|
T5954 |
Methyldopa hydrate
|
Alpha-Methyldopa Sesquihydrate,L-(-)-α-Methyldopa hydrate,MK-351 hydrate,Methyldopa Sesquihydrate |
Dopamine Receptor
,
Adrenergic Receptor
|
|
Methyldopa hydrate (MK-351 hydrate) is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system, decreases production of dopamine, ... |
|
T10989 |
Dehydroaripiprazole
|
OPC-14857,DM-14857 |
5-HT Receptor
|
|
Dehydroaripiprazole (DM-14857) is the active metabolite of aripiprazole. Aripiprazole is an antipsychotic drug, which is metabolized by CYP3A4 and CYP2D6 and mainly forms dehydroaripiprazole. Dehydroaripiprazole has anti... |
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T12490 |
Pitavastatin lactone
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|
Others
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|
Pitavastatin lactone is a major Pitavastatin metabolite in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes. |
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T7433 |
2-Phenylethylamine hydrochloride
|
&beta,-Phenylethylamine hydrochloride,benzeneethanamine hydrochloride,&beta,-aminoethylbenzene hydrochloride |
Others
|
|
2-Phenylethylamine hydrochloride (benzeneethanamine hydrochloride) acts as neuromodulator in the central nervous system. It stimulates the release of norepinephrine and dopamine and is metabolized by monoamine oxidases a... |
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T10618 |
Broflanilide
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|
GABA Receptor
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|
Broflanilide is metabolized to desmethyl-broflanilide, which is a potent antagonist at the insect resistant-to-dieldrin GABA receptor and inhibits S. litura RDL GABAR (IC50: 1.3 nM). |
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T22025 |
AG 045572
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|
P450
,
GNRH Receptor
|
|
AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone. |
|
T1266 |
Terfenadine
|
(±)-Terfenadine,MDL-991 |
Apoptosis
,
Potassium Channel
,
5-HT Receptor
,
Caspase
,
Na+/Ca2+ Exchanger
,
HER
,
AChR
,
Histamine Receptor
|
|
Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. |
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T77562 |
Methyl-a-L-fucopyranoside
|
Methyl alpha-L-fucopyranoside |
Antifungal
|
|
Methyl-a-L-fucopyranoside (Methyl alpha-L-fucopyranoside) is a rhizobial lectin inhibitor that is not metabolized by the fungus and prevents the biocontrol agent Trichoderma reesei from coiling around the rhizobial mycel... |
|
T0816 |
Acetohexamide
|
Acetohexamid,Dymelor,Gamadiabet |
Potassium Channel
,
NADPH
|
|
Acetohexamide (Acetohexamid) is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) wi... |
|
T15773 |
Lofepramine
|
Gamanil,Amplit,Leo 640,Lopramine |
5-HT Receptor
,
Norepinephrine
|
|
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, ... |
|
T0893 |
Tinidazole
|
CP12574 |
Antibacterial
,
Antibiotic
|
|
Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitr... |
|
T1408 |
Capecitabine
|
Xeloda,Capecitibine,Capiibine,RO 09-1978 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moie... |
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T36665 |
Dehydro Nifedipine
|
BAY-b 4759 |
|
|
Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used i... |
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T25466 |
GS-9191
|
GS 9191 |
DNA/RNA Synthesis
|
|
GS-9191 is a potent inhibitor of DNA polymerase alpha and ß , a prodrug of the novel nucleoside analogue 9-(2-phosphonomethoxyethyl)guanine (PMEG) , which penetrates the skin and is metabolized in the epithelium to an ac... |
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T19661 |
8-Chloroadenosine
|
NSC 354258,8-Cl-Ado,NSC354258,NSC-354258 |
AMPK
|
|
8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Ch... |
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T68943 |
Mesulergine
|
|
|
|
Mesulergine is metabolized into dopaminergic agonists. |
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T71221 |
CGS 21595
|
|
|
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CGS 21595 inhibits the formation of 5-hydroxyeicosatetraenoic acid and leukotriene B4; rapidly metabolized to CGS 19213. |
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T21161 |
Ancitabine
|
|
|
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Ancitabine, a congener of cyterabine, is metabolized to cytarabine, thereby maintains a more constant antineoplastic action. |
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T37866 |
9(S)-HpODE
|
|
|
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9(S)-HpODE is produced by the action of arachidonate 5-LO on linoleic acid. It can be further metabolized by potato hydroperoxide dehydratase to colneleic acid. |
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T37247 |
Pantoprazole Sulfide
|
|
|
|
Pantoprazole sulfide is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isomers CYP2C19 and CYP3A4 to form pantoprazole sulfide. |
|
T24043 |
Erythromycin glutamate
|
|
|
|
Erythromycin glutamate is a macrolide bacteriostatic antibiotic. This antibiotic is metabolized through the liver and inhibits cytochrome enzyme P450A 3A41. |
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T31433 |
Dichlobenil
|
Decabane,Casoron 133,Norosac,Casoron,Cyclomec |
|
|
Dichlobenil is a herbicide and is slightly toxic for humans. It is metabolized in the liver by the enzyme CYP2A6. |
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T1488L |
Procarbazine free base
|
CB 400-497,NSC-77213,Ro 4-6467/1,Ro 4-6467,Procarbazine |
|
|
Procarbazine is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects ... |
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T34307 |
Revenast
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|
|
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Revenast is a potent new anti-allergic compound. The substance is rapidly and extensively metabolized in the body, resulting in an anti-allergic effect. |
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T10145 |
4-Hydroxyatomoxetine
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|
Others
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4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor. |
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T37239 |
(±)19(20)-EpDTE
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|
|
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(±)19(20)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA and can be further metabolized to (±)19(20)-DiHDTE by epoxide hydrolase. |
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T40861 |
Nerindocianine
|
|
|
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Nerindocianine is a hydrophilic, fluorescent diagnostic contrast agent that is predominantly metabolized by the kidneys, enabling non-invasive, intraoperative ureteral imaging. |
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T19421 |
Methyl aminolevulinate
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|
Others
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Methyl aminolevulinate is a prodrug that can be metabolized to Protoporphyrin IX. Methyl aminolevulinate is an agent used as a sensitizer in photodynamic therapy (PDT). |
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T25324 |
Dichloromethotrexate
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NSC 29630,3988-B-129-4,NSC29630,Dichloroamethopterin,NSC-29630 |
|
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Dichloromethotrexate is an enzyme dihydrofolate reductase inhibitor, thus preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by th... |
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T35724 |
4-hydroxy Atorvastatin (calcium salt)
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|
|
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4-hydroxy Atorvastatin is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by ... |
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T12806 |
(S)-Mirtazapine D3
|
(S)-Org3770 D3,(S)-6-Azamianserin D3 |
5-HT Receptor
|
|
(S)-Mirtazapine D3 is a deuterium labeled (S)-Mirtazapine. (S)-Mirtazapine is a stereoselective antagonist of 5-HT2 receptor. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2. |
|
T14040 |
4-Hydroxytolbutamide
|
Hydroxytolbutamide |
Potassium Channel
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|
4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2]. |
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T19360 |
Hydroxy bosentan
|
Ro 48-5033 |
Others
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|
Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Hydroxy bosentan assists BOS pharmacologically, retaining 10%-20% activities. |
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T36530 |
Pantoprazole sulfone
|
|
|
|
Pantoprazole sulfone is a metabolite of the gastric H+/K+ ATPase pump inhibitor pantoprazole . Pantoprazole is metabolized by the cytochrome P450 (CYP) isoforms CYP2C19 and CYP3A4 to form pantoprazole sulfone. |
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T39230 |
Contezolid acefosamil
|
MRX-4,Contezolid acefosamil |
|
|
Contezolid acefosamil (MRX-4), an orally active prodrug, is metabolized into Contezolid (MRX-I), an oxazolidinone derivative with potent in vitro efficacy against multidrug-resistant Gram-positive bacteria, including MRS... |
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T37515 |
Hydroxy Ebastine
|
|
|
|
Hydroxy Ebastine is an ebastine metabolite. Ebastine undergoes rapid first-pass metabolism by the cytochrome P450 isoform CYP2J2 to form hydroxy ebastine which is then metabolized by CYP2J2 and CYP3A4 to form carebastine... |
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T74640 |
Ilaprazole sulfone
|
|
|
|
Ilaprazole sulfone, primarily metabolized by CYP3A4/5, constitutes the chief metabolite of Ilaprazole (IY-81149), an orally active proton pump inhibitor [1]. |
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T38065 |
5(S)-HpEPE
|
|
|
|
5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA. It is metabolized to LTA5, a key intermediate in the formation of the 5-series leukotrienes. Alternatively, 5(S)-HpEPE is ... |
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T37226 |
(±)7(8)-EpDTE
|
|
|
|
(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid . It is formed via cytochrome P450 (CYP) metabolism of DPA, and can be further metabolized to (±)7(8)-DiHDTE by epoxide hydrolase. |
|
T60435 |
Propacetamol
|
|
|
|
Propacetamol is an analgesic agent and a prodrug that is metabolized to paracetamol. It can be used for postoperative pain, acute trauma, and gastrointestinal disorders[1]. |
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T36237 |
5-hydroxy Propranolol
|
|
|
|
5-hydroxy Propranolol is a metabolite of propranolol , a β-adrenergic receptor antagonist. Propranolol is primarily metabolized in the liver, with cytochrome P450 isoform 2D6 directing ring hydroxylation and the generati... |
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T31824 |
Fluoroglutamine (2S,4R)
|
FDG |
|
|
Fluoroglutamine (2S,4R) is a Glutamine analog, not metabolized in the TCA cycle, but it can be incorporated into proteins and peptides. Fluoroglutamine (2S,4R) can be used as assess transporter (ASCT2) activity or protei... |
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T36603 |
(±)5-HEPE
|
|
|
|
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5... |
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T36319 |
C6 L-erythro Ceramide (d18:1/6:0)
|
C6 L-erythro Ceramide (d18:1/6:0) |
|
|
C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide... |
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T68919 |
Nabumetone Alcohol
|
|
|
|
Nabumetone alcohol is the alcohol form of nabumetone, a non-steroidal anti-inflammatory drug (NSAID) that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid, which inhibits... |
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T16279 |
Nebicapone
|
BIA 3-202 |
Others
|
|
Nebicapone is a reversible catechol-O-methyltransferase (COMT) inhibitor and is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to ... |
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T10144 |
4-Hydroxyatomoxetine D3
|
|
Others
|
|
4-Hydroxyatomoxetine D3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inh... |
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T37180 |
Avanafil metabolite M16
|
|
|
|
Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites ava... |
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T35717 |
N-desmethyl Rosiglitazone
|
|
|
|
N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone , a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome ... |
|
T36518 |
Resveratrol-4'-O-D-Glucuronide
|
|
|
|
Resveratrol-4'-O-D-Glucuronide has anti-fat accumulation properties, is metabolized by resveratrol, and can be used in metabolism-related studies. |
