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T5524 |
Aurora kinase inhibitor-3
|
Aurora Kinase Inhibitor III |
Aurora Kinase
|
|
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR. |
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T9040 |
Aurora kinase inhibitor-2
|
IUN-70219,Aurora Kinase Inhibitor II |
Aurora Kinase
|
|
Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M). |
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T12010 |
Aurora B inhibitor 1
|
|
Aurora Kinase
|
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|
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T6767 |
TCS7010
|
Aurora A Inhibitor I |
Apoptosis
,
Aurora Kinase
|
|
TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. |
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T10412 |
Aurora inhibitor 1
|
|
Aurora Kinase
|
|
Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase). |
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T23044 |
N,N'-Dicyclohexylurea
|
DCU,1,3-Dicyclohexylurea,NSC 17013,Dicyclohexylurea,Dicyclohexylcarbodiamide,AURORA KA-3582 |
Epoxide Hydrolase
|
|
N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor. |
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T78753 |
Aurora Kinases-IN-4
|
|
Aurora Kinase
|
|
Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM. It demonstrates cell proliferation inhibition in SJSA-1, MDA-MB-231, A549, and HeLa cell lines ... |
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T63773 |
Aurora kinase inhibitor-8
|
|
|
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Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase. |
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T62789 |
Aurora kinase inhibitor-9
|
|
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Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B bipolar kinase inhibitor, acting on Aurora A (IC50: 0.093 μM), Aurora B (IC50: 0.09 μM). broad-spectrum anti-proliferative activity. |
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T82931 |
Aurora A inhibitor 3
|
|
Aurora Kinase
|
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Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-231 cell lines with GI50 values of 0.12 μM and 0.63 μM, respe... |
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T72522 |
Aurora kinase-IN-1
|
|
|
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Aurora kinase-IN-1, a potent aurora kinase inhibitor, modulates cell cycle progression and induces apoptosis by upregulating G1 cell cycle inhibitory proteins (including p21 and p27), elevating G1 progressive cyclin D1, ... |
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T72504 |
Aurora Kinases-IN-3
|
|
|
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Aurora Kinases-IN-3, an orally active inhibitor of AURKB, suppresses AURKB activity by hindering its mitotic localization rather than by inhibiting its phosphorylation of H3 at Ser10. |
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T62484 |
Aurora Kinases-IN-2
|
|
|
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Aurora Kinases-IN-2 (compound 12Aj) is a potent inhibitor of Aurora kinases, acting on Aurora A (IC50: 90 nM) and Aurora B (IC50: 152 nM). Aurora Kinases-IN-2 can be used in cancer research. |
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T63436 |
Aurora A inhibitor 1
|
|
|
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Aurora A inhibitor 1 is a potent and selective Aurora A inhibitor. Aurora A is associated with cancers of multiple histological origins and may exhibit oncogenic activity when overexpressed. aurora A inhibitor 1 exhibits... |
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T62647 |
Aurora A inhibitor 2
|
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|
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Aurora A inhibitor 2 (Compound 16h) is a potent inhibitor of Aurora A kinase (IC50: 21.94 nM). |
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T63853 |
Aurora kinase inhibitor-10
|
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Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects. |
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T60783 |
Aurora/LIM kinase-IN-1
|
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Aurora/LIM kinase-IN-1 (Compound F114) is a potent aurora and lim kinase dual inhibitor. Aurora/LIM kinase-IN-1 inhibits the proliferation and invasion of GBM that may be used in drug development efforts for GBM, further... |
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T62945 |
Aurora A/PKC-IN-1
|
|
|
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Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, θ), acting on AurA (IC50: 6.9 nM) and PKCα (IC50: 16.9 nM). Aurora A/PKC-IN-1 showed anti-proliferative and anti-metastati... |
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T6532 |
Hesperadin
|
|
Influenza Virus
,
Parasite
,
Aurora Kinase
,
Autophagy
|
|
Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo. |
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T1825 |
Reversine
|
|
Aurora Kinase
,
Adenosine Receptor
,
Autophagy
|
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Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM). |
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T21981 |
Phthalazinone pyrazole
|
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Aurora Kinase
|
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Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity. |
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T2611 |
CCT 137690
|
CCT137690 |
Apoptosis
,
Aurora Kinase
|
|
CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM). |
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T6315 |
MLN8054
|
|
Casein Kinase
,
PKA
,
Src
,
Aurora Kinase
|
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MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM. |
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T6338 |
PHA-680632
|
PHA 680632,PHA680632 |
FGFR
,
PLK
,
Aurora Kinase
|
|
PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3. |
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T1886 |
TAK-632
|
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Raf
,
FGFR
,
PDGFR
,
Aurora Kinase
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TAK-632 is a potent pan-Raf inhibitor. |
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T6077 |
ZM-447439
|
|
Apoptosis
,
MEK
,
Src
,
Aurora Kinase
|
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ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect aga... |
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T2471 |
MK-8745
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Apoptosis
,
Aurora Kinase
|
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MK-8745 is a potent and selective Aurora A inhibitor. |
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T6458 |
CYC-116
|
|
VEGFR
,
FLT
,
CDK
,
S6 Kinase
,
Aurora Kinase
|
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CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ... |
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T2709 |
TAK-901
|
TAK901 |
JAK
,
CDK
,
Src
,
Aurora Kinase
|
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TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others. |
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T10215 |
AAPK-25
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Apoptosis
,
PLK
,
Aurora Kinase
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T17267 |
XL228
|
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IGF-1R
,
Bcr-Abl
,
Src
,
Aurora Kinase
|
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XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively). |
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T16359 |
NU6140
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|
CDK
,
Aurora Kinase
|
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NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e... |
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T6126 |
JNJ-7706621
|
JNJ 7706621 |
Apoptosis
,
CDK
,
Aurora Kinase
|
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JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2. |
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T2094 |
Danusertib
|
PHA-739358 |
FGFR
,
Trk receptor
,
c-RET
,
Bcr-Abl
,
Aurora Kinase
,
Autophagy
|
|
Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in ... |
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T8866 |
GW779439X
|
|
Apoptosis
,
Antibacterial
,
CDK
,
Aurora Kinase
|
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GW779439X is an inhibitor of CDK. |
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T41256 |
SP-96
|
|
Aurora Kinase
|
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SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negati... |
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T6785 |
BI-847325
|
|
Apoptosis
,
MEK
,
Aurora Kinase
|
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BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. |
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T64338 |
AKI603
|
AKI 603,AKI-603 |
Aurora Kinase
|
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AKI603 is a novel small molecule inhibitor of Aurora kinase A (AurA)(IC50 = 12.3 nM). AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in l... |
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T6129 |
GSK-1070916
|
GSK-1070916A,GSK1070916 |
Apoptosis
,
Tie-2
,
FLT
,
AMPK
,
Aurora Kinase
|
|
GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex. Phase 1. |
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T35570 |
Chiauranib
|
CS2164 |
c-Fms
,
VEGFR
,
FLT
,
PDGFR
,
c-Kit
,
Aurora Kinase
|
|
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-... |
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T6380 |
AMG 900
|
AMG900,AMG-900 |
p38 MAPK
,
Tyrosine Kinases
,
Aurora Kinase
|
|
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1. |
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T14371 |
Barasertib
|
AZD1152 |
Apoptosis
,
Aurora Kinase
|
|
AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay. |
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T6068 |
MK-5108
|
VX-689,MK5108 |
Aurora Kinase
,
Autophagy
|
|
MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM. |
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T4428 |
CCT241736
|
|
FLT
,
Aurora Kinase
|
|
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica... |
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T2509 |
Tozasertib
|
MK-0457,VX 680 |
Aurora Kinase
,
Autophagy
|
|
Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases. |
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T2341 |
KW-2449
|
KW2449 |
Apoptosis
,
FGFR
,
FLT
,
JAK
,
Bcr-Abl
,
Src
,
c-Kit
,
Aurora Kinase
|
|
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR. |
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TQ0059 |
Ilorasertib
|
ABT-348 |
VEGFR
,
FLT
,
c-RET
,
PDGFR
,
Aurora Kinase
|
|
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: ... |
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T3068 |
AT9283
|
J-504568 |
Apoptosis
,
FLT
,
JAK
,
Bcr-Abl
,
Aurora Kinase
,
Autophagy
|
|
AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I). |
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T2358 |
ENMD-2076
|
|
Apoptosis
,
VEGFR
,
FGFR
,
FLT
,
c-RET
,
PDGFR
,
Src
,
Aurora Kinase
|
|
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα. |
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T2617 |
SNS-314 Mesylate
|
SNS-314 |
Aurora Kinase
|
|
SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor (IC50: 9/31/3 nM). It is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2. |
