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Search Results for " Hepatotoxicity "

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天然化合物

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カタログ番号	製品名	別名	ターゲット
T36125	Tienilic Acid		P450
	Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity		P450
T37906	Dibenamine hydrochloride		Adrenergic Receptor
	Dibenamine hydrochloride is a competitive and irreversible blocking agent of the β-adrenergic receptor.		Adrenergic Receptor
T0840	Methimazole	Tapazole,Thiamazole	Thyroid hormone receptor(THR)
	Methimazole (Thiamazole) is an antithyroid compound with significant hepatotoxicity and is often used in the study of hyperthyroidism.		Thyroid hormone receptor(THR)
T7747	Datelliptium chloride hydrochloride		DNA/RNA Synthesis
	Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.		DNA/RNA Synthesis
T13231L	Trovafloxacin mesylate		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
	Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the ...		Others , DNA/RNA Synthesis , Topoisomerase , Antibacterial
T21439	Tacrine	CS 12602,Tacrinum,Tetrahydroaminocrine	AChR
	Tacrine (CS 12602) is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.		AChR
T8845	UTL-5g	3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g	TNF
	UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) is a novel potential chemoprotective agent, TNF-α inhibitor that reduces cisplatin-induced side effects including nephrotoxicity, hepatotoxicity and hemat...		TNF
T1090	Perphenazine	Perphenazin,Etaperazine,Trilafon	CaMK , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
T13231	Trovafloxacin		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
	Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive.		DNA gyrase , Topoisomerase , Antibacterial , Antibiotic
T67509	Cholesteryl Hemisuccinate	Cholesterol hydrogen succinate	Apoptosis , DNA/RNA Synthesis , Topoisomerase
	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl ...		Apoptosis , DNA/RNA Synthesis , Topoisomerase
TF0106	Cholesteryl Hemisuccinate Tris Salt		Apoptosis
	Cholesteryl Hemisuccinate Tris Salt is an acidic cholesteryl ester with hepatoprotective and anticancer activity.Cholesteryl hemisuccinate is a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing C...		Apoptosis
T33707	N-Nitrosofenfluramine, (S)-	J1.936.463A
	N-Nitrosofenfluramine is a compound that is thought to cause hepatotoxicity in subjects.
T69613	Ar-H047108 free base
	Ar-H047108 free base is an imidazopyridine potassium competitive acid blocker (P-CAB). This drug may be used to treat early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity.
T31043	CP-199330	UNII-V4WYK6T8QA,CP 199330,UNII-74573Q728X,CP-199330 sodium
	CP-199330 is a cysteyl LT1 receptor antagonist with no hepatotoxicity and is equivalent to the commercially available CYSLT1 receptor antagonists Zafirlukast and Pranlukas.
T71358	Nialamide monohydrochloride
	Nialamide monohydrochloride is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of...
T38312	L-Cysteine-glutathione disulfide
	L-Cysteine-glutathione disulfide, a glutathione derivative endogenous to mammalian cells, is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine. It has been shown to p...
T62057	Anticancer agent 12
	Anticancer agent 12 shows cytotoxic activity in malignant cells with no hepatotoxicity.
T60771	Metamizol
	Metamizol (Methamizole) blocks thyroid hormone production from the thyroid gland which is an anti-thyroid agent. However, Metamizol has hepatotoxicity as adverse effect [1].
T36837	(E,Z)-2-propyl-2-Pentenoic Acid
	(E,Z)-2-propyl-2-Pentenoic acid is a bioactive metabolite of valproic acid that exhibits the same profile and potency of anticonvulsant activity in animal models as its parent compound without any observed teratogenicity...
T83050	Anti-inflammatory agent 62
	Anti-inflammatory agent 62 mitigates acetaminophen-induced hepatotoxicity in HepG2 cells by modulating inflammatory and oxidative stress pathways [1].
T37463	CAY10704
	CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM). It displays good pharmacokinetics in m...
T38206	3-Cysteinylacetaminophen (trifluoroacetate salt)	APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)
	3-Cysteinylacetaminophen is an acetaminophen-protein adduct formed during the metabolism of acetaminophen.[1],[2] 3-Cysteinylacetaminophen has been found in isolated human serum following therapeutic and supratherapeutic...
T73245	AChE-IN-9
	AChE-IN-9, a Tacrine glycoconjugate connected to acetylated β-Glucose, acts as an AChE inhibitor, demonstrating an IC 50 value of 0.4 μM and exhibiting reduced hepatotoxicity in healthy cells. This compound finds use in ...
T73255	Akt1-IN-1
	Akt1-IN-1 is a potent and selective inhibitor of Akt1, demonstrating an IC50 of 18.79 nM in MIA PaCa-2 cells, indicating its high efficacy in inhibiting this specific kinase. Notably, it shows no significant teratogenici...
T74717	12-Hydroxynevirapine
	12-Hydroxynevirapine (12-hydroxy-NVP; 12-OH-NVP), a significant oxidative metabolite of Nevirapine—an antiviral drug used for HIV-1 infections known for potential idiosyncratic hepatotoxicity and skin rashes—undergoes bi...
T62822	CT1-3
	CT1-3 is a potent anti-cancer agent. CT1-3 regulates the JNK/Bcl-2/Bax/XIAP pathway, which induces mitochondria-mediated apoptosis. CT1-3 regulates the E-cadherin/Snail axis to inhibit epithelial mesenchymal transition (...
T79454	Anti-NASH agent 1		PPAR
	Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH). At dosages of 3-10 mg/kg over four weeks, this compound ameliorates hy...		PPAR

Compounds

Dibenamine hydrochloride

T37906

Synonym:

Target: Adrenergic Receptor

Methimazole

T0840

Synonym: Tapazole,Thiamazole

Target: Thyroid hormone receptor(THR)

Datelliptium chloride hydrochloride

T7747

Synonym:

Target: DNA/RNA Synthesis

Trovafloxacin mesylate

T13231L

Synonym:

Target: Others, DNA/RNA Synthesis, Topoisomerase, Antibacterial

Tacrine

T21439

Synonym: CS 12602,Tacrinum,Tetrahydroaminocrine

Target: AChR

UTL-5g

T8845

Synonym: 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g

Target: TNF

Perphenazine

T1090

Synonym: Perphenazin,Etaperazine,Trilafon

Target: CaMK, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Trovafloxacin

T13231

Synonym:

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Cholesteryl Hemisuccinate

T67509

Synonym: Cholesterol hydrogen succinate

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase

Cholesteryl Hemisuccinate Tris Salt

TF0106

Synonym:

Target: Apoptosis

N-Nitrosofenfluramine, (S)-

Synonym: UNII-V4WYK6T8QA,CP 199330,UNII-74573Q728X,CP-199330 sodium

Target:

Nialamide monohydrochloride

T71358

Synonym:

Target:

L-Cysteine-glutathione disulfide

(E,Z)-2-propyl-2-Pentenoic Acid

T36837

Synonym:

Target:

Anti-inflammatory agent 62

3-Cysteinylacetaminophen (trifluoroacetate salt)

T38206

Synonym: APAP-Cys,3-(cysteine-S-yl)acetaminophen,3-Cysteinylacetaminophen (trifluoroacetate salt)

カタログ番号	製品名	別名	ターゲット
T4S0790	Diosbulbin B		Others
	1. Diosbulbin B exhibits potential hepatotoxicity. 2. Diosbulbin B has potential anti-tumor effects which may be related to influencing the immune system for the first time.		Others
T3913	Saikosaponin D		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
	Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.		Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT
T6S0234	Toosendanin		Others
	1. Toosendanin possesses hepatotoxicity. 2. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. 3. Toosendanin i...		Others
T7036	2,4'-Dihydroxybenzophenone		Antioxidant
	2,4'-Dihydroxybenzophenone can effectively protect C57BL/6J mice from APAP-induced hepatotoxicity. Its mechanisms might be associated with its Antioxidant activity.		Antioxidant
T3999	D(+)-Galactosamine hydrochloride	D-Galactosamine HCl	Others
	D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice.		Others
T5S0285	Cistanoside A		Others
	1. Cistanoside A possesses protective activities on CCl4 induced hepatotoxicity in mice, which is involved with increasing free radicals clearing activities, alleviating lipid-overoxidation damage, and improving respirat...		Others
T6S2246	Alisol B 23-acetate	Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B	Others
	1. Alisol B 23-acetate (Alisol B Acetate) produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. 2. Alisol B 23-acetate produces promotiv...		Others
TWS1977	Kamebakaurin	Kamebakaurine	NF-κB
	1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression...		NF-κB
T4S2326	Cornuside	7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside	ERK , p38 MAPK , NF-κB , JNK
	1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...		ERK , p38 MAPK , NF-κB , JNK
T20635	Senkirkin	Renardin
	Senkirkin is a pyrrolizidine alkaloid with hepatotoxicity.
TN3871	Diosbulbin C		Others
	Diosbulbin C has hepatotoxicity.		Others
TN1588	Dihydroisotanshinone I		ATPase , Potassium Channel , Calcium Channel
	Dihydroisotanshinone I has protective action against menadione-induced hepatotoxicity, attributed to its antioxidant properties including the free radical scavenging activity and inhibition of lipid peroxidation.		ATPase , Potassium Channel , Calcium Channel
TN4513	Meliasenin B		Others
	Meliasenin B may cause hepatotoxicity, it displays dose-dependent toxicity on HepG2 cells.		Others
TN1670	Ganodermanondiol		HIV Protease , Nrf2 , AMPK
	Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.		HIV Protease , Nrf2 , AMPK
T81795	Microcystin-WR
	Microcystin-WR, a hepatotoxic metabolite derived from cyanobacteria, has been demonstrated to induce hepatotoxicity in mice [1].
TN5278	Zederone		NADPH-oxidase , P450 , TNF , Nrf2 , Antifection
	Zederone has anti-bacterial activity,it inhibits gram-positive bacteria activity. Zederone induces hepatotoxicity implicated the induction of Cyps, which leads to the formation of biological reactive metabolites and that...		NADPH-oxidase , P450 , TNF , Nrf2 , Antifection
TN3412	Andrographiside		Others
	Andrographiside shows protective effects on hepatotoxicity induced in mice by carbon tetrachloride or tert-butylhydroperoxide (tBHP) intoxication, the effects could be due to its glucoside groups which may act as strong ...		Others
TN5336	9-Oxo-10,11-dehydroageraphorone	4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone
	9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell ...
TN1478	Celosin I		Others
	Celosin H, celosin I, and celosin J could be used as chemical markers for the quality control of C. argentea seeds. Celosin I exhibited significant hepatoprotective effect on carbon tetrachloride-induced and N,N-dimethyl...		Others
T82310	Glomeratide A
	Glomeratide A, a benzophenone C-glucoside, exhibits hepatoprotective properties and safeguards rat liver epithelial stem-like cells from d-galactosamine-induced hepatotoxicity.
T82748	Celosin L
	Celosin L, a triterpenoid saponin, demonstrates hepaprotective activity and exerts protective effects against APAP-induced hepatotoxicity in HepG2 cells [1].
T82219	Heilaohuguosu F
	Compound 6, known as Heilaohuguosu F, is a tetrahydrofuranolignan demonstrating weak hepatoprotective properties. It exhibits a mild protective effect against acetaminophen (APAP)-induced hepatotoxicity in HepG2 cells.
TN4223	Homopterocarpin		Antifection
	Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribu...		Antifection
T37770	Taurohyodeoxycholic acid
	Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .1THDCA decreases the size and weight of human gallstonesin vitro. It increases bile flow, biliary cholesterol ...

天然物製品

Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT

2,4'-Dihydroxybenzophenone

T7036

Synonym:

Target: Antioxidant

D(+)-Galactosamine hydrochloride

T3999

Synonym: D-Galactosamine HCl

Synonym: Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B

Target: Others

Kamebakaurin

TWS1977

Synonym: Kamebakaurine

Target: NF-κB

Cornuside

T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Dihydroisotanshinone I

TN1588

Synonym:

Target: ATPase, Potassium Channel, Calcium Channel

Target: HIV Protease, Nrf2, AMPK

Target: NADPH-oxidase, P450, TNF, Nrf2, Antifection

9-Oxo-10,11-dehydroageraphorone

TN5336

Synonym: 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone

Taurohyodeoxycholic acid

T37770

Synonym:

Target:

カタログ番号	製品名
L5510	Drug-induced Liver Injury (DILI) Compound Library	1001 compounds
	A unique collection of 1001 hepatotoxicity causing compounds, a powerful tool for drug toxicity study, can be used for HTS and HCS screening；
L8700	Ferroptosis Compound Library	779 compounds
	A unique collection of 779 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study；

ライブラリー

Drug-induced Liver Injury (DILI) Compound Library

L5510

Compounds: 1001

Ferroptosis Compound Library

L8700

Compounds: 779