|
T10168 |
5-HT1A modulator 1
|
5-HT1Amodulator1 |
Phospholipase
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
|
|
T37197 |
5-HT1A modulator 2 hydrochloride
|
|
5-HT Receptor
|
|
5-HT1A modulator 2 hydrochloride, a derivative of 8-OH-DPAT , is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding[1].
[1]. Naiman, N.,et al. 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotoni... |
|
T0280 |
Spiperone
|
Spiroperidol,Spiropitan |
Dopamine Receptor
|
|
Spiperone (Spiropitan) is a spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA. |
|
TQ0311 |
GSK163090
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3). |
|
T9272 |
Xaliproden hydrochloride
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Xaliproden is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist. |
|
T21011 |
Buspirone
|
Buspirone free base,Ansial |
5-HT Receptor
|
|
Buspirone (Buspirone free base) is an azaspiro compound which has a role as an anxiolytic drug, a sedative, a serotonergic agonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor. |
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
T4560 |
Alprenolol
|
Alpheprol,(RS)-Alprenolol,dl-Alprenolol |
5-HT Receptor
,
Adrenergic Receptor
|
|
Alprenolol (Alpheprol) is a non-selective β-adrenergic receptor (β-AR) antagonist that is also an antagonist of the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT1B. |
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T62843 |
5-HT1A antagonist 1
|
|
|
|
5-HT1A antagonist 1 (compound 6f) is a potent and selective 5-HT1Areceptor antagonist (Ki: 35 nM). 5-HT1A antagonist 1 can be used in the study of central nervous system disorders. |
|
T22236 |
Alprenolol hydrochloride
|
|
5-HT Receptor
|
|
Alprenolol hydrochloride is a non-selective blocker of beta, and also is a antagonist of5-HT1A receptor. |
|
T8593 |
RU 24969
|
5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole |
5-HT Receptor
|
|
RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) is a selective agonist of 5-HT1A and 5-HT1B receptors. |
|
T2132 |
Buspirone hydrochloride
|
Buspirone HCl,Narol,Buspar |
Dopamine Receptor
,
5-HT Receptor
|
|
Buspirone hydrochloride (Buspar) is a 5HT(1A) receptor agonist, used to treat generalized anxiety disorder (GAD). |
|
T6241 |
Quetiapine hemifumarate
|
Quetiapine Fumarate,ICI-204636 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression. |
|
T3046 |
BMY 7378 dihydrochloride
|
BMY7378 HCl |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
BMY 7378 dihydrochloride (BMY7378 HCl) , α1D-adrenergic receptor antagonist, is a weak partial agonist/antagonist of 5-HT1A receptor. |
|
T8136 |
Perospirone hydrochloride
|
Perospirone HCl,SM-9018 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
|
|
Perospirone hydrochloride (Perospirone HCl) is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist. |
|
T6647 |
Rotigotine-
|
Neupro,N-0923,N-0437,SPM 962 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Rotigotine (N-0923) is a non-ergot dopamine receptor agonist used in the therapy of Parkinson disease and restless leg syndrome. Administered as a once-daily transdermal patch, Rotigotine has not been associated with ser... |
|
T7412 |
Tandospirone citrate
|
SM-3997 citrate |
5-HT Receptor
|
|
Tandospirone citrate (SM-3997 citrate) is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM) |
|
T7498 |
Eltoprazine hydrochloride
|
DU 28853 hydrochloride |
5-HT Receptor
|
|
Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively). |
|
T0088 |
Urapidil hydrochloride
|
Urapidil HCl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Urapidil hydrochloride (Urapidil HCl) is 5-HT1A receptor agonist and an α1-adrenoceptor antagonist. |
|
T7281 |
F-15599
|
|
5-HT Receptor
|
|
F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist(Ki : 3.4 nM). |
|
T3431 |
Pardoprunox hydrochloride
|
SLV-308 hydrochloride,DU-126891 hydrochloride |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Pardoprunox hydrochloride (SLV-308 hydrochloride) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A recept... |
|
T2395L |
Vortioxetine hydrobromide
|
Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,Lu AA21004 hydrobromide |
5-HT Receptor
,
Serotonin Transporter
|
|
Vortioxetine hydrobromide (Lu AA21004 hydrobromide) is a serotonin (5-HT) modulator and stimulator (SMS), inhibits 5-HT1A/1B/3A/7 receptor and SERT (IC50: 15/33/3.7/19/1.6 nM). |
|
T5387 |
LP-211
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
LP-211 is a brain penetrant selective agonist for a 5-HT7 receptor (Ki: 0.58 nM), and >300-fold selectivity over the 5-HT1A receptor. |
|
T2306 |
Brexpiprazole
|
OPC-34712 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Brexpiprazole (OPC-34712) is a partial agonist of human 5-hydroxytryptamine (5-HT) 5-HT1A and dopamine D2 receptors. |
|
T1566 |
Aripiprazole
|
OPC-14597 |
5-HT Receptor
|
|
Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a... |
|
T6423 |
BRL-15572 dihydrochloride
|
BRL 15573 dihydrochloride |
5-HT Receptor
|
|
BRL-15572 dihydrochloride (BRL 15573 dihydrochloride) is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B recepto... |
|
T21337 |
Lurasidone
|
SM-13496 |
Dopamine Receptor
,
5-HT Receptor
|
|
Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7(IC50=1.68 and 0.495 nM, respectively).It also a partial agonist of 5-HT1A receptor(IC50 : 6.75 nM). |
|
T68113 |
Naluzotan hydrochloride
|
PRX 00023 hydrochloride |
EGFR
,
5-HT Receptor
|
|
Naluzotan hydrochloride (PRX 00023 hydrochloride) is a hERG K+ channel blocker with an IC50 value of 3800 nM and is commonly used in the study of anxiety and depression.Naluzotan hydrochloride is also a novel, potent, an... |
|
T19917 |
Gepirone
|
|
5-HT Receptor
|
|
Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs. |
|
T4577 |
Cariprazine
|
RGH-188 |
Dopamine Receptor
,
5-HT Receptor
|
|
Cariprazine (RGH-188) is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T23285 |
S 14506 hydrochloride
|
|
5-HT Receptor
|
|
S 14506 hydrochloride is a 5-HT1A receptor full agonist. |
|
T16265 |
Naluzotan
|
PRX 00023 |
EGFR
,
5-HT Receptor
|
|
Naluzotan（PRX 00023） is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+ channel blocker with an IC50 value of 3800 nM.Naluzotan exhi... |
|
T61934 |
Repinotan
|
BAY x 3702 free base |
5-HT Receptor
|
|
Repinotan (BAY x 3702 free base) is an orally active and selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), has neuroprotective activity, antagonizes morphine-induced depression of ventilation ... |
|
T1735 |
Lurasidone hydrochloride
|
Lurasidone HCl,SM-13496 (Hydrochloride),SM-13496 |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antag... |
|
T28270 |
Osemozotan HCl
|
Osemozotan hydrochloride,MN-305,MCI-242,MKC-242,MKC242,MCI242 |
|
|
Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder. |
|
T80805 |
WAY-607695
|
|
5-HT Receptor
|
|
WAY-607695 is a potential 5-HT1A receptor agonist. |
|
T14782 |
Brilaroxazine
|
RP5063 |
Dopamine Receptor
,
5-HT Receptor
|
|
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... |
|
T12489 |
Pimethixene
|
Calmixen,Pimetixene |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... |
|
T0428 |
Alverine citrate
|
NSC 35459 |
5-HT Receptor
|
|
Alverine citrate (NSC 35459) is utilized in functional gastrointestinal disorders. |
|
T28258 |
Org-13011 fumarate
|
Org13011,Org 13011 |
5-HT Receptor
|
|
Org-13011 fumarate1 is an agonist of the 5-HT1A receptor and can be used to study neurological disorders. |
|
T23007 |
MM 77 dihydrochloride
|
|
5-HT Receptor
|
|
MM 77 dihydrochloride (FITC-Dextran (60842-46-8 MW 4000)) is an effecitve 5-HT1A receptor postsynaptic antagonist with anxiolytic-like activity. |
|
T6600 |
Naftopidil dihydrochloride
|
KT-611,KT-611 2HCl,Naftopidil DiHCl |
5-HT Receptor
,
Adrenergic Receptor
|
|
Naftopidil dihydrochloride (KT-611 2HCl) is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively. |
|
T22591 |
ATC 0175 hydrochloride
|
|
GPR
,
5-HT Receptor
,
Melanin-concentrating Hormone Receptor (MCHR)
|
|
ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A rece... |
|
T62711 |
OPC-14523 hydrochloride
|
|
|
|
OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist with antidepressant-like activity. OPC-14523 shows a high affinity for the sigma receptor σ1/2 (IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 ... |
|
T3179 |
Eptapirone
|
F 11440 |
5-HT Receptor
|
|
Eptapirone (F 11440) is a highly effective and selective 5-HT1A receptor agonist with marked antidepressant and anxiolytic potential. |
|
T6232 |
Vilazodone Hydrochloride
|
SB659746A,EMD 68843,Vilazodone HCl |
Others
,
5-HT Receptor
,
Serotonin Transporter
|
|
Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder. |
|
T61816 |
EMD 56551
|
|
5-HT Receptor
|
|
EMD 56551 is a selective small molecule 5-HT1A receptor agonist with anxiolytic activity for the study of anxiety disorders. |
|
T68172 |
Zalospirone
|
|
5-HT Receptor
|
|
Zalospirone is a 5-HT1A receptor agonist that can be used to study anxiety disorders and major depressive disorder. |
|
T23631 |
Adatanserin
|
WY-50324,WY 50324,WAY SEB 324,WY50324 |
5-HT Receptor
|
|
Adatanserin (WY 50324) is a mixed 5-HT1A receptor partial agonist and a 5-HT2A and 5-HT2C receptor antagonist with potential neuroprotective activity for the study of anxiety and depression. |
