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T19508 |
Peroxidase
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Others
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Peroxidase, found in the roots of horseradish, actively involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis, and pathogenesis of several diseases. |
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T80056 |
Glutathione Peroxidase
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GSH-Px,EC 1.11.1.9 |
Glutathione Peroxidase
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Glutathione Peroxidase (GSH-Px; EC 1.11.1.9), a member of the peroxidase family, catalyzes the oxidation of reduced glutathione (GSH) to oxidized glutathione (GSSG) by forming a disulfide bridge, concurrently reducing hy... |
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T37314 |
JKE-1674
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GPX
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JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4). JKE-1674 is an active metabolite of the GPX4 inhibitor ML-210. |
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T83780 |
GPX4 24
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Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24 |
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GPX4 24, a derivative of (1S,3R)-RSL3, acts as a potent inhibitor of glutathione peroxidase 4 (GPX4) through covalent binding in a concentration-dependent manner within 4T1 murine mammary carcinoma cells. This compound e... |
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T8375 |
ML-210
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CID 49766530 |
Ferroptosis
,
GPX
,
Glutathione Peroxidase
,
Ras
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ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity |
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T5340 |
MPO-IN-28
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Glutathione Peroxidase
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MPO-IN-28 is a novel potent, irreversible Myeloperoxidase (MPO) inhibitor with IC50 of 44 nM. |
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T4090 |
PF-06282999
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Glutathione Peroxidase
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PF-06282999 is a potent and selective myeloperoxidase inhibitor which is potentially useful for the treatment of cardiovascular diseases. |
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T14379 |
AZD5904
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Glutathione Peroxidase
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AZD5904 is a potent and irreversible human Myeloperoxidase (MPO) inhibitor(IC50 of 140 nM and has similar potency in mouse and rat). |
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T12189 |
NBDHEX
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Apoptosis
,
Glutathione Peroxidase
,
Autophagy
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NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) . |
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T8970 |
ML162
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Ferroptosis
,
GPX
,
Glutathione Peroxidase
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ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively) |
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T5463 |
Verdiperstat
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AZD3241,AZD 3241 |
Glutathione Peroxidase
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Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders. |
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T3646 |
RSL3
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RSL3 1S,1S,3R-RSL3 |
Ferroptosis
,
GPX
,
Glutathione Peroxidase
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RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS. |
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T4313 |
Tinoridine hydrochloride
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Nonflamin,Y-3642 hydrochloride |
COX
,
Glutathione Peroxidase
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Tinoridine hydrochloride (Y-3642 hydrochloride) is a non-steroidal anti-inflammatory drug. Tinoridine hydrochloride (5-100 μM), produced a concentration-dependent inhibition on the simultaneous increases in lipid peroxid... |
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T26389 |
4-POBN
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NSC-640,NSC640,4-Aminobenzohydrazide,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH |
Glutathione Peroxidase
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4-POBN (Myeloperoxidase Inhibitor 1) is a potent and irreversible inhibitor of myeloperoxidase (IC50 = 0.3 µM). 4-POBN can be used in studies about subacute stroke. |
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T0825 |
Ebselen
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SPI-1005,PZ-51,CCG-39161 |
Phosphatase
,
Virus Protease
,
Calcium Channel
,
COX
,
HIV Protease
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Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... |
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T1374 |
2-Pyridinecarbohydrazide
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2-Picolinyl hydrazide |
Dehydrogenase
,
CAT
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2-Pyridinecarbohydrazide (2-Picolinyl hydrazide) is an effective inhibitor of Catalase-peroxidase-NAPDH. |
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T18908 |
ABTS diammonium salt
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AzBTS-(NH4)2 |
Others
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ABTS diammonium salt (AzBTS-(NH4)2) is used as a substrate for horseradish peroxidase (HRP) conjugate. |
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T1309 |
Propylthiouracil
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Pseudocapsaicin,NSC 6498,NSC 70461,6-n-Propylthiouracil,6-Propyl-2-thiouracil |
Thyroid hormone receptor(THR)
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Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor. |
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T18912 |
ADHP
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10-Acetyl-3,7-dihydroxyphenoxazine |
Others
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ADHP (10-Acetyl-3,7-dihydroxyphenoxazine) is a fluorogenic peroxidase substrate (λex=530 nm, λem=590 nm). |
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T0050 |
Ampyrone
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Minoazophene,Aminoantipyrin,NSC 60242,4-Aminoantipyrine,Solnapyrin-A |
COX
,
Drug Metabolite
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Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol. |
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T9734 |
InhA-IN-2
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CDK
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InhA-IN-2 directly inhibits InhA and does not require activation by the catalase peroxidase KatG. |
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T9416 |
Dansylglycine
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Others
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Dansylglycine is a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase[1]. |
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T19069 |
TMB dihydrochloride
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BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride |
Others
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TMB dihydrochloride (Sure Blue TMB dihydrochloride) is an enzyme-linked immunosorbent assays (ELISA) and an excellent colorimetric substrate for the detection of horseradish peroxidase (HRP)-labeled probes used in staini... |
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T9423 |
Alkyne tyramide
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Others
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Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe which enable biotin-independent detection of labeled proteins. |
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T0664 |
Nicotinic acid hydrazide
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Others
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Nicotinic acid hydrazide (NAH) is a hydrazide derivative of nicotinic acid, a heterocyclic organic compound. It is a peroxidase inhibitor and can form solid metal complexes with strong biological activity. |
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T18972 |
DHBS
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DCHBS |
Others
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DHBS (DCHBS) is used in conjunction with 4-aminoantipyrine (4-AAP) and H2O2 for chromogenic quantitation of peroxidase in coupled enzymatic reactions. |
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T36935 |
PKUMDL-LC-101-D04
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GPX4-Activator-1d4,PKUMDL-LC-101-D04 |
GPX
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PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of iron death. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free... |
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T38010 |
PPHP
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PPHP is a substrate for the measurement of peroxidase enzymes. PPHP has been used to quantitate the peroxidase activity of COX-1 and COX-2. |
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T38914 |
MPO-IN-3
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MPO-IN-3, a powerful inhibitor of myeloperoxidase (MPO), is described as such in example 191 of WO2013068875A1. MPO, a heme-containing enzyme, is classified under the peroxidase superfamily. |
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T38902 |
Cyanine 5 Tyramide
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Tyramide-Cy5 |
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Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in sit... |
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TP1096 |
Elamipretide TFA
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SS-31 (TFA),MTP-131 (TFA),RX-31 (TFA) |
Others
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Elamipretide TFA (RX-31 TFA) is a cardiolipin peroxidase inhibitor and mitochondria-targeting peptide[1]. |
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T39152 |
4-Hydroxyphenylbutazone
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4-Hydroxyphenylbutazone, a metabolite of Phenylbutazone, functions as an effective reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone is a nonsteroidal anti-inflammatory drug ... |
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T39686 |
1-Methoxynaphthalene
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1-Methoxynaphthalene is employed as a substrate for scrutinizing the enzymatic activity of cytochrome c peroxidase (CcP). Additionally, 1-Methoxynaphthalene can serve as a precursor for the synthesis of prenyl naphthalen... |
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T39181 |
Cyanine 3 Tyramide
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Cyanine 3 Tyramide,Tyramide-Cy3 |
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Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic a... |
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Fr16629 |
4-(Imidazol-1-yl)phenol
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4-(Imidazol-1-yl)phenol is a highly potent signal enhancer in a horseradish peroxidase (HRP)–luminol chemiluminescence (CL) immunoassay [1]. |
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T40137 |
MPO-IN-1
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MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-... |
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T81340 |
Pyridine-2-carboxaldehyde 4-nitrophenylhydrazone
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PCNPH |
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Pyridine-2-carboxaldehyde 4-nitrophenylhydrazone (PCNPH) serves as a chromogenic substrate for peroxidase enzymes, reacting to form a purple indamine dye in the presence of peroxidases and peroxides [1]. |
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T37805 |
JKE-1716
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JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additi... |
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T38099 |
APF
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APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals. It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase... |
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T11357 |
Gamma-glutamylcysteine TFA
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γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA) |
IL Receptor
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Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), a crucial dipeptide in glutathione (GSH) synthesis and a vital cofactor for the enzyme glutathione peroxidase (GPx), significantly modulates inflammatory response... |
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T63729 |
GPX4-IN-3
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GPX4-IN-3 (26a) is a potent inhibitor of glutathione peroxidase 4 (GPX4), selectively inducing ferroptosis. It demonstrates a 71.7% inhibition rate of GPX4 at a concentration of 1 μM [1]. |
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T36516 |
RC574
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RC574 |
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RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons... |
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T67498 |
3-Amino-1,2,4-triazole
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Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B |
Reactive Oxygen Species
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3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathi... |
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T74073 |
Cyanine 5 Tyramide methyl indole
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Cyanine 5 Tyramide (Tyramide-Cy5) methyl indole, a red fluorescent dye, is used as a reporter fluorescent substrate for horseradish peroxidase (HRP)-catalyzed deposition, facilitating signal amplification in immunoassay ... |
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T36515 |
RC363
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RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a... |
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T75028 |
TMV-IN-4
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TMV-IN-4 (Compound 3), a tobacco mosaic virus (TMV) inhibitor, effectively strengthens plant resistance and tolerance to TMV by binding with the TMV helicase. Furthermore, it boosts activities of peroxidase and superoxid... |
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T78406 |
Cyanine 3 Tyramide methyl indole
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Cyanine 3 Tyramide methyl indole, a derivative of the orange fluorescent dye Cyanine 3 Tyramide, serves as a reporter fluorescent substrate in the horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification... |
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T60281 |
MPO-IN-4
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MPO-IN-4 (compound 12) is a potent and selective myeloperoxidase (MPO) inhibitor with an IC 50 of 25 nM. MPO-IN-4 also demonstrates inhibition of thyroid peroxidase (TPO) with IC50 of 2.2 μM. MPO-IN-4 has no effect on me... |
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T71288 |
Phenylbutazone-d9
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Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity... |
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T36610 |
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
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(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP r... |
