|
T3934 |
Isavuconazonium sulfate
|
|
Antifungal
|
|
Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh... |
|
T9211 |
Mito-LND
|
Mito-Loidamine |
OXPHOS
,
Reactive Oxygen Species
,
Mitochondrial Metabolism
,
Autophagy
|
|
Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation. |
|
T5519 |
Bivalirudin
|
BG-8967,Hirulog-1 |
Thrombin
|
|
Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities. |
|
T14322 |
ARP-100
|
MMP-2 Inhibitor III |
MMP
|
|
ARP-100 (MMP-2 Inhibitor III) is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with the S1' pocket of MMP-2 and exhibits anti-invasive properties in an in vitro invasion ... |
|
T25384 |
Erbulozole
|
R-55104,R55104,R 55104 |
Microtubule Associated
|
|
Erbulozole (R 55104) is a potent synthetic microtubule inhibitor with anti-invasive, anti-tumour and radiosensitising activity that induces Wernicke's encephalopathy-like neurotoxicity. |
|
T25813 |
Milenperone
|
R 34009,R-34009,R34009 |
Others
|
|
Milenperone (R 34009) is a novel anti-invasive compound for the control of behavioral disorders in patients with epilepsy and alcoholism. |
|
T1898 |
RKI-1447
|
RKI1447 |
ROCK
|
|
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities. |
|
T34705 |
SR4554
|
SR 4554 |
Others
|
|
SR4554 is a fluorinated 2-nitroimidazole non-invasive tumor hypoxia probe for the detection of tumor hypoxia as detected by 19F magnetic resonance spectroscopy (MRS). |
|
T64695 |
IR-808
|
MHI-148 |
|
|
IR-808 (MHI-148) is a near-infrared elastomeric dye for non-invasive cancer imaging, diagnostics and image-guided photothermal therapy. |
|
T21483 |
Tricaine methanesulfonate
|
MS-222 |
Others
|
|
Tricaine methanesulfonate (MS-222) (TMS) is an anesthetic. Many hatcheries and research studies use TMS to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. |
|
T17239 |
VU0155069
|
CAY10593 |
Phospholipase
|
|
VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 46 nM in vitro). |
|
TD0087L |
Sulfo-Cy5.5 Trifluoroacetate
|
|
Others
|
|
Sulfo-Cy5.5 Trifluoroacetate is a kind of cyano dye, which is very suitable for non-invasive in vivo near-infrared imaging, and is suitable for applications that require a low fluorescence background. |
|
TQ0223 |
Lusutrombopag
|
S-888711,Mulpleta |
Thrombin
,
Thrombopoietin Receptor
|
|
Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery. |
|
T9912 |
Trastuzumab
|
|
EGFR
|
|
Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastr... |
|
T60952 |
Fluridone
|
EL-171 |
Others
|
|
Fluridone (EL-171) is a potent inhibitor of abscisic acid (ABA) synthesis, inhibits the expression of AchnFAR and TF genes, and reduces the formation of primary alcohol. Fluridone is often used as an aquatic herbicide to... |
|
T30040 |
Amphocil
|
Amphotericin B cholesteryl sulfate |
|
|
Amphocil is used to treat patients with invasive fungal infection. |
|
T25925 |
P-DDAP
|
pDDAP,p-Dodecylaminophenol |
|
|
p-DDAP is an anti-invasive agent that acts by significantly suppressing cell invasion, and the activity and mRNA expression of matrix metalloproteinase-9 (MMP-9). |
|
T68425 |
Saracatinib difumarate
|
|
|
|
Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. |
|
T40861 |
Nerindocianine
|
|
|
|
Nerindocianine is a hydrophilic, fluorescent diagnostic contrast agent that is predominantly metabolized by the kidneys, enabling non-invasive, intraoperative ureteral imaging. |
|
T11325 |
Frondoside A
|
|
Others
|
|
possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa, |
|
T70703 |
DK-139
|
|
|
|
DK-139 is an inhibitor of NF-kappaB-mediated GROalpha expression, suppressing the TNFalpha-induced invasive capability of MDA-MB-231 human breast cancer cells. |
|
T69769 |
BDP8900
|
|
|
|
BDP8900 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. BDP8900 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character. |
|
T35368 |
N-butyl-N-(4-hydroxybutyl) nitrosamine
|
4-Hydroxybutylbutylnitrosamine,N-Nitrosobutylbutanolamine,OH-BBN,N-butyl-N-(4-hydroxybutyl) nitrosamine,BBN,N-Butyl-N-(4-hydroxybutyl)nitrosamine,4-(Butylnitrosamino)-1-butanol |
Others
|
|
N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN, OH-BBN) is a model compound that can induce high-level invasive tumors in the bladder. |
|
T71965 |
KRIBB3
|
|
|
|
KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocki... |
|
T11314 |
Fosmanogepix
|
APX001,E1211 |
Others
|
|
Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This... |
|
T79789 |
DT-6
|
|
TGF-beta/Smad
|
|
DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing potential for cancer research applications [1]. |
|
T74959 |
Antifungal agent 41
|
|
|
|
Antifungal Agent 41 (compound B01), an effective inhibitor of Candida albicans both in vitro and in vivo, is a potential research tool for invasive fungal infections [1]. |
|
T80591 |
Efungumab
|
|
|
|
Efungumab, a monoclonal antibody exhibiting antifungal properties, specifically targets HSP 90 to inhibit a conformational alteration crucial for fungal survival. It is employed in investigations concerning invasive cand... |
|
T72569 |
Cathepsin L/S-IN-1
|
|
|
|
Cathepsin L/S-IN-1, a dual inhibitor targeting Cathepsin L and Cathepsin S, exhibits potent and selective inhibition with IC50 values of 4.10 μM and 1.79 μM, respectively. Demonstrating significant antimetastatic and inv... |
|
T69269 |
DMGF
|
|
|
|
DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, a... |
|
T74956 |
Chitin synthase inhibitor 10
|
|
|
|
Chitin Synthase Inhibitor 10, as a potent chitin synthase inhibitor, exhibits remarkable inhibitory activity with an IC50 of 0.11 mM. It also functions as an antifungal agent, demonstrating substantial effectiveness agai... |
|
T63077 |
Chitin synthase inhibitor 12
|
|
|
|
Chitin synthase inhibitor 12, a Chitin synthase (CHS) inhibitor, showed excellent CHS inhibition (IC50: 0.16 mM). Chitin synthase inhibitor 12 is also a broad-spectrum antifungal agent resistant to resistant fungal varia... |
|
T22343 |
HKB99
|
|
Others
|
|
HKB99 is a mutational inhibitor of phosphoglycerate mutase 1 (PGAM1).HKB99 increases oxidative stress, activates JNK/c-Jun, and inhibits AKT and ERK[1].HKB99 inhibits the formation of invasive pseudopods and raises the l... |
|
T75363 |
Fluorescein Di-β-D-Glucuronide
|
|
|
|
Fluorescein Di-β-D-Glucuronide, a fluorescent probe, enables non-invasive imaging of intestinal bacterial β-glucuronidase activity in nude mice. This compound's utilization for both in vitro and in vivo imaging offers va... |
|
T62090 |
(Rac)-Tanomastat
|
|
|
|
Rac)-Tanomastat ((Rac)-BAY 12-9566) is a racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally active, zinc carboxy-containing inhibitor of non-peptide biphenyl matrix metalloproteinases (MMPs) that inhibits MMP-... |
|
T30783 |
CDy9
|
CDy 9,CDy-9 |
|
|
CDy9 is a highly selective fluorescent probe for the detection and isolation of mESC using fluorescence microscopy and flow cytometry. CDy9 allows the detection and isolation of intact stem cells with marginal impact on ... |
