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T30751 |
Carotegrast methyl
|
AJM300 |
Integrin
|
|
Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist. |
|
T16133 |
MRK-560
|
|
Gamma-secretase
|
|
MRK-560 is an effective and brain-penetrant inhibitor of γ-secretase. |
|
T9104 |
TJ191
|
|
Apoptosis
|
|
TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. |
|
T9595 |
LP-261
|
|
Microtubule Associated
|
|
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest. |
|
T6603 |
Nelarabine
|
GW 506U78,Nelzarabine,506U78 |
Apoptosis
,
Nucleoside Antimetabolite/Analog
,
DNA/RNA Synthesis
|
|
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells. |
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T9079 |
Apostatin-1
|
Apt-1 |
Others
|
|
Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD. |
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T3977 |
Lifitegrast
|
SHP-606,SAR 1118 |
Integrin
|
|
Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist. |
|
T0370 |
Pheniramine maleate
|
Daneral,Inhiston,Trimetose |
5-HT Receptor
,
Histamine Receptor
|
|
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re... |
|
T5858 |
Sertindole
|
Lu 23-174 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Autophagy
|
|
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
|
T37558 |
Necrostatin-5
|
Nec-5 |
RIP kinase
,
Necroptosis
|
|
Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM. |
|
T64387 |
2-Nitrobenzoic acid
|
o-Nitrobenzoic acid |
Others
|
|
2-Nitrobenzoic acid (o-Nitrobenzoic acid) is a antiproliferation agent. 2-Nitrobenzoic acid shows IC50 of 8.3 μM to jurkat cell line expressing T type calcium channel alpha 1H or its splice variant delta 25. |
|
T35569 |
CTA 056
|
|
Apoptosis
|
|
CTA 056 is an interleukin-2 induced T cell kinase (ITK) inhibitor, inhibits the growth of MOLT-4 xenograft tumors in mice, induces apoptosis in Jurkat cells, and can be used in the study of autoimmune disorders and T cel... |
|
T24816 |
SP-100030
|
SP100030,SP 100030 |
NF-κB
|
|
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and ... |
|
T10565 |
BMS-1001 hydrochloride
|
|
PD-1/PD-L1
|
|
BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activat... |
|
T1847 |
Necrostatin-1
|
Nec-1,Necrostatin 1 |
Indoleamine 2,3-Dioxygenase (IDO)
,
Ferroptosis
,
Autophagy
,
RIP kinase
|
|
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO. |
|
T73149 |
HPK1-IN-33
|
|
|
|
HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cel... |
|
T80497 |
KTX-Sp2
|
|
Potassium Channel
|
|
KTX-Sp2, a potassium channel toxin, effectively blocks exogenous voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.3, as well inhibits the endogenous Kv1.3 channel and suppresses Ca2+ signaling in Jurkat T cells. Ad... |
|
T39342 |
4-Maleimidosalicylic acid
|
|
|
|
4-Maleimidosalicylic acid is a polar maleimide compound that does not exhibit suppressive effects on IL-2 production in JURKAT T cells. |
|
T81394 |
PRO-HD1
|
|
HDAC
|
|
PRO-HD1, a PROTAC (proteolysis-targeting chimera) HDAC6 degrader, effectively degrades HDAC6 in A549 cells and inhibits Jurkat cell proliferation with an IC50 of 5.8 µM [1]. |
|
T12203L |
Necrostatin 2
|
|
Others
|
|
|
|
T72586 |
Lck Inhibitor III
|
|
|
|
Lck Inhibitor III, a potent inhibitor of Lck, exhibits an IC50 value of 867 nM. Additionally, this compound effectively inhibits IL-2 synthesis in Jurkat cells, demonstrating an IC50 of 1.270 μM. |
|
T36286 |
Protease-Activated Receptor-3 (PAR-3) (1-6), human
|
|
|
|
TFRGAP-amide, human PAR-3-derived tethered ligand sequence which does not activate PAR-3 but rather activates PAR-1 and PAR-2, either in Jurkat or in other PAR-expressing cells. |
|
TP2101 |
Z-VRPR-FMK trifluoroacetate salt
|
|
|
|
Irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable. |
|
T39913 |
TMX-4100
|
|
|
|
TMX-4100 is a potent degrader of phosphodiesterase 6D (PDE6D), exhibiting high degradation selectivity towards PDE6D with DC50 values below 200 nM in MOLT4, Jurkat, and MM.1S cells. This compound holds significant potent... |
|
T78189 |
JAK-IN-26
|
|
JAK
|
|
JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in suppressing IFN-α2B-induced STAT3 phosphorylation in Jurkat cells wit... |
|
T36331 |
Z-AEVD-FMK
|
Z-AEVD-FMK,Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone |
|
|
Z-AEVD-FMK is an irreversible inhibitor of caspase-10 and related caspases.[1] At 10 µM, it can prevent the initiation of Fas signaling by caspase-10 in Jurkat T lymphoma cells, preventing Bid cleavage into its activ... |
|
T40958 |
Milategrast
|
E6007 |
|
|
Milategrast is a chemical compound that functions as a potent cell adhesion inhibitor and cell infiltration inhibitor. In vitro studies have demonstrated its ability to effectively inhibit the adhesion of Jurkat cells to... |
|
T61754 |
TMX-4116
|
|
|
|
TMX-4116, a casein kinase 1α (CK1α) degrader, preferentially degrades CK1α in MOLT4, Jurkat, and MM.1S cells, exhibiting degradation concentration 50s (DC50s) below 200 nM. TMX-4116 is utilized in the research of multipl... |
|
T76185 |
N-Myristoyl-Lys-Arg-Thr-Leu-Arg
|
|
|
|
N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor, demonstrating an IC50 value of 75 μM. It effectively inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat [1]. |
|
T83947 |
HDAC4 CHDI Degrader 11
|
|
|
|
HDAC4 CHDI Degrader 11 is a potent, selective degrader of HDAC4 (PROTAC) with DC_50 values of 4 nM and 6 nM in Jurkat E6-1 and Jurkat cells, respectively. This compound integrates the class IIa HDAC inhibitor trifluorome... |
|
T79110 |
JAK-IN-27
|
|
JAK
|
|
JAK-IN-27, also known as compound 1, is an orally active, potent inhibitor of the JAKS family kinases, displaying inhibitory concentrations (IC50s) of 3.0 nM for TYK2, 7.7 nM for JAK1, and 629.6 nM for JAK3. Moreover, JA... |
|
T35906 |
Padanamide A
|
|
|
|
Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines... |
|
T62680 |
(R)-MLT-985
|
|
|
|
(R)-MLT-985 (compound 11) is a potent inhibitor of MALT1 protease (IC50: 3 nM). (R)-MLT-985 has an IC50 value of 20 nM for MALT1-dependent IL-2 in Jurkat cells.(R)-MLT-985 inhibits growth and aberrant CARD11/BCL10/MALT1 ... |
|
T79705 |
LP23
|
|
PD-1/PD-L1
|
|
LP23, a non-arylmethylamine PD-1/PD-L1 inhibitor (IC 50: 16.7 nM), exhibits anti-tumor activity through the restoration of immune cell function in HepG2/Jurkat T cells and induction of HepG2 cell death. Additionally, LP2... |
|
T74843 |
ITK degrader 1
|
|
|
|
ITK Degrader 1, a highly selective interleukin-2-inducible T-cell kinase (ITK; DC50=3.6 nM in vivo in mice) degrader, induces rapid and prolonged degradation of ITK and effectively suppresses IL-2 secretion (EC50=35.2 nM... |
|
T36291 |
Integrin modulator 1
|
|
|
|
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1].
Integ... |
|
T61202 |
TDO-IN-1
|
|
Others
|
|
TDO-IN-1 is an orally active, potent, and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), which inhibits indoleamine-2,3-dioxygenase.TDO-IN-1 has antitumor activity and is able to act by reversing local immune t... |
|
T36046 |
LH1306
|
|
|
|
LH1306 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 25 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation ... |
|
T79314 |
PD-L1-IN-3
|
|
PD-1/PD-L1
|
|
PD-L1-IN-3 (Compound 4a) functions as an inhibitor targeting the PD-1/PD-L1 axis, with an IC50 value of 4.97nM for PD-L1 inhibition and an EC50 value of 2.70 μM for Jurkat T cell modulation. It antagonizes the PD-1/PD-L1... |
|
T37276 |
2,5-Deoxyfructosazine (hydrochloride)
|
|
|
|
2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by p... |
|
T36047 |
LH1307
|
|
|
|
LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation o... |
|
T83946 |
CHDI 00484077
|
|
|
|
CHDI 00484077, a potent and selective class IIa histone deacetylase (HDAC) inhibitor, demonstrates significant efficacy with IC50 values ranging from 10-30 nM in vivo and specific activity at 0.01 nM and 0.04 nM in HEK29... |
|
T36034 |
CAY10774
|
|
|
|
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay).1It increases the activation of Jurkat... |
|
T36073 |
S-Acetyl-L-glutathione
|
|
|
|
S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-... |
|
T37851 |
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III)
|
|
|
|
Chlorido[N,N'-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.1 It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 μM.1 Chlorido[N,N... |
|
T35940 |
Darinaparsin
|
Dimethylarsinic glutathione,Darinaparsin |
|
|
Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM)... |
|
T83763 |
EPI-X4 TFA
|
Endogenous Peptide Inhibitor of CXCR4 |
|
|
EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4). It effectively prevents calcium mobilization and receptor in... |
|
T36659 |
Boromycin
|
|
|
|
Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affectin... |
|
T69221 |
BMS-554417
|
|
|
|
BMS-554417 is a novel inhibitor of IGF-IR, which inhibits IGF-IR and insulin receptor kinase activity and proliferation in vitro, and reduces tumor xenograft size in vivo. In a series of carcinoma cell lines, the IC50 fo... |
|
T35775 |
HT-2 Toxin-13C22
|
HT-2 Toxin-13C22 |
|
|
HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene... |
