cells, natural killer (NK), ...
TMPK-00827	CD43 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3 Treg, and T cell apoptosis. ...
TMPJ-01169	SEMA4A Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Semaphorin-4A (SEMA4A) belongs to the semaphorin family which contains a Ig-like C2-type domain, a PSI domain and a Sema domain. SEMA4A is expressed from day 10 in the embryo, and low levels are found between days 10-12....
TMPJ-01096	SLP-76 Protein, Human, Recombinant (His)	Human	E. coli
	Lymphocyte cytosolic protein 2（LCP2）contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cel...
TMPJ-00129	BTLA Protein, Human, Recombinant (His)	Human	HEK293 Cells
	B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed...
TMPJ-01056	IL-18 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Interleukin-18 (IL-18）is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63...
TMPJ-00837	LAMP1 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intral...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus Insect Cells
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...