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T9925 |
Ofatumumab
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|
Others
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|
Ofatumumab is a fully human monoclonal antibody to CD20 which appears to inhibit early-stage B lymphocyte activation |
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T15235 |
Enocitabine
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|
Nucleoside Antimetabolite/Analog
,
HCV Protease
,
DNA/RNA Synthesis
|
|
Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a ... |
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T9060 |
STM2457
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|
Apoptosis
,
Others
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STM2457 is an inhibitor of the RNA methyltransferase METTL3 (IC50=16.9 nM) with selective and oral activity.STM2457 can be used in acute myeloid leukemia (AML) studies. |
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T6916 |
OICR-9429
|
OICR 9429 |
Histone Methyltransferase
,
JAK
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|
OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro. |
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T6603 |
Nelarabine
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GW 506U78,Nelzarabine,506U78 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
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T6588 |
Mitoxantrone
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mitozantrone |
Topoisomerase
,
PKC
|
|
Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisome... |
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T14871 |
Carboxyamidotriazole Orotate
|
L-651582 Orotate,CAI Orotate |
Calcium Channel
|
|
Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate (L-651582 Orotate) is the o... |
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T0158 |
Mitoxantrone dihydrochloride
|
Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride |
Topoisomerase
,
PKC
|
|
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. |
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T77647 |
Tubulin polymerization-IN-43
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|
Apoptosis
,
Microtubule Associated
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|
Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell c... |
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T24212 |
XX-650-23
|
XX65023,XX 650 23 |
Apoptosis
,
Epigenetic Reader Domain
|
|
XX-650-23 is a small molecule CREB inhibitor that blocks the critical interaction between CREB and its required coactivator, CBP (CREB-binding protein), inducing apoptosis and cell cycle arrest in AML cells, and can be u... |
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T60654 |
KDM4C-IN-1
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|
Histone Demethylase
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KDM4C-IN-1 is a selective and potent KDM4C inhibitor (IC50: 8 nM) with potential anticancer activity.KDM4C-IN-1 inhibits the growth of HepG2 and A549 cells, and can be used for the study of leukaemia. |
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T62702 |
Senexin C
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CDK
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Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senexin B. Senexin C inhibits the growth of MV4-11 leukaemia cel... |
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T4564 |
Ethacrynic acid
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Edecrin,Etacrynic Acid,Hydromedin |
Others
,
Calcium Channel
,
NF-κB
,
GST
|
|
Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase a... |
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T63746 |
Vamotinib
|
PF-114 |
Apoptosis
,
Tyrosine Kinases
,
Bcr-Abl
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|
Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCR/ABL and BCR/ABL-T315I, which promotes apoptosis. ... |
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T79745 |
IDH2R140Q-IN-2
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|
Dehydrogenase
|
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IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation ... |
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T34311 |
RG7775
|
RO 6839921,RO-6839921,RG 7775,RG-7775,RO6839921 |
|
|
RG7775, also known as RO 6839921, a small molecule prodrug for the treatment of solid tumours and acute myeloid leukaemia. |
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T63127 |
PDGFRα/FLT3-ITD-IN-3
|
|
|
|
PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to be studied in acute myeloid leukaemia or chronic eosinophilic leuk... |
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T21911 |
Rilmenidine hemifumarate
|
Rilmenidine (hemifumarate),S-3341 hemifumarate |
Apoptosis
,
Imidazoline Receptor
|
|
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulate... |
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T9958 |
DB818
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|
Others
|
|
DB818 is a synthetic Homeobox A9 (HOXA9) inhibitor and can be used for research on the treatment of acute myeloid leukaemia associated with HOXA9 overexpression. |
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T10050 |
1alpha-Hydroxy VD4
|
1α-Hydroxy vitamin D4 |
Others
|
|
1alpha-Hydroxy VD4 can effectively induce the differentiation of monoblastic leukaemia U937, P39/TSU, and P31/FUJ cells. |
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T64129 |
MAX-40279 hemiadipate
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|
|
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MAX-40279 hemiadipate is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 hemiadipate has shown investigational potential in acute myeloid leukaemia (AML). |
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T63094 |
MAX-40279 hydrochloride
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|
|
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MAX-40279 hydrochloride is a potent, dual inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hydrochloride has potential for acute myeloid leukaemia (AML) studies . |
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T64152 |
Purinostat mesylate
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|
|
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Purinostat mesylate is a selective HDAC inhibitor. purinostat mesylate inhibits type I and type IIb HDACs (IC50: 0.81-11.5 nM). purinostat mesylate affects the cell cycle of LAMA84 and 188 BL-2 cells and induces apoptosi... |
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T71242 |
AZD-1897
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|
|
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AZD-1897 is an ATP-competitive pan-PIM inhibitor. When combined with the Akt inhibitor AZD5363, AML cells from putative leukaemia stem cells incur a reduction in levels of the anti-apoptotic protein MCL1. The combination... |
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T63916 |
MAX-40279 hemifumarate
|
|
|
|
MAX-40279 hemifumarate is a potent dual inhibitor of FLT3 kinase and FGFR kinase. MAX-40279 hemifumarate has shown investigational potential in acute myeloid leukaemia (AML). |
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T63880 |
DHODH-IN-22
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|
|
|
DHODH-IN-22 is a potent, selective, orally active inhibitor of dihydroorotic dehydrogenase (DHODH) (IC50: 0.3 nM) and can be used in acute myeloid leukaemia (AML) studies. |
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T60942 |
MC2652
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|
|
|
MC2652 (compound 1a) is a potent LSD1 inhibitor that shows high inhibitory effects in leukaemia cells MV4-11 and NB4. MC2652 has antiproliferative activity against LNCaP cells of prostate cancer [1]. |
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T62863 |
FLT3/ITD-IN-4
|
|
|
|
FLT3/ITD-IN-4 (Compound 16) is a selective inhibitor of FLT3 internal tandem repeat mutations (FLT3-ITD) (IC50: 2.3 nM). FLT3/ITD-IN-4 can be used to study acute myeloid leukaemia. |
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T62099 |
LSD1-IN-13
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|
|
|
LSD1-IN-13 (compound 7e) is an orally active LSD1 inhibitor (IC50: 24.43 nM) that also activates CD86 expression (EC50: 470 nM).LSD1-IN-13 induces differentiation of AML (acute myeloid leukaemia) cell lines. |
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T72784L |
OTUB1/USP8-IN-1 HCl
|
OTUB1/USP8-IN-1 HCl（2858800-98-1 Free base） |
DUB
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|
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8. OTUB1/USP8-IN-1 may be used in the study of leukaemia. |
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T64283 |
Pacritinib hydrochloride
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|
|
|
Pacritinib hydrochloride is a potent inhibitor of wild-type JAK2 (IC50: 23 nM) and the JAK2V617F mutant (IC50: 19 nM). Pacritinib hydrochloride can be used in the study of acute myeloid leukaemia (AML) and myelofibrosis ... |
|
T70008 |
Bomedemstat ditosylate
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|
|
|
Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndro... |
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T63168 |
VEGFR-2-IN-26
|
|
|
|
VEGFR-2-IN-26 (compound 5h) is a potent inhibitor of VEGFR-2 (IC50: 15.5 nM).VEGFR-2-IN-26 exhibits good anti-proliferative effects on leukaemia, CNS, non-small lung, ovarian, renal, prostate and breast cancer cells. |
|
T62392 |
PI3K-IN-34
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|
|
|
PI3K-IN-34 (Compound 6g) is a highly selective inhibitor of PI3K that acts on PI3K-α (IC50: 11.73 μM), PI3K-β (IC50: 6.09 μM) and PI3K-δ (IC50: 11.18 μM). PI3K-IN-34 can be used to study leukaemia. |
|
T63924 |
XY153
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|
|
|
XY153 (compound 8l) is a BD2 selective BET inhibitor that selectively binds BRD4 BD2. XY153 binds BRD4 BD2 (IC50: 0.79 nM), BRD3 BD2 (IC50: 5.31 nM) and BRD2 BD2 (IC50: 5.09 nM). XY153 can be used to study acute myeloid ... |
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T64208 |
EZH2-IN-9
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|
|
|
EZH2-IN-9 is a potent inhibitor of EZH2, whose overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) cause abnormal elevations in H3K27me3 and contribute to the growth and development... |
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T21898 |
MI-192
|
|
|
|
MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC 50 s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. MI-192 has pot... |
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T62779 |
PI3K-IN-35
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|
|
|
PI3K-IN-35 (Compound 6l) is a highly selective inhibitor of PI3K, acting on PI3K-α (IC50: 13.98 μM), PI3K-β (IC50: 7.22 μM) and PI3K-δ (IC50: 10.94 μM). PI3K-IN-35 blocks the cell cycle in G2/M phase and induces apoptosi... |
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T62496 |
IST5-002
|
|
|
|
IST5-002 is a potent inhibitor of Stat5a/b and selectively inhibits the transcriptional activity of Stat5a/b with IC50 values of 1.5 μM and 3.5 μM for Stat5a and Stat5b, respectively. IST5-002 can be used to study prosta... |
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T62801 |
FLT3/TrKA-IN-1
|
|
|
|
FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor, capable of acting on FLT3 (IC50: 43.8 nM), FLT3-ITD (IC50: 97.2 nM), FLT3-TKD (IC50: 92.5 nM) and TrKA (IC50: 23.6 nM). -FLT3/TrKA-IN-1 has potential for acute ... |
|
T64277 |
ODN 1585
|
|
|
|
ODN 1585 is a potent inducer of IFN and TNFα production, a potent stimulator of NK (natural killer) and can be used as a vaccine adjuvant.ODN 1585 enhances the function of CD8+ T cells, including CD8+ T cell-mediated IFN... |
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T37602 |
GSK 143
|
|
|
|
Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines.
Liddle et al (2011) Discovery of... |
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T69771 |
MS-177
|
|
|
|
MS177, a potent and rapid EZH2 degrader, functions as a PROTAC comprised of a CRBN ligand, linker, and a powerful enzymatic EZH2 inhibitor C24 (C24 IC50: 12 nM). It successfully targets and depletes both canonical EZH2–P... |
|
T36695 |
TAS-103
|
|
|
|
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103... |
