|
T8239 |
Cromoglicic acid
|
|
Others
|
|
Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells. |
|
T21404 |
Fluticasone furoate
|
Veramyst,Allermist,Avamys,Fluticasone furoate |
Glucocorticoid Receptor
|
|
Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure... |
|
T0211 |
Azelastine
|
Azelastina,Astelin,Azelastinum |
SARS-CoV
,
Histamine Receptor
|
|
|
|
T3979 |
Emedastine
|
LY188695,Emadine |
Histamine Receptor
|
|
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its... |
|
T0118 |
Mizolastine
|
SL 850324 |
Histamine Receptor
|
|
Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives. |
|
T6242 |
Rupatadine Fumarate
|
Rinialer,Rupafin,Alergoliber |
PAFR
,
Autophagy
,
Histamine Receptor
|
|
Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM. |
|
T0059 |
Diphenylpyraline hydrochloride
|
4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor
|
|
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine re... |
|
T3185 |
R112
|
(E)-Elafibranor |
Syk
|
|
R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase. |
|
T1030 |
Triprolidine hydrochloride monohydrate
|
Triprolidine hydrochloride |
Histamine Receptor
|
|
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma. |
|
T0211L |
Azelastine hydrochloride
|
Optivar,Azelastine HCl,Allergodil,Astelin |
SARS-CoV
,
Histamine Receptor
|
|
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity. |
|
T1269 |
Tripelennamine hydrochloride
|
Pyribenzamine hydrochloride,Tripelennamine HCl,Pyribenzamine HCl |
Histamine Receptor
|
|
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. |
|
T3520 |
Setipiprant
|
KYTH-105,ACT-129968 |
GPR
,
Prostaglandin Receptor
|
|
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in vari... |
|
T0205 |
Brompheniramine maleate
|
Dimotane,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane |
5-HT Receptor
,
Histamine Receptor
|
|
Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors. |
|
T0188 |
Fluticasone (propionate)
|
CCI-187881,Fluticasone propionate |
Glucocorticoid Receptor
,
Virus Protease
,
Estrogen/progestogen Receptor
,
Phospholipase
,
Endogenous Metabolite
|
|
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist. |
|
T2335 |
Ebastine
|
Ebastel,LAS-W 090,Ebastin,Kestine,RP64305 |
Histamine Receptor
|
|
Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tiss... |
|
T0089 |
Cetirizine dihydrochloride
|
P071,UCB P071,Cetirizine DiHCl |
Histamine Receptor
|
|
Cetirizine dihydrochloride (UCB P071) is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced asthma. Unlike other conventiona... |
|
T6660 |
SB-705498
|
|
TRP/TRPV Channel
|
|
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis. |
|
T21472 |
Dimethindene maleate
|
UNII-6LL60J9E0O,SU 6518,SU-6518 |
Histamine Receptor
|
|
Dimethindene maleate (SU 6518) is a histamine H1 antagonist and can be used in studies about the treatment of hypersensitivity reactions, pruritus and rhinitis. |
|
T1470 |
Fexofenadine hydrochloride
|
Terfenidine carboxylate hydrochloride,MDL-16455 hydrochloride,Telfast,Fexofenadine HCl,Allegra,MDL 16455A |
Histamine Receptor
|
|
Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) is a second generation antihistamine that is used for the treatment of allergic rhinitis, angioedema and chronic urticaria. |
|
T1553 |
Chlorpheniramine maleate
|
NCI-C55265,Chlorphenamine maleate |
Histamine Receptor
|
|
Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. |
|
T77426 |
Pascolizumab
|
SB-240683 |
IL Receptor
|
|
Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can be used to study allergic rhinitis. |
|
T16476 |
PF-03654746
|
|
Histamine Receptor
|
|
PF-03654746 is a selective antagonist of the histamine H3 receptor. PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease. PF-03654746 can be used in studies about the treatment of ... |
|
T2396 |
Ramatroban
|
BAY u3405 |
GPR
,
Prostaglandin Receptor
,
PPAR
|
|
Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. |
|
T22354 |
Levocetirizine Dihydrochloride
|
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor
|
|
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydro... |
|
T1097 |
Loratadine
|
SCH 29851,Loratidine |
Influenza Virus
,
Histamine Receptor
|
|
Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central ne... |
|
T4563 |
Thonzylamine
|
neohetramine |
Histamine Receptor
|
|
Thonzylamine (neohetramine) is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhin... |
|
T2270 |
Trans-Tranilast
|
Tranilast trans- |
RAAS
|
|
Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993.... |
|
T2392 |
Nafamostat mesylate
|
FUT-175 |
Apoptosis
,
Serine/threonin kinase
,
SARS-CoV
,
Serine Protease
|
|
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. |
|
T1531 |
Mometasone furoate
|
Sch32088 |
Glucocorticoid Receptor
|
|
Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for ski... |
|
T77601 |
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid
|
|
GPR
|
|
(2-{[2-(2-fluorophenoxy)ethyl]sulfanyl}-1H-benzimidazol-1-yl)acetic acid is a prostaglandin-like CRTH2 antagonist with an IC50 < 10 μM, which can be used in studies of rhinitis, COPD, rheumatoid arthritis, eczema and con... |
|
T0098 |
Ipratropium bromide monohydrate
|
Ipratropium bromide hydrate |
AChR
|
|
Ipratropium bromide monohydrate (Ipratropium bromide hydrate) is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial... |
|
T1278 |
Astemizole
|
Laridal,Histaminos,Paralergin |
Potassium Channel
,
Histamine Receptor
|
|
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re... |
|
T29951 |
Ambicromil
|
|
|
|
Ambicromil is used for allergic rhinitis. |
|
T21112 |
Triprolidine hydrochloride
|
295 C 51,Pro-Entra,Entra,Actidilat,Triprolidine hydrochloride anhydrous,Actidil,Pro-Actidil |
|
|
Triprolidine hydrochloride anhydrous, a Histamine H1 antagonist, is used in asthma, allergic rhinitis, and urticaria. |
|
T27556 |
HSR-609
|
HSR609,FY609,FY-609,FY 609 |
|
|
HSR-609, a histamine H1 receptor antagonist, is used potentially for the treatment of allergic rhinitis. |
|
T20630 |
M 12325
|
Lasamide,M12325,M-12325 |
|
|
M 12325 is used in the production of furosemide; rhinitis and occupational asthma were observed in workers from a lasamide production line. |
|
T0785L |
Dexchlorpheniramine free base
|
Polaramine,Dexchlorpheniramine Maleate,Mylaramine |
|
|
Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus. |
|
T27445 |
GSK-1004723
|
GSK 1004723 |
|
|
GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis. |
|
T10437 |
AZD8848
|
|
TLR
|
|
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis. |
|
T69737 |
SCH-79687
|
|
|
|
SCH-79687 is a histamine antagonist selective for the H3 subtype. This H3 antagonist may play a role in allergic rhinitis. |
|
T21247 |
Carbinoxamine
|
Allergefon,(+-)-Carbinoxamine,Paracarbinoxamine |
|
|
Carbinoxamine, an anticholinergic and antihistamine agent, is used for hay fever, angioedema, vasomotor rhinitis, mild urticaria, dermatographism and allergic conjunctivitis. It is a histamine antagonist, specifically an... |
|
T62604 |
Flunisolide hemihydrate
|
|
|
|
Flunisolide hemihydrate is a corticosteroid, an orally active Glucocorticoid receptor activator with anti-inflammatory effects. flunisolide hemihydrate induces apoptosis in eosinophils and can be used in asthma or rhinit... |
|
T69025 |
Ipratropium Free Base
|
|
|
|
Ipratropium Free Base is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial disorders, in rhinitis, and as an antia... |
|
T73789 |
5(S)-HETE
|
|
|
|
5(S)-HETE, an endogenous metabolite found in the blood, is utilized in researching Rheumatoid Arthritis, Rhinitis, and Asthma [1] [2]. |
|
T37386 |
Dihydro Montelukast
|
|
|
|
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing ... |
|
T60514 |
Triprolidine
|
|
|
|
Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3]. |
|
T68280 |
Adriforant
|
|
|
|
Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of ... |
|
T26770 |
Bencycloquidium Bromide
|
BCQB |
|
|
Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in C... |
|
T69918 |
Adriforant tartrate hydrate
|
|
|
|
Adriforant tartrate hydrate, also known as ZPL-3893787 tartrate hydrate, PF-3893787 tartrate hydrate and ZPL-389 tartrate hydrate, is a novel histamine H4 receptor antagonist. Adriforant tartrate hydrate shows an excelle... |
|
T74646 |
PM-81I
|
|
|
|
PM-81I, a potent STAT6 inhibitor targeting the SH2 structural domain, effectively reduces STAT6 phosphorylation levels. It is applicable in the research of allergic lung disease, allergic rhinitis, chronic obstructive pu... |
