|
T6393 |
ARQ 621
|
|
Kinesin
|
|
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1. |
|
T11689 |
ITI-214
|
ITI214 |
PDE
|
|
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ... |
|
T13554 |
Arimoclomol maleate
|
BRX-220 |
HSP
|
|
Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer. |
|
T22103 |
ML-193
|
CID 1261822 |
Cannabinoid Receptor
|
|
ML-193 (CID 1261822) is a potent and selective GPR55 antagonist( IC50 : 221 nM). It shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2, and can improve the motor and the sensorimotor deficits of Parkin... |
|
T1030 |
Triprolidine hydrochloride monohydrate
|
Triprolidine hydrochloride |
Histamine Receptor
|
|
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma. |
|
T13553 |
Arimoclomol
|
BRX-220 free base |
HSP
|
|
Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS). |
|
T4641 |
Branaplam
|
LMI 070,NVS-SM1 |
Others
,
Potassium Channel
,
DNA/RNA Synthesis
|
|
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. |
|
T24047 |
Etilevodopa hydrochloride
|
Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester |
Others
,
Dopamine Receptor
,
Drug Metabolite
|
|
Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration. |
|
T27084 |
Crisdesalazine
|
AAD2004,AAD 2004,AAD-2004 |
Prostaglandin Receptor
|
|
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre... |
|
T28680 |
SB-215505
|
|
|
|
SB215505 is a potent 5-HT2B/2C receptor antagonist (pKi values are 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A respectively). It Increases wakefulness and motor activity in rats. |
|
T4029 |
BTB-1
|
BTB 1,NSC156750 |
Microtubule Associated
|
|
BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A. |
|
T3336 |
Rg3039
|
PF-06687859 |
Others
|
|
Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an... |
|
T6209 |
CW-069
|
CW069 |
Kinesin
,
Microtubule Associated
|
|
CW-069 (IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP. |
|
T8631 |
Pyridostigmine
|
Regonol,Mestinon-SR,UNII-19QM69HH21,PyridostigmineBromine,Pyridostigminum |
Others
|
|
Pyridostigmine(Regonol) is an acetylcholinesterase inhibitor that can treat myasthenia gravis by increasing acetylcholine at the postsynaptic motor endplate. |
|
T34399 |
Rovatirelin
|
KPS-0373,S0373,S-0373,S 0373 |
AChE
|
|
Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine an... |
|
T2039 |
GSK-923295
|
|
Apoptosis
,
Kinesin
|
|
GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM). |
|
T23331 |
SC 51089
|
SC 51089 free base |
Prostaglandin Receptor
|
|
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and antinociceptive activity that improves motor deficits and rescues memory decline in the Huntington's... |
|
T16757 |
Risdiplam
|
RO7034067,RG7916 |
DNA/RNA Synthesis
|
|
Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor neuron (SMN) protein levels[1]. |
|
TP1852L |
Myomodulin acetate(110570-93-9 free base)
|
|
Potassium Channel
,
Calcium Channel
,
Sodium Channel
|
|
Myomodulin acetate is present in two identified aplysia neurons that contain myomodulin A the ARC motor neuron B16 and the abdominal neuron L10. |
|
T77586 |
Eg5-IN-1
|
|
Kinesin
|
|
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research. |
|
T7352 |
Pridopidine
|
ACR16,ASP2314,FR310826 |
Dopamine Receptor
|
|
Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model. |
|
TP2047L |
CRF (6-33) acetate(120066-38-8 free base)
|
|
CRFR
|
|
CRF (6-33) acetate is a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo. |
|
T8741 |
MitoBloCK-10
|
3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m |
Others
|
|
MitoBloCK-10 (3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m) inhibits Tim44 binding to the precursor and to Hsp70.MitoBloCK-10 is the first small molecule modulator to attenuate protein-associated motor (PAM) complex activity... |
|
T14965 |
Ciliobrevin D
|
|
ATPase
,
Hedgehog/Smoothened
|
|
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibits dynein-dependent microtubule gliding and ATPase activity ... |
|
T10659 |
Ca2+ channel agonist 1
|
|
Calcium Channel
,
CDK
|
|
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction. |
|
T16398 |
Opicapone
|
BIA 9-1067 |
Transferase
|
|
Opicapone (BIA 9-1067) reduces the ATP content of the cells (IC50: 98 μM). Opicapone is an effective third-generation catechol-O-methyltransferase inhibitor for the research of Parkinson's disease and motor fluctuations. |
|
T13248 |
UK-240455
|
|
NMDAR
,
iGluR
|
|
UK-240455 is a potent and selective N-methyl-D-aspartic acid (NMDA) glycine receptor antagonist with neuroprotective effects and improved motor function in Parkinson's disease models, and is a potential candidate compoun... |
|
T0166 |
Pancuronium dibromide
|
Pancuronium bromide,Pavulon |
AChR
|
|
Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing ... |
|
TP1325L |
Gastrin-Releasing Peptide, human(TFA)
|
|
Others
|
|
Gastrin-Releasing Peptide, human(TFA) is a regulatory human peptide that elicits gastrin release and regulates gastric acid secretion and enteric motor function. The post-ganglionic fibers of the vagus nerve that innerva... |
|
T24754 |
Hh-Ag1.5
|
SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened
|
|
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... |
|
T67729 |
UCM-1306
|
|
Dopamine Receptor
|
|
UCM-1306 is a potent and orally active allosteric modulator (PAM) of human dopamine D1 receptor. UCM-1306 could increase the maximal effect of endogenous dopamine (DA) both in human and mouse D1 receptors. UCM-1306 could... |
|
T2546 |
Pimozide
|
R6238 |
Potassium Channel
,
Dopamine Receptor
,
Adrenergic Receptor
,
STAT
|
|
Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby... |
|
T0939 |
Phenytoin
|
Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease
,
Sodium Channel
|
|
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor... |
|
T28866 |
Stemazole
|
|
Apoptosis
|
|
Stemazole is a novel small molecule human stem/progenitor cell proliferation activator that promotes the survival of human embryonic stem cells and maintains stemness, and promotes the survival of oligodendrocyte precurs... |
|
T35689 |
MTP 131 acetate
|
|
Others
|
|
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
|
T30167 |
ASP-5854
|
UNII-BJS8Y4IC5V,ASP 5854,C524699 |
|
|
ASP-5854 is an adenosine A(2A) receptor antagonist with the potential to improve motor deficits in Parkinson's disease. |
|
T21466 |
MK-212
|
MK 212,MK212 |
|
|
MK-212 is a 5HT2C-receptor agonist. Intraperitoneal injection of MK-212 in 0.5 and 1.0 mg/kg increased the blood level of corticosterone in mice and reduced their motor activity. In 0.1 and 0.2 mg/kg, the agonist reduced... |
|
T21393 |
Ethopropazine Hydrochloride
|
Lysivane,Parphezein,Dibutil,Parfezin,Profenamine HCl,Pardisol |
|
|
Ethoproprazine hydrochloride is an butyrylcholinesterase inhibitor. It reduces extrapyramidal motor effects and used as an antidyskinetic, characteristic of Parkinson′s disease. It also alleviates thermal hyperalgesia in... |
|
T34664 |
SMN2-Stablizer-27
|
SMN2-Stablizer 27,SMN2 Stablizer-27 |
|
|
SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA). |
|
T63612 |
ATX inhibitor 8
|
|
|
|
ATX inhibitor 8 is an inhibitor of the autocrine motor factor Autotaxin (ATX). |
|
T30576 |
Brasofensine
|
BMS-204756,CID9554198,BMS204756,UNII-1YP2S94RVH,BMS 204756 |
|
|
Brasofensine is a monoamine reuptake blocker, which is a benztoalkane. In animal models of Parkinson's disease, Brasofensine is effective in stimulating LMA and reversing motor inactivity. Brasofensine is being developed... |
|
TP2047 |
CRF(6-33)(human)
|
CRF (6-33) |
|
|
CRF(6-33)(human) is a Corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide; displaces CRF from CRFBP. Suppresses body weight gain and increases motor activity in obese rats in vivo. |
|
T68881 |
OL-135
|
|
|
|
OL-135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. OL-135 exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism. |
|
T71828 |
Syntelin
|
|
|
|
Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highl... |
|
T69017 |
Ibotenic acid hydrate
|
|
|
|
Ibotenic acid hydrate is a neurotoxic isoxazole (similar to Kainic acid and Muscimol) found in Amanita mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitat... |
|
T21345 |
MCOPPB
|
|
|
|
MCOPPB is a potent and selective agonist for the nociceptin receptor with a pKi of 10.07, much weaker activity at other opioid receptors. In animal studies, MCOPPB produces potent anxiolytic effects, with no inhibition o... |
|
T12859 |
SB 243213 hydrochloride
|
|
5-HT Receptor
|
|
SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It has improved anxiolytic profile and has the potential for schi... |
|
T69152 |
Bromopride hydrochloride
|
|
|
|
Bromopride hydrochloride is the salt form of Bromopride, a dopamine D2 receptor blocker. Bromopride exerts is a gastrointestinal prokinetic exploited clinically for the management of motor disorders of the upper gastroin... |
|
T21586 |
Methsuximide
|
|
|
|
Methsuximide is an anticonvulsant agent which appeared to be effective in petit mal, psychomotor and focal motor attacks [1]. |
|
T3525 |
PD150606
|
|
Cysteine Protease
|
|
PD150606 is a selective nonpeptide calpain inhibitor with neuroprotective activity that inhibits μ-calpains and m-calpains.
Inhibits erythrocyanine-induced Ca2+ efflux and interferes with excitotoxicity-dependent motor n... |
