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T4039 |
BIBB 515
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Others
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BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of... |
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T64006 |
Lipid-lowering agent-1
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Lipid-lowering agent-1 is a potent lipid-lowering agent that significantly inhibits the pharmacological effects of low-density lipoprotein cholesterol (LDLC) and promotes the production of high-density lipoprotein choles... |
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T10900 |
CUDA
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PPAR
,
Epoxide Hydrolase
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CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR... |
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T3978 |
Linerixibat
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GSK2330672,Iinerixibat |
HBV
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Linerixibat (GSK2330672) is a highly effective, nonabsorbable ASBT inhibitor (IC50: 42 ± 3 nM). It can lower glucose in an animal model of type 2 diabetes and shows excellent developability properties. |
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T7133 |
Anagliptin
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SK-0403 |
Proteasome
,
DPP-4
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Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus. |
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T61151 |
Beclobrate
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Beclobrate (Sgd 24774), a fibric acid derivative, exhibits potent lipid-lowering efficacy in rodent models [1]. |
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T9010 |
IMM-H007
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Others
,
AMPK
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IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression |
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T13563 |
AZ-1355
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Prostaglandin Receptor
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AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties. |
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T28501 |
Ragaglitazar
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NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029 |
PPAR
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Ragaglitazar(NNC-61-0029) is a potent dual PPARα and PPARγ agonist that has shown potent lipid-lowering and insulin sensitizing effects in animal models.Ragaglitazar can be used to study type 2 diabetes. |
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T6450 |
Clinofibrate
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S-8527,Lipoclin |
HMG-CoA Reductase
,
Autophagy
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Clinofibrate (Lipoclin)(IC50 of 0.47 mM), a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood. |
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T3625 |
Bempedoic acid
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ETC1002,ESP-55016,ETC 1002,ETC-1002 |
ATP Citrate Lyase
,
AMPK
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Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic ... |
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T11386L |
Gemcabene
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PD-72953 |
Others
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T14933 |
Cetaben
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Others
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Cetaben is a PPARα-independent peroxisome proliferator and is a non-fibrate hypolipidemic drug. It potent reduces the concentration of cholesterol and triglycerides. |
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T4072 |
Methyl-β-cyclodextrin
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Methyl-beta-cyclodextrin,beta-Cyclodextrin methyl ethers |
Others
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Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a macrocyclic compound used as a solubilizer for hydrophobic compounds in biological experiments. Methyl-β-cyclodextrin is also a lipid raft inhibitor with cholesterol-... |
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T20928 |
Febuprol
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H33,K-10033,H 33,H-33,NSC 30151 |
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Febuprol, a choleretic drug, stimulates bile secretion. In addition, it also has lipid-lowering (lowering blood lipid) and spasmolytic (anticonvulsant) properties. |
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T32346 |
K 13-004
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K 13004,K13004 |
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K 13-004 is a lipid-lowering agent. |
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T31720 |
Etiroxate, (S)-
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Etiroxate, (S)- has a lipid-lowering effect. |
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T30917 |
CI 924
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EINECS 279-174-7,CI-924,CI924 |
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CI 924 is a lipid-lowering drug. CI 924 increased anti-atherosclerotic HDL and decreased VLDL at 600 mg/day. |
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T30297 |
Bay-02752
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BAY-02752 is a lipid lowering agent that has been shown in rats to inhibit the absorption of intestinal cholesterol. |
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T71734 |
Muraglitazar glucuronide
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Muraglitazar glucuronide is a Peroxime Proliferator Activated (PPAR) Agonist that has glucose- and lipid-lowering activities. |
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T10506 |
PPAR agonist 1
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PPAR
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PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol. |
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T15710 |
Lapaquistat
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T-91485 |
Others
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Lapaquistat is a cholesterol biosynthesis inhibitor and is the active metabolite of TAK-475. Lapaquistat can reduce statin-induced myotoxicity in lipid-lowering therapy. |
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T10767 |
Cerivastatin sodium
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HMG-CoA Reductase
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Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent and orally active HMG-CoA reductase inhibitor (Ki: 1.3 nM). It also inhibits the proliferation and invasiveness of MDA-MB-231 cells, mainly by R... |
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T82434 |
Etiroxate
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CG-635 |
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Etiroxate (CG-635) is a lipid-lowering agent utilized in hyperlipoproteinemia studies [1]. |
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T10187 |
6-Raloxifene-β-D-glucopyranoside
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Others
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6-Raloxifene-β-D-glucopyranoside is a benzothiophene glucuronidated at the 6' position. It is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone l... |
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T27519 |
GW 9578
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GW9578,GW-9578 |
PPAR
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GW 9578 is a selective and potent PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes. |
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T28882 |
Sultosilic acid, piperazine salt
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A-585,Mimedran,piperazine-sultosylate,A585,A 585 |
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Sultosilic acid piperazine salt is a drug with lowering lipid activity. It causes significant shortening of the euglobulin lysis time and a significant diminution of platelet adhesiveness, as well as statistically signif... |
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T11386 |
Gemcabene calcium
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PD-72953 calcium |
Others
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T77113 |
Ongericimab
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Ongericimab (JS002) is a humanized monoclonal antibody targeting PCSK9 with demonstrated lipid-lowering efficacy. It is utilized in the research of hypercholesterolemia and hyperlipidemia [1]. |
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T13483 |
RP 54275
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2-Octadecyl-1H-indole-5-carboxylic acid |
Others
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RP 54275 is a naturally occurring fatty acid derivative, a new cholesterol-lowering compound. It activates the peroxisome proliferator-activated receptor gamma (PPARγ) pathway, which is involved in the regulation of lipi... |
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T77058 |
Lerodalcibep
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Lerodalcibep (LIB003), a lipid-lowering agent, consists of a PCSK9-binding domain (adnectin) fused with human serum albumin, forming a recombinant fusion protein. It is utilized in the research of hypercholesterolemia an... |
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T37255 |
12-methyl Myristic Acid methyl ester
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12-methyl Myristic acid methyl ester is a methylated fatty acid methyl ester that has been found in vermicomposts of cattle manure, carica papaya leaves, and cuticular wax of K. africana. It is a volatile compound in lip... |
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T77144 |
Recaticimab
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Recaticimab (SHR-1209) is a humanized monoclonal antibody targeting PCSK9 to enhance the degradation of this enzyme. By binding to PCSK9, Recaticimab elevates low-density lipoprotein (LDL) receptor presence on hepatocyte... |
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T37996 |
17-phenyl trinor Prostaglandin E2 ethyl amide
|
17-phenyl trinor Prostaglandin E2 ethyl amide |
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17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rat... |
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T35632 |
Pinolenic Acid
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Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime... |
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T82900 |
Bemfivastatin hemicalcium
|
PPD 10558 hemicalcium |
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Bemfivastatin hemicalcium (PPD 10558), an orally active HMG-CoA reductase inhibitor, serves as a lipid-lowering agent. It amplifies liver extract activity and exhibits no-observed adverse effect levels (NOAEL) at dosages... |
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T35633 |
Pinolenic Acid ethyl ester
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Pinolenic acid is a polyunsaturated fatty acid found in Korean pine (Pinus orientalis) and maritime pine (Pinus pinaster) seed oils. Both oils have been found to have lipid-lowering properties. A diet containing maritime... |
