|
T68260 |
Calmidazolium (cation)
|
|
|
|
Calmidazolium (cation) is a powerful inhibitor of or red blood cell Ca -ATPase & Ca transport into inside-out red blood cell vesicles; an antagonist of calmodulin. |
|
T32984 |
LX-201 cation
|
|
|
|
LX-201 cation is a bioactive chemical. |
|
T34817 |
Tetrabutylphosphonium cation
|
Tetra-n-butylphosphonium,J279H,Tetrabutylphosphonium ion,Tetrabutylphosphonium,Phosphonium, tetrabutyl- |
|
|
Tetrabutylphosphonium cation is a light orange solid and is the salt of the liphilic tetrabutylammonium cation and linear tribromide anion. |
|
T25628 |
Lapyrium
|
Lapyrium cation |
|
|
Lapyrium is a cationic surfactant that is used in personal care products as a biocide and antistatic. It is also used by the chloride salt, lapyrium chloride, in waste-water treatment and corrosion inhibition formulation... |
|
T32592 |
Lauralkonium
|
Lauralkonium ion,Lauralkonium cation |
|
|
Lauralkonium is a bioactive chemical. |
|
T25636 |
Laudexium
|
Laudexium ion,Laudexium cation |
|
|
Laudexium is a neuromuscular blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs. It is used adjunctively in surgical anesthesia to facilitate endotracheal intubatio... |
|
T25640 |
Laurolinium
|
Laurolinium ion,Laurolinium cation |
|
|
Laurolinium is an antimicrobial. |
|
T26666 |
ASM-024
|
|
AChR
|
|
ASM-024, a potent nicotinic receptor agonist, is a small molecule synthetic piperazine compound that promotes different targets and signaling pathways of β2-adrenergic receptors mediating smooth muscle relaxation, and is... |
|
T21623 |
AS1269574
|
AS 1269574 |
GPR
,
TRP/TRPV Channel
|
|
AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes. |
|
T68783 |
Stercuronium
|
|
|
|
Stercuronium is an aminosteroid neuromuscular blocking agent which was never marketed. It acts as a competitive antagonist of the nicotinic acetylcholine receptor, and is also reported to be an acetylcholinesterase inhib... |
|
T68735 |
Ciclotropium (free base)
|
|
|
|
Ciclotropium (free base) is quaternary ammonium compound with anticholinergic and parasympatholytic activity. Oral Cyclotropium bromide inhibited fasting and meal-stimulated colonic motility significantly without causing... |
|
T70310 |
INCB-39110
|
|
|
|
INCB-39110 is a JAK1 inhibitor. |
|
T68502 |
Dibrospidium Free Base
|
|
|
|
Dibrospidium Free Base is a dispirotripiperazine derivative and alkylating agent with potential antineoplastic and anti-inflammatory activities. The duration of DNA synthesis inhibition in tumor cells was found to correl... |
|
T9776 |
TRPM4 inhibitor 8
|
|
TRP/TRPV Channel
|
|
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion. |
|
T9245 |
TRPM4-IN-1
|
CBA,4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid |
TRP/TRPV Channel
|
|
TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM. |
|
T1050 |
Prazosin hydrochloride
|
Prazosin hydrochloride,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,Minipress |
Potassium Channel
,
MRP
,
Adrenergic Receptor
,
ABC
,
Autophagy
|
|
Prazosin hydrochloride (Vasoflex) reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. Prazosin hydrochloride is a synthetic ... |
|
TQ0157 |
EIPA
|
L593754,MH 12-43 |
Sodium Channel
,
TRP/TRPV Channel
|
|
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. |
|
T81449 |
PKC-ε translocation inhibitor peptide
|
|
PKC
|
|
PKC-ε Translocation Inhibitor Peptide is a selective modulator that controls the FcγR-mediated internalization rate of opsonized beads without affecting FcαR trafficking [1]. |
|
T80024 |
Cationic Bovine Serum Albumin
|
cBSA, chemically modified cationic bovine serum albumin |
|
|
Cationic Bovine Serum Albumin, a protein of 583 amino acids with three homologous alpha structural domains, exhibits significant neuroprotective effects against ischemic stroke when used in conjunction with Tanshinone II... |
|
T74550 |
Cemdisiran, terminal sugar modification-
|
|
|
|
Cemdisiran, an investigational N-acetylgalactosamine-conjugated RNAi (RNA interference) agent with terminal sugar modification, is a small interfering RNA (siRNA) designed to specifically target and suppress the C5 mRNA,... |
|
T10247 |
Adenosine 5'-diphosphoribose sodium
|
Adenosine 5'-diphosphoribose sodium,ADP ribose sodium |
Endogenous Metabolite
,
TRP/TRPV Channel
,
Autophagy
|
|
|
|
T22537 |
9-Phenanthrol
|
|
TRP/TRPV Channel
|
|
9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. |
|
T22353 |
Lanthanum(III) chloride heptahydrate
|
|
Calcium Channel
|
|
Lanthanum(III) chloride is an inorganic compound which used in biochemical research to block the activity of divalent cation channels, especially calcium channels. |
|
T28020 |
Mesendogen
|
|
TRP/TRPV Channel
|
|
Mesendogen is an inhibitor of TRPM6. Mesendogen alters magnesium homeostasis, promotes mesoderm and definitive endoderm differentiation. |
|
T7538 |
Tetraethylammonium chloride
|
|
Potassium Channel
|
|
Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties. |
|
T1098 |
Denatonium benzoate
|
THS-839 |
Others
|
|
Denatonium benzoate (THS-839) , a quaternary ammonium cation, is a compound of a salt with an inert anion like saccharide or benzoate. Its structure is involved in the local anesthetic lidocaine which difference only is ... |
|
T16763 |
RN-1747
|
|
TRP/TRPV Channel
|
|
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 agonists (EC50: 0.77 μM, 4.0 μM, and 4.1 μM for hTRPV4, mTRPV4, and rTRPV4 respectively). RN-1747 also antagonizes TRPM8 (IC50: 4 μM... |
|
T16686 |
Pyr10
|
|
TRP/TRPV Channel
|
|
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits... |
|
TP1910L1 |
CALP1 acetate
|
CALP1 acetate(145224-99-3 free base) |
CaMK
|
|
CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blo... |
|
T70540 |
Pinokalant
|
LOE-908 |
SARS-CoV
,
TRP/TRPV Channel
|
|
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem... |
|
TP2158 |
TRV-120027 TFA
|
TRV-120027 TFA (1234510-46-3 free base) |
RAAS
,
Arrestin
|
|
TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling. |
|
T22929 |
LOE 908 hydrochloride
|
|
Others
|
|
Broad spectrum cation channel blocker |
|
T68693 |
AZ12099548
|
|
|
|
AZ12099548 is a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist. |
|
T40757 |
1-Stearoyl-2-arachidonoyl-sn-glycerol
|
|
|
|
1-Stearoyl-2-arachidonoyl-sn-glycerol, a diacylglycerol (DAG) encompassing polyunsaturated fatty acids, possesses the ability to activate PKC. Moreover, this compound has the potential to enhance nonselective cation chan... |
|
T38516 |
IDT307
|
|
|
|
IDT307, an analog of the organic cation MPP+, serves as a specific fluorescent substrate for DAT, identified as APP+. |
|
T0979L |
Dequalinium acetate
|
Dequadin acetate,Decalinium acetate |
|
|
Dequalinium is a quaternary ammonium cation and bolaamphiphile commonly available as the dichloride salt. The bromide, iodide, acetate, and undecenoate salts are known as well. |
|
T22370 |
Mitoquinol mesylate
|
|
Others
|
|
Mitoquinol, a ubiquinone derivative, specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. Mitoquinol is an antioxidant, protecting mitochondria from oxidative damage... |
|
T81986 |
Kayexalate
|
|
|
|
Kayexalate, a cation-exchange resin, functions as an oral inhibitor of plasma potassium levels and is utilized in the investigation of hyperkalemia [1] [2]. |
|
T37086 |
PDDHV
|
|
|
|
PDDHV is a resiniferatoxin-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat transient receptor potential cation channel subfamily V member 1 (TRPV1), formerly known as vanilloid receptor 1. It i... |
|
T37658 |
MitoP
|
|
|
|
MitoP is a phenol product produced by the reaction of H2O2 with the ratiometric mass spectrometry probe MitoB . MitoB contains a triphenylphosphonium cation component that drives its accumulation in mitochondria where it... |
|
T71295 |
SOR-C13
|
|
|
|
SOR-C13 is an inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and pr... |
|
T76374 |
SPAI-1
|
|
|
|
SPAI-1, a peptide isolated from porcine duodenum, serves as a specific inhibitor to monovalent cation transporting ATPases, effectively inhibiting Na+, K+-ATPase and H+, K+-ATPase while stimulating Mg2+-ATPase in vitro [... |
|
T62272 |
TRPC6-IN-3
|
|
|
|
TRPC6-IN-3 (compound 17) is an orally active inhibitor of the transient receptor potential C6 ion channel (TRPC6), which regulates intracellular calcium concentration and also regulates cation fluxes including calcium an... |
|
T35965 |
MitoTEMPOL
|
|
|
|
MitoTEMPOL is a mitochondria-targeting superoxide dismutase mimetic that reduces mitochondrial O2- to H2O2. Like the related compound MitoTEMPO , MitoTEMPOL combines an antioxidant moiety (here, TEMPOL, also known as 4-h... |
|
T28047 |
Mitoquinone-cyclodextrin
|
MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin |
|
|
Mitoquinone-cyclodextrin is a 1:1 molar ratio complex of Mitoquinone mesylate with cyclodextrin. Mitoquinone mesylate is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to ... |
|
T35964 |
MitoTEMPO hydrate
|
|
|
|
MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.[1] This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophili... |
|
T37550 |
Bacitracin Complex
|
|
|
|
Bacitracin complex is a bacitracin antibiotic complex composed of cyclic dipeptides that has been found inBacillus.1It is metal-dependent and is complexed to a divalent metal cation, such as Cu2+, Ni2+, Co2+, Zn2+, or Mn... |
|
T37697L |
D-GsMTx4 TFA
|
|
TRP/TRPV Channel
,
Piezo Channel
|
|
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective s... |
|
T35963 |
MitoPerOx
|
|
|
|
MitoPerOx is a ratiometric fluorescent probe that can be used to assess changes in lipid peroxidation within mitochondria. It is composed of a BODIPY fluorophore conjugated via a dienyl link to a triphenylphosphonium cat... |
|
T78513 |
Sodium zirconium cyclosilicate
|
|
Others
|
|
Sodium zirconium cyclosilicate, an orally administered, non-absorbed, microporous zirconium silicate, acts as a highly selective cation exchanger to remove excess potassium (K+) in vivo. It has potential use in the resea... |
