|
TP1120 |
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP)
|
IRBP,Interphotoreceptor Retinoid Binding Protein Fragment IRBP |
|
|
Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visual pigment Binding Protein peptide (I... |
|
TP1120L |
IRBP acetate(211426-18-5 free base)
|
Interphotoreceptor Retinoid Binding Protein Fragment IRBP |
Others
|
|
IRBP acetate(211426-18-5 free base) (Interphotoreceptor Retinoid Binding Protein Fragment IRBP) is a 20-residue peptide, which is a major pathogenic epitope. It exists in the first homologous repeat of interstitial visua... |
|
T6831 |
Etretinate
|
Retinoid,Tegison,Etretinato,Ethyl etrinoate,Ro 10-9359 |
Apoptosis
,
Others
|
|
Etretinate (Ro 10-9359) is an oral aromatic retinoid acid which is effective in psoriasis and other dermatological syndromes. It activates retinoid receptors, causing an induction of cell differentiation, inhibition of c... |
|
TP1119 |
Interphotoreceptor retinoid-binding protein(668-687)
|
IRBP(668-687) |
|
|
Interphotoreceptor retinoid-binding protein(668-687)is an amino acid residue of human retinoid-binding protein(IRBP) 668-687, which can induce uveitis. |
|
T82059 |
Interphotoreceptor retinoid-binding protein(668-687) TFA
|
IRBP(668-687) TFA |
|
|
Interphotoreceptor retinoid-binding protein(668-687) TFA, a peptide fragment corresponding to amino acids 668-687 of the human interphotoreceptor retinoid-binding protein (IRBP), has been implicated in the induction of u... |
|
T15585 |
IRBP(668-687) (TFA)
|
Interphotoreceptor retinoid-binding protein(668-687) TFA |
Others
|
|
Interphotoreceptor retinoid-binding protein TFA is the amino acid residue 668 to 687 of human interphotoreceptor retinoid-binding protein (IRBP). It also induces uveitis. |
|
T83681 |
IRBP (1-20) (human, rat) TFA
|
IRBP1-20,Interphotoreceptor Retinoid-Binding Protein (1-20) |
|
|
Interphotoreceptor retinoid-binding protein (1-20) (IRBP1-20), a dodecapeptide fragment of retinoid-binding protein 3, plays a crucial role in pigment regeneration by facilitating the transport of retinol and retinal bet... |
|
T83700 |
IRBP (651-670) (human) TFA
|
IRBP651-670,Interphotoreceptor Retinoid-Binding Protein (651-670) |
|
|
Interphotoreceptor retinoid-binding protein (651-670) (IRBP651-670), a peptide fragment of retinoid-binding protein 3 (also known as IRBP), plays a crucial role in the visual cycle by facilitating the transport of retino... |
|
T8529 |
WYC-210
|
|
Others
|
|
WYC-210 is a retinoid compound,and with lower anticancer activity |
|
T1093 |
Adapalene
|
CD271 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
|
T21714 |
BMS453
|
BMS 453,BMS-189453 |
Retinoid Receptor
|
|
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. |
|
TP1118 |
IRBP(668-687) (TFA) (1977546-93-2 free base)
|
IRBP(668-687) (TFA),Interphotoreceptor retinoid-binding protein(668-687) TFA |
|
|
Interphotoreceptor retinoid-binding protein(668-687) TFA is the 668-687 amino acid residue of human Interphotoreceptor retinoid binding protein(IRBP), which can induce uveitis. |
|
T22843 |
HX 531
|
|
Retinoid Receptor
|
|
RXR antagonist |
|
TQ0097 |
AGN 193109
|
|
Retinoid Receptor
,
Autophagy
|
|
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ). |
|
T17209 |
UVI 3003
|
|
Retinoid Receptor
,
Autophagy
|
|
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively). |
|
T5341 |
WYC-209
|
WYC209 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR). |
|
T6410 |
Bexarotene
|
Ro 26-4455,Targretin,LGD1069 |
Retinoid Receptor
,
Autophagy
|
|
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). |
|
T23384 |
SR 11302
|
|
DNA/RNA Synthesis
|
|
SR 11302 is an inhibitor of activator protein-1 (AP-1). |
|
T3955 |
AR7
|
|
Retinoid Receptor
|
|
AR7 is a retinoic acid receptor α (RARα) antagonist. |
|
TQ0064 |
Peretinoin
|
NIK333 |
HCV Protease
,
Retinoid Receptor
,
S1P Receptor
,
Autophagy
|
|
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR. |
|
T7370 |
Talarozole
|
R115866 |
Others
,
P450
,
Retinoid Receptor
,
Autophagy
|
|
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of... |
|
T7586 |
Trifarotene
|
CD5789 |
Retinoid Receptor
,
Autophagy
|
|
Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM). |
|
T6696 |
Tazarotene
|
Tazorac,AGN 190168,Zorac |
Retinoid Receptor
,
Autophagy
|
|
Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati... |
|
T23383 |
SR11237
|
SR 11237 |
Others
,
RAR/RXR
|
|
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element. |
|
T11844 |
LG-100064
|
|
Retinoid Receptor
,
Autophagy
|
|
LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ) |
|
T4538 |
Palovarotene
|
Ro 3300074,R 667 |
Retinoid Receptor
,
Autophagy
|
|
Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ). |
|
T6694 |
Tamibarotene
|
NSC 608000,Am 80,Amnolake |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. |
|
T21314 |
Amsilarotene
|
TAC-101,TAC 101,TAC101 |
CDK
|
|
Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy... |
|
T1872 |
Fenretinide
|
4-HPR,MK-4016,4-hydroxy(phenyl)retinamide |
Retinoid Receptor
,
Autophagy
|
|
Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities. |
|
T5843 |
Tarenflurbil
|
MPC7869,(R)-Flurbiprofen,R-flurbiprofen |
Retinoid Receptor
,
Autophagy
|
|
Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease. |
|
T11847L |
Liarozole
|
R75251 dihydrochloride |
P450
,
Retinoid Receptor
|
|
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1... |
|
T7894 |
Tazarotenic acid
|
AGN-190299 |
Others
|
|
Tazarotenic acid (AGN-190299) is a retinoid prodrug which is converted to its active form |
|
T5854 |
AM580
|
NSC608001,CD336,Ro 40-6055 |
Retinoid Receptor
,
Autophagy
|
|
AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ) |
|
T4371 |
CD437
|
AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI |
Retinoid Receptor
,
Autophagy
|
|
CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist. |
|
T1288 |
TTNPB
|
AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively. |
|
T0499 |
Oxybenzone
|
KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone. |
|
T15811 |
LY2955303
|
|
Others
,
Retinoid Receptor
|
|
LY2955303 is an effective and selective retinoic acid receptor gamma (RARγ) antagonist (Ki: 1.09 nM). |
|
T74051 |
Pyridinium bisretinoid A2E
|
|
|
|
Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis . Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species [1] [2] . |
|
T78404 |
Pyridinium bisretinoid A2E TFA
|
A2E TFA |
Apoptosis
|
|
Pyridinium bisretinoid A2E (A2E) TFA, a fluorophore derived from retinal pigment epithelium (RPE) lipofuscin, initiates blue-light-induced apoptosis, mediates autophagy, and generates reactive oxygen species. This compou... |
|
T14912 |
CD3254
|
|
Retinoid Receptor
|
|
CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation. |
|
T9635 |
Cedirogant
|
ABBV-157 |
ROR
|
|
Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study. |
|
T15196 |
EC23
|
BASF-46928,AGN 190205 |
Others
|
|
EC23 (AGN 190205) is a stable synthetic retinoid analogue. It is also induces neuronal differentiation. |
|
T7388 |
GSK805
|
|
ROR
|
|
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi... |
|
TP1313L |
Cecropin B acetate
|
Cecropin B acetate(80451-05-4 Free base) |
P450
,
Retinoid Receptor
,
Parasite
|
|
Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA sequences. Cecropin B acetate exhibits strong antimicrobial a... |
|
T11303 |
Fluorobexarotene
|
|
Retinoid Receptor
|
|
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RX... |
|
T77499 |
MSU-42011
|
|
NOS
,
Retinoid Receptor
,
NO Synthase
,
PERK
,
Lipid
|
|
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated anti... |
|
T77600 |
Methyl-4-oxoretinoate
|
|
Apoptosis
|
|
Methyl-4-oxoretinoate is a synthetic retinoid compound with anticancer compounds that can induce differentiation and apoptosis in cancer cells.Methyl-4-oxoretinoate is used in the treatment of acne, psoriasis, and other ... |
|
T34299 |
Retinaloxime
|
trans-Retinaloxime |
|
|
Retinaloxime is a retinoid. |
|
T28554 |
Ro 12-7310
|
Ro-12-7310 |
|
|
Ro 12-7310, a synthetic retinoid, inhibits arachidonic acid release. |
|
T32201 |
Isoacitretin
|
Ro-13-7652,Ro 13-7652,Ro13-7652 |
|
|
Isoacitretin is an oral retinoid effective and can be used to treat psoriasis. |
