p38α | TargetMol

カタログ番号	製品名	別名	ターゲット
T67830	p38α inhibitor 3		p38 MAPK
	p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation.		p38 MAPK
T78652	p38α inhibitor 4		p38 MAPK
	p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.		p38 MAPK
T36012	p38α inhibitor 2
	P38α Inhibitor 2, a potent and selective inhibitor of p38α MAPK, exhibits a pIC50 value of 9.6. It also demonstrates inhibition of the hERG ion channel (IC50=27 μM) and maintains promising selectivity, with <30% inhibiti...
T7661	SD-169	SD 169	p38 MAPK
	SD-169 (SD 169) is a selective and ATP competitive the MAP kinases p38α and p38β inhibitor.		p38 MAPK
T13018	SU3327	halicin	JNK
	SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).		JNK
T12997	SR-318		p38 MAPK , TNF
	SR-318 is a potent and highly selective inhibitor of p38 MAPK(IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively), has anti-cancer and anti-inflammatory activity.		p38 MAPK , TNF
T12347	P38-α MAPK-IN-1		p38 MAPK , Autophagy
	p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor(IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay).		p38 MAPK , Autophagy
T16812	RWJ-67657	JNJ 3026582	p38 MAPK
	RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor (IC50s: 1 and 11 μM, respectively). RWJ-67657 shows no activity at p38γ and p38δ and shows a cardioprotective effect.		p38 MAPK
T6496	Vactosertib	TEW-7197,EW-7197	ALK , TGF-beta/Smad
	Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia...		ALK , TGF-beta/Smad
T6927	Pamapimod	R1503,Ro4402257	p38 MAPK , Autophagy
	Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38α and p38β enzymatic activity with IC50 values of 0.014±0.002 and 0.48± 0.04 microM, respectiv...		p38 MAPK , Autophagy
T5494	MW-150	MW01-18-150SRM	p38 MAPK , Autophagy
	MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.		p38 MAPK , Autophagy
T6089	Neflamapimod	VX-745	p38 MAPK , Autophagy
	Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.		p38 MAPK , Autophagy
T2513	VX-702		p38 MAPK , Autophagy
	VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifical...		p38 MAPK , Autophagy
T12871	Talmapimod	SCIO-469	p38 MAPK
	Talmapimod (SCIO-469) is an selective, orally active, and ATP-competitive p38α inhibitor with IC50 of 9 nM and 90 nM for p38α and p38β, respectively. Talmapimod exhibits at least 2000-fold selectivity over a panel of 20 ...		p38 MAPK
T7367	Acumapimod	BCT-197	p38 MAPK , Autophagy
	Acumapimod (BCT-197) is an orally active inhibitor of p38α MAPK (IC50 <1 μM).		p38 MAPK , Autophagy
T3462	BMS-582949 hydrochloride	BMS-582949 HCl	p38 MAPK , Autophagy
	The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).		p38 MAPK , Autophagy
T1974	PH-797804	PH797804	p38 MAPK , Autophagy
	PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.		p38 MAPK , Autophagy
T2277	Losmapimod	GSK-AHAB,GW856553X,GW856553,SB856553	p38 MAPK , Autophagy
	Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).		p38 MAPK , Autophagy
T10277	AL 8697		p38 MAPK
	AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.		p38 MAPK
T6150	TAK-715		p38 MAPK , Casein Kinase , JNK
	TAK-715 is a p38 MAPK inhibitor for p38α.		p38 MAPK , Casein Kinase , JNK
T2301	SB 202190	FHPI,SB202190	Apoptosis , p38 MAPK , Autophagy
	SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i...		Apoptosis , p38 MAPK , Autophagy
T7667	R1487		p38 MAPK
	R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.		p38 MAPK
T4597	UM-164	UM164,DAS-DFGO-II	p38 MAPK , Src , Autophagy
	UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.		p38 MAPK , Src , Autophagy
T9581	ARRY-797	ARRY-371797	IL Receptor , p38 MAPK
	ARRY-797 (ARRY-371797) is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6.		IL Receptor , p38 MAPK
T15572	IN-1130		ALK
	IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 μM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein and p38α mitogen-activated protein kinase.		ALK
T63067	Emprumapimod
	Emprumapimod is a selective, orally active inhibitor of p38α MAPK. emprumapimod acts on RPMI-8226 cells and directly inhibits LPS-induced IL-6 production with an IC50 value of 100 pM. emprumapimod can be used to study di...
T2293	SGX-523		Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl
	SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.		Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl
T1953	L-779450	L 779450	Raf , Autophagy
	L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.		Raf , Autophagy
T7123	AMG-47a		VEGFR , p38 MAPK , JAK , Src
	AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protei...		VEGFR , p38 MAPK , JAK , Src
T6784	BI-78D3		JNK
	BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.		JNK
T6380	AMG 900	AMG900,AMG-900	p38 MAPK , Tyrosine Kinases , Aurora Kinase
	AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.		p38 MAPK , Tyrosine Kinases , Aurora Kinase
T6976	SB 239063	SB239063	p38 MAPK , Autophagy
	SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.		p38 MAPK , Autophagy
T1811	WH-4-023	KIN112,KIN001-112,Dual LCK/SRC inhibitor	Src
	WH-4-023 (Dual LCK/SRC inhibitor) is a potent and orally active Lck/Src inhibitor. It also potently inhibits SIK.		Src
T7276	SD 0006	SD-06	p38 MAPK , Autophagy
	SD 0006 (SD-06) is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.		p38 MAPK , Autophagy
T38752	EW-7195		ALK , TGF-beta/Smad
	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i...		ALK , TGF-beta/Smad
T68134	Ro-3201195		p38 MAPK
	Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.		p38 MAPK
T6047	Ralimetinib dimesylate	LY2228820 dimesylate,Ralimetinib,LY2228820,Ralimetinib Mesylate	Apoptosis , p38 MAPK , Autophagy
	Ralimetinib dimesylate (LY2228820 dimesylate) is the dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally available, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential an...		Apoptosis , p38 MAPK , Autophagy
T6130	Skepinone-L	CBS3830	p38 MAPK , Autophagy
	Skepinone-L (CBS3830) is a selective p38 mitogen-activated protein kinase inhibitor.		p38 MAPK , Autophagy
T7162	R1487 Hydrochloride	R1487 (Hydrochloride)	p38 MAPK , Autophagy
	R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.		p38 MAPK , Autophagy
T39343	MW-150 hydrochloride	MW01-18-150SRM hydrochloride,MW-150 hydrochloride
	MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a potent and selective inhibitor of p38α MAPK, with a Ki value of 101 nM. It exhibits excellent CNS penetration and oral bioavailability. MW-150 hydrochloride (MW01-...
T23408	SX 011		Others
	SX 011 is a p38α inhibitor.		Others
T12871L	Talmapimod hydrochloride	SCIO-469 hydrochloride	p38 MAPK
	Talmapimod hydrochloride is a selective and ATP-competitive p38α inhibitor (IC50: 9 nM). It also shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including o...		p38 MAPK
T18682	SJFδ		Others
	SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].		Others
T36017	PF-05381941
	PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1]. PF-05381941 inhibits LPS-stimulated release of TNF-αfrom human peripheralmononuclear (PMN) cells with an IC50 of 8 nM[1]....
T22765	EO 1428		Others
	p38α and p38β2 inhibitor		Others
T22885	JX 401		Others
	JX 401 is a p38α inhibitor.		Others
T72202	Anti-inflammatory agent 33
	Anti-inflammatory agent 33, a potent p38α inhibitor, effectively reduces NO production and suppresses LPS-induced expression of iNOS, COX-2, p-p38α, and p-MK2 proteins, thereby demonstrating anti-inflammatory activity.
T16477	PF-03715455		p38 MAPK
	PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respectiv...		p38 MAPK
T16721	Ralimetinib	LY2228820	Others
	Ralimetinib selectively inhibits phosphorylation of MK2 (Thr334) and has no effect on phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc. Ralimetinib is an effective and selective, ATP-competitive inhibitor...		Others
T28993	TOP1210	TOP 1210,TOP-1210
	TOP1210, a narrow spectrum kinase inhibitor, potently inhibits P38α, Src, and Syk kinase activities.

Compounds

p38α inhibitor 3

T67830

Target: p38 MAPK, TNF

p38-α MAPK-IN-1

T12347

Synonym:

Target: p38 MAPK, Autophagy

Synonym: TEW-7197,EW-7197

Target: ALK, TGF-beta/Smad

Pamapimod

T6927

Synonym: R1503,Ro4402257

Target: p38 MAPK, Autophagy

MW-150

T5494

Synonym: MW01-18-150SRM

Target: p38 MAPK, Autophagy

Neflamapimod

T6089

Synonym: VX-745

Target: p38 MAPK, Autophagy

VX-702

T2513

Synonym:

Target: p38 MAPK, Autophagy

Target: p38 MAPK, Autophagy

BMS-582949 hydrochloride

T3462

Synonym: BMS-582949 HCl

Target: p38 MAPK, Autophagy

PH-797804

T1974

Synonym: PH797804

Target: p38 MAPK, Autophagy

Losmapimod

T2277

Synonym: GSK-AHAB,GW856553X,GW856553,SB856553

Target: p38 MAPK, Autophagy

Target: p38 MAPK, Casein Kinase, JNK

SB 202190

T2301

Synonym: FHPI,SB202190

Target: Apoptosis, p38 MAPK, Autophagy

Synonym: UM164,DAS-DFGO-II

Target: p38 MAPK, Src, Autophagy

ARRY-797

T9581

Synonym: ARRY-371797

Target: IL Receptor, p38 MAPK

Target: Raf, p38 MAPK, c-Met/HGFR, Bcr-Abl

L-779450

T1953

Synonym: L 779450

Target: Raf, Autophagy

AMG-47a

T7123

Synonym:

Target: VEGFR, p38 MAPK, JAK, Src

Synonym: AMG900,AMG-900

Target: p38 MAPK, Tyrosine Kinases, Aurora Kinase

SB 239063

T6976

Synonym: SB239063

Target: p38 MAPK, Autophagy

WH-4-023

T1811

Synonym: KIN112,KIN001-112,Dual LCK/SRC inhibitor

Target: p38 MAPK, Autophagy

EW-7195

T38752

Synonym:

Target: ALK, TGF-beta/Smad

Ralimetinib dimesylate

T6047

Synonym: LY2228820 dimesylate,Ralimetinib,LY2228820,Ralimetinib Mesylate

Target: Apoptosis, p38 MAPK, Autophagy

Skepinone-L

T6130

Synonym: CBS3830

Target: p38 MAPK, Autophagy

R1487 Hydrochloride

T7162

Synonym: R1487 (Hydrochloride)

Target: p38 MAPK, Autophagy

MW-150 hydrochloride

T39343

Synonym: MW01-18-150SRM hydrochloride,MW-150 hydrochloride

Talmapimod hydrochloride

T12871L

Synonym: SCIO-469 hydrochloride

Anti-inflammatory agent 33

Synonym: TOP 1210,TOP-1210

Target:

カタログ番号	製品名	Species	Expression System
TMPY-04260	P38 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as prol...
TMPK-00351	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)	Human	HEK293
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...
TMPK-00723	RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio...

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ターゲット

阻害剤

リコンビナントタンパク質

Compounds

Recombinant Proteins