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ターゲット

阻害剤

天然化合物

102

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8676	FOY 251		Others , Serine/threonin kinase , SARS-CoV
	FOY 251 is a proteinase inhibitor, and is an anti-proteolytic active metabolite camostate.		Others , Serine/threonin kinase , SARS-CoV
T2154	MG-132	Z-LLL-al,Z-Leu-Leu-Leu-CHO	Apoptosis , Proteasome , Autophagy
	MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.		Apoptosis , Proteasome , Autophagy
T20490	Z-Arg(Z)2-OH	NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine	Others
	Z-Arg(Z)2-OH can be used in the assay to screen proteolytic activities in mite homogenates.		Others
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T7675	Substance P (1-7) 2TFA(68060-49-1(free base))		Others
	Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effec...		Others
T2016	MLN9708	Ixazomib Citrate	Proteasome
	MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.		Proteasome
TP1266	γ-Glu-Phe TFA(7432-24-8 free base)	γ-Glu-Phe TFA(7432-24-8,FREE)	Endogenous Metabolite
	γ-Glu-Phe TFA(7432-24-8 free base) is a dipeptide composed of gamma-glutamate and phenylalanine and is a proteolytic breakdown product of larger proteins. It is probably formed by transpeptidation between glutathione and...		Endogenous Metabolite
TP1597L	Secretoneurin, rat acetate	Secretoneurin, rat acetate(149146-12-3 Free base)	Others
	Secretoneurin, rat acetate is a 33-amino acid polypeptide generated by proteolytic processing of secretogranin II (SgII). Secretoneurin, rat acetate induces dopamine release in the rat striatum in vivo and in vitro, and ...		Others
T63790	Cbl-b-IN-3		E1/E2/E3 Enzyme
	Cbl-b-IN-3 is a potent proto-oncogene-B (CPL-B) inhibitor of casitas B-series lymphoma (ic50 < 1 nM). Cpl-b, a cyclic E3 ubiquitin protein ligase, is involved in the setting of T lymphocyte activation thresholds. Cpl-b n...		E1/E2/E3 Enzyme
T3226	Paritaprevir free base	ABT-450,Veruprevir	HCV Protease
	Paritaprevir free base(ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential acti...		HCV Protease
T32677	Leucylproline	Leu-pro
	Leucylproline is a peptide that proteolytic breakdown product by larger proteins.
T37011	Boc-LRR-AMC
	Boc-LRR-AMC is a fluorogenic substrate for the trypsin-like activity of the 26S proteasome or 20S proteolytic core. Upon enzymatic cleavage by the 26S proteasome or 20S proteolytic core, amino-4-methylcoumarin (AMC) is r...
T11316	FOY 251 free base		Others
	FOY 251 free base acts as a proteinase inhibitor. FOY 251 free base is an anti-proteolytic active metabolite camostate.		Others
T69640	MI-1851
	MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.
TP1597	Secretoneurin, rat
	Secretoneurin, rat, a 33-amino acid polypeptide, is generated by proteolytic processing of secretogranin II (SgII).
T37697	D-GsMTx4	D-GsMTx4
	TRPC1/6 and Piezo2 inhibitor. Exhibits same effect as L-enantiomer, GsMTx4 (Cat. No. 4912) on TRPC channels. Inhibits mechanosensitive currents by ~70%. Protects against myocardial infarction in mouse ischemia/reperfusi...
T75124	BTK-IN-24
	BTK-IN-24 (compound 195) is a potent BTK inhibitor via a ubiquitin proteolytic pathway [1] .
TP1664	Proinsulin C-Peptide (55-89), human
	Human proinsulin, the single-chain peptide precursor of insulin, consists of the insulin A and B chains connected by the 31 amino acid C-peptide. Cleavage of proinsulin by proteolytic enzymes produces insulin and free C-...
T76155	Glutamic acid protease
	Glutamic protease, a proteolytic enzyme characterized by the presence of a glutamic acid residue [1], is exclusive to fungi.
T78194	Skp2 inhibitor 2		E1/E2/E3 Enzyme
	Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1. This compound targets Skp2, a component of cullin-RING ligases that recruit...		E1/E2/E3 Enzyme
T70280	KB-R7785
	KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect b...
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2	Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a cruc...
T74173	PROTAC PARP/EGFR ligand 1
	PROTAC PARP/EGFR ligand 1 is a potent compound utilized in the creation of dual PARP-EGFR degraders through Proteolytic Targeting Chimera (PROTAC) technology [1].
TP1864	[Glu1]-Fibrinopeptide B
	[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically gener...
T76145	Clostripain
	Clostripain (Clostridiopeptidase B), a proteolytic enzyme derived from Clostridium histolyticum, exhibits esterase, amidase, and protease activities. It is notably specific for cleaving carboxy-terminal arginine residues...
T78402	Boc-Gln-Ala-Arg-AMC acetate
	Boc-Gln-Ala-Arg-AMC acetate is a fluorogenic substrate primarily used for assaying trypsin activity and additionally suitable for evaluating the proteolytic function of TMPRSS2[1][2].
TP1725	Bradykinin (1-5)
	Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).The bradykinin (BK) fragment (1-5) (RPPGF) is among the most stable of naturally occurr...
T37417	Z-LLE-AMC
	Z-LLE-AMC is a fluorogenic substrate for the caspase-like post-glutamate peptide hydrolase of the 26S proteasome or 20S proteolytic core. Caspase-like activity can be quantified by fluorescent detection of free AMC (also...
T37418	Z-LLL-AMC
	Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-am...
T80076	Ac-ESMD-CHO		Casein Kinase
	Ac-ESMD-CHO functions as an inhibitor of both caspase-3 and caspase-7, specifically obstructing the proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site [1] [2].		Casein Kinase
T7396	Substance P(1-7)	Substance P 1-7	Others , Neurokinin receptor
	Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects		Others , Neurokinin receptor
TP1514	α-Neoendorphin (1-8)	α-Neoendorphin 1-8
	α-Neoendorphin (1-8) is a 8-amino acid peptide derived from the N-terminal of α-Neoendorphin. α-Neoendorphin is an endogenous opioid peptide and is a part for the neoendorphins which are a group of endogenous opioid pept...
T36942	SSAA09E1	SSAA09E1
	SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based ...
T77014	Frovocimab
	Frovocimab (LY 3015014), a humanized IgG4 monoclonal antibody (mAb), acts by neutralizing PCSK9. This mechanism effectively prevents PCSK9 from binding to the LDL receptor (LDLR) while allowing for the normal proteolytic...
T75993	Pepsin A
	Pepsin A, a primary gastric protease in both pigs and humans, functions similarly to minor gastric proteolytic enzymes. It plays a crucial role in the proteolysis of food proteins within the vertebrate stomach [1] [2].
T71420	RO314724
	RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage m...
T81838	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) is a peptide utilized as a fluorescence resonance energy transfer (FRET) based substrate for proteolytic activity assays, wherein the cleavage-induced change in f...
T81372	Proteasome-activating peptide 1
	Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m...
T36189	CAY10406
	CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively...
TP1580	Activated Protein C (390-404), human TFA
	The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular subs...
T83689	Histatin 8 TFA	Hst-8
	Histatin 8, a salivary antimicrobial peptide derived from proteolytic fragments of histatin 3 and histatin 5, exhibits activity against A. baumannii strains, both colistin-susceptible and -resistant, at a concentration o...
T80239	TFLLRNPNDK-NH2		Thrombin
	TFLLRNPNDK-NH2 is a biologically active peptide and a thrombin receptor activating peptide (TRAP). As a PAR-1 agonist, it reversibly binds to PAR-1, mimicking the 'tethered ligand' created by thrombin through proteolytic...		Thrombin
T73701	Urokinase (peptidolytic)
	Urokinase peptidolytic (Urokinase-type plasminogen activator) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in t...
T76243	Proteasome-activating peptide 1 TFA
	Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,...
T78805	AD4		Others
	AD4, an artemisinin derivative functioning as a proteolytic targeting chimera (PROTAC) for PCLAF, effectively degrades PCLAF in RS4;11 cells with an IC50 of 0.6 nM. This degradation activates the p21/Rb axis, resulting i...		Others
T76119	Rennin
	Rennin (Chymosin) is a proteolytic enzyme related to pepsin, produced in the stomachs of certain animals, that effectively coagulates liquid milk into a semi-solid form, prolonging its retention in the stomach. It specif...
T82252	GTPγS tetralithium
	GTPγS (tetralithium) is a G-protein activator known for its role in preventing proteolytic degradation of proteins, facilitating tyrosine kinase-dependent GLUT4 translocation, stimulating phospholipases, and promoting ac...
T75775	Compstatin TFA
	Compstatin TFA, a potent inhibitor of the complement system C3 characterized by species specificity, is a 13-residue cyclic peptide. It selectively binds to baboon C3 and demonstrates resistance to proteolytic cleavage i...
T37747	N-tetradecanoyl-L-Homoserine lactone	C14-HSL,tDHL,N-tetradecanoyl-L-Homoserine lactone
	Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising fie...

Compounds

FOY 251

T8676

Synonym:

Target: Others, Serine/threonin kinase, SARS-CoV

MG-132

T2154

Synonym: Z-LLL-al,Z-Leu-Leu-Leu-CHO

Target: Apoptosis, Proteasome, Autophagy

Z-Arg(Z)2-OH

T20490

Synonym: NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine

Target: Proteasome, Caspase, Autophagy

PI-1840

T6941

Synonym: PI 1840

Target: PARP, Proteasome

Substance P (1-7) 2TFA(68060-49-1(free base))

Synonym: Ixazomib Citrate

Target: Proteasome

γ-Glu-Phe TFA(7432-24-8 free base)

TP1266

Synonym: γ-Glu-Phe TFA(7432-24-8,FREE)

Target: Endogenous Metabolite

Secretoneurin, rat acetate

TP1597L

Synonym: Secretoneurin, rat acetate(149146-12-3 Free base)

Target: E1/E2/E3 Enzyme

Paritaprevir free base

T3226

Synonym: ABT-450,Veruprevir

Proinsulin C-Peptide (55-89), human

TP1664

Synonym:

Target:

Glutamic acid protease

Target: E1/E2/E3 Enzyme

Fmoc-Ala-Glu-Asn-Lys-NH2

T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Target:

PROTAC PARP/EGFR ligand 1

T74173

Synonym:

Target:

[Glu1]-Fibrinopeptide B

Boc-Gln-Ala-Arg-AMC acetate

Target: Casein Kinase

Substance P(1-7)

T7396

Synonym: Substance P 1-7

Target: Others, Neurokinin receptor

α-Neoendorphin (1-8)

TP1514

Synonym: α-Neoendorphin 1-8

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)

T81838

Synonym:

Target:

Proteasome-activating peptide 1

Activated Protein C (390-404), human TFA

Urokinase (peptidolytic)

T73701

Synonym:

Target:

Proteasome-activating peptide 1 TFA

N-tetradecanoyl-L-Homoserine lactone

T37747

Synonym: C14-HSL,tDHL,N-tetradecanoyl-L-Homoserine lactone

Target:

カタログ番号	製品名	別名	ターゲット
T13827	Pronase E (Activity ≥ 7000 U/g)	Pronase,Pronase E	Others
	Pronase E is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids.		Others
T1614	Hydrocortisone	Cortisol	Glucocorticoid Receptor , Endogenous Metabolite
	Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilizatio...		Glucocorticoid Receptor , Endogenous Metabolite
T64812	Collagenase Type I	Collagenase I,Collagenase Type I (From microorganisms)	Others
	Collagenase Type I is a proteolytic enzyme that breaks down the peptide bonds in collagen, the main structural protein of connective tissue. Collagenase has been explored as a potential treatment option to break down her...		Others
TN4046	Excisanin A		MMP , FAK , PARP , GSK-3 , NF-κB , Wnt/beta-catenin , Akt , Caspase , PI3K , Prostaglandin Receptor , JNK
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatm...

天然物製品

Pronase E (Activity ≥ 7000 U/g)

T13827

Synonym: Pronase,Pronase E

Target: Glucocorticoid Receptor, Endogenous Metabolite

Collagenase Type I

T64812

Synonym: Collagenase I,Collagenase Type I (From microorganisms)

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-00408	ClpP Protein, Clostridium botulinum, Recombinant (His & SUMO)	Clostridium botulinum	E. coli
	ClpP Protein, Clostridium botulinum, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-00582	Endopeptidase Clp Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
TMPH-00209	CLPP2 Protein, Borrelia burgdorferi, Recombinant (His & Myc)	Borrelia burgdorferi	E. coli
	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
TMPY-05717	Integrin alpha V beta 8 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cyto...
TMPY-02078	HtrA2/Omi Protein, Human, Recombinant (His)	Human	E. coli
	Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the ...
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain)	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ...
TMPH-02256	Trypsin-3 Protein, Human, Recombinant (His)	Human	E. coli
	Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors.
TMPH-02284	USP26 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
TMPY-06179	IdeS Protein, Streptococcus pyogenes, Recombinant (His & GST)	Streptococcus pyogenes	E. coli
	IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic...
TMPY-06023	IdeS Protein, Streptococcus pyogenes, Recombinant (His)	Streptococcus pyogenes	E. coli
	IdeS (IgG-degrading enzyme of Streptococcus pyogenes) is a secreted cysteine endopeptidase from the human pathogen S. pyogenes with an extraordinarily high degree of substrate specificity, catalyzing a single proteolytic...
TMPH-03439	STE13 Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	E. coli
	Responsible for the proteolytic maturation of the alpha-factor precursor. STE13 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.0...
TMPH-02601	C1RL Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum. C1RL Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.5 ...
TMPH-01063	Cathepsin O Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predic...
TMPH-01770	Neurotrypsin Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations. Neurotrypsin Protein, Human, Recombinant (His & SUMO) is expressed in...
TMPH-02643	Enteropeptidase Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes in...
TMPH-02250	TPP2 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-01062	Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag...
TMPH-00648	LapB Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of prote...
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-02945	TMPRSS4 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC. TMPRSS4 Protein, Mouse, Recombinant (Hi...
TMPH-01316	ECM1 Protein, Human, Recombinant (GST & His & Myc)	Human	E. coli
	Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. ECM1 Protein, Human, ...
TMPH-00031	Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)	Aeromonas sobria	E. coli
	Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by trans...
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-...
TMPH-01693	MAP3K14 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-ka...
TMPH-03153	Gingipain R2 Protein, Porphyromonas gingivalis, Recombinant (His)	Porphyromonas gingivalis	E. coli
	Thiol protease. Acts synergistically with RgpA to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defen...
TMPH-00134	AcMNPV Viral cathepsin Protein (His & SUMO)	AcMNPV	E. coli
	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. Accumulates within infected cells as an inactive proenzyme (proV-CATH), which is activated by proteo...
TMPJ-00452	Serpin A1a Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elast...
TMPH-03151	Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (His)	Porphyromonas gingivalis	P. pastoris (Yeast)
	Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defen...
TMPH-02644	Enteropeptidase Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes in...
TMPK-00870	AREG Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine...
TMPK-01342	3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPH-03757	TPP2 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPK-01338	3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01340	3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPH-03152	Gingipain R1 Protein, Porphyromonas gingivalis, Recombinant (B2M & His)	Porphyromonas gingivalis	E. coli
	Thiol protease. Acts synergistically with RgpB to catalyze the maturation of fimbrial subunits, such as FimA. Its proteolytic activity is a major factor in both periodontal tissue destruction and in evasion of host defen...
TMPK-01344	3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01346	3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01335	3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01336	3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01337	3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01347	3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPH-02953	TPP2 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPK-01341	3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01339	3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPH-03762	TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)	Mouse	E. coli
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPK-01343	3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPJ-00415	HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated	Human	HEK293 Cells
	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which un...
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-01345	3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and al...
TMPK-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting d...
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