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T5458 |
Darusentan
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Lu-135252 |
Endothelin Receptor
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|
Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries |
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TQ0003 |
740 Y-P
|
740YPDGFR,PDGFR 740Y-P |
PI3K
,
Autophagy
|
|
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. |
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T3965 |
Fevipiprant
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QAW039,NVP-QAW039 |
GPR
,
Prostaglandin Receptor
|
|
Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. |
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T6991 |
Nitroprusside disodium dihydrate
|
Sodium Nitroferricyanide(III) Dihydrate,Sodium Nitroprusside Dihydrate |
Guanylate cyclase
,
Autophagy
|
|
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood. |
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T10101 |
Calcium channel-modulator-1
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Others
,
Calcium Channel
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|
Calcium channel-modulator-1 is a calcium channel-modulator (IC50:0.8 μM) with specialisation to block aortic constriction. |
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T33868 |
Palmitoyl glutamic acid
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N-Palmitoyl-L-glutamic acid,Palmitoylglutaminic acid |
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Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) is an acyl amino acid that blocks aortic constriction and antagonizes haloperidol-induced oral motility disorders. |
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T62893 |
SM-2470
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|
Adrenergic Receptor
|
|
SM-2470 is an α1-adrenoceptor antagonist with antihypertensive activity that decreases anterior ganglionic adrenal nerve activity and aortic descending nerve activity.SM-2470 has hypocholesterolemic activity and inhibits... |
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TQ0057 |
AVE 0991
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Others
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AVE 0991, a nonpeptide analog of angiotensin-(1-7) [Ang-(1-7)], is an orally active Mas agonist with inhibitory effects on [125I]-Ang-(1-7) binding to bovine aortic endothelial cell membranes, and inhibits astrocyte-medi... |
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T11598 |
IAXO-102
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TLR
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|
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdomin... |
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T7284 |
Argipressin acetate (113-79-1(free base))
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Others
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Vasopressin acetate is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle... |
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T11076 |
Dooku1
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Others
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Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yod... |
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T30140 |
Arotinolol hydrochloride
|
Arotinolol HCl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Arotinolol hydrochloride（Arotinolol HCl） is a non-selective α/β-adrenergic receptor blocker.Arotinolol hydrochloride inhibits the binding of the radioligand 125I-ICYP to the 5HT1B-hydroxytryptamine receptor. Arotinolol h... |
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T68123 |
Oxodipine
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|
Calcium Channel
|
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Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri... |
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T33440 |
MK785
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MK-785,MK 785 |
|
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MK785 is part of the association between inhibition of aortic histamine formation, aortic albumin permeability, and atherosclerosis. Aortic histamine synthesis was inhibited by partial inhibition of aortic histidine deca... |
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T32406 |
KMUP-4
|
KMUP 4 |
|
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Kmup-4 is an enhancer of cGMP activity and an aortic smooth muscle relaxant. |
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T28779 |
SIM-6080
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|
|
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SIM-6080 is a calcium channel antagonist. SIM-6080 inhibits the proliferation of rat aortic myocytes. |
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T25946 |
Phenyl butyrate
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AI311761,AI3 11761,AI3-11761 |
|
|
Phenyl butyrate is a non-selective ERS inhibitor that attenuates angiotensin II-induced abdominal aortic aneurysm. |
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T32405 |
KMUP-3
|
KMUP 3,KMUP3 |
|
|
KMUP-3 is an enhancer of cGMP activity, and acts as an aortic smooth muscle relaxant. |
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T32426 |
KT 1
|
KT-1,KT1 |
|
|
KT 1 decreased aortic pressure, renal blood flow, left ventricular enddiastolic pressure and resistances of total peripheral, vertebral, coronary and renal vasculatures and increased aortic blood flow, vertebral blood fl... |
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T3580L |
FIPI HCl
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FIPI hydrochloride,FIPI |
|
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FIPI is an effective and selective phospholipase D inhibitor that reduces mercury-induced lipid signaling and thus protects aortic endothelial cells from cytotoxicity. |
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T81782 |
MLR12
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|
|
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mLR12 is a Trem1 inhibitory peptide that reduces the incidence of aortic rupture in a mouse model of BAPN-induced Thoracic Aortic Aneurysm and Dissection (TAAD) [1]. |
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T28487 |
Quininib
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|
|
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Quininib is a regulator of Ocular Angiogenesis. Quininib significantly inhibits angiogenic tubule formation in HMEC-1 cells, angiogenic sprouting in aortic ring explants and retinal revascularisation in OIR mice. |
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T27347 |
Fonsartan free acid
|
HR720,HOE720,HR-720,HOE-720 |
|
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Fonsartan is an angiotensin receptor antagonist. Fonsartan inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro. |
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T14354 |
AVE 0991 sodium salt
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Others
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T27325 |
FK-739 free acid
|
FK-739,FK 739,FK739 |
|
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FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125... |
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T70280 |
KB-R7785
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|
|
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KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect b... |
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T36198 |
Avenanthramide-C methyl ester
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|
|
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Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits t... |
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TP1620 |
Cyclic MKEY
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|
|
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MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinf... |
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T17189 |
U-46619
|
9,11-Methanoepoxy PGH2 |
Progesterone Receptor
,
PPAR
|
|
U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (SM) of mice with a myosin light chain 9 (Myl9) gene deletion. |
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T37459 |
Lipoxin A5
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|
|
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Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes. LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4. However, LXA5 does not exe... |
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T26665 |
AS604872
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AS-604872,AS 604872 |
|
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AS604872 is a selective antagonist of the FP receptor.. AS604872 significantly accelerated degeneration of the media in both cerebral artery and aorta as evidenced by thinning of the media and disruption of the elastic l... |
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T7434 |
Argipressin
|
Arg8-vasopressin,Vasopressin,AVP |
Vasopressin Receptor
|
|
Argipressin (Vasopressin) is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth ... |
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T78011 |
Cyclic MKEY TFA
|
|
|
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Cyclic MKEY TFA, a synthetic cyclic peptide, inhibits CXCL4-CCL5 heterodimer formation, thus guarding against atherosclerosis and aortic aneurysm by mitigating inflammation. Additionally, it affords protection against st... |
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T27351 |
Fostedil
|
KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546 |
|
|
Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardi... |
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T28321 |
PD 122860
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PD-122860,PD122860 |
|
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PD 122860 is a dihydropyridine with calcium channel blocking and sodium channel stimulating properties. In the rat heart, PD 122860 increased left ventricular contractility, decreased coronary resistance and altered the ... |
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T73645 |
ARL67156 triethylamine
|
|
|
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ARL67156 (FPL 67156) triethylamine, a selective ecto-ATPase inhibitor, functions as a competitive inhibitor for NTPDase1 (CD39), NTPDase3, and NPP1, exhibiting inhibition constants (Kis) of 11, 18, and 12 μM, respectivel... |
|
T21814 |
ONO 4817
|
|
|
|
ONO-4817 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor that potentially mitigates atherosclerotic neointimal proliferation and atheromatous plaque progression by suppressing matrix metalloproteinases (MMPs... |
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T73644 |
ARL67156 trisodium hydrate
|
|
|
|
ARL67156 (FPL 67156) trisodium hydrate is a selective ecto-ATPase inhibitor. ARL67156 trisodium hydrate is a competitive inhibitor of NTPDase1 (CD39), NTPDase3 and NPP1, with K i s of 11, 18 and 12 μM, respectively. ARL6... |
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T35943 |
15(S)-HpETE
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|
|
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15(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 15-lipoxygenase (15-LO) on arachidonic acid. It is either metabolized to 14,15-leukotriene A4 [1] or reduced to 15(S)-HETE by ... |
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T60832 |
(S)-Bromoenol lactone
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|
|
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(S)-Bromoenol lactone ((S)-BEL) inhibits the arachidonate release induced by vasopressin from cultured rat aortic smooth muscle (A10) cells with an IC 50 of 2 μM. (S)-Bromoenol lactone is an irreversible, chiral, mechani... |
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T74778 |
ASM-IN-1
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|
Phospholipase
|
|
ASM-IN-1 is a potent, orally active inhibitor of acid sphingomyelinase (ASM) with an IC50 of 1.5 µM, demonstrating antiatherosclerotic and anti-inflammatory activity. It effectively reduces lipid plaques in the aortic ar... |
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T71870 |
CP21
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|
|
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CP21 is an iron chelator that binds to iron in a 3:1 (ligand:iron) ratio. It is active against P. falciparum when used at concentrations of 10 and 100 µM. CP21 inhibits production of prostaglandin I2 induced by epinephri... |
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T35988 |
CAY10564
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|
|
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S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low m... |
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T35505 |
(±)11-HDHA
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|
|
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(±)11-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 11(S)-HDHA by human platelet... |
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T36601 |
(±)17-HDHA
|
|
|
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(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of D... |
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T35989 |
CAY10565
|
|
|
|
S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low m... |
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T35987 |
CAY10563
|
CAY10563 |
|
|
S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low m... |
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T35509 |
(±)14-HDHA
|
|
|
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(±)14-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. DHA is metabolized to 14(S)-HDHA by human platelet... |
|
TP2097 |
ELA-32(human)
|
ELA-32 (human) |
|
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Potent, high affinity apelin receptor agonist (IC50 = 0.27 nM; Kd = 0.51 nM). Exhibits no binding GPR15 and GPR25. Activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein ... |
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T36554 |
TMB 8 (hydrochloride)
|
|
|
|
TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and α3β4 subunit-containing ganglionic nAChRs expressed in TE671... |
