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ターゲット

阻害剤

天然化合物

カタログ番号	製品名	別名	ターゲット
T12654	(Rac)-Acolbifene	(Rac)-EM-652,EM-343	Estrogen Receptor/ERR
			Estrogen Receptor/ERR
T33876L	Panomifene HCl	EGIS5650 HCl,GYKI 13504 HCl,Panomifene HCl(77599-17-8 Free base),EGIS 5650 HCl	HER
	Panomifene HCl is a selective anti-estrogenic compound with antitumor activity for the treatment of breast cancer.		HER
T9796	22393-62-0_peak 2
	22393-62-0_peak 2 exhibits some aspects of the antiestrogenic activity and other actions that may be connected to the estrogenic properties. A mixture of the (Z)- and (E)-isomers (Broparestrol, INN) is used in dermatol...
T13684	Equilin	7-Dehydroestrone	Calcium Channel
	Equilin (7-Dehydroestrone) is a neurotrophic estrogenic steroid with vasodilatory activity that increases monocyte-endothelial adhesion through NF-κB signalling.Equilin similarly relaxes mesenteric arterial resistance by...		Calcium Channel
T23647	Zindoxifene	D 16726	Estrogen/progestogen Receptor
	Zindoxifene (D 16726) is an anti-estrogenic compound with antitumor activity that can be used in studies of breast and prostate cancer.		Estrogen/progestogen Receptor
T7465	4-Methylbenzylidene camphor	Enzacamene,4-MBC	AChE
	4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activities.		AChE
T8981	WAY-169916	WAY 169916,WAY169916	NF-κB
	WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity.		NF-κB
T8984	FLTX1		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally,...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T1514	Norethindrone	Norethisterone	Estrogen/progestogen Receptor , Progesterone Receptor
	Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties...		Estrogen/progestogen Receptor , Progesterone Receptor
T2569	Chlorotrianisene	tris(p-methoxyphenyl)chloroethylene,CTA,tri-p-anisylchloroethylene,TACE	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , COX
	Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor , COX
T21375	Clomifene	Omifin,D,Chloramiphene,Clomiphene,Clomiphene free base,Citrate
	Clomifene is a selective estrogen receptor modulator (SERM), it has both estrogenic and anti-estrogenic activities. This agent causes the release of the pituitary gonadotropins follicle-stimulating hormone (FSH) and lute...
T23737	Anordiol	H 241,H241,AF-45,AF 45,AF45
	Anordiol is an antiestrogen with estrogenic activity. It also is known to inhibit fertility.
T20764	Dienestrol diacetate	NSC 81279,NSC81279,Cycladiene,Retalon-oral,Oestrasid C,NSC-81279
	Dienestrol diacetate, a derivative of the synthetic non-steroid phenolic compound, DIENESTROL, exhibits estrogenic activities.
T20938	O,p'-DDT	2,4'-DDT,ortho,para'-DDT
	O,P'-DDT, a chlorinated organic pesticide, has estrogenic activity.
T70980	PBRM
	PBRM is the first selective, potent, non-estrogenic, irreversible inhibitor of 17β-HSD1.
T10273	AhR modulator-1		Others
	AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrog...		Others
T38272	Thiacloprid		AChR , Parasite
	Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 nM forDrosophilanAChRs and M10 mouse fibroblast cells expres...		AChR , Parasite
T38379	4-tert-Octylphenol diethoxylate
	4-tert-Octylphenol diethoxylate is a degradation product of the multi-purpose surfactant, Triton X. A known environmental contaminant, 4-tert-octylphenol diethoxylate is reported to be an endocrine disruptor in animal an...
T37647	5α-dihydro Levonorgestrel
	5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel . It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg pe...
T69696	TAS-108 citrate
	TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland an...
T39259	Arzoxifene	LY353381,Arzoxifene,SERMIII
	Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator (SERM) exhibiting a fixed ring structure analogous to raloxifene. This compound demonstrates potent antiestrogenic effects on breast cancer ...
T82366	Fulvestrant 3-β-D-Glucuronide
	Fulvestrant 3-β-D-Glucuronide, a glucuronide and sulfate conjugate metabolite of the pure anti-estrogenic steroid Fulvestrant, is utilized in breast cancer research [1].
T62572	Enclomiphene hydrochloride
	Enclomiphene ((E)-Clomiphene) hydrochloride is an orally active, potent non-steroidal estrogen receptor antagonist with anti-estrogenic effects. Enclomiphene hydrochloride can be used to study ovarian dysfunction, testos...
T35783	Zearalenone-13C18	Zearalenone-13C18
	Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to huma...
T36913	17-Epiestriol
	17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding af...

Compounds

(Rac)-Acolbifene

T12654

Synonym: (Rac)-EM-652,EM-343

Target: Estrogen Receptor/ERR

Panomifene HCl

T33876L

Synonym: EGIS5650 HCl,GYKI 13504 HCl,Panomifene HCl(77599-17-8 Free base),EGIS 5650 HCl

Synonym: 7-Dehydroestrone

Target: Calcium Channel

Zindoxifene

T23647

Synonym: D 16726

Target: Estrogen/progestogen Receptor

4-Methylbenzylidene camphor

T7465

Synonym: Enzacamene,4-MBC

Target: AChE

WAY-169916

T8981

Synonym: WAY 169916,WAY169916

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Norethindrone

T1514

Synonym: Norethisterone

Target: Estrogen/progestogen Receptor, Progesterone Receptor

Chlorotrianisene

T2569

Synonym: tris(p-methoxyphenyl)chloroethylene,CTA,tri-p-anisylchloroethylene,TACE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, COX

Clomifene

T21375

Synonym: Omifin,D,Chloramiphene,Clomiphene,Clomiphene free base,Citrate

Target:

Anordiol

T23737

Synonym: H 241,H241,AF-45,AF 45,AF45

Target:

Dienestrol diacetate

T20764

Synonym: NSC 81279,NSC81279,Cycladiene,Retalon-oral,Oestrasid C,NSC-81279

Target:

o,p'-DDT

T20938

Synonym: 2,4'-DDT,ortho,para'-DDT

Target: AChR, Parasite

4-tert-Octylphenol diethoxylate

T38379

Synonym:

Target:

5α-dihydro Levonorgestrel

Synonym: LY353381,Arzoxifene,SERMIII

Target:

Fulvestrant 3-β-D-Glucuronide

T82366

Synonym:

Target:

Enclomiphene hydrochloride

Synonym: Zearalenone-13C18

カタログ番号	製品名	別名	ターゲット
T1009	Estrone	Oestrone,Fluoroethyl,Aquacrine	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is pr...
T12581	Puerarin-4'-O-β-D-glucopyranoside	Puerarin4'-O-glucoside	Others
	Puerarin-4'-O-β-D-glucopyranoside (Puerarin4'-O-glucoside) is a natural product isolated from Pueraria lobata root having estrogenic activity and anti-proliferation in MCF-7 human breast carcinoma cells.		Others
T9454	4-Hydroxyestrone		Estrogen Receptor/ERR , Endogenous Metabolite
	4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage.		Estrogen Receptor/ERR , Endogenous Metabolite
T1424	Ethynyl estradiol	17α-Ethynylestradiol,Ethinyl Estradiol	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , Endogenous Metabolite
	Ethynyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES...
T0345	Estropipate	Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Estropipate (Piperazine estrone sulfate) is a natural estrogenic substance composed of estrone sulfate and piperazine.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor
T7957	2-Isopropyl Thioxanthone		Others
	2-Isopropyl Thioxanthone has potential anti-estrogenic and anti-androgenic properties.		Others
T6S0325	Glycitein	Glycetein	Apoptosis , Others
	1. Gycitein has weak estrogenic activity. 2. Glycitein (Glycetein) inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression.		Apoptosis , Others
T3665	Tectoridin	Shekanin	Estrogen Receptor/ERR , Reductase
	Tectoridin (Shekanin) possesses an estrogenic and thyroid hormone-like agent by activating estrogen and thyroid hormone receptors. Tectoridin has anti-oxidant, anti-inflammatory and hypoglycemic activities; Tectoridin an...		Estrogen Receptor/ERR , Reductase
TN1146	8-Prenylnaringenin	8-Prenylnaringenin	Apoptosis , ROS
	8-Prenylnaringenin is a phytoestrogen with high estrogenic activity,		Apoptosis , ROS
T5S0993	Kurarinone		BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT
	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameli...		BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT
T5625	Zearalenone	Mycotoxin F2,RAL,F2 toxin,Toxin F2	Others
	Zearalenone (F2 toxin) is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in cattle, pigs and sheep, with low acute toxicity. Causes precocious develo...		Others
T64353	4-tert-Octylphenol		Endogenous Metabolite
	4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), m...		Endogenous Metabolite
T36914	2-Hydroxyanthraquinone		Others
	2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg/ml, respectively)...		Others
TN4875	Quercetin 3,3'-dimethyl ether		Others
	Quercetin 3,3'-dimethyl ether may have moderate estrogenic activity.		Others
TN1573	Desmethylxanthohumol		Others
	Desmethylxanthohumol shows estrogenic activity.		Others
T13577	β-Zearalenol		Others
	β-Zearalenol, a non-steroidal estrogenic mycotoxin synthesized by Fusarium species, potentially influences transcription and affects gene expression on the translational level.		Others
T13391	Zearalanone		Others
	Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains.		Others
TN2045	Pelargonidin-3-O-glucoside chloride		Others , Estrogen/progestogen Receptor
	Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflammatory, anti-estrogenic, and angiotensin-converting enzyme ...		Others , Estrogen/progestogen Receptor
TN1679	Genistein 7,4'-di-O-β-D-glucoside	Genistein 7,4'-di-O-beta-D-glucopyranoside	Others , Estrogen/progestogen Receptor
	Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.		Others , Estrogen/progestogen Receptor
TN2224	Soyasapogenol A		TNF
	Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α±, which consequently resulted in the prevention of liv...		TNF
T83301	5,7-Dimethoxy-2,3-phenanthrenediol
	5,7-Dimethoxy-2,3-phenanthrenediol exhibits estrogenic activity by promoting the proliferation of MCF-7 cells and enhancing the expression of ERβ within this cell line [1].
TN3380	Alloisoimperatorin		AChR
	Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. Alloisoi...		AChR
TN5456	Isoerysenegalensein E
	Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 ...
TN3397	Alpinumisoflavone		ERK , LDL , NF-κB , MEK , MAPK , Antifection
	Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is endowed with estrogenic properties accounting, at least in p...		ERK , LDL , NF-κB , MEK , MAPK , Antifection
TN4383	Kazinol U		IL Receptor , IκB/IKK , NOS , NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-...		IL Receptor , IκB/IKK , NOS , NF-κB
TN3539	Broussonin A		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-lucife...		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt