|
T7008 |
Vacquinol-1
|
Vacquinol 1 |
JNK
|
|
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death. |
|
T1785 |
Palbociclib
|
PD 0332991 |
CDK
|
|
Palbociclib (PD 0332991) is a CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM) and is orally active. Palbociclib has anti-tumorigenic activity and has investigational potential for use in ER-positive and HER2-ne... |
|
T6481 |
Droxinostat
|
NS 41080 |
Apoptosis
,
HDAC
|
|
Droxinostat (NS 41080) is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inhibition to HDAC1, 2, 4, 5, 7, 9, and 10. |
|
T0334 |
Rosiglitazone
|
BRL49653 |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer. |
|
T22443 |
Triglycidyl isocyanurate
|
Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,TGI |
Apoptosis
|
|
Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alk... |
|
T9945 |
MNK8
|
3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione |
STAT
|
|
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good growth inhibition effect on liver cancer cells [1]. |
|
T6646 |
Rosiglitazone hydrochloride
|
BRL-49653 HCl,Rosiglitazone HCl |
Ferroptosis
,
TRP/TRPV Channel
,
PPAR
,
Autophagy
|
|
Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells. |
|
T6240 |
Palbociclib Isethionate
|
Palbociclib (PD0332991) Isethionate,PD 0332991 isethionate |
CDK
|
|
Palbociclib Isethionate (PD 0332991 isethionate) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. |
|
T6239 |
Palbociclib monohydrochloride
|
PD 0332991 hydrochloride,Palbociclib hydrochloride,Palbociclib (PD-0332991) HCl |
CDK
|
|
Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. |
|
T77440 |
Codrituzumab
|
RG-7686,RO5137382,GC33 |
|
|
Codrituzumab (GC3) is a humanized antibody against the glypican-3 hepatocellular carcinoma protein that can be used in combination with sorafenib to study incurable advanced hepatocellular carcinoma (HCC). |
|
T4368 |
Miriplatin
|
SM-11355 |
DNA Alkylator/Crosslinker
|
|
Miriplatin (SM-11355) (SM-11355) is a platinum complex used in TACE that has promise for the therapy of hepatocellular carcinoma (HCC). |
|
T64529 |
MDL-800
|
MDL 800,MDL800 |
Sirtuin
|
|
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer. |
|
TP1472 |
Tyroserleutide
|
|
Others
|
|
Tyroserleutide (YSL), isolated from the degradation products of porcine spleen, is a small molecular tripeptide which inhibits tumor growth both in vitro and in vivo.Tyroserleutide inhibits the growth and metastasis of h... |
|
T76858 |
Ascrinvacumab
|
PF-03446962 |
ALK
,
TGF-beta/Smad
|
|
Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has an inhibitory effect on TGF-β and can be used to study hepa... |
|
T21297 |
Miriplatin hydrate
|
SM-11355 (hydrate),Miripla,Miriplatin,SM 11355,SM11355,SM-11355,Miriplatin hydrate |
DNA Alkylation
|
|
Miriplatin hydrate (SM-11355 (hydrate)) (MPT) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC). Miriplatin hydrate is a lipophilic platinum complex that can ... |
|
T3226 |
Paritaprevir free base
|
ABT-450,Veruprevir |
HCV Protease
|
|
Paritaprevir free base(ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential acti... |
|
T60277 |
2-Acetamidofluorene
|
|
Others
|
|
2-Acetamidofluorene, a potent carcinogen, is utilized for the induction of hepatocellular carcinoma (HCC) and multiple primary tumors [1] [2]. |
|
T62151 |
CHNQD-01255
|
|
Others
|
|
CHNQD-01255 is an orally active inhibitor of Arf-GEFs that is effective against hepatocellular carcinoma (HCC). |
|
T38977 |
Autophagy-IN-C1
|
Autophagy-IN-C1 |
Others
|
|
Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea. Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells. |
|
T74768 |
Antitumor agent-92
|
|
Apoptosis
|
|
Antitumor Agent-92, an Icaritin derivative, induces G0/G1 phase cell cycle arrest and promotes apoptosis. This compound shows promise for hepatocellular carcinoma (HCC) research [1]. |
|
T62676 |
DS89002333
|
|
Others
|
|
DS89002333 is a potent, orally active PRKACA inhibitor (IC50: 0.3 nM).DS89002333 has shown good antitumor effects in a patient-derived xenograft model of FL-HCC expressing a DNAJB1-PRKACA fusion gene.DS89002333 can be us... |
|
T62704 |
HBV-IN-23
|
|
Others
|
|
HBV-IN-23 (Compound 5k) is an inhibitor of HBV DNA replication (IC50: 0.58 μM). HBV-IN-23 inhibits drug-sensitive and drug-resistant strains. HBV-IN-23 induces apoptosis in HepG2 cells and exhibits anti-hepatocellular ca... |
|
T78819 |
VEGFR-2-IN-33
|
|
VEGFR
|
|
VEGFR-2-IN-33 (Compound 4d), a potent VEGFR inhibitor with an IC50 value of 61.04 nM, demonstrates significant inhibition of HepG2 cell proliferation, achieving an IC50 of 4.31 nM. This compound is utilized for hepatocel... |
|
T68875 |
Xylocydine
|
|
Others
|
|
Xylocydine is a novel Cdk inhibitor, which is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Xylocydine also strongly inhibits the activity of Cdk7 and Cdk9, in vitro as well as... |
|
T68942 |
Caricotamide
|
|
Others
|
|
Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the pro... |
|
T79407 |
HL23
|
|
Others
|
|
HL23 is a histone deacetylase (HDAC) inhibitor that effectively targets hepatocellular carcinoma (HCC). It promotes acetylation at the TXNIP promoter and increases TXNIP expression, which in turn modulates potassium chan... |
|
T61961 |
Pyruvate Carboxylase-IN-2
|
|
Others
|
|
Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC). In cell lysate-based and cell-based PC activity assays, Pyruvate Carbo... |
|
T60341 |
Pyruvate Carboxylase-IN-1
|
|
Others
|
|
Pyruvate Carboxylase-IN-1 (compound 37), a natural analog of erianin, is a potent inhibitor of pyruvate carboxylase (PC), exhibiting inhibitory concentrations (IC50) of 0.204 μM and 0.104 μM in cell lysate-based and cell... |
|
T79271 |
FGFR4-IN-14
|
|
FGFR
|
|
FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutant strains. Specifically, it registers IC50 values of 21 nM aga... |
|
T35573 |
Adenosine 5’-methylenediphosphate (hydrate)
|
|
Others
|
|
Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or ... |
|
T75134 |
MC-GGFG-AM-(10Me-11F-Camptothecin)
|
|
Others
|
|
MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD... |
