|
T12920 |
Sirt2-IN-1
|
|
Sirtuin
|
|
Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM). |
|
T62515 |
SIRT2-IN-9
|
|
Sirtuin
|
|
SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used for cancer research. |
|
T16667 |
PROTAC Sirt2 Degrader-1
|
|
Sirtuin
,
PROTACs
|
|
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Si... |
|
T63712 |
Sirt2-IN-5
|
|
|
|
Sirt2-IN-5 is a potent inhibitor of SIRT2. |
|
T74937 |
Sirt2-IN-7
|
|
|
|
Sirt2-IN-7 (compound 22) is a selective SIRT2 inhibitor with an IC50 of 178.2 nM and a Ki of 154.3 nM, utilized in cancer research [1]. |
|
T63102 |
SIRT2-IN-10
|
|
|
|
SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases. |
|
T63417 |
Sirt2-IN-6
|
|
|
|
Sirt2-IN-6 is a potent and selective inhibitor of SIRT2 (IC50: 0.815 μM) and can be used to study cancer. |
|
T73000 |
SIRT2-IN-11
|
|
|
|
SIRT2-IN-11 (AEM1) is a selective inhibitor of SIRT2, demonstrating an inhibitory concentration (IC50) of 18.5 μM. It induces apoptosis in a p53-dependent manner and activates the expression of CDKN1A, PUMA, and NOXA, wh... |
|
T82167 |
HSP70/SIRT2-IN-2
|
|
HSP
|
|
HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1]. |
|
T82168 |
HSP70/SIRT2-IN-1
|
|
Sirtuin
|
|
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesses antitumor activity [1]. |
|
T18641 |
SirReal1-O-propargyl
|
PROTAC Sirt2-binding moiety 1 |
Others
|
|
SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates by binding to the cereblon ligand through a linker, facilita... |
|
T9998 |
MIND4-19
|
|
Sirtuin
|
|
MIND4-19 is an inhibitor of SIRT2 with antitumor activity. |
|
T22026 |
AGK7
|
|
Others
,
Sirtuin
|
|
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3, SIRT1, and SIRT2, respectively). |
|
T6371 |
AGK2
|
|
Apoptosis
,
Sirtuin
|
|
AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor. |
|
T6984 |
SirReal2
|
|
Sirtuin
|
|
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
|
T5490 |
AK-7
|
|
Sirtuin
|
|
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM. |
|
TN7093 |
N-Caffeoyltryptophan
|
trans-Caffeoyl-L-tryptophan |
Sirtuin
|
|
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM). |
|
T3447 |
Thiomyristoyl
|
|
Sirtuin
|
|
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
|
T5096 |
SRT 1720
|
|
Sirtuin
,
Autophagy
|
|
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3. |
|
T5618 |
AK-1
|
|
Sirtuin
|
|
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells. |
|
T5124 |
SRT 1720 dihydrochloride[925434-55-5(free base)]
|
|
Sirtuin
|
|
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM). |
|
T77605 |
WAY-323061
|
|
Sirtuin
|
|
WAY-323061 is a SIRT2 inhibitor. |
|
T8480 |
Tenovin-6 Hydrochloride
|
|
Dehydrogenase
,
Sirtuin
,
HDAC
,
p53
,
Autophagy
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |
|
T28543 |
RK-9123016
|
RK9123016,RK 9123016 |
Sirtuin
|
|
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer ce... |
|
T2412 |
SRT1720 hydrochloride
|
SRT1720 HCl,SRT 1720 Hydrochloride |
Sirtuin
|
|
SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM). |
|
T4328 |
OSS_128167
|
SIRT6-IN-1 |
HBV
,
Sirtuin
|
|
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
|
T3953 |
Salermide
|
|
Apoptosis
,
Sirtuin
|
|
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death. |
|
T1919 |
Tenovin-1
|
Tenovin 1 |
Mdm2
,
Dehydrogenase
,
Sirtuin
,
p53
,
Autophagy
|
|
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. |
|
T4108 |
3-TYP
|
3-(1H-1,2,3-triazol-4-yl) pyridine |
Sirtuin
|
|
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor. |
|
T2105 |
Veliparib dihydrochloride
|
ABT-888 dihydrochloride |
PARP
,
Autophagy
|
|
Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2. |
|
T7058 |
Selisistat S-enantiomer
|
EX-527 S-enantiomer,EX-527 (S-enantiomer) |
Sirtuin
|
|
Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3. |
|
T1818 |
Tenovin-6
|
Tenovin 6 |
Dehydrogenase
,
Sirtuin
,
Autophagy
|
|
Tenovin-6 is a p53 transcriptional activity agonist. |
|
T4019 |
Cambinol
|
SIRT1/2 Inhibitor IV,NSC 112546 |
Apoptosis
,
Phospholipase
,
Sirtuin
|
|
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Ca... |
|
T23592 |
A1B11
|
A-1-B-11,A 1 B 11 |
|
|
A1B11 is a selective SIRT2 inhibitor. |
|
T23593 |
A2B57
|
A 2 B 57,A-2-B-57 |
|
|
A2B57 is a selective SIRT2 inhibitor. |
|
T24790 |
SirReal-1
|
SirReal 1 |
|
|
SirReal-1 is an effective and selective inhibitor of Sirt2. |
|
T24515 |
MZ-242
|
MZ242,MZ 242 |
|
|
MZ-242 is an effective and selective inhibitor of Sirt2. |
|
T6671 |
Sirtinol
|
|
Apoptosis
,
Sirtuin
,
Autophagy
|
|
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM). |
|
T12918 |
SIRT-IN-1
|
|
Sirtuin
|
|
|
|
T26259 |
Tenovin-D3
|
TenovinD3 |
|
|
Tenovin-D3 is a sirtuin SirT2 inhibitor. It acts by increasing p21 (CDKN1A) expression in a p53-independent manner. |
|
T70817 |
NCO-90
|
|
|
|
NCO-90 is a SIRT2 inhibitor. |
|
T62240 |
Sirt1/2-IN-1
|
|
|
|
Sirt1/2-IN-1 (Compound 7) is an inhibitor of SIRT1 and SIRT2 and is capable of acting on SIRT1 (IC50: 1.81 μg/mL), SIRT2 (IC50: 2.10 μg/mL) and SIRT3 (IC50: 20.5 μg/mL) and has α-microtubulin hyperacetylation activity ( ... |
|
T15610 |
JFD00244
|
|
Others
|
|
JFD00244 is an inhibitor of sirtuin 2 (SIRT2). It has an anti-tumor effect. |
|
T81725 |
Mz325
|
|
HDAC
|
|
Mz325 serves as a dual inhibitor of both HDAC and Sirt2, exhibiting an IC50 of 9.7 µM against Sirt2, which are implicated in the pathogenesis of cancer and neurodegenerative diseases [1]. |
|
T60257 |
SIRT-IN-3
|
|
|
|
SIRT-IN-3, a potent inhibitor of SIRT1 with an IC50 value of 17 μM, exhibits approximate 4-fold and 14-fold greater selectivity for SIRT1 over SIRT2 and SIRT3, with respective IC50 values of 74 μM for SIRT2 and 235 μM fo... |
|
T80752 |
YM-08
|
|
Sirtuin
|
|
YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1]. |
|
T24998 |
AC-93253 iodide
|
AC93253 iodide |
|
|
AC-93253 iodide is a selective inhibitor of SIRT2. It significantly enhances the acetylation of tubulin p53 and histone H4. |
|
T72238 |
SRT 1720 dihydrochloride
|
|
|
|
SRT 1720 dihydrochloride is a compound that selectively and effectively activates SIRT1 when taken orally, with an EC50 value of 0.10 μM. It exhibits lower potency towards SIRT2 and SIRT3. |
|
T24158 |
ICL-SIRT078
|
ICLSIRT078,ICL SIRT 078,ICL SIRT078,ICL-SIRT-078 |
|
|
ICL-SIRT078 is a highly selective inhibitor of substrate-competitive SIRT2 that acts by displaying a significant neuroprotective effect in a lactacystin-induced model of Parkinsonian neuronal cell death in the N27 cell l... |
|
T68569 |
Aristoforin
|
|
|
|
Aristoforin is a SIRT1 and SIRT2 inhibitor that induces cell cycle arrest, shows potent antitumor effects, and inhibits lymphangiogenesis in vivo. |
