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T14981 |
Clobetasone butyrate
|
|
Glucocorticoid Receptor
|
|
Clobetasone butyrate, a synthetic glucocorticoid with topical anti-inflammatory activity, is effective in treating corticosteroid-responsive dermatoses, such as atopic dermatitis and psoriasis, especially within skin tis... |
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T27172 |
Difamilast
|
|
PDE
|
|
Difamilast is an inhibitor of phosphodiesterase IV. |
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T7893 |
Bepotastine
|
Bepotastine free base |
Others
,
Histamine Receptor
|
|
Bepotastine (Bepotastine free base) free base is a histamine 1 (H1) receptor antagonis. |
|
T6405 |
Bepotastine Besilate
|
Talion,TAU 284,Bepreve,Bepotastine Beslilate |
Histamine Receptor
|
|
Bepotastine Besilate (TAU 284) is a non-sedating and selective H1 receptor antagonist (pIC50: 5.7). |
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T4966 |
Ufenamate
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Flufenamic acid butyl ester,Butyl flufenamate |
Others
|
|
Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases |
|
T1090 |
Perphenazine
|
Perphenazin,Etaperazine,Trilafon |
CaMK
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
|
T2648 |
Pimecrolimus
|
SDZ-ASM 981,ASM 981 |
Others
|
|
Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri... |
|
T0891 |
Dapsone
|
DDS,4,4‘-Sulfonyldianiline,Bis(4-aminophenyl) sulfone,Sulphadione,4,4'-Diaminodiphenylsulfone,4-Aminophenyl sulfone |
Reactive Oxygen Species
,
Antibacterial
,
Antibiotic
,
Parasite
|
|
Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. |
|
T16792 |
Rovazolac
|
ALX-101 |
Liver X Receptor
|
|
Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis. |
|
T31645 |
EO-1606
|
EO1606,EO 1606 |
p38 MAPK
|
|
EO-1606 is a p38MAP kinase inhibitor with anti-inflammatory activity and may be used in studies of Alzheimer;s disease and dermatitis. |
|
T3987 |
Lotamilast
|
E6005,RVT-501 |
PDE
|
|
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis. |
|
T29096L |
Vapitadine
|
R 129160 |
Histamine Receptor
|
|
Vapitadine is a non-sedative antihistamine compound that relieves itching caused by atopic dermatitis. |
|
T25982 |
Pramiconazole
|
R-126638,R126638,R 126638,Azoline |
Antifungal
|
|
Pramiconazole (R126638) is an orally available antifungal compound.Pramiconazole is a candidate for the treatment of dermatophytes and cutaneous yeast infections in seborrheic dermatitis. |
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T83624 |
Selenium sulfide
|
|
Antibiotic
|
|
Selenium sulfide has antimicrobial activity and is commonly used to control dandruff, seborrheic dermatitis and psoriasis. |
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T24755 |
Salnacedin
|
G-201,SCY,G-201,G201,SCY,G 201 |
Others
|
|
Salnacedin (G-201) is a small molecule compound used in the treatment of immune system disorders, skin and musculoskeletal disorders, and can be used in studies of acne vulgaris, dermatitis and psoriasis. |
|
T77369 |
Telazorlimab
|
ISB-830,GBR-830 |
Immunology/Inflammation related
|
|
Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells. Telazorlimab can be used to treat lupus erythematosus and atopic dermatitis. |
|
T75113 |
GLPG2534
|
GLPG-2534 |
IRAK
|
|
GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 inhibits human and mouse IRAK4 and could be used to study psoriasis and atopic dermatitis. |
|
T76775 |
Fezakinumab
|
ILV 094 |
Interleukin
|
|
Fezakinumab is a potent monoclonal antibody to interleukin-22 (IL-22). Fezakinumab can be used to study immune system diseases and inflammation-related conditions such as psoriasis, rheumatoid arthritis and atopic dermat... |
|
T0339 |
Resorcinol monoacetate
|
Resorcin monoacetate |
Others
|
|
Resorcinol monoacetate (Resorcin monoacetate) is an antiseptic and a disinfectant, is a chemical intermediate for the production of many other pharmaceuticals, and can be used to treat acne, seborrheic dermatitis, eczema... |
|
T76724 |
Nemolizumab
|
CIM331 |
Interleukin
|
|
Nemolizumab (CIM331) is a humanized monoclonal antibody against human interleukin-31 receptor A that inhibits the binding and subsequent signal transduction of interleukin-31 (IL-31) to its receptor. Nemolizumab can be u... |
|
T2270 |
Trans-Tranilast
|
Tranilast trans- |
RAAS
|
|
Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993.... |
|
T2392 |
Nafamostat mesylate
|
FUT-175 |
Apoptosis
,
Serine/threonin kinase
,
SARS-CoV
,
Serine Protease
|
|
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. |
|
T0053 |
Hydroxyzine Pamoate
|
Hydroxyzine embonate,Bobsule,Equipose |
Histamine Receptor
|
|
Hydroxyzine Pamoate (Bobsule) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIRIZINE, it does ca... |
|
T0500 |
Chloroxine
|
Capitrol |
Antibacterial
,
Antibiotic
|
|
Chloroxine (Capitrol) is a synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epi... |
|
T76704 |
Tralokinumab
|
CAT-354,LP 0162 |
IL Receptor
|
|
Tralokinumab is a fully human IgG4 monoclonal antibody with a high affinity for IL-13 alone. Tralokinumab's potential anti-inflammatory activity prevents IL-13 receptor interaction and subsequent downstream signaling and... |
|
T13666 |
Dupilumab
|
REGN-668,SAR-231893 |
IL Receptor
|
|
Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and... |
|
T2200 |
Hydroxyzine dihydrochloride
|
Hydroxyzine 2HCl |
Histamine Receptor
|
|
Hydroxyzine dihydrochloride (Hydroxyzine 2HCl) is a histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis, and histamine-mediated pruritus. Unlike its major metabolite CETIR... |
|
T76884 |
Spesolimab
|
BI 655130 |
IL Receptor
|
|
Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the immune system and is associated with a reduction in biomarkers associated with congenital Th1/Th17 and neutrophil p... |
|
T39646 |
Atinvicitinib
|
|
|
|
Atinvicitinib, a pyrazole compound, exhibits promise for investigating atopic dermatitis. |
|
T14154 |
Alclometasone
|
7a-Chloro-16a-methyl prednisolone |
|
|
Alclometasone (7a-Chloro-16a-methyl prednisolone), a glucocorticoid, inhibits leukocytes from releasing pro-inflammatory mediators. It is effective in treating corticosteroid-responsive dermatoses such as atopic dermatit... |
|
T72391 |
Clocortolone pivalate
|
|
|
|
Clocortolone pivalate, a synthetic glucocorticoid corticosteroid and corticosteroid ester, is used to treat seborrheic dermatitis, contact dermatitis, atopic dermatitis, and psoriasis. |
|
T20150 |
C.I. 37505
|
3-Hydroxy-2-naphthanilide,2-Naphthanilide, 3-hydroxy- (8CI) |
|
|
C.I. 37505 is an azo dye coupling component.It implicated in occupational pigmented contact dermatitis. |
|
T26555 |
Acreozast
|
TYB 2285,TYB-2285,TYB2285 |
|
|
Acreozast, a histamine release inhibitor, is used potentially for the treatment of asthma and atopic dermatitis. |
|
T29039 |
UCB-35440
|
UCB 35440,UCB35440 |
|
|
UCB-35440, a 5-lipoxygenase inhibitor and a histamine H1 receptor antagonist, is used potentially for the treatment of dermatitis. |
|
T70974 |
Cipamfylline
|
|
|
|
Cipamfylline is a xanthine, a theophylline analogue, and is a potent and selective inhibitor of phosphodiesterase type 4 (PDE-4). Cipamfylline was tested in patients with a diagnosis of atopic dermatitis and in two human... |
|
T38540 |
BAY 1003803
|
|
|
|
BAY 1003803 is a glucocorticoid receptor agonist for the topical treatment of psoriasis or severe atopic dermatitis. |
|
T35076 |
VTP-766
|
|
|
|
VTP-766 is an effective orally active and selective liver X receptor β (lxrβ) agonist, targeted to treat atopic dermatitis and acute coronary syndrome. |
|
T67202 |
Benvitimod
|
|
|
|
Benvitimod is a non-steroidal anti-inflammatory drug (NSAID) potentially for the treatment of atopic dermatitis. |
|
T21374 |
Clocortolone
|
Clocortolona,Clocortolonum,Cloderm |
|
|
Clocortolone is a Corticosteroid Hormone Receptor Agonist. It is used in the form of an ester, clocortolone pivalate, and applied as a cream. clocortolone pivalate is used to treat dermatitis and is considered a medium-s... |
|
T76679 |
Etokimab
|
|
|
|
Etokimab (Antibody ANB 020), a humanized monoclonal antibody, specifically targets IL-33. It is utilized in the research of atopic dermatitis [1]. |
|
T78333 |
Rocatinlimab
|
AMG 451,KHK4083 |
|
|
Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated IgG1 anti-OX40 monoclonal antibody indicated for atopic dermatitis (AD) research [1]. |
|
T69950 |
Delgocitinib EtOH
|
|
|
|
Delgocitinib, also known as LEO-124249 and JTE052, is a potent and selective JAK inhibitor. JTE-052 reduces skin inflammation and ameliorates chronic dermatitis in rodent models: Comparison with conventional therapeutic ... |
|
T76816 |
Lokivetmab
|
|
|
|
Lokivetmab, an Anti-Canine IL31 Recombinant Antibody, is a monoclonal antibody targeting canine IL-31, utilized in research related to atopic dermatitis (AD) in dogs [1]. |
|
T78207 |
Lepzacitinib
|
|
JAK
|
|
Lepzacitinib, a Janus kinase inhibitor, specifically targets JAK 1/3. It demonstrates an anti-inflammatory effect and efficacy in inhibiting atopic dermatitis as well as other skin diseases [1]. |
|
T78299 |
Amlitelimab
|
KY1005,SAR445229 |
|
|
Alvircept sudotox, an anti-OX40 Ligand (OX40L) monoclonal antibody (mAb), disrupts the OX40-OX40L interaction and is used in atopic dermatitis research [1] [2] [3]. |
|
T71561 |
LEO-29102
|
|
|
|
LEO-29102 is a potent, selective, and soft-drug phosphodiesterase 4 (PDE4) inhibitor, which may be potentially useful for treatment of dermatological diseases. LEO 29102 shows properties suitable for patient-friendly ... |
|
T10210 |
A-9758
|
|
ROR
|
|
A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 s... |
|
T33914 |
Pentaerythrityl tetracaprate
|
Pentaerythritol tetradecanoate,Pentaerythritol tetracaprate |
|
|
Pentaerythrityl tetracaprate is an ester found in cosmetics and beauty products because of its binding and moisturizing properties; it is also used as a viscosity increasing agent. It is a synthetic compound derived from... |
|
T82074 |
Immune cell migration-IN-1
|
|
|
|
Immune cell migration-IN-1 (compound 2) serves as a potent inhibitor of immune cell migration, with potential research applications for mitigating conditions such as dry eye diseases, eczema dermatitis, and psoriasis [1]... |
|
T38002 |
LEO 39652
|
|
|
|
LEO 39652, a dual-soft PDE4 inhibitor, demonstrates potent inhibition of PDE4 subtypes A, B, C, and D with respective IC50 values of 1.2 nM, 1.2 nM, 3.0 nM, and 3.8 nM. Additionally, it inhibits TNF-α with an IC50 of 6.0... |
