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Search Results for " arrhythmias "

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59

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10

天然化合物

カタログ番号 製品名 別名 ターゲット
T13573 Arrhythmias-Targeting Compound 1 Others
Arrhythmias-Targeting Compound 1 is a compound. It is used in the research of arrhythmias.
T8391 Cesium chloride CsCl Potassium Channel
Cesium chloride (CsCl) is considered to be the most toxic of the alkali chlorides, inhibiting fungal growth.
T20898 (R)-Propranolol hydrochloride Dexpropranolol hydrochloride,(R)-(+)-Propranolol Adrenergic Receptor
(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antag...
T1496 Amiodarone hydrochloride Amiodar,Amiodarone HCl,Nexterone Potassium Channel , Adrenergic Receptor , Autophagy
Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C...
T15207 Eleclazine hydrochloride GS 6615 hydrochloride Sodium Channel
Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
T1320 Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium Potassium Channel , Sodium Channel , AChR
Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the h...
T24021 E 0747 E 747,L 29065,E0747,E-0747 Sodium Channel
E 0747 (E0747) is a new antiarrhythmic compound that inhibits arrhythmias by inhibiting Na channels in cardiac cells.
T7477 Antazoline Others
Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias.
T29050 UK 66914 UK66914,UK-66914 Potassium Channel
UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.
T7386 Bretylium tosylate Others
Bretylium tosylate is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters, a available antiarrhythmic drug for ventricular arrhythmias.
T28686 SB-237376 HCl SB-237376 hydrochloride Calcium Channel , Sodium Channel
SB-237376 HCl (SB-237376 hydrochloride) is a calcium and potassium channel antagonist used in the treatment of cardiac arrhythmias.
T7827 Glycyrrhizinic acid, potassium salt Others
Glycyrrhizinic acid, potassium salt can reduce ventricular arrhythmias caused by veratrol
T30520 BMS-394136 BMS394136,BMS 394136,BMS394136;UNII-M694U7167K Potassium Channel
BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.
T28686L SB-237376 Calcium Channel , Sodium Channel
SB-237376 is a calcium and potassium channel antagonist used to treat cardiac arrhythmias.
T27630 Isbogrel CV4151,CV-4151,CV 4151 Prostaglandin Receptor
Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks and thrombosis.
T11239 Ethacizine hydrochloride NIK-244,Ethacizin,NIK-244 hydrochloride Sodium Channel
Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.
T28748 Selodenoson RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009 Adenosine Receptor
Selodenoson (RG-14202) is a selective adenosine A1 receptor agonist used to slow the heart rate in patients with atrial fibrillation and to treat arrhythmias.
T31213L Dazmegrel HCl UK-38,485 HCl,Dazmegrel HCl(76894-77-4 Free base) Prostaglandin Receptor
Dazmegrel HCl is a platelet thromboxane inhibitor used in the study of myocardial infarction and arrhythmias.
T25701 Levosemotiadil SD 3212,SA 3212 LDL , Calcium Channel
Levosemotiadil(SA 3212) is a novel calcium antagonist and a very potent inhibitor of low-density lipoprotein oxidation.Levosemotiadil may be used to prevent lethal cardiac arrhythmias.
T68038 Celivarone Potassium Channel
Celivarone is a potassium channel blocker used in the study of arrhythmias, atrial flutter and atrial fibrillation.
T32155 Indecainide Ricainide,Ricainid,Decabid,Indecainidum,Indecainida Others
Indecainide (Ricainid) is a novel antiarrhythmic compound that is carcinogenic and can be used to study chronic stable ventricular arrhythmias secondary to coronary artery disease or cardiomyopathy.
T6955 Propafenone hydrochloride Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,Rythmol Sodium Channel
Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.
T23536 Xamoterol hemifumarate ICI 118587 hemifumarate,Corwin hemifumarate Adrenergic Receptor
Xamoterol hemifumarate is a potent and selective β1-adrenoceptor agonist.Xamoterol hemifumarate is a potential compound for the study of the relationship between cardiac arrhythmias and β1-adrenergic stimulation with IKr...
T77550 O-Desmethyl Quinidine Others
O-Desmethyl Quinidine is a novel quinidine analog with significant antiarrhythmic activity and low acute toxicity that may be useful in the treatment of cardiac arrhythmias.
T30586L Brefonalol HCl Brefonalol HCl(103880-26-8 Free base) Adrenergic Receptor
Brefonalol HCl is an ADRA antagonist used in the treatment of neurological disorders and cardiovascular diseases and can be used in the study of angina pectoris, arrhythmias and hypertension.
T68164 Tolamolol Adrenergic Receptor
Tolamolol is a selective β-adrenergic blocker that significantly reduces the degree of exercise-induced inhibition of the S-T segment and can be used in the treatment of cardiac arrhythmias.
T0112L Diltiazem Diltiazem free base,Dilticard,CRD-401,CRD401,Dilzen,CRD 401
Diltiazem is a non-dihydropyridine (non-DHP) calcium channel blocker that relaxes the smooth muscle in arterial walls, thus opening (dilating) arteries, allowing easier blood flow, and lowering blood pressure, and is use...
T83979 Sulcardine 2HCl Sulcardine 2HCl(343935-60-4 Free base),HBI-3000 2HCl HER , Sodium Channel
Sulcardine 2HCl is a multi-ion channel blocker with antiarrhythmic effects that blocks the properties of hERG and hNav1.5 channels and can be used to study atrial fibrillation and ventricular arrhythmias.
T60322 Procainamide Biocoryl,Novocainamide DNA Methyltransferase
Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmia...
T1282 Carteolol hydrochloride Arteoptic,Abbott-43326,OPC-1085 hydrochloride,Carteolol HCl,Mikelan Adrenergic Receptor
Carteolol hydrochloride (Abbott-43326) is a synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-s...
T30251 AZD-1305 UNII-CZO834LXQM,AZD 1305 Others
AZD-1305 is a novel anti-arrhythmic compound that primarily blocks the fast component of IKr, l-type calcium currents and intra-ward sodium currents in mammalian cells and ventricular cardiomyocytes and can be used in st...
T1012 Acebutolol hydrochloride Acebutolol HCl Adrenergic Receptor
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydro...
T20656 Verapamil NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil P450 , Calcium Channel , P-gp
Verapamil (CP-16533-1) is a non-dihydropyridine calcium channel blocker, a P-gp inhibitor, and a CYP3A4 inhibitor with oral activity. Verapamil can be used for the treatment of hypertension, angina pectoris, and myocardi...
T0866 Propafenone Rythmol,Propafenonum Potassium Channel , MRP , Sodium Channel
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....
T40777 Encainide Encainide,MJ9067
Encainide (MJ9067), a class IC antiarrhythmic drug, holds potential for research into life-threatening and symptomatic ventricular arrhythmias as well as supraventricular arrhythmias.
T30551 BN 52256 BN52256,BN-52256
BN 52256 helps reduce arrhythmias.
T19887 Teflurane Abbott-16900,Tefluranum,Abbott 16900,Teflurano
Teflurane is a halocarbon drug, Teflurane was investigated as an inhalational anesthetic, a high incidence of cardiac arrhythmias in patients, similarly to the cases of halopropane and norflurane.
T5336L Zacopride Racemic zacopride
Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias.
T69472 Edrophonium
Edrophonium is a rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles.
T26136 RS 2135 RS2135,RS-2135
RS 2135 is a novel class I antiarrhythmic agent to inhibit ischemia-induced ventricular arrhythmias.
T30861 CH 200 CH-200,CH200,06-14C
CH 200 is a novel antiarrhythmic drug that inhibits arrhythmias in beagles more effectively than procainamide and lidocaine.
T28130 Naltiazem RO 236152,RO-236152,RO236152
Naltiazem, a calcium channel antagonist, is used potentially for the treatment of arrhythmias, hypertension and myocardial infarction.
T83102 Antiarrhythmic peptide (cattle atrium)
Antiarrhythmic peptide (cattle atrium), a hexapeptide, exhibits a protective effect against arrhythmias induced by experimental agents [1].
T23619 Acodazole NSC 305884,NSC305884,NSC-305884
Acodazole is a synthetic imidazoquinoline. It has antimicrobial and antineoplastic properties. It also has been shown to treat arrhythmias.
T63330 Clamikalant sodium
Clamikalant sodium is a non-selective, ATP-sensitive potassium (KATP) channel blocker that can be used to study cardiac arrhythmias.
T72323 Antiarrhythmic agent-1
Antiarrhythmic agent-1 (example I), functioning as an antiarrhythmic agent and an IKr potassium channel blocker (IC 50 <1 μM), effectively inhibits cardiac arrhythmias.
T26875 BN 50739 BN50739,BN-50739
BN 50739 is an antagonist of platelet-activating factor (PAF). BN 50739 suppresses certain cardiac arrhythmias. PAF is released from ischaemic myocardium and may contribute to initiation of ischaemia-induced ventricular ...
T21373 Aprindine hydrochloride Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil
Aprindine HCl is a Class 1b antiarrhythmic agent used to manage ventricular and supraventricular arrhythmias. In one study, it delayed atrial fibrillation more than digoxin did. It has shown effectiveness when given oral...
T1271 Pronetalol
Pronethalol ((±)-Pronethalol), a non-selective β-adrenergic antagonist, effectively inhibits Sox2 expression and offers protection against Digitalis-induced ventricular arrhythmias. Additionally, it can reverse such arrh...
T31119 CVT-2759 UNII-42E8N8RC9Z,CVT2759
CVT-2759 is A potential partial agonist for A(1)-ADORs, and it may be useful to slow atrioventricular node conduction to reduce ventricular rate without causing the atrioventricular block, bradycardia, atrial arrhythmias...

Compounds

Arrhythmias-Targeting Compound 1
T13573
Synonym:
Target: Others
Cesium chloride
T8391
Synonym: CsCl
Target: Potassium Channel
(R)-Propranolol hydrochloride
T20898
Synonym: Dexpropranolol hydrochloride,(R)-(+)-Propranolol
Target: Adrenergic Receptor
Amiodarone hydrochloride
T1496
Synonym: Amiodar,Amiodarone HCl,Nexterone
Target: Potassium Channel, Adrenergic Receptor, Autophagy
Eleclazine hydrochloride
T15207
Synonym: GS 6615 hydrochloride
Target: Sodium Channel
Disopyramide
T1320
Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium
Target: Potassium Channel, Sodium Channel, AChR
E 0747
T24021
Synonym: E 747,L 29065,E0747,E-0747
Target: Sodium Channel
Antazoline
T7477
Synonym:
Target: Others
UK 66914
T29050
Synonym: UK66914,UK-66914
Target: Potassium Channel
Bretylium tosylate
T7386
Synonym:
Target: Others
SB-237376 HCl
T28686
Synonym: SB-237376 hydrochloride
Target: Calcium Channel, Sodium Channel
Glycyrrhizinic acid, potassium salt
T7827
Synonym:
Target: Others
BMS-394136
T30520
Synonym: BMS394136,BMS 394136,BMS394136;UNII-M694U7167K
Target: Potassium Channel
SB-237376
T28686L
Synonym:
Target: Calcium Channel, Sodium Channel
Isbogrel
T27630
Synonym: CV4151,CV-4151,CV 4151
Target: Prostaglandin Receptor
Ethacizine hydrochloride
T11239
Synonym: NIK-244,Ethacizin,NIK-244 hydrochloride
Target: Sodium Channel
Selodenoson
T28748
Synonym: RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009
Target: Adenosine Receptor
Dazmegrel HCl
T31213L
Synonym: UK-38,485 HCl,Dazmegrel HCl(76894-77-4 Free base)
Target: Prostaglandin Receptor
Levosemotiadil
T25701
Synonym: SD 3212,SA 3212
Target: LDL, Calcium Channel
Celivarone
T68038
Synonym:
Target: Potassium Channel
Indecainide
T32155
Synonym: Ricainide,Ricainid,Decabid,Indecainidum,Indecainida
Target: Others
Propafenone hydrochloride
T6955
Synonym: Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,Rythmol
Target: Sodium Channel
Xamoterol hemifumarate
T23536
Synonym: ICI 118587 hemifumarate,Corwin hemifumarate
Target: Adrenergic Receptor
O-Desmethyl Quinidine
T77550
Synonym:
Target: Others
Brefonalol HCl
T30586L
Synonym: Brefonalol HCl(103880-26-8 Free base)
Target: Adrenergic Receptor
Tolamolol
T68164
Synonym:
Target: Adrenergic Receptor
Diltiazem
T0112L
Synonym: Diltiazem free base,Dilticard,CRD-401,CRD401,Dilzen,CRD 401
Target:
Sulcardine 2HCl
T83979
Synonym: Sulcardine 2HCl(343935-60-4 Free base),HBI-3000 2HCl
Target: HER, Sodium Channel
Procainamide
T60322
Synonym: Biocoryl,Novocainamide
Target: DNA Methyltransferase
Carteolol hydrochloride
T1282
Synonym: Arteoptic,Abbott-43326,OPC-1085 hydrochloride,Carteolol HCl,Mikelan
Target: Adrenergic Receptor
AZD-1305
T30251
Synonym: UNII-CZO834LXQM,AZD 1305
Target: Others
Acebutolol hydrochloride
T1012
Synonym: Acebutolol HCl
Target: Adrenergic Receptor
Verapamil
T20656
Synonym: NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil
Target: P450, Calcium Channel, P-gp
Propafenone
T0866
Synonym: Rythmol,Propafenonum
Target: Potassium Channel, MRP, Sodium Channel
Encainide
T40777
Synonym: Encainide,MJ9067
Target:
BN 52256
T30551
Synonym: BN52256,BN-52256
Target:
Teflurane
T19887
Synonym: Abbott-16900,Tefluranum,Abbott 16900,Teflurano
Target:
Zacopride
T5336L
Synonym: Racemic zacopride
Target:
Edrophonium
T69472
Synonym:
Target:
RS 2135
T26136
Synonym: RS2135,RS-2135
Target:
CH 200
T30861
Synonym: CH-200,CH200,06-14C
Target:
Naltiazem
T28130
Synonym: RO 236152,RO-236152,RO236152
Target:
Antiarrhythmic peptide (cattle atrium)
T83102
Synonym:
Target:
Acodazole
T23619
Synonym: NSC 305884,NSC305884,NSC-305884
Target:
Clamikalant sodium
T63330
Synonym:
Target:
Antiarrhythmic agent-1
T72323
Synonym:
Target:
BN 50739
T26875
Synonym: BN50739,BN-50739
Target:
Aprindine hydrochloride
T21373
Synonym: Fiboran,Amidonal,Aprinidine,Aprindin,Aprindine HCl,Aprindina,Fibocil
Target:
Pronetalol
T1271
Synonym:
Target:
CVT-2759
T31119
Synonym: UNII-42E8N8RC9Z,CVT2759
Target:
1 2
カタログ番号 製品名 別名 ターゲット
T41358 2-Hydroxybenzylamine Others
2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial a...
T8183 Deslanoside Desacetyllanatoside C,Deacetyllanatoside C ATPase , Drug Metabolite
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane p...
T5S1099 Liensinine Apoptosis , Mitophagy , Others , Autophagy
1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.
T5212 Trilinolein Glycerol trilinoleate,1,2,3-Trilinoleoylglycerol Antioxidant , Endogenous Metabolite
Trilinolein (1,2,3-Trilinoleoylglycerol) is a triacylglycerol and has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. I...
T5645 Nerol Cis-Geraniol,Neryl alcohol Apoptosis , Reactive Oxygen Species , Mitochondrial Metabolism , Endogenous Metabolite , Antifungal
Nerol (Neryl alcohol) is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian heart.
T2973 Astragaloside IV AST-IV,AS-IV MMP , ERK , Estrogen/progestogen Receptor , JNK
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...
T2S2215 Crebanine Apoptosis , Others , Akt
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...
TMA0763 Methyl 3,4,5-trimethoxycinnamate Potassium Channel , Calcium Channel
Methyl 3,4,5-trimethoxycinnamate may protect the heart from arrhythmias via its inhibitory effect on calcium channel.
TN1875 Liriodenine BCL , Caspase , p53
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial isch...
TN4616 N-Methyltaxol C Others
N-methyltaxol C and paclitaxel can produce a positive inotropic effect in papillary muscle, without alterations in the action potential. They can induced conduction arrhythmias and reduce coronary flow and left ventricul...