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T64161 |
XIAP degrader-1
|
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XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP). |
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T79483 |
MDM2/XIAP-IN-3
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MDM2/XIAP-IN-3 (compound 3e), a dual inhibitor of MDM2/XIAP, diminishes MDM2 and XIAP protein levels while augmenting p53 expression, consequently suppressing cancer cell proliferation and inducing apoptosis [1]. |
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T64302 |
XIAP/cIAP1 antagonist-1
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XIAP/cIAP1 antagonist-1 is a potent, orally active XIAP/cIAP1 antagonist that acts on XIAP (EC50: 5.1 nM) and cIAP1 (EC50: 0.32 nM). xIAP/cIAP1 antagonist-1 dose-dependently inhibits tumour growth in vivo. |
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T81830 |
MDM2/XIAP-IN-1
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MDM2/XIAP-IN-1 (compound 14) is an orally active dual inhibitor of MDM2 and XIAP, exhibiting anti-cancer activity with an IC50 of 0.3 μM and potential applications in cancer research [1]. |
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T79012 |
MDM2/XIAP-IN-2
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MDM2/XIAP-IN-2 is a dual inhibitor targeting murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). It promotes the degradation of MDM2 and impedes translation of XIAP mRNA, effectively inhibit... |
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T16522 |
Phenoxodiol
|
Dehydroequol,Idronoxil,Haginin E |
Apoptosis
,
IAP
,
Caspase
,
Topoisomerase
,
p53
|
|
Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apop... |
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T14378L |
AZD5582 acetate (1258392-53-8 free base)
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IAP
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AZD5582 acetate is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis. |
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T2080 |
LCL161
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IAP
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LCL161, a SMAC mimetic, effectivity binds to and inhibits multiple IAPs (i.e. XIAP, c-IAP). |
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T36201L |
AZD5582 TFA
|
AZD5582 TFA（1258392-53-8 free base） |
Apoptosis
,
IAP
|
|
AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA induces apoptosis. |
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TQ0029 |
ASTX660
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IAP
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ASTX660 is an orally bioavailable dual antagonist of cIAP and XIAP. |
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T3653 |
MX69
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Mdm2
,
E1/E2/E3 Enzyme
,
IAP
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MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. |
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T6763 |
Xevinapant
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ARRY-334543,SM-406,AT406,Debio-1143 |
IAP
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Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, ... |
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T12932L |
SM-164
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|
Apoptosis
,
IAP
|
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SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains (IC50: 1.39 nM). It acts as an extremely potent antagonist of XIAP. |
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T6428 |
BV6
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IAP
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BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. |
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T6299 |
GDC-0152
|
GDC0152 |
IAP
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GDC-0152 is a potent inhibitor of IAPs. |
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T6007 |
Birinapant
|
TL32711 |
Apoptosis
,
IAP
,
HIV Protease
|
|
Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with po... |
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T12932 |
SM-164 Hydrochloride (957135-43-2 free base)
|
SM-164 Hydrochloride |
IAP
|
|
SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains(IC50 value of 1.39 nM) and functions as an extremely potent antagonist of XIAP. |
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T36201 |
AZD5582 dihydrochloride
|
AZD 5582 dihydrochloride |
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Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to ... |
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T14378 |
AZD5582
|
|
Apoptosis
,
IAP
|
|
AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis. |
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T26242 |
SW IV-52
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SW-IV-52,SW IV52,SW IV 52,SWIV52 |
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SW IV-52 is an XIAP-inhibitor that acts as a second mitochondria-derived activator of caspases (SMAC) mimetic. |
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T75243 |
SM-164 Hydrochloride
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SM-164 Hydrochloride, a cell-permeable Smac mimetic compound, exhibits high affinity for the XIAP protein, specifically targeting both the BIR2 and BIR3 domains, with an IC50 value of 1.39 nM. This action categorizes it ... |
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T18690 |
SNIPER(ABL)-039
|
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Others
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SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, c... |
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T69845 |
MX107
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MX107 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation. |
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T23760 |
AT-IAP
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AT-IAP is an effective dual antagonist of XIAP and cIAP1. |
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T68578 |
A-410099.1 free base
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A-410099.1 is a novel potent xiap antagonist |
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T36890 |
A 410099.1
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High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse ... |
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T36317 |
SM-1295
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SM-1295 serves as an antagonist to the inhibitor of apoptosis protein (IAP), demonstrating dissociation constant (Kd) values of 3077 nM for XIAP-BIR3, 3.2 nM for c-IAP1-BIR3, and 9.5 nM for c-IAP2-BIR3, respectively[1][2... |
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T63969 |
SM-433
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SM-433 is a Smac mimetic and inhibitor of inhibitors of apoptosis (IAPs). SM-433 has a strong affinity for XIAP BIR3 protein (IC50 <1 μM). |
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T64217 |
SM-433 hydrochloride
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SM-433 hydrochlorid is a Smac mimetic, an inhibitor of inhibitory apoptosis proteins (IAPs). SM-433 hydrochlorid is able to bind XIAP BIR3 protein with a potent IC50 <1 μM. |
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T78947 |
CST626
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PROTACs
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CST626 (Compound 9), a pan-IAP degrader PROTAC, effectively degrades XIAP, cIAP1, and cIAP2 in MM.1S cells with DC50 values of 0.7, 2.4, and 6.2 nM, respectively [1]. |
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T16905 |
SNIPER(BRD)-1
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Others
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SNIPER(BRD)-1 is a chemical compound composed of a derivative of the IAP antagonist LCL-161 and the BET inhibitor (+)-JQ-1, linked together. It promotes the degradation of BRD4 through the ubiquitin-proteasome pathway an... |
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T69840 |
MX106
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MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation. |
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T18697 |
SNIPER(ER)-87
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Others
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SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effecti... |
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T74847 |
PROTAC pan-IAP degrader-1
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PROTAC pan-IAP degrader-1 (Compound 9) is a pan- IAP degrader PROTAC . PROTAC pan-IAP degrader-1 degrades XIAP , cIAP1 and cIAP2 with DC 50 s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively [1] . |
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T3299 |
Xevinapant hydrochloride
|
AT-406 HCl,SM-406 |
Apoptosis
,
IAP
|
|
Xevinapant hydrochloride (AT-406 HCl) , an orally active antagonist of multiple inhibitor of apoptosis proteins(IAP), inhibits progression of human ovarian Y binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 66.... |
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T79248 |
Anticancer agent 128
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IAP
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Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, exhibiting IC50 values of 24.9 nM, 19.3 nM, and 10.3 nM, respectively [1]. |
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T26246 |
T-3256336
|
T3256336 |
|
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T-3256336 is an orally available IAP antagonist agent that acts by selectively binding to and antagonizing protein interactions involving cellular IAP-1 (cIAP-1), cIAP-2, and X-linked IAP (XIAP). |
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T79247 |
Anticancer agent 127
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IAP
|
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Anticancer agent 127 (142D6), an IAP inhibitor, covalently binds to the BIR3 domains of XIAP, cIAP1, and cIAP2, with IC50 values of 12 nM, 14 nM, and 9 nM, respectively, demonstrating anticancer effects [1]. |
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T68869 |
TP-110
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TP-110 is a new proteasome inhibitor, which shows potent growth inhibition in various tumor cell lines. Treatment with TP-110 for 24 h in vitro induced apoptosis in multiple myeloma cell line RPMI8226. TP-110 reduced the... |
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T70096 |
AEG40730 HCl
|
|
|
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AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in R... |
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T30095 |
APG-1387
|
SM 1387,SM-1387,SM1387,APG 1387l |
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APG-1387 (SM-1387) is an IAP inhibitor that promotes the rapid degradation of cIAP1/2 and XIAP and exerts an anti-tumor effect on nasopharyngeal carcinoma stem cells. Studies have shown that APG-1387 combined with NPC's ... |
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T70988 |
Ibulocydine
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Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomo... |
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T75010 |
TD1092
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TD1092, a pan-IAP degrader, effectively degrades cIAP1, cIAP2, and XIAP, catalyzing the activation of Caspase 3/7 and fostering apoptosis in cancer cells through IAP degradation. It also obstructs the TNFα-mediated NF-κB... |
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T62822 |
CT1-3
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CT1-3 is a potent anti-cancer agent. CT1-3 regulates the JNK/Bcl-2/Bax/XIAP pathway, which induces mitochondria-mediated apoptosis. CT1-3 regulates the E-cadherin/Snail axis to inhibit epithelial mesenchymal transition (... |
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T40419 |
IRES-C11
|
IRES-C11 |
c-Myc
|
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IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans... |
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T68980 |
MRK003
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|
|
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MRK003 is a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma. MRK003 treatment induced caspase-dependent apoptosis and inhibited proliferation of MM a... |
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T83898 |
S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine
|
SFN-Cys,D,L-Sulforaphane-L-cysteine |
|
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S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agen... |
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T38857 |
SBP-0636457
|
SBI-0636457,SB1-0636457,SBP-0636457 |
|
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SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for ... |
