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T14021 |
20-HETE
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20-hydroxy Arachidonic Acid |
Others
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20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... |
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T38070 |
Arachidonic Acid-biotin
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Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate f... |
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T22581 |
Arachidonic Acid Leelamide
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Others
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Arachidonic acid leelamide is a phospholipase A2 inhibitor. Phospholipase A is a hydrolase responsible for the release of arachidonic acid from the sn2 position of phospholipids. The released arachidonic acid is then con... |
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T38067 |
5,6-dehydro Arachidonic Acid
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5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 μM. In guinea pig leukocytes, 5-LO is inhibite... |
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T36232 |
20-carboxy Arachidonic Acid
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20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take p... |
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T81609 |
Omega-3 Arachidonic acid ethyl ester
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(all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester,ω-3 Arachidonic acid ethyl ester |
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Omega-3 Arachidonic Acid ethyl ester, a rare polyunsaturated fatty acid with limited presence in dietary sources, is crucial for infant growth and development and offers protection against heart disease, blood clots, hig... |
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T21815 |
ONO-RS-082
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Others
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ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor. |
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T2367 |
SKF-86002
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SKF86002 |
p38 MAPK
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TNF
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SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM). |
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T0412 |
Idebenone
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CV-2619 |
Apoptosis
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Antioxidant
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Mitochondrial Metabolism
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Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). |
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T27026 |
CJ-13,610
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CJ 13610,CJ-13610 |
Lipoxygenase
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CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages. |
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T62606 |
ALOX15-IN-2
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Lipoxygenase
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ALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, with IC50s of 1.55 and 2.79 μM, respec... |
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T60061 |
RU-TRAAK-2
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Potassium Channel
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RU-TRAAK-2 is a reversible inhibitor of TWIK-related arachidonic acid-stimulated K+ channel with no activity for non-K2P channels including Kv1.2, GIRK2, and Slo1. |
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T70188 |
ER-34122
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Lipoxygenase
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ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor, exhibits potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model. |
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T0961 |
Trometamol
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Tromethamine |
COX
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Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostagland... |
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T1420 |
Diethylcarbamazine citrate
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Caritrol,Loxuran,Dicarocide |
Lipoxygenase
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COX
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Parasite
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Diethylcarbamazine citrate (Caritrol) is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Loa loa. It is an inhibitor of arachidonic acid me... |
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T0477 |
Zileuton
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Abbott 64077,A 64077 |
Ferroptosis
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Lipoxygenase
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COX
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Zileuton (A 64077) is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; ca... |
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T77638 |
BIRM 271
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Phospholipase
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LTR
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BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leu... |
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T68025 |
Zoliprofen
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Others
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Zoliprofen is a potent and orally available non-steroidal anti-inflammatory agent with anti-inflammatory, antipyretic and analgesic activity, and inhibits carobolin, mycobacterium, and knife-ball protein A-induced rat pa... |
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T36536 |
SH-42
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SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dos... |
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T0196 |
Diclofenac
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Diclofenacum,Voltaren |
Apoptosis
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COX
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Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of a... |
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T1574 |
Etoricoxib
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Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine |
COX
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Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenas... |
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T0463L |
Loxoprofen sodium
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CS-600,CS600,Loxoprofen,CS 600 |
COX
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T1561 |
Clobetasol propionate
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Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,CCl 4725 |
Glucocorticoid Receptor
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P450
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Clobetasol propionate (CGP9555) exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor-mediated gene expression. This results in the synthesis of certain a... |
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T1185 |
Rofecoxib
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MK 966,MK-0966 |
COX
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Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of pheny... |
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T6529 |
Halobetasol propionate
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Halobetasol Propionate,Ulobetasol propionate,BMY-30056,CGP-14458 |
Phospholipase
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Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses acr... |
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T35666 |
PRGL493
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Others
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PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer c... |
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T2403 |
Bromfenac sodium hydrate
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Bromfenac sodium,Bromfenac monosodium salt sesquihydrate |
COX
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Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic admi... |
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T1666 |
Fludrocortisone acetate
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9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate |
Glucocorticoid Receptor
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Autophagy
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Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-respon... |
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T28554 |
Ro 12-7310
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Ro-12-7310 |
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Ro 12-7310, a synthetic retinoid, inhibits arachidonic acid release. |
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T32481 |
L 739059
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L-739059,L739059 |
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L 739059 is a radioiodinated analog of arachidonic acid that binds 5-lipoxygenase-activating protein. |
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T26072 |
Rhazimine
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Rhazimine is an indole alkaloid. It is a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. |
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T35849 |
17(S)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites.17-... |
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T25787 |
Me-Indoxam
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Methyl indoxam,Methyl-indoxam |
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Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthesis. |
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T37708 |
17(R)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17... |
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T24296 |
L 640035
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L640035,L 640,035,L-640035,L640,035,L-640,035 |
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L 640035 inhibits human platelet aggregation which is induced by arachidonic acid, collagen, and the prostaglandin-endoperoxide analog of U44069. |
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T35847 |
16(R)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation... |
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T1574L |
Etoricoxib HCl
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L-791456 monohydrochloride salt,L791456 hydrochloride,L-791456 hydrochloride,L 791456 hydrochloride,Etoricoxib hydrochloride |
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Etoricoxib HCl is a synthetic, nonsteroidal anti-inflammatory drug. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2, resulting in inhibition of the conversion of arachidonic acid into prostaglan... |
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T26071 |
Rhamnetin tetraacetate
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Rhamnetin tetraacetate is a potent antiplatelet compound that strongly inhibits platelet aggregation induced by arachidonic acid, collagen and PAF. |
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T35523 |
(±)17-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)17-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereos... |
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T35848 |
16(S)-HETE
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Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation... |
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T25377 |
EP6
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EP-6,EP 6 |
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EP6 is an inhibitor of 5-lipoxygenase (5-LO), which is a crucial enzyme of the arachidonic acid (AA) cascade and catalyzes the formation of bioactive leukotrienes (LTs) which are involved in inflammatory diseases and all... |
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T72144 |
6-trans-12-epi-Leukotriene B4
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6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent. |
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T37399 |
15(S)-HETE methyl ester
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15(S)-HETE methyl ester is a synthetic derivative of 15(S)-HETE , a major arachidonic acid metabolite from the 15-lipoxygenase pathway. Methyl esters of lipids are commonly used in formulations of nutritional supplements... |
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T36158 |
8-iso Prostaglandin A2
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8-iso Prostaglandin A2 |
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8-iso Prostaglandin A2 is an isoprostane produced by the nonenzymatic oxidation of arachidonic acid. |
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T37556 |
CAY10502
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Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme tha... |
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T36452 |
1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
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1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is... |
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T23040 |
N-Arachidonylglycine
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Others
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N-Arachidonylglycine is a biologically active lipid molecule that belongs to arachidonic acid derivatives. It has a wide range of biological activities including anti-inflammatory, anti-cancer, anti-diabetic and antioxid... |
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T32783 |
Lipoxin C4
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15-OH-Ltc3 |
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Lipoxin C4 is a bioactive autacoid metabolites of arachidonic acid made by various cell types. It is categorized as a nonclassic eicosanoid and member of the specialized pro-resolving mediator (SPMs) family of polyunsatu... |
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T37155 |
8(R)-HETE
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8(R)-HETE is biosynthesized by lipoxygenation of arachidonic acid in marine invertebrates such as gorgonian corals and starfish. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC reten... |
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T36001 |
4-hydroperoxy 2-Nonenal
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4-hydroxy Nonenal is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids, such as linoleic acid and arachidonic acid, that is widely used as a marker of oxidative stress. 4-HNE exhibits var... |
