|
T16531 |
Picaridin
|
Lcaridin |
Parasite
|
|
Picaridin (Lcaridin) is a topical insect repellent. |
|
T9461 |
AZ194
|
|
Sodium Channel
|
|
CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor. |
|
T1030 |
Triprolidine hydrochloride monohydrate
|
Triprolidine hydrochloride |
Histamine Receptor
|
|
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma. |
|
T8333 |
Aurintricarboxylic acid
|
ATA,NSC-4056,NSC4056,NSC 4056 |
Apoptosis
,
P2X Receptor
,
Influenza Virus
,
Topoisomerase
|
|
Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. |
|
T9263 |
Cim0216
|
N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide |
TRP/TRPV Channel
|
|
CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist. |
|
T1092 |
Zolmitriptan
|
311C90,BW-311C90 |
5-HT Receptor
|
|
Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and... |
|
T8776 |
FEMA 4774
|
S9632 |
Others
|
|
FEMA 4774 (S9632) is a positive allosteric modulator of T1R2/T1R3. FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests |
|
T12632 |
(R)-Mirtazapine
|
(R)-Org3770,(R)-6-Azamianserin |
5-HT Receptor
|
|
(R)-Mirtazapine ((R)-Org3770) is the R(-)-enantiomer of Mirtazapine, which has anti-injury sensory properties in an animal model of acute thermal hyperalgesia. (R)-Mirtazapine is an antagonist of 5-HT3 receptors and a po... |
|
T21483 |
Tricaine methanesulfonate
|
MS-222 |
Others
|
|
Tricaine methanesulfonate (MS-222) (TMS) is an anesthetic. Many hatcheries and research studies use TMS to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures. |
|
T0217L |
(+)-Dropropizine
|
(+)-Dropropizine |
Histamine Receptor
|
|
(+)-Dropropizine can inhibit histamine receptor, anti-allergic, and reduce a cough by modulation of neuropeptides involved in the cough reflex and by interfering with stimulus activation of peripheral endings of sensory ... |
|
T15192 |
Eact
|
|
Chloride channel
|
|
Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity. |
|
T23002 |
ML-335
|
|
Opioid Receptor
|
|
ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor)/DOR (δ-opioid receptor) heter... |
|
T10624 |
BT-13
|
|
c-RET
|
|
BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro. |
|
T29968 |
AMG-0347
|
UNII-CD7L9290QR |
TRP/TRPV Channel
|
|
AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental s... |
|
T10572L |
BMT-124110 Formate
|
BMT-124110 Formate（1679371-59-5 Free base） |
Serine/threonin kinase
,
TGF-beta/Smad
,
AAK1 (AP2 associated kinase 1)
|
|
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase BIKE with an IC50: 17 nM.BMT-124110 Formate inhibits the ce... |
|
T24754 |
Hh-Ag1.5
|
SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened
|
|
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies... |
|
T2525 |
Alosetron hydrochloride
|
Lotronex,GR 68755C,GR 68755,GR 68755X |
5-HT Receptor
|
|
Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system,... |
|
T12992 |
SPR741 acetate
|
SPR741 acetate,NAB741 acetate,SPR741 acetate (1179330-52-9 free base) |
Antibacterial
|
|
SPR741 acetate is a cationic peptide derived from polymyxin B. It exhibits antimicrobial activity against gram-negative bacteria by inhibiting severe gram-negative bacterial sensory by increasing the permeability of the ... |
|
T6602 |
Naratriptan hydrochloride
|
Naratriptan HCl,Amerge,Naramig,GR-85548A hydrochloride |
5-HT Receptor
|
|
Naratriptan Hydrochloride is the hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride (GR-85548A hydroc... |
|
T34535 |
Satratoxin G
|
Satratoxin-G |
|
|
Satratoxin G is a trichothecene mycotoxin of Stachybotrys chartarum and has been shown to selectively induces apoptosis in olfactory sensory neurons (OSNs) of the nose and brain. |
|
T28224 |
OB-2
|
|
|
|
OB-2 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-2 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. |
|
T71246 |
DD04107
|
|
|
|
DD04107 is a novel inhibitor of α-calcitonin gene-related peptide (α-CGRP) exocytotic release from primary sensory neurons, selectively interacting with Synaptotagmin 1. |
|
T28223 |
OB-1
|
|
|
|
OB-1 is an inhibitor of stomatin-like protein-3 (STOML3) oligomerization. OB-1 reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo. |
|
T60514 |
Triprolidine
|
|
|
|
Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3]. |
|
TP1631L |
Competence-Stimulating Peptide-12261 acetate
|
Competence-Stimulating Peptide-12261 acetate (1235882-91-3 free base) |
Others
|
|
Competence-Stimulating Peptide-12261 acetate is a fragment of sensory stimulation peptide, which is a quorum sensing molecule that inhibits germ tube (GT) formation |
|
T60289 |
Pemirolast
|
|
|
|
Pemirolast is an orally active antiallergic agent. Pemirolast attenuates paclitaxel hypersensitivity reactions through inhibition of the release of sensory neuropeptides, that can be used for bronchial asthma and conjunc... |
|
T76539 |
Insulin-like growth factor II
|
|
|
|
Insulin-like Growth Factor II (IGF-2), the primary somatomedin in human serum, exerts both permissive and direct influences on neurite outgrowth and significantly improves the survival of sympathetic and sensory neurons ... |
|
T62670 |
Cemdomespib
|
|
|
|
Cemdomespib (KU-596) is a potent second-generation Hsp90 modulator. cemdomespib induces a heat shock response, induces Hsp70 levels and has neuroprotective effects. cemdomespib has been shown to improve sensory deficits ... |
|
T71559 |
Melanotan II acetate
|
|
|
|
Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases... |
|
T81664 |
NMB-1
|
|
|
|
NMB-1, a conopeptide analogue, selectively inhibits sustained mechanically activated currents in sensory neurons with an IC50 of 1 μM, attenuating mechanical pain. It is utilized in research pertaining to hearing and pre... |
|
T35461 |
δ14-Triamcinolone acetonide
|
|
|
|
δ14-Triamcinolone acetonide is a potential impurity found in commercial preparations of triamcinolone acetonide. Triamcinolone acetonide is a synthetic corticosteroid. It decreases cytokine levels, the firing rate of sen... |
|
T37969 |
12(S)-HpETE
|
|
|
|
12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the sy... |
|
T76127 |
Urocortin II, mouse
|
|
|
|
Urocortin II, mouse, is a selective and potent endogenous peptide agonist for the type-2 corticotropin-releasing factor (CRF2) receptor, displaying K_i values of 0.66 nM for CRFR2 and >100 nM for CRFR1, signifying its hi... |
