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T31011 |
Coralyne chloride
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Topoisomerase
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Coralyne chloride is a protoberberine with strong anticancer activity. It can be used to prepare Coralyne derivatives, a fluorescent DNA-based molecular rectifier built into DNA duplexes through site-specific insertion. ... |
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T24269 |
KPT-251
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KPT251 |
Others
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KPT-251 is a selective nuclear export inhibitor. |
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T8308 |
NL-1
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Mitochondrial Metabolism
,
Autophagy
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NL-1 is a mitoNEET inhibitor with antileukemic effect. |
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T7673 |
ATH686
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ATH 686 |
Apoptosis
,
FLT
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ATH686 is an potent and selective Inhibitor of FLT3. |
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T27704 |
K00135
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K-00135,Imidazol[1,2-b]pyridazine 1,K 00135,IMIDAZOPYRIDAZIN 1 |
Pim
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K00135 (IMIDAZOPYRIDAZIN 1) is a selective inhibitor of Pim kinases and can be used in studies about gastric cancer and antileukemic therapeutics. |
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T15235 |
Enocitabine
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Nucleoside Antimetabolite/Analog
,
HCV Protease
,
DNA/RNA Synthesis
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Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a ... |
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T16940 |
STAT5-IN-2
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Apoptosis
,
STAT
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STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively). |
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T4409 |
Gilteritinib
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ASP2215 |
FLT
,
TAM Receptor
,
c-Kit
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Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM, respectively). In preClinicalal studies, gilteritinib showed strong an... |
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T24978 |
5,10-Dideazaaminopterin
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5,10-Dideazaaminopterin is an antileukemic drug. |
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T25503 |
Hisphen
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Synonyms Hisfen,MD 2 |
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Hisphen shows antileukemic activity. |
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T24979 |
5,10-Dideazafolic acid
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5,10-Dideazafolic acid is an antileukemic drug. |
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T15472 |
Hepsulfam
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NCI 329680,ZINC01574758 |
Others
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T24492 |
Moflomycin
|
F 860191,F-860191,F860191 |
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Moflomycin is an anthracycline derivative. It exhibits a higher antileukemic activity compared to other anthracyclines. |
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T25170 |
Botryodiplodin
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Cytostipin,Antibiotic PSX 1 |
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Botryodiplodin, an antibiotic, has antileukemic activity from Botryodiplodia theobromae. It has the property of turning the skin of the individual in various shades of pink 2-3 hrs after application. It is a toxic metabo... |
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T69829 |
GCN2iB acetate
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GCN2iB is a GCN2 inhibitor. GCN2iB may be useful for the treatment of cancer. The inhibition of GCN2 sensitizes cancer cells with low basal-level expression of asparagine synthetase (ASNS) to the antileukemic agent L-as... |
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T22132 |
PD 166326
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PD166326, a pyridopyrimidine-type inhibitor of receptor tyrosine kinases, demonstrates antileukemic activity with IC50 values of 6 nM for Src and 8 nM for Abl. [1] [2]. |
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T78733 |
ZLD115
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ZLD115 (compound 44), a derivative of FB23, functions as an inhibitor of the Fat Mass and Obesity-associated Protein (FTO) and demonstrates antiproliferative properties as an antileukemic agent against leukemic cell line... |
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T40432 |
Mezerein
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Mezerein is a chemical compound with antileukemic properties and acts as a PKC activator. It effectively inhibits the growth of yeast expressing PKC alpha (IC 50 = 1190 nM), PKC beta1 (IC 50 = 908 nM), and PKC delta (IC ... |
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T76162 |
Stem bromelain
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Stem bromelain (EC 3.4.22.32), a cysteine proteinase from pineapple (Ananas comosus) stem, is a significant type of bromelain known for its fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory properties. I... |
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T60559 |
S-(N-PhenethylthiocarbaMoyl)-L-cysteine
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S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) is an anticarcinogenic agent. S-(N-PhenethylthiocarbaMoyl)-L-cysteine shows antileukemic activity which inhibits DNA synthesis in HL60 cells [1]. S-(N-Phenethylthiocarb... |
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T73358 |
(-)SHIN2
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(-)SHIN2 is the isomer of (+)SHIN2 . (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate in vivo xenotransplantation models [1] . |
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T82774 |
Caspase-3 activator 3
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Caspase
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Caspase-3 activator 3 (compound 2h) effectively induces apoptosis in HL-60 and K562 cells by substantially activating caspase-3, demonstrating antileukemic activity with IC50 values of 42.89 μM and 33.61 μM, respectively... |
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T4791 |
Idarubicin
|
Demethoxydaunorubicin |
|
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Idarubicin, a potent anthracycline antileukemic agent, is orally active in its application. It functions by inhibiting topoisomerase II, thus interfering with DNA replication and RNA transcription. Furthermore, Idarubici... |
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T73167 |
HDAC-IN-49
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|
|
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HDAC-IN-49 is a potent, non-selective inhibitor of HDAC (HDAC), demonstrating IC50 values of 13 nM for HDAC1, 14 nM for HDAC2, 21 nM for HDAC3, 1880 nM for HDAC4, and 10 nM for HDAC6. This compound exhibits significant a... |
