|
T63597 |
RXR antagonist 2
|
|
|
|
RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases. |
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T63415 |
RXR antagonist 1
|
|
|
|
RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes. |
|
T23383 |
SR11237
|
SR 11237 |
Others
,
RAR/RXR
|
|
SR11237 is a Pan retinoid X receptor (RXR) agonist. SR11237 causes RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element. |
|
T22843 |
HX 531
|
|
Retinoid Receptor
|
|
RXR antagonist |
|
T6410 |
Bexarotene
|
Ro 26-4455,Targretin,LGD1069 |
Retinoid Receptor
,
Autophagy
|
|
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL). |
|
TQ0097 |
AGN 193109
|
|
Retinoid Receptor
,
Autophagy
|
|
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ). |
|
T17209 |
UVI 3003
|
|
Retinoid Receptor
,
Autophagy
|
|
UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits Xenopus and human RXRα in Cos7 cells (IC50s: 0.22 and 0.24 μM, respectively). |
|
T3955 |
AR7
|
|
Retinoid Receptor
|
|
AR7 is a retinoic acid receptor α (RARα) antagonist. |
|
T5341 |
WYC-209
|
WYC209 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR). |
|
T7586 |
Trifarotene
|
CD5789 |
Retinoid Receptor
,
Autophagy
|
|
Trifarotene (CD5789) is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the RARγ (EC50=7.7 nM) over RARα (EC50=500 nM) and RARβ (EC50=125 nM). |
|
TQ0064 |
Peretinoin
|
NIK333 |
HCV Protease
,
Retinoid Receptor
,
S1P Receptor
,
Autophagy
|
|
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR. |
|
T7370 |
Talarozole
|
R115866 |
Others
,
P450
,
Retinoid Receptor
,
Autophagy
|
|
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.Talarozole for the treatment of... |
|
T6696 |
Tazarotene
|
Tazorac,AGN 190168,Zorac |
Retinoid Receptor
,
Autophagy
|
|
Tazarotene (Zorac) is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiati... |
|
T1093 |
Adapalene
|
CD271 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
Adapalene (CD271) is a dual RAR and RXR agonist, utilized in the treatment of skin conditions. |
|
T11844 |
LG-100064
|
|
Retinoid Receptor
,
Autophagy
|
|
LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ) |
|
T4538 |
Palovarotene
|
Ro 3300074,R 667 |
Retinoid Receptor
,
Autophagy
|
|
Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ). |
|
T6694 |
Tamibarotene
|
NSC 608000,Am 80,Amnolake |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. |
|
T21314 |
Amsilarotene
|
TAC-101,TAC 101,TAC101 |
CDK
|
|
Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cy... |
|
T5843 |
Tarenflurbil
|
MPC7869,(R)-Flurbiprofen,R-flurbiprofen |
Retinoid Receptor
,
Autophagy
|
|
Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease. |
|
T1872 |
Fenretinide
|
4-HPR,MK-4016,4-hydroxy(phenyl)retinamide |
Retinoid Receptor
,
Autophagy
|
|
Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities. |
|
T21714 |
BMS453
|
BMS 453,BMS-189453 |
Retinoid Receptor
|
|
BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ. |
|
T11847L |
Liarozole
|
R75251 dihydrochloride |
P450
,
Retinoid Receptor
|
|
Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1... |
|
T5854 |
AM580
|
NSC608001,CD336,Ro 40-6055 |
Retinoid Receptor
,
Autophagy
|
|
AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM ) |
|
T4371 |
CD437
|
AHPN,O-Desmethyl Adapalene,Apoptosis Activator VI |
Retinoid Receptor
,
Autophagy
|
|
CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist. |
|
T0499 |
Oxybenzone
|
KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone. |
|
T1288 |
TTNPB
|
AGN191183,Arotinoid acid,Ro 13-7410,AGN-191183,Ro 13-7410 |
Apoptosis
,
Retinoid Receptor
,
Autophagy
|
|
TTNPB (Ro 13-7410,AGN-191183), a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), β (IC50: 4.5 nM), and γ (IC50: 9.3 nM), respectively. |
|
T15811 |
LY2955303
|
|
Others
,
Retinoid Receptor
|
|
LY2955303 is an effective and selective retinoic acid receptor gamma (RARγ) antagonist (Ki: 1.09 nM). |
|
T29017 |
TrxR1-IN-B19
|
TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015 |
Others
|
|
TrxR1-IN-B19 (TrxR1 IN B19), a TrxR1 inhibitor, selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. |
|
T62021 |
TrxR-IN-2
|
|
|
|
TrxR-IN-2 is a potential thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 has research value in the chemotherapy of drug-resistant hepatocellular carcinoma. |
|
T78781 |
TrxR1-IN-1
|
|
|
|
Compound 5j, also known as TrxR1-IN-1, is a TrxR1 inhibitor with an IC50 of 8.8 μM. It exhibits anticancer activity, demonstrating IC50 values of 1.5 μM in MCF-7, 1.7 μM in HeLa, 2.4 μM in BGC-823, 2.8 μM in SW-480, and ... |
|
T60453 |
TrxR-IN-3
|
|
|
|
TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and l... |
|
T61647 |
TrxR-IN-5
|
|
|
|
TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. A... |
|
T73254 |
TrxR-IN-4
|
|
|
|
Compound 1b (TrxR-IN-4) is a potent TrxR inhibitor that activates endoplasmic reticulum stress (ERS) to induce apoptosis in HepG2 cells and mitigates CCl4-induced liver damage in vivo through TrxR expression down-regulat... |
|
T29018 |
TrxR inhibitor D9
|
D9,TrxR-IN-D9 |
|
|
TrxR-IN-D9 is a novel inhibitor of thioredoxin reductase (TrxR). |
|
T14912 |
CD3254
|
|
Retinoid Receptor
|
|
CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation. |
|
T11303 |
Fluorobexarotene
|
|
Retinoid Receptor
|
|
Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RX... |
|
T77499 |
MSU-42011
|
|
NOS
,
Retinoid Receptor
,
NO Synthase
,
PERK
,
Lipid
|
|
MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist.MSU-42011 potently inhibits the expression of iNOS, low SREBP-induced and activated RXR, and p-ERK at the protein level.MSU-42011 has demonstrated anti... |
|
T63042 |
NDB
|
|
FXR
|
|
NDB is a selective and potent hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions and FXRα target gene expression in primary mouse hepatocytes.NDB is used in the study of diabetes. |
|
T16425 |
PA452
|
|
Retinoid Receptor
,
RAR/RXR
|
|
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development. |
|
TP1313L |
Cecropin B acetate
|
Cecropin B acetate(80451-05-4 Free base) |
P450
,
Retinoid Receptor
,
Parasite
|
|
Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the PXR/retinoid X receptor alpha (RXR-α) complex with DNA sequences. Cecropin B acetate exhibits strong antimicrobial a... |
|
T21497 |
9-cis-Retinoic Acid
|
Alitretinoin |
Apoptosis
|
|
9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can... |
|
T22924 |
LG 101506
|
|
Others
|
|
RXR modulator |
|
T32107 |
HX-603
|
HX 603 |
|
|
HX-603 is a selectivity agonist of RXR that inhibits the activation of RAR-RXR heterodimers as well as RXR homodimers. |
|
T70440 |
AGN-191659
|
|
|
|
AGN-191659 is a Retinoid X Receptor (RXR) pan-agonist. RXR pan-agonists have been shown to modulate endothelial cell proliferation. |
|
T22844 |
HX 630
|
|
Others
|
|
RXR agonist |
|
T15748 |
LG100754
|
UVI 2112 |
PPAR
|
|
LG100754 (UVI 2112) is an insulin sensitizer that functions through RXR. LG100754 is an RXR dimer modulator. LG100754 acts as an RXR: RXR homodimer antagonist, but functions as an agonist towards RXR: PPARα and RXR: PPAR... |
|
T35159 |
XCT0135908
|
XCT 0135908,XCT-0135908 |
|
|
XCT0135908 is a selectivity agonist of RXR -Nurr1 over a broad range of other RXR dimerization partners but with a rather low potency. |
|
T70237 |
HX-600
|
|
|
|
HX-600 is a synthetic agonist for the RXR-Nurr1 heterodimer complex. HX-600 prevents ischemia-induced neuronal damage. |
|
T19703 |
LG100268
|
LG 100268,LG-100268 |
|
|
LG100268 is an effective and selective rexinoid and retinoid-X receptor agonist. LG100268 binds to the α, β, and γ RXR receptors (IC50 = 3-4 nM). |
|
T10528 |
Bexarotene D4
|
LGD1069 D4 |
Others
|
|
Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma. |
