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T9921 |
Infliximab
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TNF
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|
Infliximab is a humanized antibody against tumor necrosis factor α TNF-α) that is used in the treatment of Crohn's disease and rheumatoid arthritis. |
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T7502L |
PF 05089771
|
PF-05089771,PF05089771 |
Sodium Channel
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|
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent. |
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T7502 |
PF 05089771 tosylate
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|
Sodium Channel
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|
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8... |
|
T27178 |
Dimiracetam
|
NT-11624,NT11624,BND11624,ISF4185,BND-11624,ISF-4185 |
|
|
Dimiracetam (NT-11624) is an orally active anti-neuropathy compound that inhibits hypersensitivity and neurological alterations and may be used in the study of cognitive disorders, depression and neuropathic pain. |
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T27248 |
Egis-11150
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|
|
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Egis-11150 is an anti-neuropathy compound with pro-cognitive effects. |
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T21389 |
Enprofylline
|
Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum |
Others
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|
Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sick... |
|
T10244 |
ACY-1083
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|
HDAC
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|
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM) and effectively reverses chemotherapy-induced peripheral neuropathy. |
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T72282 |
Ebaresdax hydrochloride
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|
Endogenous Metabolite
|
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Ebaresdax hydrochloride has analgesic activity and is used in the study of painful diabetic neuropathy caused by type I or type II diabetes. |
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T5385 |
Radiprodil
|
RGH-896 |
NMDAR
,
iGluR
|
|
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP). |
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T39024 |
PrNMI
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|
Cannabinoid Receptor
|
|
PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced pe... |
|
T1458 |
Epalrestat
|
ONO2235 |
Reductase
|
|
Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particul... |
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T8644 |
Elamipretide Triacetate
|
Elamipretide TriTFA |
Others
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|
Elamipretide Triacetate (Elamipretide TriTFA) is an aromatic-cationic tetrapeptide that readily penetrates cell membranes and transiently localizes to the inner mitochondrial membrane where it associates with cardiolipin... |
|
T1993 |
J-147
|
J147 |
Epigenetic Reader Domain
,
Dopamine Receptor
,
Monoamine Oxidase
|
|
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... |
|
T0976 |
Propoxur
|
Aprocarb,Propoxure,Baygon |
AChR
,
Antifungal
|
|
Propoxur (Propoxure) is an insecticide used to control cockroaches, flies, mosquitoes, and lawn and turf insects. Acute (short-term) exposure of humans to propoxur by ingestion leads to cholinesterase inhibition of red b... |
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T68929 |
Lidorestat monohydrate
|
|
|
|
Lidorestat monohydrate is an aldose reductase inhibitor potentially for the treatment of diabetic neuropathy and diabetic complications. |
|
T70579 |
SX 3202
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|
|
|
SX 3202 is an aldose reductase inhibitor being developed for the treatment of diabetic neuropathy. |
|
T35299 |
Zenarestat
|
CI1014,FR74366,FK-366,CI-1014,FR 74366,FR-74366 |
|
|
Zenarestat (CI-1014, FK-366, FR-74366) is an aldose reductase inhibitor being studied as a treatment for diabetic neuropathy and cataracts. |
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T79303 |
IACS-52825
|
|
|
|
IACS-52825 is a potent, selective DLK inhibitor, exhibiting a dissociation constant (Kd) of 1.3 nM, and is valuable for researching chemotherapy-induced peripheral neuropathy (CIPN) [1]. |
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T28516 |
ReN-1869
|
NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869 |
|
|
ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and ne... |
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T82475 |
Emfilermin
|
|
|
|
Emfilermin, a recombinant human leukemia inhibitory factor (LIF), is utilized in the research of chemotherapy-induced peripheral neuropathy [1]. |
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T62965 |
TDP1 Inhibitor-2
|
|
|
|
TDP1 Inhibitor-2 is a potent inhibitor of TDP1 (tyrosyl-DNA phosphodiesterase 1) (IC50: 99 nM) and inhibits SCAN1 (spinal cerebellar ataxia syndrome with axonal neuropathy) (IC50: 3.5 μM). |
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T62670 |
Cemdomespib
|
|
|
|
Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator. cemdomespib induces a heat shock response, induces Hsp70 levels and has neuroprotective effects. cemdomespib has been shown to improve sensory deficits ... |
|
T81525 |
Pegylated synthetic human c-peptide
|
|
|
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Pegylated synthetic human C-peptide exhibits similar bioactivity to natural C-peptides (non-polyethylene glycolated) and demonstrates an extended plasma half-life, making it suitable for research in diabetic peripheral n... |
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T38214 |
1-Deoxysphingosine (m18:1(4E))
|
1-Deoxysphingosine (m18:1(4E)) |
|
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1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine durin... |
|
T28897 |
T-1095A
|
T 1095A,J1.265.331J |
|
|
T-1095A is an active metabolite of T-1095, a potent and selective inhibitor of Na+-glucose cotransporters (SGLTs). Chronic administration of T-1095 (0.1% w w(-1) pellet chow, for 12 weeks) decreased blood glucose and hae... |
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T72623 |
Nampt activator-3
|
|
|
|
NAMPT Activator-3, a derivative of NAT, is a potent activator of NAMPT, demonstrating an EC50 of 2.6 μM and KD of 132 nM. It effectively shields cultured cells against toxicity induced by FK866 and has demonstrated signi... |
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T37554 |
Oleyl Anilide
|
|
|
|
AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransfera... |
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T68743 |
AZD4877 HCl
|
|
|
|
AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may re... |
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T79717 |
MHTT-IN-2
|
|
Huntingtin
|
|
mHTT-IN-2 (compound 27) is a potent inhibitor of mutant huntingtin protein (mHTT), with an EC50 value of 0.066 μM. It specifically modulates the splicing of HTT RNA exons [49-50], acting as a splicing regulator for the H... |
|
T83688 |
R 715 TFA
|
[Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK,Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH |
|
|
R 715, a bradykinin B1 receptor antagonist, inhibits contractions in isolated human umbilical cords that express bradykinin B1 receptors (pA2 = 8.49). When administered at doses of 200, 400, and 600 µg/kg, R 715 enhances... |
