|
T8819 |
SU-9516
|
|
CDK
|
|
SU9516 is a selectively potent ATP-competitive inhibitor of CDKs. |
|
T7698 |
BS194
|
|
CDK
|
|
BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor. |
|
T5533 |
MC180295
|
(rel)-MC180295 |
CDK
|
|
MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs. |
|
T5200 |
Indirubin-3'-monoxime
|
Indirubin-3'-oxime |
GSK-3
,
Lipoxygenase
,
CDK
|
|
Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). |
|
T6837 |
Flavopiridol
|
L868275,Alvocidib,NSC 649890 HCl,HMR-1275 |
Apoptosis
,
HIV Protease
,
CDK
,
Autophagy
|
|
Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially foun... |
|
T6177 |
PF-562271 besylate
|
PF-00562271 Besylate |
FAK
,
PYK2
,
CDK
|
|
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, exc... |
|
T21768 |
PF-562271 hydrochloride
|
PF-562271 HCl |
FAK
,
PYK2
,
CDK
|
|
PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other pr... |
|
T2615 |
Flavopiridol hydrochloride
|
Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl |
HIV Protease
,
CDK
,
Autophagy
|
|
Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of ... |
|
T10745 |
CDK9-IN-7
|
|
CDK
|
|
CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM). |
|
T16359 |
NU6140
|
|
CDK
,
Aurora Kinase
|
|
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also e... |
|
T6458 |
CYC-116
|
|
VEGFR
,
FLT
,
CDK
,
S6 Kinase
,
Aurora Kinase
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active against PKA, Akt/PKB, PKC, no effect on GSK-3α/β, CK2, Plk1 ... |
|
T23093 |
NSC 693868
|
|
Others
|
|
CDKs and GSK-3 inhibitor |
|
T71121 |
Milciclib maleate
|
|
|
|
Milciclib maleate is an inhibitor of cyclin-dependent kinases (CDKs) and thropomyosin receptor kinase A (TRKA). |
|
T2653 |
SB1317
|
TG02 |
FLT
,
JAK
,
CDK
|
|
SB1317 (TG02) is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3). |
|
T28532 |
RGB-286147
|
|
|
|
RGB-286147 is a potent, selective, ATP-competitive Cdks inhibitor. |
|
T70707 |
Paullone
|
|
|
|
Paullone is an inhibitor of cyclin-dependent kinases (CDKs). The CDKs are a family of protein kinases that are involved in regulation of the cell cycle. |
|
T16784 |
Roniciclib
|
BAY 1000394 |
CDK
|
|
Roniciclib (BAY 1000394) is a potent pan-CDK inhibitor and a novel oral cytotoxic agent. Roniciclib inhibits the activity of cell-cycle CDKs CDK1, CDK2, CDK3, CDK4, and of transcriptional CDKs CDK7 and CDK9 with IC(50) v... |
|
T41019 |
Histone H1-derived Peptide
|
Histone H1-derived Peptide |
|
|
Histone H1-derived peptide is a phosphopeptide with peptide substrates that consist of a sequence aligned with the optimal recognition motif for cyclin-dependent kinases (CDKs). |
|
T62943 |
ZLWT-37
|
|
|
|
ZLWT-37 is a potent, orally active inhibitor of CDKs, acting on CDK9 (IC50: 0.002 μM) and CDK2 (IC50: 0.054 μM). ZLWT-37 is capable of blocking the cell cycle of HCT116 cells in G2/M phase and apoptosis. |
|
T63362 |
Ulecaciclib
|
|
|
|
Ulecaciclib is an orally active, blood-brain barrier-transparent, cell cycle protein-dependent kinase (CDK) inhibitor that exhibits favorable pharmacokinetic profiles, with ki of 0.62 μM (CDK2/Cyclin A), 3 nM (CDK6/Cycli... |
|
T35696 |
Olomoucine II
|
|
|
|
Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 μM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 μM... |
|
T37065 |
6-Chloro-2-fluoropurine
|
|
|
|
6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the ... |
|
T78906 |
CDK/HDAC-IN-3
|
|
HDAC
|
|
CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28... |
|
T72951 |
CDK4/6-IN-14
|
|
|
|
CDK4/6-IN-14 is a potent, highly selective inhibitor of Cyclin-Dependent Kinases 4 and 6 (CDK4/6), demonstrating inhibition concentrations (IC50s) of 10 nM and 16 nM, respectively. It possesses over 60-fold greater selec... |
|
T83936 |
LL-K9-3
|
|
|
|
LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the... |
