|
T6878 |
LJI308
|
|
S6 Kinase
|
|
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. |
|
T9168 |
NSC 617145
|
NSC617145,NSC-617145 |
DNA/RNA Synthesis
|
|
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. |
|
T24925 |
UNC-2170
|
UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate |
Others
|
|
UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand. |
|
T4434 |
Tirapazamine
|
Tirazone,Win59075,SR4233,SR259075 |
Others
|
|
Tirapazamine (Win59075) is a potent cytotoxic agent under hypoxic conditions, can induce apoptosis by inducing breaks in single and double-stranded DNA, as well as chromosomal breaks. The compound sensitizes cells to oth... |
|
T9497 |
Niraparib tosylate monohyrate
|
|
PARP
|
|
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting... |
|
T14858 |
Calicheamicin
|
Calicheamicin γ1 |
Others
|
|
|
|
T3353 |
Niraparib hydrochloride
|
MK-4827 hydrochloride,MK-4827 (hydrochloride) |
Apoptosis
,
Others
,
PARP
|
|
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. Niraparib hydrochloride inhibits PARP activity, enhancing the accumulation of... |
|
T1798 |
RITA
|
NSC 652287,RITA (NSC 652287) |
Mdm2
,
DNA Alkylator/Crosslinker
,
p53
,
Autophagy
|
|
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction. |
|
T6588 |
Mitoxantrone
|
mitozantrone |
Topoisomerase
,
PKC
|
|
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome... |
|
T6336 |
Amonafide
|
NSC308847,AS1413,Nafidimide,AS1413,Quinamed |
Topoisomerase
|
|
Amonafide (NSC-308847,AS1413)(AS1413) produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
|
T21841 |
(±)-Hexanoylcarnitine chloride
|
DL-Hexanoylcarnitine chloride |
Others
|
|
(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into small compounds that can be utilized by the body. (±)-Hexanoylcarnitine chloride can be used as a biomarker by being specific fo... |
|
T9430 |
Venadaparib
|
NOV140101,IDX-1197 |
PARP
|
|
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the... |
|
T0923 |
Busulfan
|
Myleran,Sulphabutin,Busulphan |
Apoptosis
,
DNA Alkylator/Crosslinker
,
DNA Alkylation
|
|
Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation... |
|
T4047 |
Bisantrene
|
CL216942 |
Topoisomerase
|
|
Bisantrene (CL216942) is an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and ... |
|
T63228 |
Simmiparib
|
SMOCL-9112 |
Apoptosis
,
PARP
|
|
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient... |
|
T0893 |
Tinidazole
|
CP12574 |
Antibacterial
,
Antibiotic
|
|
Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitr... |
|
T24754 |
Hh-Ag1.5
|
SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened
|
|
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... |
|
T67931 |
[Tyr3]Octreotate
|
|
Others
|
|
[Tyr3]Octreotate is a long peptide compound containing 8 amino acids and is a functional DOTA chelating agent with covalent bonds. [Tyr3]Octreotate binds to transmembrane receptors of SSR2-active NETs and is actively tra... |
|
T21320 |
Methoxyamine HCl
|
TRC102,TRC 102,Methoxyamine,TRC-102 |
Others
|
|
Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is... |
|
T15826 |
Lometrexol
|
LY 264618,DDATHF |
DHFR
|
|
Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit ... |
|
T3157 |
COH29
|
RNR Inhibitor COH29 |
DNA/RNA Synthesis
|
|
COH29 (RNR Inhibitor COH29) is an orally available, aromatically substituted thiazole and inhibitor of the human ribonucleotide reductase (RNR), with potential antineoplastic activity. Upon oral administration, the RNR i... |
|
T69936 |
NK314
|
|
|
|
NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred wit... |
|
T28293 |
Pamiparib maleate
|
BGB290,BGB 290,BGB-29 maleat 0 |
|
|
Pamiparib is a highly potent and selective PARP inhibitor. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the acc... |
|
T21303 |
Etoposide Phosphate
|
Eposin Etopophos Vepesid VP16 |
|
|
Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell prolifera... |
|
T71482 |
Penclomedine
|
|
|
|
Penclomedine is an antineoplastic agent which alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. |
|
T16283 |
Neocarzinostatin
|
|
5-HT Receptor
|
|
Neocarzinostatin is an effective DNA-damaging, anti-tumor antibiotic. It recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin leads to apoptosis. Neocarzinostatin has potenti... |
|
T68985 |
Amonafide L-malate
|
|
|
|
Amonafide L-malate is the malate salt of amonafide, an imide derivative of naphthalic acid, with potential antineoplastic activity. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in DNA double-s... |
|
T19149 |
5-BrdUTP sodium salt
|
5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt |
Others
|
|
5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks. |
|
T70115 |
Pamiparib hydrate
|
|
|
|
Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of sin... |
|
T35356 |
Gibberellins A4/A7
|
Gibberellin A4&A7,Gibberellins A4/A7 |
Others
|
|
Gibberellins A4/A7 (Gibberellin A4 and A7) is the Gibberellin A4 Mixture With Gibberellin A7. Gibberellins A4/A7 promotes internode elongation & breaks certain dormancies in seeds. Gibberellins A4/A7 is an endogenous pla... |
|
T72115 |
5-Iminodaunorubicin hydrochloride
|
盐酸5-亚氨基柔红霉素 |
|
|
5-Iminodaunorubicin hydrochloride, a quinone-modified anthracycline, maintains antitumor efficacy. It induces concealed DNA strand breaks within cancer cells, mediated by protein interactions. |
|
T70533 |
Amonafide dihydrochloride
|
|
|
|
Amonafide dihydrochloride is the dihydrochloride salt of amonafide, an imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and... |
|
T19203 |
Bendamustine D4
|
SDX-105 D4 |
Others
|
|
Bendamustine D4 is the deuterium-labeled Bendamustine. Bendamustine is a DNA cross-linking compound with alkylating and antimetabolite properties. Bendamustine causes DNA breaks. |
|
T38962 |
MC-SN38
|
MC-SN38 |
|
|
MC-SN38 is a drug-linker conjugate that pairs the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for use in antibody drug conjugates (ADCs). SN38, the active metabolite of the Topoisome... |
|
T68675 |
Porfiromycin
|
|
|
|
Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radic... |
|
T68673 |
Amsacrine gluconate
|
|
|
|
Amsacrine gluconate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, result... |
|
T68672 |
Amsacrine lactate
|
|
|
|
Amsacrine lactate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resultin... |
|
T68671 |
Amsacrine Isothionate
|
|
|
|
Amsacrine Isothionate is an aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resu... |
|
T72467 |
5-Iminodaunorubicin
|
5-亚氨基柔红霉素 |
|
|
5-Iminodaunorubicin, a quinone-modified anthracycline, maintains antitumor activity by inducing concealed DNA strand breaks within cancer cells' proteins. |
|
T73615 |
β-Galactosidase
|
|
|
|
β-Galactosidase, a glycoside hydrolase, breaks down β-glycosidic bonds in galactose and its derivatives. In E. coli, it is encoded by the lacZ gene, playing a crucial role in the lac operon induction system. This enzyme ... |
|
T69669 |
Camsirubicin HCl
|
|
|
|
Camsirubicin, also known as GPX-150, MNPR-201, and CNDO1011, is a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Anthracycline analogue GPX-150 inte... |
|
T40345 |
AV-153
|
|
|
|
AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 al... |
|
T68207 |
Elsamitrucin
|
|
|
|
Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I a... |
|
T78747 |
DiPT-4
|
|
Topoisomerase
|
|
DiPT-4, a dual TOP1/PARP1 inhibitor, effectively induces DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells, with potential to circumvent drug resistance [1]. |
|
T70229 |
Laromustine
|
|
|
|
Laromustine is a sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the 06 position of guanin... |
|
T69139 |
Thalicarpine
|
|
|
|
Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces singl... |
|
T4310L2 |
Prexasertib mesylate
|
LY-2606368,LY2606368,LY 2606368 |
|
|
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe a... |
|
T79330 |
PARP-1-IN-13
|
|
PARP
|
|
PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand breaks. It induces apoptosis in cancer cells via the mitochondri... |
|
T78581 |
Selenocystine
|
|
Others
|
|
Selenocystine, a broad-spectrum anticancer agent, effectively induces DNA damage, notably DNA double-strand breaks (DSBs), in HepG2 cells, showcasing significant potential as a therapeutic or adjuvant agent in targeting ... |
|
T73023 |
PARP1-IN-12
|
|
|
|
PARP1-IN-12, a potent inhibitor of PARP1, demonstrates an IC50 value of 2.99 nM. It exhibits antiproliferative effects, induces apoptosis, and causes cell cycle arrest in the G2/M phase. Additionally, PARP1-IN-12 induces... |
