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天然化合物

リコンビナントタンパク質

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カタログ番号	製品名	別名	ターゲット
T22814	GSA-10		Hedgehog/Smoothened
	Smoothened (Smo) receptor agonist		Hedgehog/Smoothened
T9988	Wnt/β-catenin agonist 3		Wnt/beta-catenin
	Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.		Wnt/beta-catenin
T25859	Necrostatin-7	Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7	Apoptosis
	Necrostatin-7 (Necrostatin 7) is an inhibitor of necrotic apoptosis with cardioprotective effects, inhibits RANK-NFATc1 signaling, and attenuates macrophage differentiation into osteoblasts.		Apoptosis
T1210	Sodium etidronate	Didronel	Phosphatase
	Sodium etidronate (Didronel) is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, Sodium etidronate differs from endogenous pyrophospha...		Phosphatase
T21460	Teriparatide acetate	hPTH 1-34 (acetate salt),Parathar acetate,Forteo	Others
	Teriparatide acetate (Forteo) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide acetate is a recombinant form of parathyroid hormone. It is an effective anabolic (i.e., bone growing) agent used to treat...		Others
T1641	Strontium ranelate	Distrontium renelate,S12911	Calcium Channel , CaSR
	Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in...		Calcium Channel , CaSR
T11048	DIPQUO		Others
	DIPQUO is an activator of bone marker alkaline phosphatase (ALP). DIPQUO promotes the differentiation of mouse and human osteoblasts by activating p38MAPK-β. The EC50 in C2C12 cells was 6.27 μM.		Others
T74871	ODN BW001
	ODN BW001, an oligodeoxynucleotide (ODN), regulates the proliferation and activation of osteoblasts [1] [2].
T80529	VnP-16		Integrin
	VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates FAK [1].		Integrin
T40498	Dentonin	AC-100
	Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells. It does not have a significant effect...
T36065	N-Oleoyl-L-Serine
	Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the mai...
T35604	Osteocalcin (1-49) (human) (trifluoroacetate salt)
	Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D ...
T83827	Adenosine-5'-O-(3-thiotriphosphate) sodium	ATPγS,Adenosine 5'-(γ-thio)-triphosphate
	Adenosine-5'-O-(3-thiotriphosphate) (ATPγS), an agonist of the purinergic P2Y11 receptor, prompts inositol phosphate accumulation in CHO-K1 cells harboring the human or canine P2Y11 receptor with EC50 values of 1.2 and 1...
T37441	KMN-80
	The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 . Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which pla...

Compounds

GSA-10

T22814

Synonym:

Target: Hedgehog/Smoothened

Wnt/β-catenin agonist 3

T9988

Synonym:

Target: Wnt/beta-catenin

Necrostatin-7

T25859

Synonym: Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7

Synonym: hPTH 1-34 (acetate salt),Parathar acetate,Forteo

Target: Others

Strontium ranelate

T1641

Synonym: Distrontium renelate,S12911

Target: Calcium Channel, CaSR

Osteocalcin (1-49) (human) (trifluoroacetate salt)

T35604

Synonym:

Target:

Adenosine-5'-O-(3-thiotriphosphate) sodium

T83827

Synonym: ATPγS,Adenosine 5'-(γ-thio)-triphosphate

カタログ番号	製品名	別名	ターゲット
T3397	Epmedin C	Baohuoside-VI,Epimedin C	Others
	Epmedin C (Baohuoside-VI) was metabolized via desugarization, dehydrogenation, hydrogenation, dehydroxylation, hydroxylation, demethylation and glucuronidation pathways in vivo. It has potential activity against osteopor...		Others
T6S2252	Sweroside		Others
	1. Sweroside possesses strong hepatoprotective effect. 2. Sweroside is a promising osteoporosis therapeutic natural product, has anti-osteoporotic effect on the human MG-63 cells and rat osteoblasts.		Others
T6S2146	Epimedin B	Epmedin B	Others
	1. Epimedin B (Epmedin B) has potential activity against osteoporosis by stimulating osteoblasts.		Others
T2820	Glycitin	Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside	Others , Influenza Virus , Antibacterial
	Glycitin (Glycitein 7-O-β-glucoside), a natural isoflavone isolated from legumes, can promote the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover.		Others , Influenza Virus , Antibacterial
T3900	Emodin-8-glucoside	Emodin glucoside B,Anthraglycoside B	Others
	Emodin-8-glucoside (Anthraglycoside B) functions to protect from focal cerebral injury induced by ischemia and reperfusion. Emodin-8-beta-D-glucoside directly stimulates cell proliferation and differentiation of osteobla...		Others
T7190	Actein		Apoptosis , Akt , JNK , Autophagy
	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in...		Apoptosis , Akt , JNK , Autophagy
T5S2129	Sciadopitysin		TNF , NF-κB
	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o...		TNF , NF-κB
TN5888	Toddaculin		Others
	Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...		Others
T6S1966	Curculigoside	Curculigoside A	Antioxidant , NF-κB , JAK , STAT
	1. Curculigoside (Curculigoside A) can prevent bone loss , improve osteogenesis and inhibit osteoclastogenesis of hAFSCs, suggesting its potential use to regulate hAFSC osteogenic differentiation for treating bone disord...		Antioxidant , NF-κB , JAK , STAT
TN1711	Gossypetin		Antioxidant , p38 MAPK , MAPK , Antibacterial
	Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosc...		Antioxidant , p38 MAPK , MAPK , Antibacterial
TN3547	Bullatantriol		Antifection
	Bullatantriol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts. It may have weak antibacterial activities.		Antifection
TN4716	Oplodiol		Influenza Virus
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows mode...		Influenza Virus
TN4999	Serratenediol		BCL , PARP , Caspase
	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanol...		BCL , PARP , Caspase

天然物製品

Epmedin C

T3397

Synonym: Baohuoside-VI,Epimedin C

Synonym: Glycitein-7-β-O-glucoside,Glycitein 7-O-β-glucoside

Target: Others, Influenza Virus, Antibacterial

Emodin-8-glucoside

T3900

Synonym: Emodin glucoside B,Anthraglycoside B

Target: Apoptosis, Akt, JNK, Autophagy

Synonym: Curculigoside A

Target: Antioxidant, NF-κB, JAK, STAT

Gossypetin

TN1711

Synonym:

Target: Antioxidant, p38 MAPK, MAPK, Antibacterial

Target: Influenza Virus

Serratenediol

TN4999

Synonym:

Target: BCL, PARP, Caspase

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ...
TMPH-02240	TMEM119 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an...
TMPH-03293	FGF-23 Protein, Rat, Recombinant (E. coli, His)	Rat	E. coli
	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Ac...
TMPH-03294	FGF-23 Protein, Rat, Recombinant (His)	Rat	P. pastoris (Yeast)
	Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Ac...
TMPH-01595	KMO Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA r...
TMPY-02010	DMP1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of b...
TMPJ-00325	BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)	Human	HEK293 Cells
	Bone Morphogenetic Protein Receptor Type-1A (BMPR1A) belongs to the TKL Ser/Thr protein kinase family and TGFB receptor subfamily, including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. BMPR1A i...
TMPJ-01119	GPNMB Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Human Osteoactivin is a 560 amino acid type I transmembrane protein, and one...
TMPK-00387	FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region con...
TMPJ-01082	IGFBP-5 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Mouse Insulin-like growth factor-binding protein 5(IGFBP-5) belongs to the superfamily of insulin-like growth factor (IGF) binding proteins. It contains 1 IGFBP N-terminal domain and 1 thyroglobulin type-1 domain. Mouse ...
TMPY-02236	PTH1R Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Parathyroid hormone / parathyroid hormone-related peptide receptor, also known as PTH / PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor, PTH1R and PTHR, is a multi-pass membrane pr...
TMPJ-00330	GPC1 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling. Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 a...

GAS6 Protein, Mouse, Recombinant (His)

TMPY-04830

Species: Mouse

Expression System: HEK293 Cells

TMEM119 Protein, Human, Recombinant (hFc)

TMPH-02240

Species: Human

Expression System: HEK293 Cells

FGF-23 Protein, Rat, Recombinant (E. coli, His)

TMPH-03293

Species: Rat

Expression System: E. coli

FGF-23 Protein, Rat, Recombinant (His)

TMPH-03294

Species: Rat

Expression System: P. pastoris (Yeast)

KMO Protein, Human, Recombinant (His)

TMPH-01595

Species: Human

Expression System: E. coli

DMP1 Protein, Human, Recombinant (His)

TMPY-02010

Species: Human

Expression System: HEK293 Cells

BMPR1A/ALK-3 Protein, Human, Recombinant (hFc & His)

TMPJ-00325

Species: Human

Expression System: HEK293 Cells

GPNMB Protein, Human, Recombinant (His)

TMPJ-01119

Species: Human

Expression System: HEK293 Cells

FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated

TMPK-00387

Species: Human

Expression System: HEK293 Cells

IGFBP-5 Protein, Mouse, Recombinant (His)

TMPJ-01082

Species: Mouse

Expression System: HEK293 Cells

PTH1R Protein, Human, Recombinant (His)

TMPY-02236

Species: Human

Expression System: HEK293 Cells

GPC1 Protein, Human, Recombinant (His)

TMPJ-00330

Species: Human

Expression System: HEK293 Cells

カタログ番号	製品名
L7900	Osteogenesis Compound Library		317 compounds
	A unique collection of 317 osteogenesis related compounds for high throughput and high content screening;

ライブラリー

Osteogenesis Compound Library

L7900

Compounds: 317