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T2014 |
CCG-1423
|
CCG1423 |
LRRK2
,
Rho
,
Ras
|
|
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription. |
|
T11765 |
KPLH1130
|
|
Dehydrogenase
,
PDK
|
|
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions. |
|
T3312 |
AM-2394
|
AM2394 |
Glucokinase
|
|
AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel... |
|
T62238 |
AMPK activator 4
|
|
AMPK
|
|
AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in nor... |
|
T30169 |
ASP-8497
|
UNII-GC7THT248G,ASP8497,ASP 8497 |
Others
|
|
ASP8497 is a potent, long-acting DPP-IV inhibitor that improves glucose tolerance by elevating GLP-1 levels in a glucose-dependent insulin-stimulating manner. The compound is used as a therapeutic agent for impaired gluc... |
|
T38771 |
P32/98
|
P32/98 |
Others
|
|
P32/98 is a potent inhibitor of dipeptidyl peptidase IV . P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in preclinical studies using the fatty Zucker rat, an animal model for IGT (impai... |
|
T28784 |
SIRT6-IN-1
|
|
Others
|
|
SIRT6-IN-1, a novel SIRT6 inhibitor, reduces glycemia and improves oral glucose tolerance in unfed wild-type mice. |
|
T11583 |
HWL-088
|
|
Others
|
|
HWL-088 is a potent free fatty acid receptor 1 (FFA1/GPR40) agonist. HWL-088 significantly improves glucose tolerance in normal and diabetic models. |
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T29154 |
WB403
|
WB-403,WB 403 |
Others
|
|
WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores th... |
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T71251 |
DS-1558
|
|
Others
|
|
DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyp... |
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T68132 |
Quercetin-3'-o-phosphate
|
|
Others
|
|
Quercetin-3'-O-phosphate belongs to the class of organic compounds known as flavonols,has been used in trials studying the treatment of Insulin Resistance and Impaired Glucose Tolerance. |
|
TP2020 |
[Pro3]-GIP (Mouse)
|
|
|
|
GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intra... |
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T35785 |
N-Oleoyl Leucine
|
|
|
|
N-Oleoyl leucine is an N-acyl amide generated by PM20D1 that uncouples mitochondrial respiration independent of uncoupling protein 1 (UCP1) in vitro. N-Oleoyl leucine (25 mg/kg, i.p.) decreases body weight and food intak... |
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T84386 |
10-OAHSA
|
|
Others
|
|
10-OAHSA is a newly discovered endogenous lipid categorized within the group of branched fatty acid esters of hydroxy fatty acids (FAHFAs). This specific FAHFA comprises oleic acid esterified to 10-hydroxy stearic acid. ... |
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T84420 |
13-SAHSA
|
|
Others
|
|
13-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), has been found to be involved in metabolic regulation, particularly in relation to fasting, high-fat feeding, and insulin sensitivity. This compound ... |
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T84424 |
5-SAHSA
|
|
Others
|
|
15-SAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), is recognized for its involvement in metabolic regulation. This compound comprises stearic acid esterified to 5-hydroxy stearic acid and is notably i... |
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T84425 |
5-POHSA
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs), endogenous lipids influenced by fasting and high-fat diets, are linked to improved insulin sensitivity in mice. These molecules consist of a C-16 or C-18 fatty ... |
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T62542 |
GPR40 agonist 5
|
|
Others
|
|
GPR40 agonist 5 is an orally active GPR40 (G protein-coupled receptor 40) agonist (EC50: 47 nM). gPR40 agonist 5 reduces blood glucose levels and improves glucose tolerance. gPR40 agonist 5 shows adequate control of hype... |
|
T25739 |
Linogliride
|
McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida |
Others
|
|
Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassium channels in the pancreatic beta cell membrane, thereby ... |
|
T60312 |
FBPase-IN-1
|
|
Others
|
|
FBPase-IN-1 is a powerful inhibitor of Fructose-1,6-bisphosphatase (FBPase), a key enzyme involved in Type 2 diabetes (T2D) research. It exhibits an impressive IC50 value of 0.22 μM. Aside from its potency, FBPase-IN-1 a... |
|
T70390 |
YM-543 choline
|
|
Others
|
|
YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and ... |
|
T84422 |
13-OAHSA
|
|
Others
|
|
13-OAHSA, a branched fatty acid ester of hydroxy fatty acids (FAHFAs), results from the esterification of oleic acid to 13-hydroxy stearic acid. It represents a significant component of the FAHFA family, most abundantly ... |
|
T36142 |
10-PAHSA
|
|
Others
|
|
10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. A... |
|
T84429 |
12-POHSA
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) have emerged as significant regulators of metabolic processes, influenced by dietary changes such as fasting and high-fat diets, and are linked to improved insul... |
|
TP2019 |
[D-Ala2]-GIP (human)
|
|
|
|
Highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor... |
|
T25739L |
Linogliride fumarate
|
McN 3935,McN-3935,McN3935 |
Others
|
|
Linogliride fumarate is the fumarate salt of Linogliride. Linogliride is a guanidine-based inhibitor of insulin secretion and a structural analog of pirogliride with hypoglycemic activity. It blocks ATP-sensitive potassi... |
|
T35798 |
Massarigenin C
|
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Others
|
|
Massarigenin C is a fungal metabolite that has been found inM. flavoroseaand has enzyme inhibitory activities.1,2Massarigenin C inhibits neuraminidasein vitro(IC50= 4.15 μM).2It is also an inhibitor of yeast α-glucosidas... |
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T84421 |
13-POHSA
|
|
Others
|
|
13-POHSA (palmitoleic acid esterified to 13-hydroxy stearic acid) is a type of branched fatty acid esters of hydroxy fatty acids (FAHFAs), which have recently been discovered as endogenous lipids whose levels are modulat... |
|
T84387 |
10-SAHSA
|
|
Others
|
|
10-SAHSA, an endogenous lipid recently discovered, is part of the FAHFAs, a group of branched fatty acid esters of hydroxy fatty acids. It specifically consists of stearic acid esterified to 10-hydroxy stearic acid. Nota... |
|
T79475 |
GPR119 agonist 2
|
|
Others
|
|
GPR119 agonist 2 (compound 43), an orally active agonist of GPR119, exhibits favorable pharmacokinetic properties in rodents and has demonstrated efficacy in enhancing glucose tolerance in both mice and rats, indicating ... |
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T84407 |
13-PAHSA
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are lipids influenced by dietary changes, playing a crucial role in insulin sensitivity. These compounds typically consist of a C-16 or C-18 fatty acid (for exam... |
|
T79649 |
CB1R/AMPK modulator 1
|
|
Cannabinoid Receptor
|
|
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound activates AMPK and has been shown to decrease food intake and body weight, in addition to enhancin... |
|
T84426 |
5-OAHSA
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids that are influenced by fasting and high-fat diets and linked to improved insulin sensitivity in mice. These compounds typically feature a c... |
|
T69671 |
SR1903 TFA
|
|
Others
|
|
SR-1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR). It is an inverse agonist of RORγ and an agonist of LXR. It also binds to peroxisome proliferator-activated rec... |
|
T84430 |
12-OAHSA
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are recently discovered lipids that play a role in the body's response to fasting and high-fat diets, with a link to insulin sensitivity. These compounds consist... |
|
T35816 |
ZLY032
|
|
Others
|
|
ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and... |
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T35622 |
FKGK 18
|
|
Others
|
|
FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA... |
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T84428 |
9-POHSA
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are recent discoveries in endogenous lipids that are influenced by dietary changes such as fasting and high-fat diets, showing a link with enhanced insulin sensi... |
|
T16507 |
PF-5006739
|
|
Casein Kinase
|
|
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency... |
|
T35547 |
YW1128
|
|
Others
|
|
YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein ... |
|
T36590 |
9-PAHSA
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprise... |
|
T35638 |
SR 1903
|
|
Others
|
|
SR 1903 is a modulator of retinoic acid receptor-related orphan receptor γ (RORγ) and liver X receptor (LXR).1 It is an inverse agonist of RORγ (IC50 = ~100 nM in a cell-based reporter assay) and an agonist of LXR. It al... |
|
T85123 |
3-Aminoisobutyric Acid sodium
|
BAIBA,β-Aminoisobutyric Acid |
Others
|
|
3-Aminoisobutyric acid, a non-protein amino acid resultant from thymine catabolism, plays a significant role in metabolic activities. At a 5 µM concentration, it triggers browning in primary adipocytes, notably elevating... |
|
T84415 |
9-PAHSA 13C4
|
|
Others
|
|
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipids whose levels are modulated by fasting and high-fat diets, and they play a role in insulin sensitivity. These compounds consist o... |
|
T79358 |
PF-07247685
|
|
Endogenous Metabolite
|
|
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages... |
|
T79357 |
PF-07238025
|
|
Endogenous Metabolite
|
|
PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit interaction and inhibits the phosphorylation of the E1 sub... |
