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TP1344 |
Luciferase
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Others
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Luciferase is a flavin-dependent monooxygenase found in bioluminescent bacteria. Luciferase is an invaluable tool for identifying and characterizing functional variants, allowing investigations of gene expression, intrac... |
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T38310 |
Luciferase-IN-1
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Reactive Oxygen Species
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Antibacterial
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Antifungal
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Luciferase-IN-1 is a luciferase inhibitor that can be used to study bacterial and fungal infections. |
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T9943 |
Firefly luciferase-IN-1
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Others
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Firefly luciferase-IN-1 is a 2-benzylidene tetrahydronaphthone derivative and can be used as a firefly luciferase inhibitor in kit. |
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TP1774 |
Luciferase, firefly
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Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles. The enzyme catalyses the oxidation of firefly luciferin, requiring oxygen and ATP. |
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T82398 |
Firefly Luciferase circRNA
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Firefly Luciferase circRNA, originally isolated from Photinus pyralis (Firefly), expresses a luciferase protein and serves as an optimal marker for monitoring and optimizing transfection efficiency; it is also recommende... |
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T82397 |
Firefly Luciferase mRNA(N1-Me-Pseudo UTP)
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Firefly Luciferase mRNA, derived from Photinus pyralis (Firefly), codes for a bioluminescent enzyme widely utilized as a reporter in gene regulation and function analyses. This enzyme facilitates assays pertaining to gen... |
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T1971 |
WAY-262611
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Wnt/beta-catenin
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WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay. |
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T5537 |
IDF-11774
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HIF/HIF Prolyl-Hydroxylase
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HIF
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IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM). |
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T60051 |
VPC-18005
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Others
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VPC-18005 is a luciferase inhibitor. VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain thereby disrupting the ERG binding to DNA. |
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T15030 |
CycLuc1
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Others
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CycLuc1 is a brain penetrant luciferase substrate. CycLuc1 may be a superior BLI substrate as compared to D-luciferin for monitoring tumor growth of intracranial GBM xenografts. |
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T36711 |
FM19G11
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FM19G11,HIF-1alpha/2alpha Inhibitor |
HIF
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FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay). |
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T22374 |
N-(beta-Ketocaproyl)-L-hoMoserine lactone
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N-(β-Ketocaproyl)-L-hoMoserine lactone,N-(Ketocaproyl)-L-homoserine lactone,N-(β-Ketocaproyl)-L-hoMoserine lactone |
Others
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N-(beta-Ketocaproyl)-L-hoMoserine lactone (N-(Ketocaproyl)-L-homoserine lactone) is a component of quorum regulatory sensing and an autoinducer of P. fischeri luciferase. |
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T4139 |
D-Luciferin potassium
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D-Luciferin K Salt,D-Luciferin Potassium Salt |
Others
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D-Luciferin potassium (D-Luciferin K Salt) is a popular bioluminescent substrate of luciferase in the presence of ATP. |
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T22062 |
CCG-100602
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Rho
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Ras
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CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM). |
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T19743 |
D-Luciferin Sodium
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Others
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D-Luciferin Sodium is a heterocyclic light-emitting compound and natural ligand for luciferase used to detect cell activity. The salt form of luciferin dissolves in water or other typical buffers. |
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T14188 |
ALLO-2
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Hedgehog/Smoothened
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Smo
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ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. |
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T8752 |
BAR 501 impurity
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GPCR19
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BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act... |
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T78389 |
Coelenteramine 400a
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Bisdeoxycoelenterazine,Coelenterazine 400a |
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Coelenteramine 400a (Coelenterazine 400a), a Coelenterazine derivative, serves as a substrate for Renilla luciferase (RLuc), facilitating the emission of blue light at 395 nm [1] [2]. This compound alters the bioluminesc... |
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TP1616L |
Hsp70-derived octapeptide acetate
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Hsp70-derived octapeptide acetate(736171-62-3 free base) |
Others
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Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate) is a group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognat... |
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T4486 |
ICRT 14
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Wnt/beta-catenin
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iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity). |
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T68934 |
VT101 free base
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VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect ... |
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T31146 |
CycLuc7
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CycLuc 7,CycLuc-7 |
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CycLuc7 is a cyclic alkylaminoluciferin substrate for firefly luciferase. |
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T31143 |
CycLuc12
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CycLuc-12,CycLuc 12 |
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CycLuc12 is a cyclic alkylaminoluciferin substrate for firefly luciferase. |
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T31145 |
CycLuc3
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Cyc Luc 3,Cyc-Luc-3 |
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CycLuc3 is a type of mutant firefly luciferase variant with enhanced light emission. |
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T71424 |
VT-102 free base
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VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect... |
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T13364 |
YAP/TAZ inhibitor-1
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ROCK
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YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay). |
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T29796 |
AkaLumine
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Aka Lumine |
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Akalumine is a luciferin anemone. When the bioluminescence produced in the reaction with natural firefly luciferase is obtained in the near-infrared wavelength range (λ Max =677 nm). |
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T35891 |
PyCTZ TFA
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PyCTZ TFA, a pyridyl Coelenterazine (CTZ) analog, is an ATP-independent pyridyl substrate of LumiLuc luciferase. It produces intense blue bioluminescence when luciferases are present, making it suitable for aequorin-base... |
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T31144 |
CycLuc2
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CycLuc 2,CycLuc-2 |
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CycLuc2 is a cyclic alkylaminoluciferin substrate for firefly luciferase. CycLuc2 emits 4.7-fold more light than aminoluciferin, and 2.6-fold more light than D-luciferin. |
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T28276 |
OV-potentiator-28
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OV potentiator 28 |
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OV-potentiator-28 is a potentiator of cancer virotherapy. OV-potentiator-28 significantly enhances virus replication-associated luciferase expression, specifically in tumors. |
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T29336 |
2-Bromo-1-decanal
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Decanal-1-14C, 2-bromo-, (R)-,2-Bromo(1-14C)-1-decanal |
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2-Bromo-1-decanal was synthesized as an affinity labeling probe for the aliphatic aldehyde site of Vibrio harveyi luciferase. In the presence of excess amounts of this probe, the inactivation of bacterial luciferase occu... |
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T9026 |
MEISi-2
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Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide |
Others
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MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro. |
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T69241 |
MEISi-1
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MEISi-1 is a novel MEIS inhibitor (MEISi), significantly inhibiting MEIS-luciferase reporters in vitro and inducing murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo. |
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T12916 |
Silvestrol aglycone
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Others
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Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-ca... |
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T39571 |
PyCTZ
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Pyridyl CTZ |
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PyCTZ (Pyridyl CTZ), a pyridyl Coelenterazine (CTZ) analog, functions as an ATP-independent substrate for LumiLuc luciferase, producing intense blue bioluminescence when combined with luciferases. This compound is also a... |
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T19167 |
8pyDTZ
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Others
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T37027 |
MHAPC-Chol
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MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also b... |
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T81381 |
PROTAC eDHFR Degrader-1
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PROTACs
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PROTAC eDHFR Degrader-1 is a potent degrader targeting eDHFR-YFP and various proteins of interest (POIs), such as YFP and Luciferase [1]. |
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T82697 |
Coelenteramide
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Coelenteramide, an oxidative derivative of Coelenterazine, forms a complex with apoAequorin/Ca2+ known as blue fluorescent protein (BFP), exhibiting continuous, weak luminescence analogous to luciferase. It serves as an ... |
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T80539 |
[Ala28]-β Amyloid(25-35)
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β(25-35)KA |
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[Ala28]-β Amyloid(25-35) (β(25-35)KA), an electrically neutral mutant variant of Aβ(25-35), facilitates the accelerated aggregation of Firefly Luciferase [1]. |
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T78413 |
ETZ
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C3-CA-DTZ |
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ETZ (C3-CA-DTZ) represents a promising luciferase substrate (prosubstrate) that, upon activation by nonspecific esterase in vivo, facilitates enhanced delivery of luciferin to the brain [1]. |
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T37035 |
HAPC-Chol
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HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also bee... |
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T64182 |
HP590
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HP590 is a novel, potent, orally active STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). HP590 has an anti-proliferative effect on gastric cancer cells and induces apoptosis. |
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T79182 |
PPARγ agonist 8
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PPAR
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PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator response element (PPRE)-luciferase activity with an effective con... |
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T40100 |
D-Luciferin 6′-methyl ether
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6′-Methoxyluciferin,D-Luciferin 6′-methyl ether |
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D-Luciferin 6′-methyl ether (also known as 6′-Methoxyluciferin or compound 19a) is a highly effective inhibitor of luciferase obtained from the North American firefly Photinus pyralis (referred to as PpyLuc). It exhibits... |
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T78419 |
LucPpy-IN-1
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LucPpy-IN-1 (compound 9) is an inhibitor of ATP-dependent luciferase from Photinus pyralis (lucPpy), exhibiting an IC50 value of 4.0 μM. It is utilized in research to assess the druggability [1] of the target enzyme. |
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T38223 |
N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
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N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate. It has an EC50 value of 698 nM for the peroxis... |
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T37092 |
20-HEPE
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20-HEPE is a metabolite of eicosapentaenoic acid that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. It activates peroxisome proliferator-activated receptor α (PPARα) in CO... |
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T81342 |
PyCTZ hydrochloride
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Pyridyl CTZ hydrochloride |
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PyCTZ (Pyridyl CTZ) hydrochloride, a pyridyl Coelenterazine (CTZ) analog, serves as an ATP-independent substrate for LumiLuc luciferase, producing intense blue bioluminescence when used with luciferases. This compound is... |
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T36868 |
4-oxo Docosahexaenoic Acid
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4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF,... |
