|
T22514 |
4F 4PP oxalate
|
|
5-HT Receptor
|
|
4F 4PP oxalate is a 5-HT2A antagonist. |
|
T8357 |
SB-200646
|
|
5-HT Receptor
|
|
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor |
|
T39161 |
Ro60-0175
|
Ro60-0175 |
5-HT Receptor
|
|
Ro60-0175 a selective agonist for both the 5-hydroxytryptamine 2B (5-HT2B) and 5-hydroxytryptamine 2C (5-HT2C)serotonin receptor subtypes, commonly used as fumarate salt. It has a role as a 5-hydroxytryptamine 2B recept... |
|
T0162 |
Quetiapine
|
ICI204636,Quetiapin |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
AChR
,
Histamine Receptor
|
|
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago... |
|
T1445 |
Agomelatine
|
Thymanax,S-20098,Valdoxan |
Melatonin Receptor
,
5-HT Receptor
|
|
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. |
|
T6241 |
Quetiapine hemifumarate
|
Quetiapine Fumarate,ICI-204636 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression. |
|
T79802 |
5-HT2C agonist-3
|
|
5-HT Receptor
|
|
5-HT2C agonist-3 ((+)-19), a selective 5-HT2C agonist (EC 50: 24 nM, Ki: 78 nM), exhibits antipsychotic-like activity by blocking amphetamine-induced hyperactivity [1]. |
|
T79806 |
5-HT2A&5-HT2C agonist-1
|
|
5-HT Receptor
|
|
5-HT2A&5-HT2C agonist-1 (Example 2) is a dual-acting agent targeting the 5-HT2A and 5-HT2C receptors with respective IC50 values of 196 nM and 0.9 nM. It is applicable in the study of various central nervous system disor... |
|
T79803 |
5-HT2C agonist-3 free base
|
|
5-HT Receptor
|
|
5-HT2C agonist-3 ((+)-19) free base, a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM), exhibits antipsychotic drug-like activity and inhibits Amphetamine-induced hyperactivity [1]. |
|
T68565 |
ANN33840
|
|
|
|
ANN33840 is a novel selective 5-HT2C agonist with >300-fold functional selectivity over 5-HT2B and >70-fold functional selectivity over 5-HT2A, reducing food intake in an acute rat feeding model. |
|
T10871 |
CP-809101 hydrochloride
|
|
5-HT Receptor
|
|
CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
|
T13332 |
(Rac)-WAY-161503
|
|
5-HT Receptor
|
|
(Rac)-WAY-161503 is a selective and high-affinity agonist of the 5-HT2C receptor (Ki: 4 nM; EC50: 12 nM), with anti-obesity and antidepressant effects. |
|
T16856 |
SB228357
|
|
5-HT Receptor
|
|
SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively. |
|
T5158 |
N-Desmethylclozapine
|
Desmethylclozapine,Normethylclozapine,Norclozapine |
Virus Protease
,
Dopamine Receptor
,
5-HT Receptor
,
Opioid Receptor
,
AChR
,
Drug Metabolite
|
|
N-Desmethylclozapine (Desmethylclozapine) is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist at δ-opioid receptors. |
|
T13275 |
Vabicaserin hydrochloride
|
SCA 136 |
5-HT Receptor
|
|
Vabicaserin hydrochloride (SCA 136) is a selective agonist of 5-hydroxytryptamine 2C (5-HT2C) receptor (EC50: 8 nM). |
|
T22947 |
LY266097 hydrochloride
|
LY 266097 hydrochloride |
5-HT Receptor
|
|
LY266097 hydrochloride (LY 266097 hydrochloride) is an antagonist of 5-HT2 with pKis of 7.7, 9.8, and 7.6 for human 5-HT2A, 5-HT2B, and 5-HT2C and can be used in studies about depression. |
|
T7350 |
Nelotanserin
|
APD125 |
5-HT Receptor
|
|
Nelotanserin (APD125) is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM). |
|
T16401 |
Org-12962
|
|
5-HT Receptor
|
|
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptor... |
|
T12489L |
Pimethixene maleate
|
Pimetixene maleate |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... |
|
T23168 |
PNU 22394 hydrochloride
|
|
5-HT Receptor
|
|
PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist |
|
T12489 |
Pimethixene
|
Calmixen,Pimetixene |
Dopamine Receptor
,
5-HT Receptor
,
AChR
,
Histamine Receptor
|
|
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... |
|
T28680 |
SB-215505
|
|
|
|
SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats. |
|
T13110 |
Tedatioxetine hydrobromide
|
Lu AA 24530 hydrobromide |
Dopamine Receptor
,
5-HT Receptor
,
Norepinephrine
|
|
Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depress... |
|
T15414 |
GR 113808
|
GR-113808 |
5-HT Receptor
|
|
GR 113808 is a selective 5-HT4 receptor antagonist that inhibits 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT3 receptors and attenuates morphine-stimulated dopamine release in the rat striatum.CAS 번호12483-87-86-1 |
|
T19680 |
Zotepine
|
|
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second... |
|
T22987 |
MK 212 hydrochloride
|
|
5-HT Receptor
|
|
MK 212 hydrochloride is a 5-HT2C receptor agonist |
|
T23631 |
Adatanserin
|
WY-50324,WY 50324,WAY SEB 324,WY50324 |
5-HT Receptor
|
|
Adatanserin (WY 50324) is a mixed 5-HT1A receptor partial agonist and a 5-HT2A and 5-HT2C receptor antagonist with potential neuroprotective activity for the study of anxiety and depression. |
|
T12565 |
PRX933 hydrochloride
|
BVT-933 hydrochloride,GW876167 hydrochloride |
5-HT Receptor
|
|
PRX933 hydrochloride (GW876167 hydrochloride) is an agonist of 5-HT2C receptor and can be used in studies about hypertension acute treatment. |
|
T60523 |
Agomelatine hydrochloride
|
S-20098 hydrochloride |
MT Receptor
|
|
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, r... |
|
T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
|
T50039 |
3-(2-aminopropyl)phenol hydrochloride
|
|
Others
|
|
3-(2-aminopropyl)phenol hydrochloride is a phenethylamine analog used as a molecular structural unit. It is a psychoactive drug that is a partial agonist at several serotonin receptors, including 5-HT1A, 5-HT1B, and 5-HT... |
|
T37816 |
SB 243213
|
|
5-HT Receptor
|
|
SB 243213 is an orally available and selective 5-HT2C receptor antagonist.SB 243213 has anxiolytic and antidepressant activity and is used in schizophrenia and movement disorders. |
|
T0445L |
Promethazine hydrochloride
|
Promethazine HCl,Phenergan |
Adrenergic Receptor
,
Histamine Receptor
|
|
Promethazine hydrochloride (Promethazine HCl) , the first-generation antihistamine, is a strong antagonist of the H1 receptor and a moderate antagonist of the mACh receptor, moderate affinity for 5-HT2A, 5-HT2C, D2 and α... |
|
T50011 |
(2-methylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amine
|
|
Others
|
|
(2-methylpropyl)({[3-(trifluoromethyl)phenyl]methyl})amine is a selective serotonin receptor agonist that specifically targets 5-HT2A and 5-HT2C receptors. It has been used to study the role of serotonin in a variety of ... |
|
T50111 |
6-Fluorotryptamine hydrochloride
|
|
Others
|
|
6-Fluorotryptamine hydrochloride is a compound used as a molecular structural unit and is a derivative of the natural tryptamine alkaloid serotonin. It is an agonist at 5-HT2A and 5-HT2C serotonin receptors, making it a ... |
|
T23265 |
RS 67333 hydrochloride
|
RS 67333 (hydrochloride),RS 67333 HCl |
5-HT Receptor
|
|
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, inclu... |
|
T7498 |
Eltoprazine hydrochloride
|
DU 28853 hydrochloride |
5-HT Receptor
|
|
Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively). |
|
T4118 |
SB 271046 hydrochloride
|
SB 271046A |
5-HT Receptor
|
|
SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist (pKi values are 9.02-8.92, 6.35, 6.55, 6.27 at 5-HT6, 5-HT1A, 5-HT1D and D3, and 6.05, 5.95, 5.76, 5.73, 5.62, 5.55, 5.41, 5.39, 5.27 and ... |
|
T7277 |
SB 242084
|
SB 242084 dihydrochloride hydrate |
5-HT Receptor
|
|
SB 242084 dihydrochloride hydrate is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor. |
|
T6140 |
SB-334867 free base
|
SB334867A free base,SB-334867,SB 334867,SB334867 |
OX Receptor
|
|
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. |
|
T4369 |
SCH-23390 hydrochloride
|
R-(+)-SCH23390 hydrochloride |
Potassium Channel
,
Dopamine Receptor
,
5-HT Receptor
|
|
SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, and for the D1(Ki=0.2 nM) and D5(Ki=0.3 nM). |
|
T4978 |
Sarpogrelate hydrochloride
|
MCI-9042 |
5-HT Receptor
|
|
Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at ... |
|
TQ0130 |
CP-809101
|
|
5-HT Receptor
|
|
CP-809101 is an effective and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). |
|
T17275 |
YM348
|
|
5-HT Receptor
|
|
YM348 is an effective and orally active 5-HT2C receptor agonist. YM348 also shows a high affinity for the cloned human 5-HT2C receptor (Ki: 0.89 nM). |
|
T1066 |
Ketanserin
|
R41468,Ketanserin tartrate,Ketanserinum |
Potassium Channel
,
5-HT Receptor
,
Autophagy
|
|
Ketanserin (Ketanserinum) is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. Following administration,... |
|
T12859L |
SB 243213 dihydrochloride
|
|
5-HT Receptor
|
|
SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor). |
|
T60325 |
Viloxazine
|
Emovit,Viloxazin |
5-HT Receptor
,
Norepinephrine
|
|
Viloxazine (Viloxazin) (Viloxazin) is a dual-action compound that functions as a norepinephrine reuptake inhibitor and exhibits potent agonistic activity towards 5-HT 2C receptors while acting as an antagonist for 5-HT 2... |
|
T11302 |
Flumexadol
|
|
5-HT Receptor
|
|
Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analg... |
|
T10114 |
3-Hydroxy agomelatine
|
|
5-HT Receptor
|
|
3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM). |
|
T10267 |
Agomelatine (L(+)-Tartaric acid)
|
S-20098 L(+)-Tartaric acid |
5-HT Receptor
|
|
Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonis... |
